Researchers have discovered a new therapy that substitutes the missing protein dystrophin to repair weakened muscle tissue in mouse models with Duchenne muscular dystrophy. The TAT-utrophin-based protein approach addresses the cause of the disease without gene replacement or stem cell issues, offering a potential treatment option.
A combined pharmacological and behavioral intervention improved depression and pain in patients with musculoskeletal pain and co-existing depression. The intervention significantly reduced symptoms of both conditions at 12 months.
A new mouse model has been created to understand human neuronal diseases that impair feeling and movement. The mouse model mimics symptoms of Charcot-Marie-Tooth and hereditary motor neuronopathy, two conditions with no effective treatments.
Scientists have confirmed a unified theory about how the brain processes speech and language, suggesting that two parallel pathways process complex auditory signals. The findings, published in Nature Neuroscience, provide insight into disorders such as autism and schizophrenia, and may lead to better treatment options.
Research reveals ILK promotes growth in aggressive ARMS cells, while suppressing ERMS cell growth. Targeting ILK may offer therapeutic strategy for ARMS patients.
A US citizen with head and neck cancer treated with capecitabine experienced a mild case of hand-foot syndrome, leading to fingerprint loss. His doctor advises patients on capecitabine to carry a letter explaining their condition for travel to the USA.
Researchers developed a strategy to improve both depression and pain management by closely monitoring antidepressant therapy and providing pain self-management training. The study found that this approach led to substantial improvements in both conditions, with benefits lasting six months after treatment was completed.
John P. Cogswell, PhD, has been awarded the 2009 Alzheimer Award for his work on identifying microRNA changes in Alzheimer's disease brain and CSF, which yields putative biomarkers and insights into disease pathways. His research highlights the potential of microRNAs to aid clinical diagnosis.
Researchers at UC San Diego are building low-cost, low-power modems for short-range underwater networking, enabling higher sampling rates and more frequent data collection. The project aims to create a network of underwater sensors that can provide real-time environmental data, revolutionizing the way we understand our natural world.
A study found that rats in Baltimore form distinct neighborhoods, with each community spanning little more than an average alley. Rats rarely migrate, but neighborhood eradication efforts may backfire by encouraging rodents to repopulate other areas and spread disease.
Research reveals that HGPIN carries a high predictive value for future diagnosis of prostate cancer, with a 41.8% risk identified in patients. The study recommends delaying first repeat biopsies at low PSA ranges but shorter intervals for intermediate and higher PSA ranges.
Researchers used PET scanning to assess estrogen receptor positive breast cancer patients' response to standard aromatase inhibitor therapy after just two weeks. The results showed significant declines in glucose analogue FDG values, similar to earlier studies using needle biopsies.
Researchers have identified the protein ILK as promoting growth of aggressive rhabdomyosarcoma cells and suppressing ERMS cell growth. A therapy targeting ILK may provide a tailored approach for treating the lethal form of RMS, ARMS.
Researchers found that a diabetes drug, pioglitazone, significantly reduced gray matter loss in patients with relapsing remitting multiple sclerosis. The treatment showed no adverse reactions and was well-tolerated.
By leveraging the Advanced Microwave Scanning Radiometer for EOS sensor on NASA's Aqua satellite, researchers can estimate soil moisture levels with improved accuracy, leading to more precise crop forecasts. This innovation addresses the pressing issue of global food scarcity and its impact on millions of poor people.
A recent study in PLoS Biology has identified the crucial role of cohesin proteins in human gene expression, shedding light on Cornelia de Lange syndrome. The research found that dysregulation of cohesin affects hundreds of genes, leading to unique gene expression profiles.
Cancer care's high costs are impacting patients' welfare and society as a whole. The economic burden is too great to ignore, with rising costs threatening personalized medicine's promise.
Scientists use zebrafish to investigate the role of RAS mutations in melanoma formation and progression. The research found that altering signaling pathways can reduce the effects of RAS mutations, providing a potential therapeutic approach.
The NeuroFAST project will investigate the neural mechanisms underlying food intake and addiction, with a focus on the hypothalamus. The research team, led by Professor Suzanne Dickson at Sahlgrenska Academy, aims to create a comprehensive picture of obesity and its causes.
A new study found that controlling maternal feeding practices are not directly linked to future child weight gain. Instead, they may be a response to concerns over the child's increasing weight. The researchers suggest that some degree of control may actually help certain children maintain their weight.
