A systematic review and meta-analysis of 108 studies found that people with severe mental illness, including schizophrenia, have twice the cardiovascular-related mortality rate as the general population. The association has grown stronger over recent decades, with a possible link to changes in antipsychotic use and smoking prevalence.
A Canadian study of over 12,000 hospital admissions found that updated product label changes did not reduce rates of accidental acetaminophen overdose. The study suggests additional measures are needed to prevent these episodes beyond just labeling changes.
A new study found that microglia regulate neuronal subtypes differently in response to bacteria, affecting intrinsic excitability. Pyramidal cells exhibited lower excitability, while Purkinje cells showed higher excitability when modulated by microglia.
Key signalling pathways blocking by existing drug candidates limit CCHF virus reproduction. The findings offer hope for patients affected by this deadly disease, which has a high mortality rate in humans.
Researchers from HKUST have identified secondary RNA elements that control DICER's cleavage activity, improving miRNA expression and shRNA design for effective gene silencing. The study provides a foundation for designing accurate and efficient short-hairpin RNAs.
Scientists tracked Cryptosporidium in real-time, revealing a simplified lifecycle that completes in three days with only three stages: asexual cells, male cells, and female cells. This understanding paves the way for potential vaccines or therapies to combat the disease.
A team from UNIGE demonstrates that stem cells giving rise to beta cells cease to exist after birth, and defines the 'identity card' of other hormone-producing cells. This discovery has significant implications for developing cell-based therapies to treat diabetes.
A recent commentary in the Journal of the National Cancer Institute highlights the disproportionate cancer burden facing Asian Americans, largely attributed to historical prejudices and language barriers. The authors emphasize the need for increased funding and representation in clinical trials to address these disparities.
Scientists have found a new way dunes can form on Io's surface, which is icy and roiling. The researchers used mathematical equations to simulate the forces on a single grain of basalt or frost and calculate its path.
A study by Osaka University researchers reveals patients waited years for diagnosis of rare diseases like hereditary angioedema. Long diagnostic delays can be fatal, and raising awareness is key to improving treatment.
The 29th annual CNS meeting will feature scientific talks, posters, and receptions, with a focus on the latest advances in cognitive neuroscience. Registered press members will have access to these sessions, as well as a quiet Press Room, while COVID safety protocols are in place.
Researchers at Dartmouth have built the world's first superfluid circuit using pairs of ultracold electron-like atoms, allowing for controlled exploration of exotic materials like superconductors. The circuit enables analysis of electron movement in highly controllable settings.
Researchers found high levels of an enzyme called HDAC9 in healthy neurons, which decline with age and more drastically with Alzheimer's. The study suggests adjusting the enzyme's level may be a potential treatment for both conditions.
A Baylor College of Medicine study finds that type I interferon is a major driver of memory and cognitive loss in a mouse model of Alzheimer's disease. Blocking IFN reversed these memory and cognitive deficits in the animal model, suggesting that inflammation plays a key role in AD progression.
Researchers compared mechanical aeration and biofiltration systems to minimize odorous compounds in sewage treatment plants. Biofilters with pruning waste and sludge compost showed efficacy, but lasting effects were variable depending on compound type.
A new evidence-based matching program aims to improve treatment outcomes by pairing patients with therapists based on their previously established effectiveness strengths. The program, funded by PCORI, has shown promising results in reducing symptoms and improving patient care.
Researchers detected aphantasia through pupillary response to imagining dark and light objects. Participants without aphantasia showed a larger pupillary response when asked to imagine vividly, indicating the absence of visual imagery in those with aphantasia.
A new study by Scripps Research analyzed sensor data from wearable devices to track physiological responses to the COVID-19 vaccination. The findings show that resting heart rate increased significantly after vaccination, with stronger effects in younger individuals and those who had prior COVID-19 infection.
Scientists at the University of Freiburg have developed a novel process for 3D printing small and complex components made of transparent glass. Using Glassomer materials and Computed Axial Lithography, they can create structures with thicknesses as low as 50 micrometers in just a few minutes.
Research reveals that the compound eye tile pattern is controlled by geometrical patterns based on concentric circle growth, not just physical stability. The study found that individual eyes show a hexagonal pattern when evenly distributed, but change to square-type when the compound eye extends in the vertical direction.
