The Rosalind Franklin Institute has committed to developing a new detector for low-energy cryoEM, enabling atomic-scale images of biological samples. The goal is to make cryoEM more accessible and affordable, allowing for faster scientific progress in medical research and drug development.
Researchers found that inhibiting apoptosis in fruit fly neurons led to the development of 'zombie' cells that formed new olfactory neuron networks with distinct properties. These neurons expressed different receptors, including those for carbon dioxide detection, giving the flies enhanced odor perception.
A survey of over 1,000 German consumers found broad support for nutritional policy action, despite initial concerns about social acceptance. Key findings indicate that people's opinions on food policies are not tied to individual dietary struggles, with those who eat a healthy diet also being in favor of regulation.
The discovery of Oculudentavis khaungraae, a tiny bird-like skull found in Burmese amber, reveals new insights into bird evolution. The specimen's unique anatomical features suggest a never-before-seen combination of features, including a diurnal lifestyle and surprising similarities to modern lizards.
Researchers found that commercial fast-charging stations cause high temperatures and resistance damage to electric car batteries, leading to capacity loss and potential fires. The University of California, Riverside developed an adaptive fast-charging algorithm to mitigate this issue.
Tropical Storm 21S formed in the Southern Indian Ocean and was tracked by NASA-NOAA's Suomi NPP satellite. The storm is expected to make landfall in Western Australia as a tropical storm, with maximum sustained winds near 35 knots (40 mph/65 kph).
A recent survey found that most emergency physicians (over half of 1,074 respondents) encounter firearms at work annually, yet less than half feel confident in handling them. The study suggests that emergency physicians may benefit from educational interventions targeting firearms safety.
Researchers analyzed 73 studies on antibiotic use in outpatient sectors worldwide, finding city dwellers, children, and seniors take more antibiotics. Higher education and richer countries reduce antibiotic use, while urban areas and doctor concentrations increase it.
Scientists have developed a rapid and efficient delivery method that uses the power of a tiny fluid vortex to deform cell membranes, allowing for the delivery of nanomaterials such as DNA, proteins, and drugs. The device, called a spiral hydroporator, can deliver nanomaterials into around one million cells per minute with up to 96% eff...
A new study published in Environment International links poor air quality to changes in the human gut microbiome, increasing the risk of obesity and diabetes. Young adults exposed to higher levels of ozone showed less microbial diversity and more species associated with obesity and disease.
A study published in Japanese Psychological Research found that users with more mutual connections are more likely to spread dreadful information, possibly intending to share their reactions. By identifying user network characteristics, this study potentially offers a solution to prevent fake news dissemination.
Researchers have visualized the first structure of a lipin enzyme, crucial for triglyceride production, revealing how it regulates fat storage and its role in diseases like heart disease and obesity. The study provides insights into mutations that lead to abnormal triglyceride production.
A team of engineers at UNSW Sydney has successfully controlled the nucleus of a single atom using only electric fields, solving a problem that stood for over half a century. This breakthrough has major implications for the development of quantum computers and sensors, enabling precise control over individual atoms.
Researchers found a diverse community of microbes that efficiently recycle and store organic compounds to survive in hostile environments far beneath the ocean floor. The study reveals genetic material suggests many lower crust microbes rely on carbon from their surroundings to obtain energy.
Researchers identified a potential intervention for triple-negative breast cancer by targeting the MYCN oncogene. Experimental drugs called BET inhibitors showed promise when combined with MEK inhibition in model systems overexpressing MYCN.
Researchers at UNIST have developed a novel catalyst for electrochemical chlorine generation, overcoming the drawbacks of existing metal oxide-based catalysts. The new catalyst, Pt1/CNT, exhibits high efficiency and selectivity for chlorine ions, enabling more efficient and affordable production.
A new study from Tulane University has identified a protein on tumor-derived extracellular vesicles that indicates if NSCLC tumors are likely to metastasize. This discovery could lead to the development of an early diagnostic test for patients at high risk of cancer spread.
A new study found that climate change is likely to cause the extinction of the Greek Meadow Viper, with up to 90% of its habitat becoming uninhabitable by the end of the 2080s. Rising temperatures and aridification due to climate change are the primary threats to the species' survival.
A study by CAMH and ICES found that only 2-3% of patients with urgent mental health needs can access publicly-funded psychotherapist physicians. The authors suggest allowing non-physician clinicians to provide CBT as a solution to improve access.
Researchers at Cornell University found that squash and pumpkin pollen deter bumblebees from collecting and eating pollen, potentially providing an evolutionary benefit to cucurbit plants. This is because the pollen causes damage and distorted digestive tracts in adult bees and prevents them from reproducing.
