Researchers analyzed blood samples from 16 adult patients with sickle cell disease and found differences in proteins related to neurodegeneration, energy production, and other bodily functions. The study suggests the existence of previously unknown drivers of disease symptoms like pain.
Researchers have developed wave-shaped wall and roof designs that significantly reduce wind loads on low-rise buildings by up to 60%. The designs disrupt wind flow by creating a series of rounded hills and valleys, breaking up pressure zones and redirecting wind away from the building envelope.
A recent study found that wealthier ZIP codes tend to secure more competitive national park permits, highlighting a bias in the reservation system. The study, conducted by CU Boulder economist Jonathan Hughes, analyzed 11 reservation systems covering over 5 million reservations at seven national parks.
A scientist at the University of Miami Miller School of Medicine has been awarded the NIH Director's Pioneer Award for developing a novel cancer therapy that can evolve with a tumor. The therapy, known as a neoplasm emergent oncolytic virus, has shown proof of concept and could potentially treat deadly cancers like pancreatic cancer.
A clinical trial will test a caregiver wellness program for families after traumatic brain injury, aiming to reduce psychological distress and improve coping. The trial will enroll up to 354 patient-caregiver pairs and evaluate the intervention's feasibility, acceptability, and cost.
A new study from Northwestern University finds that long-term opioid use does not improve chronic pain, but rather alters brain activity and function. The study identified new molecular markers, including serotonin receptors, that could lead to new treatments for pain and opioid dependence.
Two linked studies provide effective recommendations for publishers, funders, institutions, and manufacturers to address the widespread failure to validate research antibodies. The studies estimate that millions of animal and human tissue samples have been wasted globally without adequate validation. The consensus reached by an interna...
The National Comprehensive Cancer Network hosted a summit on cancer prevention and screening, focusing on policy solutions and equity, innovation, and access. Key findings include the need to address barriers to access, the potential of new screening technologies to transform cancer detection, and the importance of value-based care mod...
Researchers at Boston University School of Medicine identified RGS4 as a key player in chronic pain conditions. Blocking RGS4 activity returned the nervous system to a calm state in experimental models, suggesting potential for new pain management therapies.
Researchers at Penn State College of Medicine discovered that blocking protein PIK3C3/VPS34 raises levels of GD2 on the surface of tumor cells, making them easier to detect and more vulnerable to treatment. This increase also creates a hostile environment for cancer growth.
The MARVEL microreactor project has completed key milestones, including the arrival of its primary coolant system, which has received federal safety approval. The system will now be integrated with other reactor systems before achieving criticality, expected to occur in December.
Dr. Samie Jaffrey's team will study metabolite-RNA interactions to comprehensively map and characterize their role in regulating messenger RNA levels. Their findings could lead to new therapeutic opportunities for diseases such as cancer, neurodegeneration, and metabolic disorders.
Researchers at Johns Hopkins Medicine have identified a distinct type of prostate cell concentrated in the transition zone of the prostate, where benign prostatic hyperplasia (BPH) commonly develops. The WIF1-positive basal cells may contribute to prostate enlargement and establish the unique biological environment of the transition zone.
The University of Stuttgart's SCALAR and COBRAS projects aim to increase productivity and sustainability in the construction industry with autonomous robotics. The projects will use a 'co-design' approach, integrating architecture, engineering, robotics, and computer science to create collaborative robotic systems on construction sites.
An international team of astronomers has captured the most detailed view yet of Pa 30, a supernova remnant in the Milky Way, revealing striking new features. The remnant is composed of chains of gas knots, each wide enough to fit the solar system multiple times, and a surviving 'zombie star' at its core. The discovery provides valuable...
A recent study by the HZI research team found that dietary fiber does not act alone in the gut microbiome, but rather interacts with existing bacteria to influence their growth. The presence of certain bacteria, such as Escherichia coli, can support the growth of other dominant bacteria, like Segatella copri, in the gut.
Researchers developed a novel sorbent, DPE6, to recover critical metals from organic effluents. The sorbent demonstrated high sorption performance and high maximum sorption capacity in various organic solvents. It successfully removed over 99% of lead from effluents using methanol, showcasing its potential for efficient metal recovery.
Sorghum production is expected to increase in Europe due to climate change, with potential yields of 3.4-3.8 tonnes/ha by 2050-2100. The crop's robustness in high temperatures and low water availability makes it a climate-resilient alternative to maize.
A yearlong study found that early depression and anxiety predicted later economic hardship, while financial strain went on to predict worsening depression, anxiety, and PTSD. Economic hardship was consistently associated with a higher likelihood of clinically significant depression, anxiety, and PTSD symptoms.
Binghamton University's Innovative Simulation and Practice Center has been named a SUNY Nursing Simulation Center of Excellence, receiving a $10 million investment to expand simulation space and experiences. The center will focus on faculty training and professional development in simulation-based education, addressing gaps in clinical...
