Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer. The combination treatment lived seven months longer than hormone treatment alone, with benefits strongest in women who had previously responded to hormone therapy.
A combination of immunotherapy and chemotherapy significantly extends survival by up to ten months in patients with triple-negative breast cancer. The treatment reduces the risk of death or cancer progression by up to 40 per cent, offering new hope for young women affected by this aggressive form of breast cancer.
Researchers have assembled the largest sets of African genomic data, creating a resource to study genetic structure, disease, and protein function. They identified 10 new associations specific to African populations, including links between genetic variants and diseases such as alpha thalassemia and diabetes.
Researchers created complex origami structures with unprecedented strength, light weight, and expandability using Digital Light Processing (DLP) 3D printing. The innovative approach enables folding and refolding of the structures without breaking, paving the way for numerous potential applications.
A Phase III clinical trial shows that combining immunotherapy with chemotherapy improves progression-free and overall survival for patients with triple-negative breast cancer. The study's results establish a new standard of care in PD-L1+ patients and provide hope for those diagnosed with this aggressive form of breast cancer.
Researchers developed a polygenic risk score for lifespan based on weighted contributions from relevant genetic variants, predicting which participants were likely to live longest. They also found associations between genetic variants and Alzheimer's disease, heart disease, and smoking-related conditions with overall lifespan.
A large study found that drugs approved for women's breast cancer are also effective and well-tolerated in men. Men with metastatic breast cancer received similar treatments to women, including hormonal therapy and chemotherapy, with similar outcomes.
Atezolizumab, an antibody targeting PD-L1, improved survival in metastatic triple negative breast cancer patients by 20%, particularly those with PD-L1 positive tumors. The combination therapy also reduced disease worsening and death risk by 38% in PD-L1 positive subgroup
A phase 3 clinical trial found that ixekizumab significantly improves AS symptoms, disease activity and quality of life after 16 weeks. The treatment was well-tolerated despite more frequent adverse events compared to placebo.
The PALOMA-3 study found that the CDK4/6 inhibitor palbociclib significantly improves progression-free survival in patients with HR+/HER2- advanced breast cancer. In a new analysis, palbociclib plus fulvestrant was shown to improve overall survival by 6.9 months compared to placebo plus fulvestrant.
A bioelectronic medicine device has been shown to significantly reduce pain and fatigue in patients with lupus. The study built on previous research and used an external stimulation device to pulse through the ear, resulting in a decrease in symptoms in participants who received real stimulation.
A study highlights the existence of barriers to the inclusion of 12 to 25-year-olds in both adult and paediatric early phase clinical trials. The legal minimum age limit in Europe is 18 years, preventing young patients from participating in trials designed for their tumor type.
A study published by Cleveland Clinic found that increased cardiorespiratory fitness is directly associated with reduced long-term mortality. Elite performers showed a significant survival benefit, particularly in older patients and those with hypertension.
Scientists at Queen Mary University of London created an app that challenges users to play Clapping Music, a complex piece written by Steve Reich. The app collected data from over 100,000 players and found that changing rhythms is harder than playing individual rhythms, with average accuracy varying greatly between difficulty levels
Researchers at UNIGE and HUG discovered that mucinous tumours of the ovary and pancreas originate from embryonic germ cells that migrate to reproductive organs. These cells can mistakenly stop in other organs, leading to cancer decades later.
A newly discovered mineral zircon in Galapagos basalts raises questions about the Earth's crust-mantle system. Geoscientists from Mainz University and partners will collaborate to investigate hypotheses and explore a geological enigma, with implications for understanding island formation.
Researchers found that adding refined fiber to processed foods can lead to liver cancer in mice with preexisting gut dysbiosis. The study suggests that enriching foods with purified fibers may not replicate the health benefits of whole foods naturally rich in fiber.
A new definition of PARDS, issued by the Pediatric Acute Lung Injury Consensus Conference, has been validated through an international study. The study found that two-thirds of children with mild and moderate PARDS would not have been accurately diagnosed using adult definitions.
A new portable vacuum gauge, developed by NIST scientists, tracks changes in the number of cold lithium atoms trapped by laser and magnetic fields to measure pressure. This innovation uses ultracold trapped lithium atoms, which have an exceptionally low vapor pressure at room temperature.
Researchers found that humans can identify parent-offspring resemblance from infancy, but it becomes more accurate with age. This study suggests that the ability to recognize kinship may be linked to increased facial similarity with parents before puberty.
