Articles tagged with Research Impact
Researchers at MedUni Vienna's Department of Thoracic Surgery have made key findings in small-cell lung cancer, including the identification of tumor subgroups associated with varying clinical behaviors. They also propose promising therapeutic strategies for patients with characteristic molecular profiles.
Research from Cornell University estimates that wildfire smoke can cause between 4,000 and 9,000 premature deaths and cost between $36 to $82 billion per year in the United States. Metropolitan regions near fire sources are likely to experience a large health burden and economic loss.
Researchers at UBC develop biodegradable gel that mimics articular cartilage properties, allowing for faster and more efficient cartilage regeneration. The gel's ability to resist compression and recover its shape after compression makes it a promising material for joint injury repair.
Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.
A randomized phase II study found that adding metformin to androgen deprivation therapy did not reduce the risk of metabolic syndrome or improve PSA response in patients with advanced prostate cancer. Metformin showed some antitumor effects through mTOR inhibition, but these were not significant.
A new analysis found that expanding Medicaid eligibility to more people improved patient outcomes, prevention measures, and screening access. The study suggests that increasing health insurance coverage results in better health outcomes for those with heart disease.
Researchers found female babies with CDH have a 32% higher risk of dying within 30 to 60 days of birth compared to males. The study, using medical records from an international registry, suggests that lower birth weights for females may be linked to the disparity in survival rates.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
A 37-year study in Finland found that evening types have a slightly increased risk of dying compared to morning types, primarily linked to smoking and drinking habits. The study tracked nearly 23,000 twins and found that lifestyle factors, such as alcohol consumption and smoking status, play a significant role in mortality rates.
A study by Swansea University found that teaching mental health literacy in schools significantly improves pupils' knowledge, behaviours, and intentions to seek help. The Guide Cymru programme, developed with Action for Children, demonstrates a positive impact on young people's wellbeing.
Generative AI raises fundamental questions about the creative process and human's role in it. Researchers highlight gaps in understanding perceptions of AI-generated content, ownership, credit, labor economics, and media ecosystem impact.
High-energy electrons pose significant radiation damage to satellites; a new study sets benchmark levels for extreme space weather events. Satellite operators must prepare against these risks as the global space economy relies on over 5,465 operational satellites.
A new study predicts Arctic sea ice will vanish by the 2030s if greenhouse gas emissions continue unchecked. The research, published in Nature Communications, analyzes 41 years of data and confirms human activities as the primary cause of Arctic sea ice decline.
Researchers are investigating methods to extract critical materials, including lithium for electric vehicle batteries and magnets for electric motors, from diverse water streams. By accelerating evaporation through porous photothermal materials, they aim to reduce energy intensity and improve supply chain security.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
UCF researcher Dr. Justine Tigno-Aranjuez has discovered a new receptor that recognizes house dust mite allergens, opening up potential for broad-spectrum therapy. The finding could lead to improved treatments for common allergies, including asthma.
Researchers found that psychedelic drugs such as LSD, psilocybin, and MDMA reopen critical periods in mice, enabling them to learn from their social environment. The length of time the critical period stayed open varied among drugs, with some lasting up to four weeks.
A study by Chinese researchers found that financial reports produced during fiscal years mismatched with annual business activity may be less reliable due to rigid accounting regulations. This can result in higher abnormal accruals, lower analyst forecast accuracy, and longer audit reporting delays for affected companies.
A study of 142 nations found a strong link between access to formal financial services and lower COVID-19 mortality rates. Access to bank accounts, credit cards, or loans from a financial institution is a key predictor of lower mortality risk, even stronger than comorbidities.
VIRTUOSO, developed by Dr. Hyunkook Lee from the University of Huddersfield's Applied Psychoacoustics Lab, enables immersive 3D audio without loudspeakers through binaural technology powered by ASPEN. This technology simulates the ambience and reflections found in a room with headphones, allowing for accurate translation to real speakers.
The ASHP Summer Meeting presented research on clinical pharmacists' impact on type 2 diabetes treatment intensification with GLP-1 receptor agonists. A study found 85% of patients received care from clinical pharmacists had their medication titrated to the first effective dose, compared to 12.5% without pharmacist involvement.
