A recent study presented at TCT symposium showed that the vast majority of patients who underwent MitraClip procedure did not need surgery three years later and experienced improved left ventricle function. The device also reduced mitral regurgitation severity and promoted reverse remodeling, leading to better patient outcomes.
In a Phase I/II clinical trial, ECO-4601 demonstrated safety and efficacy in treating advanced solid tumors. The drug targets the RAS/MAPK signaling pathway and peripheral benzodiazepine receptor, offering a unique mechanism of action.
A new study found that impulsivity is a common trait among alcoholic individuals, particularly those with antisocial and borderline personality disorders. These individuals exhibited impaired inhibitory control and difficulty delaying gratification, which may impact treatment outcomes.
The HORIZONS AMI trial demonstrated the superiority of bivalirudin over standard drug therapy in reducing net adverse clinical events by 24% and major bleeding by 40% in heart attack patients at 30 days. The study showed significant reductions in cardiac deaths, with a 27% decrease compared to standard therapy.
A new study published in JAMA found that antiretroviral drug therapy and non-physician care, such as nursing, are essential in saving the lives of HIV-infected African children. The research showed significant improvements in CD4 cell counts and weight-for-age scores among children treated with antiretrovirals.
A Northwestern University study found that tones of voices can alter visual processing, suggesting a direct input from early auditory processing to visual perception. Researchers used pure tones to test whether sounds can influence perception of face gender, with results showing bias towards male or female faces based on tone frequency.
Uncontrolled asthma is linked to significantly more school and work absences, with a new study showing up to 2-3 times more days absent. Antismoking classes may improve young children's knowledge about tobacco smoke, while phone triage programs provide safe and cost-effective care for ventilator-dependent children.
A key enzyme called CEH has been identified as a potential target for reducing heart disease by increasing the removal of cholesterol from plaques. The findings suggest that increasing CEH activity may reduce existing plaques in addition to preventing their formation.
A large study found that pregnant women are often misdiagnosed with appendicitis, leading to unnecessary operations and increased risk of fetal loss or early delivery. Advanced imaging tools like ultrasound and MRI may improve diagnostic accuracy.
Research at The Parkinson's Institute and Clinical Center found that intermittent nicotine treatment reduces medication-induced dyskinesias in Parkinson's disease models. This could lead to more effective and long-term treatment options for patients suffering from the condition.
A team of researchers explored sub-Antarctic ecosystems to estimate the diversity of tiny bryophytes and lichens, finding a hotspot for these organisms. The study emphasizes the need for conservation strategies that integrate non-vascular plants beyond charismatic mega fauna.
A recent study found significant discrepancies between the National Dysphagia Diet (NDD) guidelines and prepared dysphagia diet foods (DDFs), which may lead to malnutrition and aspiration. The researchers tested four different DDFs and found that only one aligns with NDD guidelines, prompting a change in the hospital's food selection p...
Researchers have identified the swimming and attack patterns of two tiny but deadly microbes linked to fish kills in the Chesapeake Bay. The team used digital holographic microscopy to capture three-dimensional images of the troublesome microbes, revealing distinct differences in their hunting tactics.
A new predictive model using hemoglobin level, International Normalized Ratio, and penetrating injury mechanism can accurately predict which soldiers require massive blood transfusions, allowing for timely mobilization of resources. This model has been shown to reliably predict the need for massive transfusions in combat patients.
Medical errors often lead to guilt, fear and loneliness in patients, families and caregivers, highlighting the need for open communication and emotional support. Honest dialogue can help build bridges and foster forgiveness, leading to closure and improved patient care.
In Cameroon's Waza National Park, people have learned to coexist with lions, weighing the benefits of closer grazing against the risk of losses. Researchers found that despite the risks, herdsmen continue to live near the park due to improved access to pastures and water.
Maynard Olson receives $500,000 Gruber Genetics Prize for his groundbreaking work on genome mapping and its potential to revolutionize personalized genomics. The prize honors his contributions to breaking down the human genome into manageable pieces.
Researchers have found that the vagus nerve directly communicates with the immune system, controlling inflammation. This discovery is leading to novel treatments for diseases such as sepsis and autoimmune conditions.
A study published in BMC Evolutionary Biology found that ancient fish, specifically Australian lungfish, had retinas with visual pigments similar to those of early four-legged vertebrates. This suggests these creatures may have seen their new environment in full color when they first emerged onto land.
Researchers at UMass Medical School are developing new strategies to combat HIV/AIDS, including designing inhibitors that can evade drug resistance. The $8.5M grant will support studies on the structure and function of HIV protease, aiming to create more effective treatments for patients.
