Scientists found that both drugs stimulate release of glutamate, triggering brain cell activity to control mood swings in bipolar disorder. This additive effect may explain the clinical observation that using two drugs together produces better results.
Preeclampsia occurs when cytotrophoblasts fail to invade the uterine wall and mimic blood vessel cells, leading to high blood pressure and potential complications. Early detection through testing could save lives and prevent birth defects.
A new DNA vaccine has shown promising results in protecting chimpanzees from HIV-1 infection, with two immunized animals demonstrating a strong immune response and one controlled animal showing signs of infection before recovery. The vaccine's genetic approach may lead to breakthroughs in human disease treatment.
Researchers developed a genetically-engineered protein biosensor that can identify the presence of maltose, a sugar compound, in blood. The biosensor uses a fluorophore reporter to signal its catch, providing instant analysis for various applications.
Duke University Medical Center is testing a new laser system to pierce blood-carrying channels in ailing heart muscle, showing promising results for eight treated patients. The procedure, known as transmyocardial revascularization (TMR), creates new passageways that increase oxygenation and functional heart muscle.
A new UNC-CH study reveals North Carolina's Health Maintenance Organization (HMO) consumer protection is lacking, with the state receiving only 'C-minuses' for its report card. The study highlights the need for enhanced accessibility, understandable written materials, and improved due process requirements.
A study from Rockefeller University found that a specific altered gene, COMT, may increase the risk of OCD in men. The researchers discovered that this gene affects the production of dopamine and norepinephrine, leading to a biochemical imbalance that contributes to the development of OCD.
Research at Cornell University found that children in noisy schools near airports perform worse in reading skills compared to those in quiet areas. The study suggests that kids tune out speech amidst constant background noise, making it difficult for them to acquire speech recognition skills.
Researchers at ORNL are developing medical telesensors to measure vital signs such as body temperature, blood pressure, and pulse rate in combat zones. The sensors will transmit data wirelessly to remote receivers, enabling medics to quickly identify wounded soldiers and prioritize treatment.
The USGS is tracking the northward movement of the Red River floodwaters, taking measurements to improve forecasts for evacuations upstream. Crucial to understanding the impact on upstream communities will be how much water is contributed by the Pembina River.
A new vaccine targeting the E. coli adhesin protein has shown promise in preventing urinary tract infections and bladder infections in mice. The vaccine works by blocking attachment of bacteria to bladder cells, preventing infection and reducing bacterial load.
A recent study found that African-American men are four times more likely to develop end-stage renal disease than white men, with high blood pressure and lower income contributing to the increased risk. The study analyzed data from over 332,000 men aged 35-57 and found that interventions addressing ethnic disparities in blood pressure ...
Researchers have identified a key protein in the telomerase enzyme that is selectively activated in many cancer cells. The discovery may lead to the development of new anti-cancer agents, including variants of existing pharmaceuticals.
A study led by Jackson Laboratory researcher Susan L. Ackerman identified a protein critical for brain development in mice, which may be linked to human disorders such as epilepsy and severe mental retardation. The research found that mutations in the rcm gene disrupt neuronal migration during brain development.
Researchers have discovered that GM-CSF, a cytokine produced by melanoma tumors, can stimulate the immune system to attack and eliminate tumor cells. Delivering GM-CSF directly to tumors may lead to effective treatment of advanced melanoma cases.
Mohs surgery has shown promise in preventing melanoma recurrence, particularly in patients with lentigo-maligna tumors. The technique's precision and ability to check surgical margins may provide a better chance of getting rid of tumors and preventing recurrences while conserving tissue.
Researchers found significant brain tissue loss in individuals with bipolar and unipolar depression, which may help understand the causes of mood disorders. The study's findings provide new information for developing more effective treatments.
Sarcoidosis is a mysterious disease affecting 30 people per 100,000 in the US, characterized by granulomas and inflammation. New research suggests shared environmental exposure may lead to the disease, which often affects young adults and has no cure.
Researchers from Northwestern University demonstrate a robot called Scooter that is programmed to refuse to go past a virtual surface. This innovation is part of a new class of collaborative robots called cobots, which are designed to work with humans safely and efficiently.
The current floods in North Dakota have broken multiple records, including a 100-year-old record of 85,000 cubic feet per second. The Red River's predicted crest is expected to reach 54 feet, posing significant threats to emergency managers and evacuation orders.