The researcher will develop an integrated framework to estimate degradation at the component level, enhance health prediction techniques, and design coordinated circuits with embedded systems. His work aims to inspire and educate the next generation of innovators in power electronics.
Researchers have identified LP-284 as a novel acylfulvene compound with anti-tumor activity against non-Hodgkin's lymphoma. The compound exerts nanomolar potency in 15 NHL cell lines and prolongs survival of mantle cell lymphoma xenograft mice, making it a potential therapeutic option for patients with HR or TC-NER deficiency.
Researchers at the University of Sheffield found that gentle cleansers can be just as effective in killing viruses as harsh soaps. The study tested multiple handwash products and found that gentle cleansers were effective against enveloped viruses, while non-enveloped viruses showed greater resistance. Gentle cleansers may provide a sa...
A retrospective analysis of national data found that over 20 million Americans experienced loss of smell or taste after COVID infection, with a large portion never fully recovering these senses. The study estimated that almost 28 million Americans may be left with decreased sense of smell after COVID infection.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
A University of Massachusetts Amherst researcher has updated the Pregnancy Physical Activity Questionnaire (PPAQ), a widely used tool for measuring prenatal physical activity. The new PPAQ is considered reliable and valid, providing estimates of physical activity and sedentary behavior in pregnant women.
Researchers from UTEP School of Pharmacy are exploring a new treatment for vascular dementia using the NIH grant to study the biological triggers behind the condition and test the effectiveness of candidate drug ZT-1a. The treatment aims to prevent cognitive impairments in dementia patients.
A new study from the Stowers Institute for Medical Research reveals the placenta's polyploid cells play a vital role in supporting healthy embryonic development. The modified cell cycle controlling polyploidy is governed by the regulatory gene Myc, which supports DNA replication and prevents premature cellular aging.
The Tufts Clinical and Translational Science Institute has received a $78.4 million NIH grant to accelerate the translation of laboratory and medical research into clinical use. The grant will support efforts to improve health and increase health equity, with a focus on addressing health disparities.
A new hub for plant and microbial science will be built in Norwich, UK, with £317.7 million investment from the UKRI Infrastructure Fund. The facility aims to deliver sustainable food solutions, improve human health, and reduce climate change impact.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
A new observational study published in BMJ Open found that long Covid can have a devastating effect on daily lives, with fatigue impacting social activities, work, and relationships. The study's findings suggest that long Covid can leave people with worse fatigue and quality of life than some cancers.
A study published in JMIR Formative Research found that wearable sleep devices show promise in positively impacting sleep health among marginalized populations. Participants perceived the device as easy to use and comfortable to wear, suggesting its potential for improved sleep health. However, barriers to adoption, such as housing sta...
A comprehensive analysis of 15 years of worldwide research into SDGs finds significant gaps in funding, collaboration and assessment between developed and developing countries. The authors call for equity and greater recognition for developing nations' contributions to addressing global challenges.
LSU Health New Orleans researchers found that a combination therapy using Neuroprotectin D1 and Resolvin D1 boosted brain cell survival, growth, and stability. The therapy showed promising results in reducing lesion volume and improving neurological function in acute ischemic stroke models.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
Researchers confirm increased protein marker of inflammation in long COVID patients' brains, impacting depression and cognitive symptoms. CAMH study provides hope for new treatments using anti-inflammatory medications.
The initiative aims to improve data collection methods on researchers' racial and ethnic dimensions. It seeks to overcome obstacles, including sensitive data that may be leaked, to promote structural changes and impact in the research ecosystem.
The Global Research Council has ratified a charter of principles to promote equitable and diverse research practices. The document aims to establish common standards for assessing the quality of science produced, facilitating international collaborations and recognizing the value of different research activities.
Researchers found two antimicrobial agents that are more effective in treating the disease-causing agent Treponema pallidum in a laboratory setting. The discovery opens new doors in understanding the disease and finding ways to prevent infection and intervene.