Elderly patients with DVT are less likely to present typical symptoms and receive treatment outpatient. Researchers suggest that these patients represent a high-risk group due to the combination of DVT and COPD.
BASF and Harvard University have established the BASF Advanced Research Initiative to promote innovative collaborations and develop new technologies. The initiative aims to explore various areas, including applied physics, chemical biology, and materials science, with a focus on developing new products and processes.
Researchers have discovered that vitamin supplementation can temporarily improve lung function in smokers. In contrast, athletic activity has been shown to strengthen respiratory muscles and enhance lung function. Additionally, light to moderate drinking may also be associated with better lung function, according to a recent study.
A recent study confirms that the proportion of carbon dioxide emissions absorbed by land and oceans is declining, leading to a faster increase in atmospheric CO2 levels. This trend has major implications for climate modeling and highlights the need to reduce global emissions to mitigate climate change.
Research highlights the importance of child health psychologists in disease prevention, citing the impact of early lifestyle choices on later-life health. Experts emphasize the need for more targeted prevention programs and increased involvement of child health psychologists in public health efforts.
The REVEAL Registry aims to provide reliable information on PAH demographics, clinical course, and management. Researchers found that most patients experience a significant delay between symptom onset and diagnosis, with up to 3-year delays in some cases.
A study by Yale School of Medicine researchers found that 80% of participants who 'heard' phrases in length developed a schizophrenia-related illness. The finding suggests an early warning sign for the condition, which could be identified through inexpensive preventive drug therapy.
Contrave significantly reduced food intake in both lean and obese mice by targeting the ventral tegmental area, a key region of the reward pathway. The combination of bupropion and naltrexone resulted in a 94% reduction of food intake in obese mice, demonstrating potential for effective weight loss treatment.
Researchers at the University of Manchester examined St Bernard skulls over 120 years and found features that became more exaggerated as breeders selected for desired physical attributes. This suggests sustained evolutionary change under known selective pressures.
A new study by Rensselaer Polytechnic Institute reveals that blocks of carbon nanotubes can be used to create effective and powerful pressure sensors. The material's unique electrical and mechanical properties make it suitable for applications such as automobile tire pressure gauges and semiconductor manufacturing equipment.
The SPIRIT III trial found that the Xience V everolimus-eluting coronary stent significantly reduced major adverse cardiac events, including heart attacks and deaths from cardiac causes, by 50% after 12 months compared to the Taxus paclitaxel-eluting stent. This reduction in events is an important finding for patients with heart disease.
A new study found that a synthetic form of THC increases serotonin levels in the brain at low doses, acting as an effective anti-depressant. However, at higher doses, the effect reverses and can worsen depression and psychosis.
Two carotid stenting trials, CAPTURE 2 and EXACT, demonstrated 30-day patient outcome results consistent with longstanding AHA guidelines for asymptomatic patients. The studies showed that carotid stenting achieved outcomes comparable to surgery in a population of high-risk patients.
A novel technique of image-guided fine-needle aspiration (FNA) using endoscopic ultrasound (EUS) guidance is introduced for accurate preoperative diagnosis of pancreatic solid pseudopapillary tumors. This method helps differentiate SPTP from other pancreatic neoplasms with different biologic behavior and treatment.
Experts from the American Society of Tropical Medicine and Hygiene meet to address global health concerns and share research on infectious diseases such as Chagas and Dengue fever, which pose a threat to the US blood supply. Researchers also discuss using NASA technology to monitor deadly outbreaks like Ebola and malaria.
Research at Temple University found that obese and overweight children from diverse ethnic backgrounds experience similar levels of body dissatisfaction. The study highlights the importance of addressing psychological consequences of childhood obesity beyond weight management.
Researchers investigated whether individuals with intellectual disabilities who commit sexual offenses have poorer sexual knowledge than those who do not. The study found that Type I offenders, characterized by deviant ideas about sexuality, had more sexual knowledge than a matched group of non-offenders. In contrast, Type II offenders...
Research by biologists at the University of Bonn found that older coal tit males produced significantly more 'cuckoo kids' than younger males. In contrast, younger males father only 0.3 extra-marital offspring on average.
Researchers have identified a bioactive polysaccharide from Decalepis hamiltonii that exhibits multi-step ulcer preventive activity, including gastroprotection, down-regulation of activated H+, K+-ATPase, normalization of oxidative stress and antioxidant enzymes, and recovery of damaged mucosal epithelium. The polysaccharide also shows...
David Spiegel, a Yale chemist, has received a $1.5 million NIH Director's New Innovator Award to develop a 'rational' approach for using antibodies to target various cells and diseases. He aims to design DNP-compounds that recognize pathogens and attract anti-DNP antibodies, destroying diseased cells.
