A Phase II clinical trial of 75 AML patients treated with vorinostat and chemotherapy resulted in an 85% remission rate. Higher-risk patients showed a complete response rate of 100%, while those with -5/-7 cytogenetic alterations fared less well. The Phase III trial will compare this combination to standard-of-care frontline therapies.
A standard chemotherapy regimen has been shown to increase survival rates in patients with limited-stage Hodgkin's lymphoma. This finding is significant, as it may lead to reduced radiation exposure and lower risk of long-term complications.
Researchers at the Instituto Gulbenkian de Ciencia have uncovered a molecular mechanism that enables cells to accurately inherit non-genetic information, such as protein structures. This epigenetic memory is crucial for maintaining genome organization and preventing errors in cell division, which can lead to cancer.
A new study finds that gift givers who bundle an expensive gift with a smaller item tend for recipients to perceive the overall package as less valuable. This phenomenon, known as the Presenter's Paradox, can be seen in various contexts beyond gift giving, including presentations of information and decision-making processes.
Scientists at Johns Hopkins have found that PARP inhibitors can block the ability of pre-leukemic cells to repair broken DNA, leading to their self-destruction. The treatment has shown promise in clinical trials for patients with aggressive myeloproliferative disorders.
A team of researchers has identified markers that may enable liver transplant recipients to be weaned off their immunosuppressive drugs. Higher blood levels of iron-handling proteins and specific gene expressions in the liver can predict which patients are suitable for drug-weaning protocols.
Researchers have identified a protein that contributes to brain tumor resistance to chemotherapy, while also developing a way to predict which liver transplant patients can be weaned off immunosuppressive drugs. High levels of APNG in GBM cells correlated with poorer survival rates, suggesting it may serve as a biomarker for treatment ...
Researchers found that patients who consistently take their prescribed dose of inhaled corticosteroid (ICS) medication can prevent up to a quarter of severe asthma attacks. Taking at least 75% of the prescribed dose is crucial, according to the study.
Scientists have identified a gene mutation that underlies the vast majority of cases of Waldenstrom's macroglobulinemia. The mutation causes tumor cells to produce a distorted protein, leading to activation of NF-kB and growth of Waldenstrom's tumor cells.
A large retrospective study of childhood cancer survivors found no increased risk of birth defects in their children. Researchers examined data from over 20,000 survivors and found that exposure to chemotherapy and radiation did not lead to genetic birth defects.
A study by Rhode Island Hospital researchers found a 74 percent greater risk of overdose among HIV-infected drug users, attributed to biological and behavioral factors. The study suggests that access to medication-assisted therapy, highly active antiretroviral therapy, and naloxone can help reduce this increased risk.
Two world's smallest surviving babies, Madeline and Rumaisa, have normal motor and language development despite extremely low birth weights. Advances in neonatal care have enabled the survival of smaller newborns, but successful outcomes are not typical for all micropreemies.
A survey of US human embryonic stem cell researchers found nearly four in ten faced excessive delay acquiring a line, while over one-quarter were unable to get the line they needed. The main reasons for these issues include material transfer agreements, research approval, and federal policies.
Researchers have developed a therapy using FT1050 that improves stem cell engraftment in umbilical cord blood transplant recipients, allowing for faster recovery and reduced complications. The treatment accelerates the process of stem cells taking root in patients, resulting in improved outcomes.
Researchers at TUM have developed a molecular switch with a surface area of one square nanometer, controlled by transferring protons within a porphyrin ring. The switch can be set to four distinct states and operated up to 500 times per second.
Researchers found that as spider size decreases, brain size increases proportionally, with even the smallest spiders able to weave webs and perform complex behaviors.
A recent international data analysis on school mathematics performance found that social and cultural factors, not biology, contribute to the math-gender gap. Countries with better gender equity have higher math scores for both boys and girls.
Researchers have found two new species of the miniaturized frog genus Paedophryne in southeastern New Guinea. The tiny frogs have reduced digit sizes and inhabit leaf litter, reflecting their adaptation to a unique food source.
A new study is assessing the feasibility of identifying specific genetic markers in cancer patients' tumours to deliver more targeted treatments. The Lawson research team has developed a process for analyzing tumour DNA to provide a genetic profile report within three weeks, helping oncologists create tailored treatment plans.
A multicenter study found ruxolinitib significantly reduces symptoms of myelofibrosis, including pain and enlarged spleen, compared to placebo. The study also showed ruxolinitib is more effective than best available chemotherapies in reducing symptoms.
