Researchers at the University of Cincinnati discovered a potential new target to enhance T cell infiltration in solid tumors. Targeting the KCa3.1 potassium channel can restore CD8+ T cell migration, suggesting a new therapy option for solid tumor treatment.
Research at Albert Einstein College of Medicine found that frequent soccer ball heading is associated with poorer performance on psychomotor speed and attention tasks. Players who headed the ball more frequently showed subtle reductions in neuropsychological function, which may lead to microstructural changes in the brain.
The UNC-Chapel Hill-led Clinical and Translational Science Award Program will broaden its reach across North Carolina by continuing its alliance with RTI International and NC A&T State University and adding a formal partnership with North Carolina State University. The grant will support the advancement of clinical and translational re...
A landmark study found that IBS patients who learned to control severe GI symptoms at home saw significant improvement, comparable to those treated with multiple clinic visits. The home-based behavioral treatment approach provided sustained relief for up to six months, overcoming a common barrier in rural healthcare.
A study found that only one in seven high-risk women take tamoxifen for breast cancer prevention, with social class, education, and ethnicity not affecting uptake. Women chose not to start taking the drug due to fears about its impact on their family and health.
A study by King's College London found that lonely 18-year-olds are more likely to experience mental health issues and be out of work. The research highlights the importance of early intervention to prevent loneliness from affecting young adults' lives.
A Vanderbilt team has deciphered the key to infecting entire mosquito populations with virus-killing Wolbachia bacteria. By hijacking insect reproductive systems, Wolbachia spreads rapidly, reducing risk of dengue and Zika virus transmission.
A new study published in the Proceedings of the National Academy of Sciences found that traditionally high-status Americans, particularly whites and Christians, voted for Donald Trump due to fears of losing their privileged status in America and the world. The researchers debunked the idea that voters were driven by economic grievances...
A team of City College-bred fruit flies and parasitic wasps are part of an International Space Station experiment to understand how the human immune system reacts to spaceflight conditions. The goal is to inform astronauts on potential infections during long-duration missions.
Drought regions in Europe could expand from 13% to 26% of total area with a 3-degree global warming, affecting up to 400 million people. A 1.5-degree warming limit would reduce expansion to 19%, while drought durations would increase three to four times.
A randomized trial in Norway found that sigmoidoscopy screening reduced CRC incidence and mortality in men, but had little or no effect in women. Current guidelines recommending flexible sigmoidoscopy screening for women may need to be reconsidered. The effectiveness of screening in reducing colon cancer risk for women remains uncertain.
A new study from McGill University found that southern US states with high gun ownership rates have the highest rates of white firearm suicide, while Midwestern states have the highest rates of black firearm homicide. The research suggests that different factors influence rates of firearm homicide for black and white men across states.
The project seeks to understand the evolution and organization of life by sequencing and functionally annotating the genomes of 1.5 million eukaryotic species, including plants, animals, fungi, and single-cell organisms. This initiative aims to reveal unknown species and provide a freely available resource for scientific discovery.
The Earth BioGenome Project is a 10-year scientific grand challenge to document life on Earth. The project's challenges include international coordination and governance, economic benefits, and biodiversity conservation.
Recalling traumatic memories enhances the rewarding effects of morphine in male rats, increasing freezing fear response and preference for morphine. Dopamine receptors D1R and D4R play a role in this effect, suggesting abnormal dopamine signals may underlie PTSD addiction.
Researchers have discovered a new form of DNA, called the i-motif, which forms in the nuclei of human cells. The i-motif is a four-stranded 'knot' that plays a crucial role in gene expression and cell life cycle.
Researchers at UNC Lineberger Comprehensive Cancer Center created tissue-engineered models of metastatic cancer that reflect the microenvironment around tumors. The models, which mimic liver and lung tissues, closely replicate human metastasis characteristics, including 'signet ring cells' linked to poor prognosis.
Researchers have created nanoparticles that can convert near-infrared light into visible light, potentially increasing the efficiency of solar cells. The particles are coated with organic dyes that act as antennas to gather and reemit light, raising the possibility of capturing a broader spectrum of sunlight.
An independent analysis of aggregated occurrence records found that ALA and GBIF data processing leads to significant data loss and unjustified changes in scientific names. The audit revealed up to 1 in 5 records were altered due to aggregator errors, with major disagreements on names between aggregators also reported.
Researchers found genetic adaptation for low UV exposure in North and East Asian populations, linked to increased sweat gland density and mammary ductal branching. The EDAR V370A variant may have selected for improved vitamin D biosynthesis through breast milk, enhancing offspring nutrition.