Fedorov's work focuses on understanding abrupt climate changes, including simulations of sudden climate change and investigation into permanent El Niño-like conditions. His research has significant social importance, with potential consequences for global ecosystems and economies.
A $2.5 million NSF grant will support an international collaboration between American and Korean researchers, with a focus on student education and exchange at both graduate and undergraduate levels. The program aims to develop global perspectives and foster collaboration among researchers.
Researchers have developed new means of screening vast stores of data to find potential therapies for neuroblastoma and other cancers. By targeting cellular molecules along pathways crucial for sustaining cancer cell life, they identified 47 candidates with good potential against neuroblastoma.
Researchers at the University of Illinois have discovered that uranium's U-235 to U-238 isotope ratio varies significantly in Earth materials. The new findings are consistent with other high-mass isotope systems and may represent the first evidence of a nuclear field shift in nature.
Researchers have found that mate tea can increase HDL (good) cholesterol activity by up to 10% compared to other drinks. An international agreement aims to study 84 genotypes of mate tea, including cultivated and wild varieties, to identify the most nutritionally beneficial types.
A study conducted at Wake Forest University Baptist Medical Center found that early mobility therapy in ICU patients reduced length of stay by an average of three days, compared to those who did not receive the therapy. The therapy was provided by a mobility team and proved safe, with no additional costs incurred.
Astronomers study G292.0+1.8 supernova remnant to understand complex star death and dispersal of elements like oxygen into next generation of stars and planets. The new Chandra image shows an intricately structured debris field with varying temperatures, indicating lopsided explosion.
A new bus scheduling algorithm, developed by a University of Southern California engineer, aims to reduce waiting times and improve transit reliability. The algorithm analyzes the impact of slack time on buses and finds that building in between 15 and 20 percent slack time is optimal, depending on total round trip travel time.
The Juvenile Diabetes Research Foundation (JDRF) has partnered with Housey Pharmaceutical Research Laboratories to develop small molecule compounds promoting beta cell growth and survival. This research aims to identify new therapeutics targeting key scientific pathways, accelerating drug discovery and development.
GSK923295A, a first-in-class targeted therapy, demonstrates broad activity and potential for enhanced tolerability in preclinical studies. The experimental drug inhibits the mitotic kinesin CENP-E, leading to apoptosis and misaligned chromosomes in cancer cells.
A Phase II trial of a new combination therapy for patients with platinum-resistant ovarian cancer showed a 33% overall response rate, twice as high as traditional chemotherapy regimens. The therapy combines flavopiridol and cisplatin and is promising for developing more effective treatments for this disease.
Research suggests viruses like Human Ad-36 may play a role in causing obesity in humans, with evidence showing weight gain and fat storage in infected animals. Studies also found connections between viral infections and obesity in human subjects, including exposure to the Ad-36 virus.
A new light trap design has led to the discovery of a new species of goby, with DNA barcoding technology confirming its unique genetic profile. The capture of larvae using the innovative trap provided access to previously inaccessible species, shedding new light on marine biodiversity.
Researchers found that darkness amplifies the impact of social stress on anxiety levels, with a startle response boosted in healthy volunteers. The study suggests that stress can alter nervous system function and contribute to anxiety disorders.
Exogenous sphingomyelinase was found to increase intestinal permeability in vitro by altering the composition of tight junctions. This is achieved through the localized accumulation of ceramide at cell-cell contacts, leading to increased permeability and changes in the epithelial barrier.
Scientists have discovered a simple method for detecting vision loss in patients with retinal disease, utilizing the induced twinkle after-effect. This technique, already proven effective in 75% of cases, allows patients to identify visual defects at home before seeking medical attention.
A new study reveals that the ocean was able to store more CO2 during the ice age than it can today. The team measured carbon isotope signatures in sea bed sediments and found that deep Pacific water has not been at the surface for over 2,000 years.
The AMIHOT II trial found that infusing oxygen-saturated blood into the previously blocked artery after an angioplasty procedure significantly reduced the size of the 'infarct zone', or damaged heart tissue. The study showed a 6.5% reduction in infarct zone size and no significant increase in Major Adverse Cardiac Events at 30 days.
Researchers found that quantitative index adds accurate information about patients' responses to first-line chemotherapy, improving tumor response prediction. This method can also identify disease transformation and shorten treatment for favorable responders.
Scientists at the University of Pennsylvania identified distinct patterns of brain activity associated with successful memory formation and retrieval. The study's findings may help neurosurgeons reduce cognitive deficits in epilepsy patients by identifying neural signatures of successful memory storage and retrieval.