A study comparing NFL players' health to that of other healthy young men found lower incidence of impaired fasting glucose and similar prevalence of abnormal cholesterol levels. However, NFL players had a significantly higher prevalence of high blood pressure and prehypertension compared to the general population.
A study found that hospital-acquired pneumonia is associated with a 30% increased odds of receiving acid-suppressive medications. The study analyzed data from 63,878 hospital admissions and found that proton-pump inhibitors were more strongly linked to the risk.
Honeycreepers' high-altitude refuges are vulnerable to disease invasion and habitat loss as temperatures rise, putting species at risk of extinction. The USGS predicts that climate change will displace these refuge areas, forcing birds to migrate into higher disease transmission zones.
Scientists discovered that a protein complex called cohesin plays an important role in regulating genes in humans, particularly in the rare genetic disease Cornelia de Lange syndrome. The study identified hundreds of genes that were dysregulated compared to controls, and also detected gene expression profiles unique to CdLS.
A simplified chart created by a pediatrician can help identify children with high blood pressure, improving diagnosis rates. The revised chart uses age and gender to determine abnormal readings, reducing the need for height percentile verification.
A nationwide study found a significant decrease in baseball-related injuries among children and adolescents, with emergency department treatments dropping by 25%. The most common injuries were soft tissue injuries, followed by facial and upper extremity injuries, highlighting the importance of injury prevention efforts.
Researchers at Boston University School of Medicine found that conventional methods to adjust for confounding, such as restriction and multivariable regression, leave residual confounding because of unmeasured factors. Propensity scores and instrumental variable methods have limitations in resolving confounding by indication.
A landmark study published in NEJM found that paclitaxel-eluting stents significantly reduce target lesion revascularization and binary angiographic restenosis rates compared to bare-metal stents. The study showed a lower rate of ischemia-driven target-lesion revascularization at 12 months with the use of paclitaxel-eluting stents.
Researchers at Fred Hutchinson Cancer Center identified two proteins associated with chronic inflammation linked to long-term survival in breast cancer patients. Elevated levels of C-reactive protein and serum amyloid A are associated with reduced overall survival, regardless of patient age or tumor stage.
Tim Weninger, a K-State researcher, has received a three-year National Science Foundation Graduate Fellowship to pursue a doctorate in computer science. The fellowship provides $30,000 annual stipend and tuition payment support for graduate studies.
A recent study found that carbohydrate restriction without weight loss can slow prostate tumor growth by lowering serum insulin levels. The researchers believe that this mechanism is key to fighting prostate cancer growth and potentially improving patient outcomes.
Researchers at CLEO/IQEC Meeting present advancements in electro-optics, lasers and light-based treatments for faster wound healing. Autonomous vehicle technology has made significant progress with futuristic sensors and computing capabilities, promising to revolutionize transportation and warfare.
A two-year grant from NIMH will support the adaptation and assessment of an HIV intervention designed for young, heterosexual Latino couples. The program aims to increase condom use, monogamous relationships, and decrease risky sexual behaviors.
UT Southwestern researchers accelerate efforts to eradicate worm infections by targeting a biochemical system that controls development and reproduction in parasitic nematodes. The compound dafachronic acid sends signals for the worms to mature from infective to feeding stages, making hosts sick.
Researchers discovered that CIP2A expression is associated with reduced overall survival in gastric cancer patients, as well as increased proliferation and anchorage-independent growth. Meanwhile, a RasGAP-derived peptide has been shown to improve responses to chemotherapy in mouse models of colon cancer.
Researchers found that 75% of children treated for carbon monoxide poisoning were playing video games when generators were used to power electronic gadgets. The study emphasizes the need for generator safety awareness among parents and educators to prevent such incidents.
Researchers found that Kaposi's sarcoma-associated herpesvirus uses polyadenylation to block normal gene expression in cells. The virus' SOX protein aberrantly lengthens mRNA poly(A) tails, sending a signal to the cell that its messages are wrong and holding them back.
A study revealed that inherited heart disease was present in over 30% of families of sudden unexplained death (SUD) victims. The research found that cardiological and genetic examination of surviving first-degree relatives can reveal an inherited heart disease, allowing for treatment and prevention.
Scientists at the University of Iceland and Marine Research Institute report a significant difference in Darwinian fitness between shallow-water and deep-water adapted cod. The study found that intense habitat-specific fishing pressure led to rapid elimination of shallow-water fish, drastic effects on populations and fisheries.
