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Science News Archive February 2009 - Page 5


Page 5 of 24

Chili peppers help to unravel the mechanism of pain

Researchers discovered that capsaicin, found in chili peppers, triggers a desensitization process in pain receptors, allowing them to adapt to painful stimuli. This adaptive response enables the receptor to continuously respond to varying stimuli, leading to a shift in responsiveness threshold.

SourcePLOS·JournalPLOS Biology·DateFeb 23, 2009

Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer

A study by Boston Children's Hospital researchers has identified lipocalin 2 as a protein that triggers the epithelial to mesenchymal transition in human breast cancer cells, increasing invasiveness and metastasis. The protein is detectable in urine samples, suggesting it may be used for prognostic testing.

SourceBoston Children's Hospital·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2009

Social patents

Experts explore using social networking tools to identify prior art in patent applications, streamlining the process for the US Patent and Trademark Office. The Peer-to-Patent pilot project demonstrates a promising approach to reducing backlog, with similar initiatives being investigated by UK and European offices.

SourceInderscience Publishers·JournalInternational Journal of Technology Transfer and Commercialisation·DateFeb 23, 2009

Immune system 'atlas' will speed detection of kidney transplant

A new immune-system 'atlas' will improve doctors' ability to monitor transplanted organs and shed light on the mechanisms of gradual, cumulative kidney malfunction after transplant. The atlas allows for inexpensive, noninvasive blood tests that show whether a donated kidney is infected or accruing chronic injuries.

SourceStanford Medicine·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2009

How can bias be prevented in the medical literature?

Bias in medical literature can be prevented through recognition and declaration of competing interests, detailed authorship policies, and mechanisms to control outcome reporting bias. The PLoS Medicine editors propose these measures to reestablish the integrity of the scientific record.

SourcePLOS·JournalPLOS Medicine·DateFeb 23, 2009

Mail and electronic reminders may increase colon cancer screening

A study published in Archives of Internal Medicine found that mail reminders increased colon cancer screening rates by 44% compared to non-reminded patients. Electronic physician reminders also showed promise, especially among patients with three or more primary care visits, resulting in a 59.5% screening rate.

SourceJAMA Network·JournalArchives of Internal Medicine·DateFeb 23, 2009

Tips from the American Journal of Pathology

Researchers found that HAART contributes to pulmonary hypertension in HIV-infected patients by impairing blood vessel-lining endothelial cell function. A novel treatment for chronic hypoxic pulmonary hypertension (PHTN) involves neprilysin, which protects against PHTN by regulating neural signaling molecules.

SourceAmerican Journal of Pathology·JournalAmerican Journal Of Pathology·DateFeb 23, 2009

Relationships in rank and file

Researchers Johannes Soeding and Andreas Biegert have developed a new method called CS-BLAST that takes into account the sequence context to improve similarity searches. This approach can identify twice as many distant relatives of proteins compared to traditional BLAST, leading to better insights into gene and protein functions.

SourceLudwig-Maximilians-Universität München·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2009

Lower increases in global temps could lead to greater impacts than previously thought, study finds

A new study by Stanford University scientists updates IPCC findings, suggesting even smaller temperature increases could cause significant problems in unique ecosystems, extreme weather events, distribution of impacts, aggregate damages, and risks of large-scale discontinuities. The research highlights increased evidence of climate cha...

SourceStanford University·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2009

Building a better protein

Researchers at Rensselaer Polytechnic Institute have developed a targeted strategy to substantially increase the thermodynamic stability of nearly any protein while preserving its unique function. The design technique creates proteins that remain stable at temperatures 10 degrees Celsius higher than normal.

SourceRensselaer Polytechnic Institute·JournalProceedings of the National Academy of Sciences·DateFeb 23, 2009

Fate and 'face': Cultural differences lead to different consumer approaches

A new study published in the Journal of Consumer Research found that Asian consumers are more tolerant of nonsocial failures due to their strong belief in fate, while Western consumers are more demanding. The researchers also discovered that brands emphasizing fate can increase Asian consumers' tolerance for social failures.

SourceUniversity of Chicago Press Journals·JournalJournal of Consumer Research·DateFeb 23, 2009

Kids who watch R-rated movies are more likely to smoke

A new study found that parental permission to watch R-rated movies increases the likelihood that children believe it's easy to obtain cigarettes. This perception is associated with a higher risk of smoking among kids, suggesting parental smoking and home environment can contribute to youth smoking.

SourceBurness·JournalAmerican Journal of Preventive Medicine·DateFeb 23, 2009

New twist on 40-year-old discovery

Researchers have discovered a new connection between Carter's constant and Newtonian gravity, shedding light on the behavior of rotating black holes. The findings have significant implications for gravitational-wave astronomy, potentially allowing the detection of small black hole orbits.

SourceWashington University in St. Louis·JournalPhysical Review Letters·DateFeb 23, 2009

New technique for cancer screening

Researchers have developed a new technique to determine tumor methylation status in archived tissue samples, providing a potential biomarker for early cancer diagnosis and risk assessment. The technique uses high-resolution melting analysis and has been validated on archival and fresh tissues.

SourceAmerican Journal of Pathology·JournalJournal of Molecular Diagnostics·DateFeb 23, 2009

JCI table of contents: Feb. 23, 2009

Researchers developed small molecules targeting Hsp90 in mitochondria to induce tumor cell death. This combinatorial approach may be more effective than targeting single signaling pathways. Gene therapy also restored muscle strength in a mouse model of muscular dystrophy by anchoring nNOS to the sarcolemma.

SourceJCI Journals·JournalJournal of Clinical Investigation·DateFeb 23, 2009

Get personal to improve heart health

A new study suggests that doctors and nurses should offer high-risk patients targeted advice to improve heart health. The research found that boosting patients' sense of vulnerability does not help, but rather provides personalized information on specific CHD preventative diets.

SourceUniversity of Exeter·JournalPsychology and Health·DateFeb 23, 2009