Researchers found that the abnormally active Bcl10 gene drives B cells to become cancerous, suggesting a drug blocking the gene could be effective treatment for MALT lymphoma. The study also showed that mice lacking Bcl10 genes cannot launch an effective antibody response against bacteria.
A collaboration between IFF and NIST uses slowed-down neutrons to measure fragrance and carrier molecule structures. This information can guide efforts to enhance models for formulating carriers that are optimized for specific fragrances and products.
The Army has established an Institute for Collaborative Biotechnologies (ICB) with funding of up to $50 million. The ICB aims to develop new biotechnologies that improve the effectiveness of the Army's mission by leveraging investments in biotechnology research.
Researchers found that structured treatment interruption in people with multidrug-resistant HIV led to more HIV-related complications and poorer immune response. The study suggests that continuing therapy guided by HIV drug resistance testing is a better approach for this group of HIV-infected individuals.
A University of Washington scholar argues that massive wealth disparity has severely weakened US democracy, fueling the power of corporate money in politics. This trend traces back to President Reagan's policy philosophy, which continues to shape national politics.
Researchers found that Prochlorococcus cyanobacteria traps atmospheric carbon dioxide and stores it in the deep sea through photosynthesis. The study reveals iron's critical role in this process, which could help combat global warming by increasing ocean levels of iron.
Dr. Beth Montemurro's study finds bachelorette parties reflect women's growing acceptance of their sexuality and desire for independence. The rise of bachelorette parties is linked to the sexual revolution and changing attitudes toward women's rights and freedoms.
Researchers are exploring ways to combat the devastating impact of the Asian woody adelgid on western North Carolina's hemlock forests. CAMCORE, a global forest conservation program, is working with natural predators and developing resistant tree varieties to preserve genetic diversity.
A mystery illness in western Montana was solved by researchers identifying the cause as Borrelia hermsii, a spiral-shaped bacterium. The disease is curable with antibiotics and can cause recurrent febrile illnesses, highlighting the potential for emerging diseases in previously unrecognised areas.
PNNL's new supercomputer is the US' fastest operational unclassified system, featuring an 11.8T HP Integrity system with Intel Itanium2 processors running Linux. The machine will enable novel studies in atmospheric chemistry, systems biology, and materials science.
Researchers found an 84% reduction in preterm births among pregnant women with periodontitis who received scaling and root planing therapy. The study suggests that periodontal disease may increase the risk of premature delivery, highlighting the importance of regular dental exams for pregnant women.
Scientists, led by Bartel, develop RNA enzymes in lab that can replicate and act as enzymes, but still short of the 200-nucleotide goal. The RNA-world hypothesis proposes RNA played both DNA and protein roles in early evolution, with researchers re-creating this system to study its feasibility.
A study of children with Medicaid insurance found that they received antibiotics for only 41% of the year, despite being at risk for nearly 60% of the time. The lack of antibiotic use puts these children at high risk of developing serious infections and sometimes dying.
Researchers found that coronary artery calcium scoring can predict death with high accuracy, especially in individuals with high scores. The study contributes to the debate on using calcium screening to detect latent atherosclerosis and its link to heart disease.
Researchers suggest that heightening immune response against human proteins in viral envelope could prevent HIV infection, offering a potential solution for reducing transmission rates. This approach, called alloimmunization, has the advantage of working against all strains of HIV and other retroviruses.
A recent JAMA article highlights that less than half of patients with atrial fibrillation are receiving warfarin therapy to reduce their risk of ischemic stroke. The scoring system developed by Thomas J. Wang and colleagues can easily stratify patients at high or low risk for stroke, enabling targeted treatment and counseling.
The University of California, Los Angeles (UCLA) has received a significant National Science Foundation (NSF) award for its plasma research, enabling the development of new computational infrastructure and innovation. The NSF funding will support key areas of research, including fusion energy, astrophysics, and space weather.
Victoria Hale, founder of Institute for OneWorld Health, recognized by the Schwab Foundation for her innovative approach to pharmaceutical development, providing life-saving medicines to those in need. The Institute's entrepreneurial model combines pharmaceutical expertise with a social mission to address global health disparities.
Contrast digital mammography has been shown to accurately identify cancers in patients with suspicious abnormalities, reducing false positives and unnecessary biopsies. The new technique uses intravenous iodine contrast to enhance blood vessels created by tumors, improving detection in dense breast tissue.