A new study shows that hospitals still have far to go in implementing strategies to prevent catheter-associated urinary tract infections (CAUTIs), despite 20 years of effort. The study found that only 49% of general hospitals and 32% of VA hospitals have a system in place to remind doctors of a patient's catheter status, and that highe...
A Concordia University study demonstrates the use of simulated moon soil and recyclable thermoplastics to 3D print components for future lunar missions. The composite material, created by combining regolith with recycled poly(ether ketone ketone), showed thermal stability and improved performance.
An international study found that variants in the IDUA gene, associated with mucopolysaccharidosis type I, can cause inherited retinal disease without broader health problems. The study highlights the importance of understanding how genetic variants affect the body, potentially leading to earlier recognition and treatment opportunities.
Dr. Dennis Slamon, a pioneer in breast cancer research, has been awarded the 2026 Albany Prize for his groundbreaking work on targeted cancer treatments. His discovery of the HER2 protein and the development of Herceptin have transformed the understanding and treatment of breast cancer, saving millions of lives worldwide.
The European Cardiovascular Health Data and AI Network (CHAIN) aims to improve cardiovascular care through AI adoption. The initiative will build a federated ecosystem for the safe and effective adoption of AI and health data, enabling earlier disease detection and more consistent care.
Brenda Betancourt is evaluating record linkage uncertainty's impact on analysis reliability and evidentiary confidence in real-world data. She received $286,130 from the FDA to study regulatory frameworks for assessing record linkage uncertainty in real-world evidence.
George Mason University's Daniel Rothbart and Karina Korostelina are studying justice in Sudan amidst the civil war. The researchers have secured $96,600 in funding from the UNDP to explore ways to promote justice for the country.
Researchers Daniel Tong and Siqi Ma investigated long-term trends in windblown dust activity in Texas and three upwind states. They analyzed environmental drivers of dust trends and improved a dust emission model, quantifying contributions from in-state and out-of-state dust sources to PM2.5 and PM10.
Researchers developed an AI model that accurately flags heart transplant rejection by combining electrocardiogram readings with blood test results, potentially sparing patients from invasive biopsies. The model correctly identified 94% of patients without rejection and incorrectly flagged 19 patients with blood test results.
ICFO researchers have increased the power conversion efficiency of organic solar cells by restricting light emission angles, narrowing Boltzmann losses. This innovation enables solar cells to approach efficiencies near 43%, overcoming the Shockley-Queisser limit.
Researchers developed mouse models to study hypophosphatasia, a rare inherited condition that weakens bones and teeth. The models showed that teeth and supporting tissues can be affected even with mild skeletal changes, highlighting the need for tailored dental care.
Researchers created an electrochemical biosensor that detects subtle differences in sugars attached to protein surfaces, converting them into electrical signals for accurate diagnosis. The sensor accurately detected CSF leaks at low concentrations and reduced analysis time to 95 minutes.
Advanced wastewater treatments can intensify endocrine-disrupting effects, despite removing parent pollutants. UV irradiation and ozonation increased androgen receptor-antagonistic activity beyond a risk threshold. Integrated, effect-based assessments are needed to ensure ecological safety.
Marine worms rely on bacteria for survival, but surprisingly, they form flexible partnerships that adapt to local environments and sources of food and energy. The study reveals that these symbioses are stable within species but variable between species, allowing the worms to thrive in diverse habitats.
Researchers discovered the role of ancient peptide signals in shaping apple root regeneration, identifying a key gene MdglRGF1 that influences root development. The study provides a genetic and molecular framework for future rootstock improvement and potential applications in breeding and biotechnology.
Researchers identified two amino-acid changes that enabled the transition from a serine decarboxylase gene to an alanine decarboxylase gene, leading to theanine biosynthesis in tea plants. These changes, specifically phenylalanine at position 106 and glycine at position 168, were crucial for the enzyme's alanine-specific activity.
A multi-omics study mapped key genetic controls behind verbascoside accumulation in olive fruit, identifying a major region on chromosome 21 and candidate genes associated with high verbascoside levels. The findings could support faster selection of olive cultivars with targeted phenolic profiles and more predictable fruit-quality traits.
A new study from the University of Copenhagen found that women who frequently bend forward at work face a 36% increased risk of miscarriage. Employers are advised to consider adjusting tasks and providing a chair to reduce the risk.
A University of Córdoba team has improved the production of green hydrogen using solar energy and metal photocatalysts. The study found that copper and platinum are the most efficient metals in converting sunlight into chemical energy and producing hydrogen.
Researchers developed an iron-modified titanium dioxide electrode that removed 92.1% of nitrobenzene within two hours, with 62.4% mineralization. The iron-modified electrode enhanced pollutant interactions and increased the effectiveness of a combined treatment process.