A UC Davis study reveals that children with attention problems in kindergarten are more likely to struggle in math and reading tests in high school. The research highlights the importance of addressing early attention issues to boost graduation rates and future earning potential.
A legal loophole in Canada's advertising regulations has exposed Canadians to more than $90 million worth of drug ads, including those for life-threatening medications. The study found that four out of eight heavily advertised drugs had black box warnings and five had been subject to Health Canada safety advisories.
A new clinical discussion tool, GAIN, has been developed to help physicians discuss potential reasons for using long-acting injectable antipsychotic therapies with patients. The tool addresses barriers such as needle phobia and stigma, aiming to increase patient acceptance and adherence.
Research from Northwestern University found Abraxane effectively prevents metastatic breast cancer progression and has fewer side effects compared to Taxotere. The study prolonged progression-free survival by almost seven months.
A new paper reveals that there are more genetic differences between humans and mice than previously thought. One-fifth of mouse genes are new copies that have emerged in the last 90 million years of mouse evolution.
According to a new study, nearly 952,000 California adults seek medical, dental, or prescription services in Mexico each year. The primary reasons for this trend include cost and lack of insurance.
A new study found that childhood cancer survivors have a significantly increased risk of developing second primary cancers throughout their lives. The research, published in the Journal of the National Cancer Institute, analyzed data from 47,697 people diagnosed with cancer before age 20 and found a higher incidence rate of new primary...
Researchers are developing models to test strategies for treating complex combat injuries, including segmental bone defects and massive soft tissue defects. The center is also investigating ways to protect stem cells during insertion and enhance their healing properties.
A recent study by Kaiser Permanente found that unvaccinated children are significantly more likely to contract pertussis, also known as whooping cough. The research used electronic health records to analyze the risk of vaccine refusal and its impact on pertussis infections.
Research and policy making must align to promote better sexual health, addressing curable and incurable STDs, lack of access to services, and unsafe abortion. The US healthcare system faces a significant burden of disease from 19 million new STD cases annually.
The vaccine-autism debate persists despite scientific consensus, fueled by internet misinformation and declining public trust. Pediatrician Paul Offit's efforts to set the record straight have been hindered by celebrity anti-vaccine advocates like Jenny McCarthy.
A NASA/University team developed a method to indicate the presence of oceans on extrasolar Earth-like worlds by analyzing how Earth's light changes as it rotates. The technique relies on observing blue color changes caused by oceans, which appear bluer than continents.
Researchers found a large cylindrical blob of cold material, known as a lithospheric drip, beneath the Great Basin in central Nevada. The finding provides new insights into fine-scale mantle convection processes and their connections to volcanism and mountain-building.
The American Academy of Pediatrics recommends annual private well testing for nitrate and microorganisms, particularly for infants under three months. Children are vulnerable to waterborne illnesses that can come from contaminated wells, and proper care is essential to prevent contamination.
Researchers Ulrich Gerland and Terence Hwa discovered two opposing principles guiding gene regulation in microbes: 'use-it-or-lose-it' and 'wear-and-tear'. These mechanisms adapt to environmental changes, with the latter mitigating detrimental effects of constant use.
A new study suggests a score-based system, called the Conscientiousness Index, can detect behaviours that need early investigation and provide targeted support. The index measures diligence in day-to-day behaviour and is believed to contribute to improving doctors' performance after qualification.
Researchers at Mayo Clinic have found that patients with chronic lymphocytic leukemia (CLL) can tolerate high doses of green tea extract EGCG, leading to a significant reduction in lymphocyte count. The study also showed that many participants experienced regression of CLL symptoms, particularly those with enlarged lymph nodes.
Researchers from the University of Oregon and University of California, Davis, have identified a locking mechanism that allows neurons to form synapses, essential for transmitting information. This discovery sheds light on autism development, a brain disorder affecting social and communication abilities.
A new multimeric-L2 protein vaccine shows robust antibody responses and protection against human papillomavirus (HPV) infection in mice and rabbits. The vaccine has the potential to address the limited protection of current HPV vaccines against other HPV types, which cause cancer.
Dr. Leo Lombardini is conducting a pioneering study on pecan roots to optimize tree maintenance and nutrient application. His research aims to discover ways to produce higher-quality, more nutritious nuts in an efficient and sustainable manner.
A recent study by North Carolina State University reveals that banks' Value-at-Risk (VaR) models are not accurately reflecting market fluctuations. This can lead to a lack of sufficient capital reserves, putting banks at risk of exhaustion and financial distress.