Researchers have developed a new method to analyze electrical activity in the brain, enabling better diagnosis and treatment of brain illnesses. The technique can help identify impending seizures and paralysis, allowing for more effective interventions.
Researchers aim to identify mechanisms that define embryonic olfactory epithelium stem cells, which are linked to neurological and psychiatric diseases such as Parkinson's and Alzheimer's. The goal is to harness these mechanisms for brain repair and regeneration.
A new article explores how people justify and defend corrupt systems, citing factors such as system threat, dependence, inescapability, and low personal control. The research sheds light on the conditions that make people resistant to change and open to acknowledging its necessity.
A recent study surveying tree fruit professionals found that the main concerns about new technologies are equipment cost, reliability of harvest assist systems, and sensor systems. Regional differences were also observed, with eastern US growers emphasizing price points and irrigation concerns.
Researchers have discovered two massive black holes, each with a mass equivalent to 10 billion suns, in nearby galaxies. These 'sleeping giants' are thought to be remnants of quasars that powered the early universe.
Researchers at Boston University School of Medicine have identified the A2b adenosine receptor as a potential new target for preventing early stages of atherosclerosis. The study found that the receptor plays a key role in regulating liver lipid profiles and reducing atherosclerosis in mice on high-fat diets.
Researchers found that patients receiving bone marrow transplants from unrelated donors had the same survival rates as those receiving blood stem cell transplants. However, PBSCs resulted in better engraftment but higher rates of chronic graft-versus-host disease (GVHD), a serious post-transplant complication.
Duke University engineers developed a way to produce thermal diodes that can transfer heat in both directions, overcoming existing limitations. The method uses self-propelled water droplets to transport heat, enabling applications in energy-efficient solar panels and compact electronics.
Researchers discovered nine frequently mutated genes in CLL that may help predict disease progression and guide treatment. The study identified new cancer pathway aberrant RNA splicing, which could lead to novel targeted treatments.
Scientists developed a vaccine that reduces tumors by 80% in mouse models of breast and pancreatic cancer. The vaccine uses a unique carbohydrate signature to train the immune system to target cancer cells.
A comprehensive supply chain map reveals challenges in accessing anti-malarial drugs in Africa due to economic, political and infrastructural barriers. Local transport options like donkey carts and bicycles should be considered for rural areas.
A new fracture control plan for steel bridges aims to reduce the risk of failure through improved material selection, design, and inspection. The plan has the potential to save costs on maintenance budgets by identifying critical members that need protection from brittle fracture.
Researchers detect hippocampal atrophy in Parkinson's patients with cognitive impairment, leading to early cognitive decline. A newly developed structural pattern identifies diffuse gray and white matter atrophy associated with dementia in Parkinson's disease.
Experts discuss how advances in neuroscience affect the judicial system, from challenging legal policies to aiding in diagnoses of psychological conditions. Brain maturity is a critical issue in assessing teenage crimes, while addiction affects sentencing decisions.
Researchers at University College Dublin have identified a genetic alteration causing anophthalmia, a condition where children are born without eyes. The STRA6 gene plays a crucial role in vitamin A transport, and alterations in this gene can lead to eye malformations.
A new study published in Infection Control and Hospital Epidemiology found that patients moved into isolation during hospitalization are nearly twice as likely to develop delirium. The researchers suggest that underlying illness may be the cause of this association.
A team of US-based and Rwandan physicians have developed an innovative approach to delivering expert care to children with lymphoma in rural Rwanda. Through this 'twinning' model, American-trained pediatricians supervise Rwandan-trained generalists, supported by weekly conference calls from U.S.-based pediatric oncologists.
Researchers recreated universe's first billion years using largest cosmological simulation to date. Thin streams of cold gas flowed into early black holes, causing rapid growth and challenging astrophysical theory.
A Rutgers study found that New Jersey children experienced improved access to dental care between 2001 and 2009, but gaps remain based on race/ethnicity, health insurance status, and family income. Non-Hispanic black children were more likely to receive dental care, while Hispanic and uninsured children had lower rates.
Research reveals that most seabirds are free of malaria parasites, but certain groups like frigatebirds and birds with longer fledgling periods are more susceptible. Climate conditions do play a role, but not as expected, with warmer temperatures increasing rates of infection.