Researchers found a new polysaccharide in moss with properties similar to beta glucan, a dietary fiber known for its health benefits. The discovery suggests great potential for this new compound as it relates to health, industrial and medical fields.
Researchers found that palbociclib induces substantial changes in the proteasome, degrading proteins required for cell cycle progression and driving cells into senescence. The discovery suggests that proteasomal activity may be an additional mechanism by which palbociclib stalls proliferation.
Researchers at Carnegie Mellon University created smart walls using conductive paint that can detect human touch, gestures, and appliance usage. The system operates in two modes: capacitive sensing and electromagnetic (EM) sensing, allowing for location tracking of devices and people.
Researchers used a rocket scanner to take the first whole-body CT scan of a minke whale, revealing insights on whale communication. The team modeled how whales hear low-frequency sounds using custom-developed computer simulation tools.
Researchers discovered that fish regenerate skin without scarring by controlling the proliferation of stem cells in the basal layer. This mechanism may be applicable to other vertebrates, including humans, for treating various skin diseases and regenerative medicine research.
A new study has found that researchers can detect killer whales in Puget Sound by analyzing environmental DNA (eDNA) in water samples. The eDNA persists for up to two hours after the whales have passed through, providing a potential game-changing advance in whale tracking and identification.
A new study found that stronger firearm laws are associated with fewer crime guns originating from neighboring states. The researchers analyzed data from 2006-2016 and found that states with more lax gun laws had a higher percentage of traced in-state crime guns.
A Baylor University study reveals that living arrangements have a more significant impact on shaping racial attitudes than congregational composition. The study found that attending white-only churches decreases comfort with non-white individuals, while living near diverse neighborhoods increases friendships across racial lines.
A Drexel University study linked past experiences with bias and discrimination to avoidance of doctors in women with higher body weights. The study's findings suggest that a weight-inclusive approach could reduce healthcare stress and anxiety, promoting healthier interactions between patients and providers.
Researchers developed a method to 'decorate' gold nanoparticles with proteins, allowing drugs to target specific areas in the body. This technology can improve drug delivery and overcome biological barriers.
Researchers at Stanford University School of Medicine successfully used CRISPR-Cas9 to genetically edit coral, demonstrating its potential as a resource for coral biologists. The technique allowed them to identify critical genes in coral biology and alter multiple gene copies, offering hope for conserving coral reefs.
Researchers at UT Dallas developed a new control strategy using supercomputers to extract more power from wind turbines. The approach has the potential to increase wind energy production by up to six percent and generate $100 million in value per one percent improvement.
The Earth BioGenome Project proposes sequencing genomes of all known eukaryotic species, an undertaking estimated to take 10 years and cost $4.7 billion. This initiative aims to create a complete digital library of life that will guide future discoveries, building on the success of previous genomics projects like the Human Genome Project.
A recent $5 million NIH grant will fund a five-year research consortium aimed at reducing firearm injuries among US children and teens. The consortium, led by Michigan State University, brings together experts from various fields to investigate policy interventions and develop evidence-based solutions.
A study led by the University of Cambridge found that women who feel in control of their lives and find purpose and meaning are less likely to have anxiety disorders. The research highlights inner strengths that can protect against anxiety in tough times, offering new approaches for therapy development.
A study by the Hebrew University of Jerusalem found a link between prolonged acetaminophen use during pregnancy and an increased risk of attention deficit hyperactivity disorder (ADHD) and autistic spectrum disorder (ASD). The analysis shows a 30% increase in relative risk for ADHD and a 20% increase in relative risk for ASD.
Researchers have discovered a genetic switch in the bacteria that can be targeted by small molecules to prevent its virulent form from emerging. By disabling this switch, the bacteria become more vulnerable to host defense molecules and disinfectants, making it a potential key for new antibiotics.
Dr. Steven Galetta has been awarded the 2018 A.B. Baker Award for Lifetime Achievement in Neurological Education by the American Academy of Neurology. He is recognized for his contributions to neurological education and leadership, as well as his research on MS, concussion, and optic nerve disorders.
Researchers generated an atlas of the human genome using human embryonic stem cells, identifying essential genes for growth and survival. The study also analyzed the role of cancer-causing genes in early development and growth.
Researchers found that parasitic ants are accepted by host colonies due to their potent chemical weaponry, which protects against a more deadly invader. The study suggests a mutually beneficial relationship between the hosts and parasites, where the enemy of your enemy is your friend.