Researchers discovered Src activates mTORC1 through amino acid signals, found to be hyperactive in cancer. Src's malfunction leads to continuous signaling for cell growth and cancer progression.
A nationwide study found large regional differences in endoscopic sinus surgery rates due to chronic rhinosinusitis in Finland. The highest rates were observed in public hospitals, suggesting a correlation between the availability of medical services and ESS rates.
A multiyear clinical trial found that patients who chose their form of treatment, whether medication or therapy, improved more than those who were simply prescribed one or the other. Patients who received prolonged exposure therapy showed a significant reduction in PTSD symptoms and were more likely to lose their diagnosis over time.
Researchers found that the Biermann effect can sever magnetic field lines, triggering magnetic reconnection. The discovery was made through computer simulations of high-energy-density plasma experiments, revealing a previously unknown mechanism in astrophysical plasmas.
A recent national survey of internal medicine doctors found that three-quarters reported financial ties to industry, with drug samples and food/beverage being the most common benefits. The study also revealed significant reductions in certain types of payments compared to a previous survey in 2009.
A Stanford University School of Medicine study found that teens and young adults who use Juul e-cigarettes fail to recognize the product's addictive potential, with some reporting addiction despite infrequent smoking. The study emphasizes the need for clear public-health messages about the risks of new types of e-cigarettes.
Researchers describe a DNA immunization platform that stimulates innate and adaptive immunity to produce high levels of antigen-specific antibody responses. The approach activates multiple pathways of innate immunity, leading to the development of high-affinity antibodies in mouse, rabbit, and human models.
A study suggests that immunotherapy is safe and feasible for HIV-positive cancer patients. The treatment appears to be well-tolerated as long as antiretroviral therapy is continued in parallel, the key finding of the study.
A study of US hospital statistics from 2010-14 found a rise in stroke incidence among marijuana users, with rates increasing from 1.3% to 1.5%. Young stroke survivors also face long-term risks, with nearly 3 times the risk of adverse events compared to older patients.
The ESMO 2018 Congress emphasizes the importance of integrating scientific advances into sustainable treatments, ensuring optimal cancer care reaches those who need it. Research highlights variations in European countries' approval times for new cancer drugs, emphasizing the need for timely reimbursement decisions.
Professor Harry Hilton combines da Vinci-Euler-Bernoulli theory with Timoshenko theory and viscoelastic materials to create a unified model for flying vehicles. The analysis considers both deterministic and probabilistic approaches, aiming to improve the design of future aircraft.
A recent study found that US air pollution deaths decreased by 47% between 1990 and 2010, resulting in nearly 135,000 fewer deaths. The improvement coincided with increased federal air quality regulations.
MSU researchers developed a new course 'Integrative Biology: From DNA to Populations' featuring Avida-ED, a digital evolution software program. This approach allows students to engage with biological concepts in a familiar and interesting context, resulting in increased understanding of evolution-influenced topics.
Researchers developed a novel technology to analyze hundreds of genes at single cell level, revealing critical immune system weakness in cancer. The Pro-Code technique identified disease-causing genes and potential drug targets for cancer immunotherapy.
A study of breast cancer survivors found that natural pregnancies are possible after chemotherapy, but many no longer wish to have children. The study also showed that fertility preservation measures are not widely needed among young breast cancer patients.
ORNL scientists created a 20-kilowatt wireless charging system that transfers 120 kilowatts of power with 97 percent efficiency. The system enables faster and more convenient charging, rivaling the speed of gas station fill-ups.
A Florida State University study found that nicotine exposure in fathers can cause cognitive deficits in their children and grandchildren. The study showed that changes in the father's sperm attributed to nicotine exposure led to problems in genes related to memory and learning.
The University of Massachusetts Amherst has been selected as one of the National Science Foundation's Innovation Corps Sites. The program aims to increase research commercialization and campus startups, with a focus on enriching existing innovation infrastructure. Key findings include the importance of diversity and inclusion in techno...
Researchers found that fostering gratitude among adolescents can decrease materialism and increase generosity. By keeping a daily journal, teens showed significant decreases in materialism and increases in gratitude, demonstrating the potential of this simple strategy to curb materialistic tendencies.
Research from the LBJ School of Public Affairs found that Northern Ireland's strict abortion laws have negative consequences for women's physical and mental well-being. Women often face barriers to accessing care, including fear of prosecution, lack of clarity on healthcare provider duties, and challenges in arranging travel or childcare.