Researchers are conducting a study to examine the effects of exercise and computerized memory training on executive function in people with Parkinson's disease. The goal is to determine if these interventions can slow or reverse memory changes and improve cognitive function.
A study reveals that plant cells use sugar to control the size of plasmodesmata, regulating the passage of signaling molecules. This spatial and temporal control influences root formation during plant development.
Researchers identified a key protein mutation that enables brain tumors to invade healthy brain tissue. Excessive epidermal growth factor receptor (EGFR) signals trigger the production of GBP1, rendering tumors more invasive and allowing them to spread into surrounding tissue.
Researchers found that strip-till improved nutrient uptake and increased yield in soybeans, but had no impact on yield when fertilizers were applied through broadcast or deep banding methods. Subsurface banding of phosphorus and potassium fertilizers may reduce surface phosphorus levels and offer environmental benefits.
Researchers at IUPUI have created a line of lab mice that prefer alcohol over water and binge drink like humans. These mice can reach blood-alcohol levels of over 260mg/dl, allowing scientists to study the genetic and behavioral determinants of alcoholism.
A new analysis found that breast cancer survivors may experience mental abilities problems several years after treatment, regardless of therapy type. Chemotherapy was linked to persistent cognitive issues, while radiation also caused similar problems in some cases.
A team of researchers identified APNG as a contributor to GBM resistance to temozolomide, with high nuclear expression correlating to poorer survival. Monitoring APNG levels may provide insight into patient response to temozolomide treatment.
Researchers at Texas A&M AgriLife Communications identified heat-tolerant rose varieties that performed well despite extreme temperatures. These plants exhibit high levels of black spot tolerance and produce abundant white, single flowers.
New research by William Anderegg and colleagues reveals that carbon starvation is unlikely to be the primary cause of tree death during droughts. The study found significant losses of function in the trees' water-transportation systems, especially in the roots, resulting in a 70% loss of water conductivity.
Researchers developed a method to detect cognitive decline in Parkinson's patients using MRI brain scans, revealing higher Alzheimer's patterns of atrophy predict worsening cognition. The study found an overlap between the two neurodegenerative diseases, raising hopes for early diagnosis and treatment.
A study in Pakistan reveals trends and potential for export-quality rose products, with more than half of growers entering the business in the last five years. However, the industry faces challenges such as outdated production systems, limited greenhouses, and lack of professional education.
A team of researchers at UCSF has discovered that tiny immune cells called macrophages can switch on the brown fat in response to cold temperatures, inducing it to burn energy and produce heat. This finding suggests that the immune system plays a role in thermoregulation, potentially leading to new strategies for enhancing metabolism.
A new study found a possible link between resistance to immunomodulator therapy and the presence of protein cereblon. Lowering cereblon levels allows IMiDs to work properly, suggesting that other mechanisms may play a role in drug resistance.
Researchers discovered a mutation in the GATA6 gene linked to pancreatic agenesis, a rare condition where the pancreas fails to develop. This finding provides insight into how stem cells can be programmed to become pancreatic cells, potentially leading to new treatments for type 1 diabetes.
Researchers at Stanford University School of Medicine have identified the molecular pathway through which physical force contributes to scarring in mice. They found that blocking this enzyme can reduce inflammation and fibrosis, offering a potential new approach for treating fibrotic diseases such as pulmonary fibrosis and rheumatoid a...
A new treatment using leukemia patients' own infection-fighting cells appears to protect them from infections and cancer recurrence after fludarabine-based chemotherapy. With a restored immune system, patients can stop taking prophylactic antibiotics and may have prolonged progression-free survival.
A Phase I/II clinical trial for patients with relapsed or resistant chronic lymphocytic leukemia (CLL) showed impressive potential for PCI-32765, a B cell receptor inhibitor, achieving durable remissions and minimal toxicity. The study demonstrated six-month progression-free survival of 90-92%.
Researchers have developed a multi-purpose photonic chip that generates, manipulates, and measures entanglement and mixture on a tiny silica chip. This device can perform various experiments in a straightforward way using a single reconfigurable chip.
Researchers have discovered that cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide. This finding helps understand which patients may be more or less likely to respond to therapy, enabling the development of targeted treatments.
A Danish research team has developed a new DNA-based method to monitor rare and threatened animal species in freshwater environments, showing it can be effective even for extremely rare populations. The study found a clear correlation between DNA detection and population density, enabling the estimation of population sizes.