Two new articles published in Annals of Internal Medicine provide guidance on how US hospitals can prepare for the ongoing COVID-19 pandemic. The first article offers ideas for protecting hospitals from the invisible threat of coronavirus, while the second article provides recommendations for preparing hospitals for a surge in cases.
A study analyzing Barcelona's 'Superblocks' program reveals how political struggles for municipal power hindered its implementation. The program aimed to reduce car traffic and emissions, but resistance from local forces and public participation issues threatened its success.
Researchers developed a room-temperature bonding technique that integrates wide bandgap materials like gallium nitride with thermally-conducting materials like diamond. The interface layer is just four nanometers thick, allowing for two times more efficient heat dissipation.
The Collaborative Water-Energy Research Center (CoWERC) aims to reduce energy needed for desalination, improve water recovery and support safe water reuse through research, development and commercialization of new technologies. CoWERC will enable the creation of energy-water systems that could be implemented worldwide.
A new study from the University of California, Davis found that ibuprofen causes significant changes in liver enzymes in laboratory mice. The research highlights marked differences in how males and females metabolize the drug, with potential implications for human health.
Researchers discovered that a combination of small molecules and CHK1 inhibitors can boost cancer cell killing, even in cancers resistant to current treatments. Targeting B-family DNA polymerases also increased effectiveness.
A study published in JAMA Cardiology found that individuals who maintain intermediate to ideal cardiovascular health for longer periods are 33% less likely to develop hypertension and other diseases. This suggests that promoting healthy behaviors throughout life may be beneficial for reducing the risk of chronic diseases and mortality.
Researchers have measured atomic positions of all atoms in a 2D material and calculated its impact on electronic properties. They found that materials are far from perfect, with constant misalignment, missing, or replaced atoms affecting the system's behavior.
The study reveals how twisted graphene sheets behave and their stability at different sizes and temperatures, providing insights into self-alignment mechanisms and forces. This fundamental research could pave the way for manufacturers to achieve fine control over twist angles in 2D material structures.
Researchers investigated how users choose their mobile phone PINs and found that six-digit PINs do not provide more security than four-digit ones. The study also showed that Apple's blacklist could be optimized and would make sense on Android devices.
A team of palaeontologists has discovered stegosaur fossil footprints on the Isle of Skye, shedding light on dinosaur diversity in the Middle Jurassic period. The findings reveal that stegosaurs roamed the island around 170 million years ago and provide a clearer picture of Scotland's dinosaur evolution during this time.
A new two-step technique repairs herniated discs by re-inflating the disc with hyaluronic acid gel and sealing the hole with collagen gel. This method maintains mechanical function and prevents collapse or deterioration, offering a promising alternative to existing treatments.
Scientists have proposed using permanent magnets to simplify the design and production of stellarators, which are twisty fusion facilities that can produce massive amounts of energy. This innovation could lead to the creation of simpler, non-twisted coils and lower costs for engineering and manufacturing.
Researchers found that smaller tropical forest fragments experienced greater losses than larger ones between 2001 and 2018. Connecting small fragments to reestablish wide-ranging tree cover is crucial in Central America, West Africa, and Southeast Asia.
Researchers surveyed remote South American kelp forests for the first time in 45 years, finding relatively unchanged ecosystems despite global threats from climate change and human activities. No signs of destructive sea urchin grazing were observed, but fish populations varied by location within the study area.
Researchers found that weight-loss surgery increased colorectal cancer risk by 20% and mortality rates among obese patients, highlighting the need for post-operative surveillance.
Researchers at Stanford University have discovered the invisible pattern that growing neurons follow to form a brain using microscopy and mathematics. The technique could be used to coax stem cells to grow into replacement body parts, such as artificial organs.
A new study by Duke University reveals that piracy in the Strait of Hormuz can have a significant toll on smaller Persian Gulf countries, including Bahrain and Kuwait. These nations export refined petroleum products, which make up a larger proportion of their GDP, making them more vulnerable to slowdowns in energy shipping.
Using DES data, researchers found more than 300 trans-Neptunian objects, including 245 discoveries made by DES. The method developed by Pedro Bernardinelli can also be used to search for TNOs in upcoming astronomy surveys.
Researchers found that pairing Abraxane with Intralipid enhances tumor-killing macrophages, reducing cancer growth and protecting organs from damage. The combination also decreases the amount of expensive drugs needed for treatment.