The NWO/Spinoza prize is awarded to Dutch researchers who rank among the world's top scientists. Four winners were recognized for their outstanding contributions in economics, history, and physics.
A new study links workplace exposure to chronic obstructive pulmonary disease (COPD), affecting three to five million people in the US. The research suggests that controlling hazardous exposures can play a significant role in reducing COPD cases.
Researchers found that amphetamine and cocaine exposure blocked environmental-induced structural changes in the nucleus accumbens and parietal cortex. Exposure to complex environments increased dendritic branching and spine density in these areas, but was hindered by prior drug exposure.
A recent study of 118 heart patients found that while they made significant progress reducing fat intake, many failed to adopt a diet rich in fruits and vegetables. After two years, only 23% were meeting the recommended daily intake, highlighting the need for targeted nutrition education.
The UGA team will expand on their glancing angle deposition technique to fabricate nanoscale 3-D pillars, providing unique features for biosensing applications. The project aims to solve pressing health-related problems through interdisciplinary research and cooperation.
The American Chemical Society is honoring a high school chemistry teacher for his exceptional mentoring skills and commitment to the ACS Scholars Program. The program has provided scholarships to 28 students from Puerto Rico who took Mr. Fonseca's chemistry class, with some going on to win national awards.
David Anderson receives Rumelhart Prize for 30 years of research on human thought processes and learning, leading to effective computer-based tutoring systems. His work explores the neural basis of cognition, contributing to our understanding of the human mind.
Researchers are developing an automated search and retrieval process for drug names to minimize medication errors caused by soundalike words. The software will use intelligibility and perceptual neighborhood measurements to predict confusability scores.
A recent study identified 35 genes that may be linked to prognosis in pediatric acute myeloid leukemia (AML), providing new insights into the disease. These unexpected genes were found independently of current classification methods and separated patients into high- and low-risk groups.
Research suggests that planets with high tilt angles may be habitable if they have suitable geography, such as large oceans or continents near the equator. While extreme temperatures would make it difficult for simple life forms to survive, advanced water-dependent life could thrive in these environments.
A new nomogram model predicts prostate cancer likelihood in men with PSA levels below 10 ng/ml, helping to reduce unnecessary biopsies. The model identifies four independent risk factors for positive biopsy results and provides a score to calculate the likelihood of cancer presence.
Researchers at UCSD create tiny silicon chips, 'smart dust,' that can detect chemical or biological compounds and report information to the outside world. The dual-sided particles can collect at a target and self-assemble into a larger reflector for remote sensing applications.
Researchers found that infants as young as four months old learn object concepts through visual observation, not manual exploration. The study used eye-tracking experiments to show that babies quickly grasp fundamental concepts by watching objects in motion.
Researchers developed a novel computer protein design method that created a more efficient and stable version of the peptide Compstatin, which prevents autoimmune-mediated damage. The new method cut down on trial and error, allowing for faster development of potential biopharmaceuticals.
Research shows a shift toward 'medicalization' of deviation from women's traditional roles, while men's depressive illness is increasingly described in terms connoting work and aggression. The study highlights the importance of accurate media representation in influencing patient-doctor communication about mental health concerns.
A study found that 63% of patients with intractable epilepsy who underwent surgery remained seizure-free for over eight years. The duration of epilepsy before surgery was a significant factor in predicting seizure freedom, with patients having longer episodes more likely to remain free from seizures.
Researchers found that Indomethacin keeps phosphate levels normalized without causing life-threatening complications, offering a potential treatment alternative to conventional therapies for X-linked hypophosphatemia.
Donepezil has been shown to improve cognitive function in vascular dementia patients, while a study found that brain volume loss can predict Alzheimer's disease. However, a clinical trial of topiramate in ALS patients found no benefits and an increased risk of adverse events.
A Canadian study found that appreciation and emotional reactiveness to humor doesn't change with age. However, the ability to comprehend more complex forms of humor diminishes in later years due to decreased cognitive abilities. Older adults still enjoy a good laugh but struggle with understanding nuanced humor.
Biologists at Rice University are investigating the genetic and environmental factors behind Chinese tallow trees' success in Texas. The research aims to understand how the trees' low defenses against insects contribute to their rapid growth and success as an invasive species.
Researchers at the Mayo Clinic have identified a key finding about how donor kidneys adapt to new bodies. By analyzing gene expression patterns, the study found that donor kidneys can develop protective processes that shield them from the recipient's immune system, potentially reducing rejection rates and improving transplant outcomes.