A study found that small genetic variations impact an organism's ability to utilize energy from various nutrients. Researchers identified several genes contributing to sugar tolerance in fruit flies, which are also present in humans and linked to obesity and type 2 diabetes.
Researchers at Queen Mary University of London identified a way to overcome resistance to cancer drugs in leukemia cells by manipulating cellular pathways. By using a sequential treatment approach, the team was able to kill about 50% of leukemia samples and potentially develop a new treatment strategy for this devastating disease.
The April issue of SLAS Discovery highlights innovative approaches to accelerating lead identification for pancreatic cancer therapies. Authors explore the potential of completely scaffold-free 3D models and automated organoid assays to improve disease modeling and drug discovery.
Researchers developed an algorithm to analyze wearable heart rate data, discovering new signals indicating COVID-19 infection and disease progression. The study's findings could enable the use of wearables in tracking disease at home or during pandemics.
Researchers created two scales to measure factors related to time spent in nature, finding correlations between TSN and self-efficacy, intentions, and age. The study aims to inform future interventions to increase outdoor activities among adults.
A new model predicts how oil and gas wells heat up the surrounding permafrost, causing it to thaw and release methane. The study shows that operating a single well for 30 years can melt the surrounding permafrost in a 10-meter radius, releasing up to 500,000 cubic meters of methane.
Researchers at ACS Sustainable Chemistry & Engineering have identified a less toxic dye called pigment red 254 (PR254) as a greener alternative to current anthraquinone dyes used in signal smokes. PR254 forms a red-colored smoke cloud more effectively and is thermally stable, making it suitable for use in heat-generating systems.
Researchers at UCLA have discovered that amyloid fibrils in the brains of patients with frontotemporal degeneration are composed of the protein TMEM106B, not TDP-43 as expected. This finding may lead to new focus on TMEM106B in FTLD and similar brain diseases.
Five medical societies release recommendations for preventing central line-associated bloodstream infections (CLABSIs) in hospitals. The new guidance highlights the need to strengthen infection prevention programs amid worsening rates of these infections during the COVID-19 pandemic.
A study of 118 PPA autopsies found five diseases causing language impairments, each impacting a distinct part of the language network. The findings can inform targeted interventions and treatment approaches for patients with PPA.
The 9th World Congress on Targeting Microbiota 2022 will focus on recent advances in the microbiota field and therapeutic strategies. Key findings include research on probiotic strains, natural mineral waters, and extracellular vesicles.
A study published in Brain reveals a dedicated neural circuit responsible for post-sepsis anxiety and depression. The researchers identified a potential pharmacological treatment by silencing the amygdala circuit during sepsis, reducing the risk of developing anxiety disorders.
Deforestation in Indigenous lands, particularly in Apyterewa Territory, poses a significant threat to Brazil's ability to meet its international climate change mitigation targets. The Brazilian government must take effective action to enforce environmental laws and protect the Amazon region.
Girls perform better in English than boys from ages three to seven, leading to a possible explanation for the STEM gender gap in adults. Parents who invest more time teaching math to their children show weaker association with later-life math skills.
A new study has identified a strong predictor for the development of clinically important liver problems in people with Hemochromatosis. Researchers found that 84% of those with advanced liver fibrosis also had arthritis, highlighting the importance of early detection and monitoring.
A study in eLife found that fine air pollution particles can increase the risk of lung cancer by altering lung tissue structure and reducing immune cell infiltration. The researchers identified peroxidasin as a key enzyme responsible for this effect, which could lead to new approaches for preventing or treating lung disease.
Researchers have developed a new optical microscopy platform that allows them to visually track the timing and location of fat storage within intact cells of fruit flies. The tool is being used to untangle links between diet and phenomena like obesity, diabetes, and aging.
A survey study found increased risk factors and worse outcomes among transgender and gender-questioning high school students compared to their cisgender peers. The study highlights the need for targeted support and interventions to address these health disparities.
Researchers at UC Berkeley have developed a new way to 3D-print glass microstructures using computed axial lithography (CAL), which produces objects with higher optical quality and design flexibility. The CAL process enables smooth surfaces and complex geometries, making it ideal for manufacturing microscopic glass objects.
Researchers at Karolinska Institutet study how the immune system protects against malaria, finding that people who have contracted the disease before develop a tolerance that prevents severe disease. This knowledge can aid in the development of more effective vaccines.