Research reveals a single missing gene in mothers leads to miscarriages due to placenta problems, including fewer blood vessels and altered shape. The study provides new insights into recurrent miscarriage in humans and lays the foundation for further research on placenta development.
A comprehensive national registry for pediatric chronic kidney disease (CKD) is essential to improve lifespan and quality of life. The study emphasizes the importance of identifying children at risk, with high mortality rates among those requiring renal replacement therapy.
Boston Medical Center reduced unnecessary diagnostic testing and increased postoperative order sets after implementing electronic medical record-based interventions. The study demonstrates the impact of deploying multiple interventions simultaneously within the electronic medical record on delivering high-value care.
A nine-week course of adjuvant trastuzumab was associated with similar disease-free survival and lower risk of cardiac toxicity compared to a one-year course in patients with HER2-positive early breast cancer. A six-month course of trastuzumab was also shown to be cost-effective, with an average cost saving of nearly £10,000 per patient.
A recent study found that invasive cattle forage grass, tall fescue, is associated with nest failure in dickcissels, small grassland birds. The researchers identified tall fescue as a key factor influencing nest survival, and suggested that removing the invasive species could benefit wildlife and people's livelihoods.
This book by East China Normal University and Singapore Management University researchers delves into network data mining and analysis to identify social communities, assess network robustness, and predict links. The research focuses on bipartite graphs and signed graphs, offering insights into user behavior across heterogeneous networks.
Researchers found that similar brain regions are involved in both spatial navigation and odor identification, suggesting an intrinsic association between the two. Participants with better spatial memory were also better at identifying smells, supporting the idea that these skills evolved together.
A new study found that healthy diets are associated with a lower risk of death from colorectal cancer, both before and after diagnosis. Those who followed the American Cancer Society's guidelines on nutrition and physical activity had a 22% lower risk of all-cause mortality.
A new study finds that pelvic floor muscle exercises can significantly improve overactive bladder symptoms in patients with neurogenic and non-neurogenic conditions. The study suggests that PFM training activates the frontal cortex of the brain, leading to improved conscious control of bladder function.
Researchers found that short apneas and hypopneas were associated with higher mortality risk, even when controlling for AHI. The study suggests a new phenotype of OSA linked to genetic factors and increased risk of hypertension.
A study by Duke-NUS researchers found that brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin receptor kinase B (TrkB) affect social dominance in mice. The research sheds light on the neurobiology of aggression and bullying.
A study by Brigham and Women's Hospital found that 15.7% of emergency department visits could be denied coverage based on discharge diagnoses. Patients may face difficulties self-determining their medical needs, highlighting the need for alternative solutions.
This study examined pod-based e-cigarette use among California adolescents and young adults, finding that most users also used other e-cigarettes and traditional cigarettes. The average perceived risk of social and health risks from pod-based e-cigarettes was around 40%.
Researchers at Boston University School of Medicine discovered a strong link between chronic inflammation and increased risk for Alzheimer's disease in ApoE4 carriers. Sequential measurements of C-reactive protein revealed that ApoE4 linked with chronic low-grade inflammation significantly increases AD risk.
Ramesh Sitaraman and his team won the prestigious award for building the Akamai content delivery network, which serves a quarter of all Internet traffic. The team's work on CDNs has transformed the Internet and spawned a business sector valued at tens of billions of dollars.
Researchers found evidence of rapid adaptation in Burmese python genomes, with changes in genes related to cell division and organ growth. The study suggests that the snakes are adapting to more regular feeding opportunities, leading to increased efficiency as predators.
French researchers conclude that including exercise in cancer care can significantly improve symptom management, quality of life, and fitness. Studies show that regular exercise reduces pain, fatigue, and body fat while improving overall fitness, with benefits seen even among patients at highest risk of poor quality of life.
A recent survey found that social vulnerability and medical skepticism are major barriers to cancer screening participation, particularly for colorectal and lung cancer screenings. Researchers call for a combined approach incorporating new technologies and personalized messaging to address inequalities in screening uptake.
Researchers at University of Sussex have developed a non-invasive sensor to measure a baby's heartbeat, providing accurate results without hospital visits. This technology will give expectant mothers peace of mind and enable early detection of congenital disorders.
Patients with sleep apnea who experience short interruptions in breathing while sleeping are at a higher risk of death than those with longer interruptions. The study found that patients with the shortest apneas were 31% more likely to die during follow-up.