A study published in the Journal of Clinical Psychiatry found that divalproex improved mood and behavioral disorders in over 78% of at-risk children. The medication may delay or prevent the onset of bipolar disorder, offering an alternative treatment option.
A WSU ecologist's research shows that induction of plant resistance to pathogens can also make plants more susceptible to certain insects. Salicylate, a natural plant chemical, plays a key role in this phenomenon.
Researchers discovered that visually impaired individuals like Michael May struggle with object and face recognition due to delayed development of these processes. Despite challenges, May has made progress in interpreting motion and shading cues, adapting to his new visual world.
A group of polyphenols found in red wine and vegetables have been shown to activate sirtuins, enzymes that help cells survive environmental stresses and may promote longevity. These molecules, called STACs, were found to stimulate human sirtuin SIRT1, increasing cell survival rates.
Young adults who experienced major depressive disorder during adolescence showed pervasive impairments by mid-20s. They struggled with work performance, social difficulties, and low physical well-being. The study emphasizes the importance of preventing depression in adolescence through effective interventions.
A new study found that managers who supervise predominantly female teams receive lower pay, while those who work with mostly male teams earn more. The study also discovered that younger and older workers are perceived as less valuable, resulting in lower compensation for managers supervising these age groups.
A study found that diuretic amiloride improved cerebral blood flow in cocaine-dependent subjects, reversing cognitive impairments and depressive symptoms. The medication's ability to dilate arteries in the brain may be responsible for this improvement.
Multifocal lenses offer improved unaided near vision, but also reduce contrast sensitivity. The study found that only 26-47% of patients with multifocal lenses were spectacle-free, compared to 1-11% with monofocal lenses.
A University of Michigan study reveals that working overtime is driven by a desire to improve social status and cultivate a sense of belonging, rather than just financial gain. The research found that blue-collar workers who work overtime are motivated by the desire to consume luxury items and keep up with their white-collar counterparts.
Silverman's research focuses on inhibiting an enzyme that produces nitric oxide, a compound linked to high blood pressure, stroke, and neurological diseases. His work aims to block the overproduction of nitric oxide in the brain without affecting its normal function.
Kende has won the Arthur C. Cope Scholar Award for his work on rearrangement reactions, including discovering how dioxins relate to their toxic effects. He also recreated autoinducers, chemical signals that activate bacteria's growth or attack on the body.
A New York chemist has made groundbreaking discoveries in synthesizing molecules, including pharmaceuticals, using a novel approach. His research reveals the importance of controlling the 'handedness' of compounds and introduces new reactions using pseudoephedrine.
Chicago chemist Milan Mrksich has won a national award for his research on how cells communicate with the matrix proteins that anchor them to surfaces. His approach involves dissecting the complex system and creating simple mimics of the matrix to study in controlled experiments.
Researchers Robert Young, Robert J. Zamboni and Marc Labelle recognized for developing commercial products that improve children's health and wellness with Singulair asthma treatment.
A meta-analysis of nine community-based studies found that health workers can effectively manage pneumonia in the community, leading to a significant reduction in child mortality. The intervention resulted in a 24-36% decrease in total and pneumonia-specific child mortality rates, with a notable impact on neonates.
Researchers studied two binary star systems, predicting regular flare cycles similar to the Sun's magnetic cycle. The team used continuous monitoring of radio waves to discover patterns in flare strength, indicating active and inactive cycles every 50-120 days.
A renowned chemist has won a prestigious award for his groundbreaking work on creating molecules found in nature, including lapidilectine B. He developed a new method to build nitrogen ring structures and successfully recreated the molecule step-by-step in the laboratory.
A study suggests that women are more likely to turn to their GPs than the internet when seeking information about HRT. Despite increased access to health information online, many women lack 'information literacy' and struggle to navigate online resources.
Teams from Abbott, Merck, Pfizer, and Wyeth Pharmaceuticals have developed commercial products based on chemistry to improve children's health and wellness. These products include Kaletra, Singulair, Neurontin, and Prevnar, which have advanced the health and well-being of children worldwide.
Purdue University chemist Jean Chmielewski has won a national award for developing new compounds that disrupt the AIDS virus's ability to reproduce. Her approach involves creating molecular 'wedges' that block HIV proteins from binding together, promising initial results in testing with infected cells.