Researchers are taking stock of advancements in ultrawide bandgap (UWBG) photodetectors with deep UV capabilities, highlighting their efficiency and potential for solar-blind applications. Further work is needed to optimize device performance, particularly in assembling materials over large area substrates.
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
Scientists have created a 3D model of two rare neuromuscular diseases using a tissue chip platform. The model mimics the biology of chronic inflammatory demyelinating polyneuropathy and multifocal motor neuropathy, allowing researchers to study how a drug could potentially treat these devastating conditions.
The University of the Basque Country is taking steps to cut its environmental and social footprint by analyzing its impact through life-cycle assessment and modeling. By identifying areas for improvement, such as reducing transportation emissions and extending computer lifespan, the university aims to reduce its impact by up to 30%.
A new study by Hiroshima University introduces a novel AI-based technique for estimating site amplification factors from microtremor data. The model demonstrated potential as a predictive tool for characterizing site amplification factors, but notes are needed for further optimization with a larger dataset.
Researchers have shed light on how immune checkpoint protein LAG3 modulates T cell activity, providing crucial information for the development of new LAG3-blocking therapies. The study found that LAG3 suppresses T cell activation by disrupting coreceptor-Lck association, even in the absence of MHC Class II molecules.
A new report from Oak Ridge National Laboratory identifies supply chain must-haves for maintaining the pivotal role of hydropower in decarbonizing the nation's grid. The report also highlights advances in safer battery technologies and innovative electron microscopy techniques for imaging lithium in energy storage materials.
The conference features over 2,000 technical presentations, plenary speakers Dana Anderson, Hui Cao, Peter Delfyett, and Michal Lipson, and showcases market-ready technologies in lasers and photonics. Industry-leading companies demonstrate new products and technologies
Researchers at KIST developed a new charging technique that uses ultrasonic waves to charge batteries of underwater devices, such as sensors, and body-implanted electronic devices. The method improves efficiency by up to 4% and can transfer more than 8mW power over short distances.
Researchers at Ural Federal University improved the composition of borate glasses by adding heavy metal oxides, significantly increasing their density. The new glass samples showed good results as radiation shielding material in low and medium energy gamma radiation.
Researchers at Shibaura Institute of Technology discovered that tocotrienols, a subtype of vitamin E, can lower body weight, reduce white adipose tissue, and protect the liver in mice fed with a high-fat diet. The study suggests a potential compound to prevent obesity and its secondary diseases.
A Stanford University team developed a solar-powered technology to improve the quality and quantity of dried agricultural produce, increasing incomes for smallholder farmers in India. The equipment boosted prices by 14-22% compared to traditional open-air sun drying methods.
A simulated crisis-care event revealed the moral distress experienced by triage team members who had to prioritize patients for scarce resources. The study aimed to operationalize a process for making life-and-death patient decisions, but triage-team members struggled with balancing individual patient needs with fair resource allocation.
Scientists at UF/IFAS have recorded the first North American case of 'Candidatus Phytoplasma brasiliense' in yellow nutsedge, a highly invasive and aggressive weed. This discovery poses significant threats to agriculture and ornamental industries in the US.
A new UC Riverside study finds that the timing of rainfall is crucial for drought-stricken plants, with summer rains resulting in higher plant biomass. In contrast, winter rains have less impact on plant growth and may lead to negative effects.
The Linyi Lagerstätte, a new middle Cambrian fossil site in North China, has provided valuable insights into the evolution of animals during this period. The discovery has shed light on the morphological disparity and community structure of marine fauna following the Cambrian explosion.
The new computational tool, AF2Complex, predicts the structure of protein complexes and their interactions, offering insights into biomolecular mechanisms. The model is based on AlphaFold 2 and performs well in predicting protein structures and complex formations.
A recent study published in Public Opinion Quarterly found that anxiety about crime is a key predictor of presidential approval, with individuals who believe crime has worsened being more likely to punish presidents for it. The researchers also discovered that racial differences play a significant role in how Americans hold presidents ...
Scientists at OSU have developed a new nanotechnology approach for locating and removing endometriosis lesions using magnetic nanoparticles. These particles accumulate in lesions, making them easier to see via MRI, and can be heated to high temperatures, allowing for safe removal through non-invasive procedures.
A study by Cornell researchers found that recreational marijuana access significantly decreases prescriptions for pain, depression, anxiety, sleep, psychosis, and seizures in state Medicaid programs. This reduction could lead to significant cost savings for state Medicaid programs.