Articles tagged with Nuclear Factors
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
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Researchers studied jet energy loss in nucleus-nucleus collisions, revealing a decrease in the jet transport coefficient with increasing medium temperature. This discovery provides a more accurate understanding of jet quenching in high-energy collisions.
Researchers found that P2-HNF4α expression is associated with p-STAT3 and c-Myc expression in NAFLD patients, suggesting potential biomarkers for hepatocellular carcinoma (HCC) risk. Additionally, p-STAT3 expression was linked to hypertension, while c-Myc expression was associated with advanced fibrosis.
Researchers at Ural Federal University improved the composition of borate glasses by adding heavy metal oxides, significantly increasing their density. The new glass samples showed good results as radiation shielding material in low and medium energy gamma radiation.
Researchers believe that wind and hydropower are the most promising renewable energy sources in Russia, with suitable areas for installation identified. However, the transition to these energy sources has been slow due to reliance on fossil fuels and nuclear energy.
A new gene delivery system promotes healing in rat models by preventing inflammation and bone degradation after tooth replantation. The study found that teeth treated with the system showed significantly greater dental root thickness and fewer osteoclasts, leading to improved success rates.
A team of researchers has identified a novel splicing mechanism for human short introns, involving the distinct factor SPF45. This discovery sheds light on alternative splicing and its potential applications in cancer treatment.
NRF2 helps keep muscles from weakening in low gravity by regulating oxidative stress. In mice, NRF2 deficiency accelerates fast-twitch fiber type transition and changes energy metabolism during space flight.
A new study suggests that US presidents with high levels of narcissism are more likely to initiate conflicts with other great power countries, accounting for factors such as political party and military experience. The research found that the top three most narcissistic presidents initiated nearly all of their disputes alone.
A study by Prof. Gaku Ichihara's team found that Nrf2 increases the expression of protective genes in response to acrylamide toxicity, reducing neurotoxic effects and inflammation. The research provides valuable insights into the mechanisms of immune response to acrylamide-induced toxicity.
A new analysis by MIT researchers details the underlying issues causing cost overruns on US nuclear power plants, highlighting ways to reimagine engineering strategies to reduce delays and expenses. The study suggests that designing plants with resilience to variable construction conditions can help minimize costs.
A study found that per capita radiation exposure in the US decreased by 20% between 2006 and 2016, mainly due to a decline in nuclear medicine procedures. Meanwhile, CT scans increased but saw a small drop in effective dose thanks to advancements in dose modulation technology.
Researchers from the Chinese Academy of Sciences uncovered the structural and functional mechanism of SigI/RsgI factors, a new class of σ/anti-σ factors responsible for regulating cellulosomes in Clostridia and Bacilli. The study reveals a unique complex structure and critical recognition specificity among different pairs of proteins.
Researchers have created a two-pronged approach to cloning mice by stimulating two epigenetic factors, improving efficiency and uncovering key mechanisms. This breakthrough overcomes significant hurdles in the development of cloned animals.
Scientists at Jefferson Lab measured the pressure distribution inside a proton for the first time, revealing a pressure cooker environment. The results show that quarks are subjected to a high outward-directed pressure near the center of the proton.
Researchers discovered a unique mechanism involving intrinsically disordered polypeptides in nuclear pore complexes that enable rapid recognition and binding of transport factors. This 'fuzzy' interaction allows for specific and speedy cell signaling, preventing DNA data breaches by viruses or faulty functioning.
Researchers at Tokyo Tech have developed a new Langevin model that predicts low-energy fission more accurately by accounting for the deformation of nuclear fragments. The four-dimensional model fits empirical data better than previous models and has potential applications in radioactive waste containment and nuclear power generation.
Researchers used partial cellular reprogramming to reduce signs of aging and extend lifespan in mice with premature aging mutations. The approach altered epigenetic changes, suggesting that aging is a plastic process.
A new spring model simulates atomic-level interactions to predict bentonite clay swelling. The model shows quantitative agreement with experimental measurements, providing insights into the effects of structural and environmental factors on swelling pressure.
Research reveals that FIH-1 nuclear entry is dependent on HIF-1α translocation from the cytoplasm to the nucleus, and is also regulated by the presence of copper. Gene silencing of HIF-1α decreased its nuclear location, while reducing intracellular copper levels suppressed nuclear entry of FIH-1.
Researchers found that soils with rich organic material and low phosphate absorption show low radiocesium interception potential. Soils with high clay or silt content adsorb radiocesium more readily due to higher mica content.
Scientists have measured high-quality factors of up to 5 million in carbon nanotube mechanical resonators, outperforming previous records. This breakthrough enables the development of ultra-sensitive sensors and quantum systems, such as magnetic resonance imaging at the atomic level.
Researchers found that lifespan in fruit flies depended more on interactions among dietary, genetic and mitochondrial factors than on individual factors. This study suggests that looking at complex combinations can lead to a deeper understanding of the aging process.
Researchers confirm existence of Efimov state, a bound state of three particles, at vast distances between particles. The state was previously elusive to prove experimentally.
A recent study published in Neural Regeneration Research found that propofol can inhibit damage caused by proinflammatory cytokines and exert protective effects on the central nervous system. The experimental findings indicate that propofol promotes regeneration following sciatic nerve injury by reducing inflammation and apoptosis.
A team of MIT researchers investigated the factors controlling boiling heat transfer from a surface to a liquid, finding that surface porosity is the most important factor. They developed methodologies for systematically depositing nanoparticles onto surfaces with controlled wettability and porosity, leading to improvements in heat-tra...
The Lancet Series proposes human-security based reforms to maintain Japan's universal health coverage. Local governments must take more responsibility for healthcare resources and funding, while consolidated institutions will improve physician quality and provide opportunities for domestic and global health experts to interact.
Scientists have described a chemical interaction vital to blood clotting in atomic detail, resolving a decades-long mystery. The interaction between a clotting factor and cell membrane was first observed using nanodiscs and advanced modeling techniques.
Researchers block COUP-TFII to suppress tumor blood vessel growth and tumor formation. This discovery identifies a new pathway for fighting tumors and offers hope for developing new treatments, including antagonists that can intervene to halt tumor growth.
Investigators at Burnham Institute for Medical Research identified 295 human cell factors that influenza A strains must harness to infect a cell. The team also found small molecule compounds that act on several of these factors and inhibit viral replication, pointing to new ways to treat flu.
Researchers at Caltech have challenged the long-held theory on fruit-fly development, showing that a key transcription factor's influence is less widespread and varies over time. The study reveals a more complex system where cells respond to changing signals from the transcription factor Dorsal.
Scientists at Goethe University report a paradigm shift in immune response regulation, revealing the crucial role of linear ubiquitin chains in nuclear factor kappa B activation. This finding may lead to structure-based drug design for targeting the NF-κB pathway in diseases such as cancer and inflammation.
The USC-Harvard team identified a protein switch that regulates the immune response, shedding light on the balance between tolerance and aggression in autoimmune diseases. The finding supports the combinatorial control theory of gene expression, with implications for understanding signal transduction and transcriptional networks.
Researchers at Cold Spring Harbor Laboratory have identified shared components in histone and poly(A) pre-mRNA processing. These findings highlight the importance of cross-talk between distinct RNA processing pathways, shedding light on cellular regulation and gene expression.
A case-control study involving 445 men found an association between cumulative cosmic radiation dose and nuclear cataract risk among commercial airline pilots. The odds ratio was 3.02 for pilots compared with nonpilots, indicating a potential causative factor in nuclear cataracts.