Researchers develop analytical framework to predict when large interconnected systems will shift from steady to oscillatory states. The study shows how network complexity, propagation delays, and interaction types jointly determine transitions between steady and oscillatory states.
Research suggests marine organic particles are underrepresented in climate models, with a bimodal size distribution and a significant impact on cloud formation and radiative effects. The findings have implications for aerosol-cloud interactions and assessments of marine cloud brightening.
A research team has uncovered a key antagonistic regulatory module, GhRCD1-GhMYC3, that constrains cotton improvement. GhRCD1 promotes fiber elongation, while GhMYC3 suppresses seed vigor. The module acts as a fine-tuning rheostat, adjusting ROS concentration and pectin methylesterification to modify seed coat hardness. By targeting th...
A recent study has raised concerns about the safety of antifungal treatments during pregnancy, finding potential changes in fetal hormone production and its effects on children. Researchers analyzed data from 589 Danish mother-child pairs and found altered adrenal hormone levels in children after birth.
Researchers at Institute of Science Tokyo have developed a process to recover magnesium from desalination brine using liquid tin. The process, which combines direct-contact distillation with vacuum degassing, enables the recovery of magnesium-rich precipitates with high efficiency and purity.
Artificial intelligence helps identify alternative recipes for growing carbon nanotubes with prescribed structural features, such as array height, density, and alignment. The approach allows researchers to explore routes beyond familiar recipes, accommodating practical processing constraints while preserving selected structural features.
Scientists created FINDSPINGROUP to systematically distinguish between magnetic geometry and spin-orbit effects in unconventional magnets. The platform allows researchers to compare these contributions directly and determine the physical origin of responses, enabling a better understanding of these materials.
The Juno spacecraft has revealed a rippling current sheet in Jupiter's magnetodisk, which is generated by magnetic reconnection. This wave-like structure is created by numerous small reconnection sites across the magnetosphere, causing the current sheet to break and push away from its equilibrium position.
Researchers identified two tea plant genes, CsIPT3 and CsCKX5, that regulate leaf development by altering cytokinin levels. These genes were found to increase or decrease cytokinin accumulation, producing contrasting changes in leaf cell structure and size.
Scientists at IISc created a data-driven computational framework to model 9,389 elementary reactions, predicting 40-fold increase in CO₂ conversion and identifying major products like methanol and carbon monoxide. The approach can enhance catalyst design and fuel production by uncovering mechanistic pathways.
Researchers found that CDC20 is essential for mitotic progression in rice, but has distinct roles in meiosis. Disruptions in CDC20 activity led to defects in gametophyte development and chromosome segregation during meiosis.
A recent study published in The Quarterly Journal of Economics found that noncompete agreements reduce worker mobility and earnings without providing measurable benefits in protecting trade secrets. The researchers evaluated over 14,000 job offers and found that workers often overlook fine-print noncompetes and receive no wage premium ...
A new policy analysis highlights the inadequate protection of older adults from extreme heat, as aging infrastructure and financial barriers hinder access to cooling systems and safe living conditions. Regional policies must be tailored to local climates and housing conditions to address these challenges.
A study redefines the biology of honey bee colonies as superorganisms, where individual bees contribute to the colony's development and functioning. This new perspective offers insights into dealing with parasites and challenges modern beekeeping methods.
The European biotech sector is at risk of losing its ability to build internationally competitive companies due to structural bottlenecks in innovation chains. Key findings suggest the need for reforms in financing, scaling, and technology transfer to address these challenges.
Researchers from Heinrich-Heine University Düsseldorf have identified phosphite and palladium as a novel precursor of ATP, the energy currency of cells. This discovery provides a geochemically continuous route of prebiotic phosphorylation, suggesting that life may have arisen at hydrothermal vents.
The NIH grant will support programs that pioneer lifesaving healthcare innovations and spur team science and multidisciplinary collaborations. The funding will also support workforce development programs and collaborations with experts in artificial intelligence and bioinformatics.
A new study from Virginia Commonwealth University finds that young adults consider physician-influencers on TikTok to be more accessible, credible, and altruistic than their own doctors. Followers do not verify the influencers' medical credentials, and instead, trust their authority based on their appearance and personal stories.
Dr. Michael Taylor, a pediatric neurosurgeon and researcher, has received a Texans Conquer Cancer Award from CPRIT for his work on childhood brain tumors. His research aims to identify effective treatments that improve survival while reducing long-term effects.
Dr. Elemento's team will develop an AI-human discovery engine to generate hypotheses from human cell and tissue data, test them using robotics testing platforms, and refine the process with human oversight. The goal is to discover new mechanisms that can be targeted pharmacologically and democratize access to AI tools for research.