A group of genes has been discovered that makes wild tomatoes resistant to wilt disease, allowing breeders to speed up the development of new disease-resistant varieties. The findings also enable the design of genetically engineered crops with optimal resistance properties.
Researchers found a significant delay in disease progression with selegiline and Vitamin E treatment, particularly among those with moderately severe disease. The drugs showed promise in reducing symptoms, but further studies are needed to confirm their effectiveness.
The Smart Start program has seen significant improvements in child care quality, with a 7% increase in evaluation scores and 11% more centers meeting good standards. The study found that child care quality is related to Smart Start efforts and that the level of quality is improving over time.
Researchers found that rush immunotherapy targeting a single allergen makes distinct changes in T cells and prevents allergic reactions. The study showed that T cells produce more interferon gamma, an element that lowers allergic responses, and shut off production of pro-allergic cytokines.
Researchers have found evidence of a 'missing' form of ordinary matter, known as baryonic matter, that was thought to be needed to form the cosmos billions of years ago. The findings suggest that this matter was spread throughout intergalactic space in a diffuse gas of hydrogen and helium atoms.
A team of astrophysicists discovered fewer low-energy photons in the universe than previously thought, suggesting that high-energy gamma rays may not be interacting with as many low-energy photons as expected. This observation could alter current theories of the history of the universe and galaxy formation.
Engineer Max Lagally and colleagues create tiny pyramids assembled from several thousand germanium atoms, perfectly shaped and uniform across the surface. The pyramid crystals can hold a single charge and represent some of the smallest materials structures ever created.
Evidence suggests that neutrinos have mass and change flavors, altering our understanding of the elusive particles. Super-Kamiokande laboratory is tracking millions of particle reactions daily to gather data, which may confirm or rule out these theories.
A University of Washington study found that patients of certified nurse-midwives used 12% fewer resources than those of physicians, with lower rates of continuous fetal monitoring and epidural anesthesia. Midwives also delivered babies with a lower Caesarean-section rate compared to obstetricians.
Researchers at Oak Ridge National Laboratory have developed 'Critters On A Chip,' a living sensor integrated circuit that detects pollutants and explosives. The bioluminescent bacteria emit a visible signal when exposed to targeted substances.
Researchers find that the unique island brogue is losing traditional features such as distinct vowel sounds and words like 'pizer' for 'porch.' The dialect's survival largely depends on the island's former isolation from the mainland. Despite its decline, linguists emphasize the importance of preserving languages and cultures.
Stanford researchers have successfully used native bacteria to reduce TCE levels in groundwater by 96-98% through in situ bioremediation. This method conserves water and reduces pumping costs, but requires hydrogen peroxide as a catalyst.
The NIH team identified the MEN1 gene, a tumor suppressor gene that inhibits abnormal cell growth. This discovery enables easier screening for families at risk of MEN1 and provides a target for designing drugs to prevent or treat endocrine tumors.
Researchers found an unexpected orientation in space, measured through light polarization from distant galaxies. The 'corkscrew effect' indicates a universal axis that orients the universe.
A University of North Carolina study found that most NC police officers think the state law restricting tobacco sales to adults only should be changed due to its ineffectiveness in preventing youth access. Only a small percentage of officers try to enforce the law, citing barriers such as lack of manpower and poorly written legislation.
Researchers at Georgia Institute of Technology have isolated massive gold-cluster molecules with exceptional quantum properties. The gold cluster materials can be used in single-electronics and exhibit charge-quantization effects, offering a breakthrough for nanoelectronic applications.
Researchers from Emory University and CDC report high rates of microbial resistance to antibiotics in intensive care unit (ICU) hospital settings. The study found that pathogens isolated from ICUs were most resistant to treatment, while those from outpatients were least resistant.
Researchers have developed microporous ceramic materials that can remove extremely fine particles from indoor air and water. These materials offer a durable, inexpensive, and environmentally friendly alternative to conventional technologies, such as incineration.
A Duke University study found that short, vigorous workouts can temporarily reduce symptoms of depression by up to 82% in participants over 50. The results also showed an increase in feelings of vigor after the test.
A recent study published in The New England Journal of Medicine found that a diet rich in fruits, vegetables, and low-fat dairy products can significantly lower blood pressure. Among participants with high-normal or stage 1-mild hypertension, the DASH combination diet reduced systolic and diastolic blood pressure by an average of 3.5 m...