Researchers investigated the interaction between induced membrane vesicles and target cells, finding that proteinase K treatment inhibits internalization. The study suggests that artificial microvesicles can be designed to specifically deliver anti-tumor drugs to cancer cells.
Researchers at Stanford University have found cost-effective carbon capture and sequestration (CCS) technologies commercially feasible with existing technology in the US. CCS can be profitable through tax credits and low-carbon fuel standards, incentivizing its deployment to meet climate goals.
A Stanford study found a link between early-life obesity and depression in children's brains, revealing abnormalities in reward-processing areas. Young people with both conditions had lower volumes in the hippocampus and anterior cingulate cortex.
A new international study has found that galaxies grow bigger and more ordered with age, with stars moving in all directions. The research team measured the movement of stars in 843 galaxies using an instrument called SAMI on the Anglo-Australian Telescope.
A study of a majority-black cohort found no clear upward trend in cognitive abilities among older adults, contradicting previous observations. Cognitive performance differed significantly by race and function, with black participants scoring lower than their white counterparts.
A study published in CMAJ found that peer reviewers' characteristics, including gender and previous success rates with grants, can introduce bias into grant applications. This bias results in lower scores, making applications less likely to be funded. The researchers suggest that training of reviewers, policy changes, and monitoring ma...
Yale researchers have achieved a major milestone in quantum computing by transmitting quantum data between two separate points using a new 'pitch-and-catch' technology. This innovation allows qubits to be interfaced with each other, enabling more complex algorithms and potentially faster computation speeds than classical computers.
A study found that dogs living in rural environments had distinct skin microbiota and lower allergy prevalence compared to urban dogs. Exposure to rural microbes through urban planning may improve urban health.
Researchers found that Heriaeus melloteei spider venom can block leakage currents through mutated ion channels, potentially treating hypokalemic periodic paralysis. The toxin fixes the voltage-sensing domain of the channel, preventing ions from leaking out and restoring normal muscle function.
Researchers found that trace amounts of beta-amyloid predicted future levels of tau and both preceded memory decline. Early intervention is crucial in slowing Alzheimer's disease progression by targeting anti-amyloid therapies before symptoms appear.
A study found that girls are more likely than boys to struggle with social-emotional learning problems, academic difficulties, and behavioral issues in high school. The researchers identified five patterns among youths, with girls accounting for nearly 66% of students with high needs across all domains.
Glioblastoma tumors exhibit cell-to-cell differences that contribute to therapy resistance. Extrachromosomal DNA is found to play a key role in oncogene amplification, driving cancer progression and evolution. Researchers are developing novel combination therapies targeting ecDNA elements to improve treatment outcomes.
A team of researchers has developed a glowing contact lens that reduces the retina's oxygen demands at night, potentially preventing diabetic retinopathy. Early testing shows promising results, with rod cell activity reduced by up to 90 percent when worn in the dark.
The new American Academy of Pediatrics guidelines have led to an increase in the prevalence of elevated blood pressure among US children. This is largely due to the exclusion of overweight or obese children from normal blood pressure charts and revised diagnostic thresholds aligned with adult definitions.
By combining fossil occurrence data with social network analysis, researchers identified distinct associations of ancient marine animal life and investigated the representation of these communities over geologic time. This approach enabled the quantification of ecological impacts of mass extinctions and major ecological shifts.
Researchers at Oxford University have identified a genetic catalyst, ampR, that accelerates the evolution of antibiotic resistance in bacteria. The study found that species carrying the ampR gene evolve resistance at a higher rate than those lacking it.
A new cell therapy has been developed to aid heart recovery without implanting cells, using extracellular vesicles secreted by cardiomyocytes derived from human pluripotent stem cells. The therapy shows promising results in recovering cardiac function and reducing arrhythmias in rat models of myocardial infarction.
A study of 2.3 million LinkedIn users found that revealing the number of applicants increases applications from diverse backgrounds, including women and inexperienced workers. This could help companies close diversity gaps and bolster labor markets.
Researchers used neutron scattering to study the microscopic structure and optoelectronic properties of hybrid perovskite materials. The study found that hydrogen bonding plays a key role in the material's performance, enabling manufacturers to design solar cells with increased efficiency.
Researchers found mice with induced heart failure fared better after being treated with antibiotics for five weeks, which sterilized the gut. This suggests that modulating the microbiota could modulate T cell activation and changes in the heart that lead to heart failure.