A new study published in the Journal of the American Heart Association found that elevated levels of two protein biomarkers associated with heart damage were linked to undetected or symptomless cardiovascular disease in adults with Type 2 diabetes. The study analyzed health information and blood samples from over 10,300 adults and foun...
Researchers found that MALAT1 inhibition decreased BRAF RNA and protein levels, while increasing correlation with MAPK-associated genes. MALAT1-ASO treatment also reduced melanoma cell growth and tumor size in xenograft models.
Alternative gene splicing has been linked to an increased risk of alcohol use disorder (AUD), according to a recent study published in Molecular Psychiatry. The researchers identified 27 exon skipping events that may contribute to AUD risk, opening up new possibilities for finding new therapeutics.
Two researchers will receive $1 million each for their five-year studies on new medication-based approaches to repair damaged aortas, as well as the effects of exercise on healing heart muscle and brain tissue after a heart attack or stroke. The American Heart Association's Merit Award supports innovative research with high impact.
A new study published by LSU Health New Orleans found that a diet high in fruits, dark-green vegetables, and beans can significantly lower the risk of genital high-risk-HPV infection, which is associated with cervical cancer. The research also showed that women who eat healthily tend to practice other healthy behaviors.
Researchers can reduce stigma in scientific literature by implementing practices such as referencing language guides, updating terminology, and connecting with the community. This change is crucial for promoting non-stigmatizing language and respecting preferred terms used by individuals living with HIV.
A multicenter study found that deep learning-based computer-aided diagnosis significantly improved radiologists' diagnostic performance for breast lesion classification on ultrasound. The use of CAD resulted in a 6.0% upgrade of BI-RADS category 3 assessments to category 4A, with 16.7% being malignant.
A new identification tool called IDphy has been developed to accurately identify Phytophthora species, which cause significant economic and environmental losses. The tool uses data from ex-type cultures and includes features such as an interactive key, factsheets, and a mobile app.
A study by McGill University found that microplastic pollution alters the gut microbiomes of seabirds, increasing pathogens and antibiotic-resistant microbes. The research warns humans to be wary of microplastics in their environment and food, as they can also impact human health.
Research published in Children and Youth Services Review found that approximately two-thirds (63%) of adult survivors of childhood physical abuse are in complete mental health. Barriers to achieving this include a lack of social support, chronic pain, and a history of mental illness like depression or substance use disorders.
A new study calls on organizations to adopt a 'dialectic of zest' tool to destigmatize menopause and encourage women's liberation in the workplace. The research highlights the need for a holistic approach to organizational care, considering both objective and ambitious concerns of women experiencing menopause.
A comprehensive review of consumer research journals reveals growth in non-marketing journals focusing on consumer research, particularly since 2019. Emerging topics such as food waste, technology, and sustainability reflect contemporary issues pertinent to consumers.
A Texas A&M team is studying the impact of cryptocurrency mining on the state's power grid, revealing a potential for demand flexibility during times of peak energy usage. The research suggests that when the grid is stressed due to heatwaves or other factors, cryptocurrency miners can shut down, providing a buffer against strain.
New research highlights the benefits of family-based care for children exposed to early psychosocial deprivation, improving cognitive function, emotional well-being, and social development. The study found that high-quality foster care had a lasting impact on children's brain development and risk of psychopathology.
Current measures to protect grasslands in the Qinghai-Tibetan Plateau are damaging the ecosystem and should be stopped. Small burrowing mammals, like the plateau pika and zokor, play crucial ecological roles in maintaining ecosystem health and biodiversity.
A recent study published in Current Biology found that humidity plays a crucial role in attracting pollinators to plants, alongside scent. The researchers discovered that the weevil responsible for pollinating Zamia furfuracea was equally sensitive to humidity as to scent.
Researchers discovered that FDA-approved HDAC-inhibitors can impact energy metabolism in solid tumor cells, including glioblastoma. The combination of HDAC-inhibitors and imipridones may synergize to enhance killing of GBM cells by reversing cellular respiration.
A new study reveals that Surgical Site Infection (SSI) is a major financial burden on health services in LMICs, with patients experiencing higher costs for postoperative care. Investing in health technologies to reduce SSI could help improve healthcare quality and save lives.