University at Buffalo chemists have developed a new method to generate coatings for electronic devices, eliminating toxic precursors and enabling the creation of unique materials with photonics applications. The technique uses high temperatures and quenching to produce uniform films without fail.
Patients prefer bedside discussions by physicians and medical students over conference room presentations, finding them more comfortable and attended to. More educated patients were more likely to understand their treatment plans and express satisfaction with care.
A new experimental vaccine has been developed to block viral entry in cattle, which may have implications for the development of vaccines against human herpes viruses. The vaccine stimulates the animal's immune system to make antibodies that line the nasal passages and block the virus from entering the animal.
Hepatitis A virus is the most severe foodborne viral disease, causing liver damage and debility. Viruses are transmitted through direct or indirect contamination of foods with human feces, highlighting the importance of good hygiene practices in preventing transmission.
Researchers infected mouse melanocytes with a retrovirus and observed transformed cells behaving like melanoma cells. The study aims to understand the molecular mechanisms underlying melanoma in people by identifying cellular genes disturbed by the virus.
Researchers develop tiny coated beads that can release drugs directly onto tumors in response to chemical signals. The beads are designed to remain intact until exposed to sodium-rich blood plasma, at which point they swell and burst explosively, releasing the entrapped drug. This technology has potential for targeted cancer treatment.
Researchers have developed a two-part seismic device that can detect ground vibrations given off by an approaching tornado, allowing users to seek shelter. The 'sensor' portion of the device is designed to be affordable for everyone and can provide up to five minutes warning before a tornado strikes.
The Isle Royale moose population has declined significantly, with only about 500 remaining after a devastating winter. This decline is attributed to the island's moose being severely stressed from lack of food and deep snows, with an abundance of balsam fir browse providing limited sustenance.
A graduate student at Purdue University has developed a gel-like material that expands and contracts in response to changes in acidity, mimicking the natural response of the body. The gel could be used as a 'molecular gate' to deliver insulin in real-time, responding to glucose levels.
A study by Technion Researchers found that licorice extract delays LDL oxidation, reducing cholesterol build-up in arteries. Glabridin, a compound in the licorice root, traps free radicals causing oxidation and increases blood's resistance to it.
Newborn ferrets' brains develop visual abilities through internal patterns of electrical activity before birth, suggesting an interaction between nature and nurture in brain development. The study found that stimulating the optic nerves disrupted this process, leading to altered neural responses.
A new cockpit display system being developed at Michigan Technological University aims to alert pilots of nearby aircraft and reduce mid-air collisions. The system uses passive radar and GPS squitter signals to provide real-time traffic information, greatly improving flight safety.
Researchers have developed a new polymer-based LED that can change color with ease, making it suitable for flat-panel computer and television screens. The device outshines traditional materials in terms of brightness and efficiency, offering potential power savings in traffic lights.
Researchers at the University of Washington have discovered a potential new target for therapeutic drugs to treat hepatitis C. The study found that a protein called NS5A can bind to and inactivate a key component of interferon response, PKR. This could lead to the development of a new treatment for the disease.
Eukarion's antibody lipidation technology successfully blocks HIV-1 viral replication in human lymphocytic cells by targeting the Tat protein. The modified anti-Tat antibody is effective against laboratory and patient-strain viruses, offering new potential for cell-specific AIDS immunotherapies.
Research sheds light on climate change by showing fish in Antarctica and Arctic independently evolved similar antifreeze glycoproteins, linked to environmental adaptation. The genes arose around 5-14 million years ago, providing new evidence for the Southern Ocean's freezing timeline.
Protein binding events control many biological processes; removing water from binding sites provides energy that drives reactions. Duke researchers used a supersensitive instrument to measure minute temperature changes in normal and heavy water to separate protein-water interactions from ligand-water interactions.
Researchers discovered a way to disrupt the aggregation of proteins that form poisonous plaque deposits in Alzheimer's patients. By synthesizing specific inhibitor molecules, they successfully blocked the toxicity of beta amyloid proteins, potentially leading to new treatments for the devastating disease.
Researchers at the University of Pittsburgh Cancer Institute have found that vitamin D significantly reduces prostate cancer growth in rats. Tumors in treated rats were 88% smaller than those in control rats, and lung metastases were also reduced.
Researchers at the University of Delaware have developed a new theory on how chemical additives alter the growth rate of silicon and silicon-germanium alloys. By understanding this mechanism, they hope to improve the control of electronic properties in films grown from chemical vapors at low temperatures.