Astronomers detected velocities of both brown dwarfs in a system orbiting each other, confirming the hypothesis that 2M1510 is composed of two brown dwarfs. The discovery provides rare data on the mass, radius, and age of brown dwarfs, allowing for verification of theoretical models.
Researchers at NIST identified acetic acid as a prime suspect in accelerating the degradation of polyamide-based backsheets, which are common in solar panels. The study highlights the importance of interplay between solar panel components in determining their longevity.
A team of Cornell researchers compiled a 'cell atlas' of muscle regeneration, cataloging the activity of almost every type of cell involved in muscle repair. The dataset provides a comprehensive picture of cellular interactions and may lead to improved rehabilitation strategies for patients recovering from muscle injuries.
Researchers discovered rocaglate compounds capable of killing Candida auris, a challenging pathogen with limited treatment options. The compounds inhibit translation initiation in C. auris, leading to cell death, and have potential as a therapeutic strategy for fungal infections.
Researchers found that degrading perineuronal nets improves learning abilities in mice but disrupts memory storage. Children's brains have flexible connections allowing for better learning and recovery from brain injury due to intact perineuronal nets.
Researchers created a new model to account for wine tears' complex fluid structures, which form due to changes in surface tension induced by alcohol evaporation. The study reveals the interplay between gravity, surface tension, and fluid physics leading to these unusual phenomena.
Scientists classify neurons into three classes based on their response to heartbeat-induced brain motion, revealing differences in firing properties and coordination with cognitive waves. This work aims to bridge scales between microscopic cell behavior and macroscopic cognition.
Researchers at Chalmers University of Technology identified Atox1 as a copper-binding protein that facilitates breast cancer cell migration. High Atox1 levels in tumours are linked to lower survival times, suggesting it may be a biomarker for disease aggressiveness.
Graphite has been found to be intrinsically lithiophilic at 500K, contradicting previous conclusions that it was lithiophobic. The study uses ab initio molecular dynamics simulation and shows that surface chemistry plays a key role in the wetting performance of Li metal on graphite.
A study by University of Helsinki researchers identified a gene variant in the regulatory region of the retina responsible for canine blindness in Miniature Schnauzers. The finding provides valuable insights into retinal biology and offers a new model for understanding related diseases, such as retinitis pigmentosa.
Researchers found that biomass fuels derived from grasses like switchgrass and giant miscanthus can reduce carbon emissions by 78-290% compared to petroleum-based fuels. The study suggests that these crops could provide a significant portion of the decarbonization needed to curb global warming.
Researchers find historically rare events in Indian Ocean have become more frequent and intense, with potential dire impacts on Australia's climate. The study uses coral records to reconstruct variability over the last millennium, providing new insights into how the Indian Ocean interacts with ENSO.
A new study by Texas A&M University biologist Dr. Charles Criscione and collaborators reveals that family ties play a crucial role in the survival of parasitic organisms. Brain flukes sacrifice themselves to ensure the survival of their relatives, who co-infect the same ant's abdomen.
Researchers at NREL developed a new formula to boost perovskite solar cell longevity and efficiency by suppressing light-induced phase-segregation. The tandem perovskite/silicon solar cell achieved an efficiency of 27%, outperforming existing silicon-based cells.
A new study found that people who experienced the greatest levels of hardship, stress, and personal loss were five times more likely to experience a lower quality of life, with significantly more health and physical difficulties in later life. Those raised by emotionally cold mothers were also less likely to experience good quality of ...
Excess electrons can shatter carbon-fluorine bonds in PFAS, breaking them down into by-products that may accelerate the process. The discovery offers a potential method to tackle widespread contamination of water supplies across America.
The National Comprehensive Cancer Network (NCCN) has published a list of high-impact measures for assessing quality improvements in cancer care. The recommendations reflect a landscape analysis from leading oncology experts and include endorsement of 15 existing measures and seven new concepts proposed for development.
FAIR Health has launched a groundbreaking website feature that combines clinical and cost information to support seriously and chronically ill patients in shared decision making with clinicians. The new tool offers three palliative care scenarios, including kidney dialysis, nutrition options, and breathing assistance.
Researchers have identified a new target in 'normal cells' for a potential treatment of triple negative breast cancer. Using PIK3Cδ inhibitors, the study found a reduction in tumour growth and improved survival outcomes when levels of the protein were controlled in surrounding healthy tissue.
A study of 46 Finnish Leonbergers found that 15% had severe arrhythmia and 15% had milder cardiac changes, with sudden deaths linked to cardiac arrhythmia. The researchers aim to identify the genetic cause of the disorder to develop early diagnostics, breeding programs, and potential drug therapies.