A human trial has shown that the diabetes drug empagliflozin reduces inflammatory cell clumps and promotes metabolic reprogramming in patients with obesity and prediabetes. This finding suggests that the medication may have heart-protective benefits beyond weight loss.
Researchers investigated the effects of mini-GRID radiotherapy on glioma cells, finding it reduced senescence and preserved growth inhibition, whereas conventional radiotherapy induced senescence. The study suggests that mini-GRID's spatial dose distribution may be responsible for this difference.
Researchers developed a novel approach to reduce neuropathic pain by targeting specific nerve cell interactions. By disrupting the interaction between voltage-gated sodium channels and ankyrin-G, they reduced pain-like behaviors in mouse models and paved the way for new therapeutics.
A new study found that the timing of Deep Brain Stimulation (DBS) surgery is critical for preserving cognitive function in Parkinson’s disease patients with a specific genetic mutation. Performing DBS within the first seven to eight years of diagnosis delays significant cognitive decline, while early intervention optimizes physical mob...
Researchers will compare brain cells from women and men with Parkinson's disease to look for biological differences that may explain sex-specific variations in the disease. The study aims to address the underrepresentation of women in Parkinson's research and advance the understanding of the disease's biological underpinnings.
Research suggests that people with dementia who are overweight or obese at diagnosis tend to live longer, pointing to the importance of nutrition in the degenerative disease. Studies adjusting for biases found no significant contribution to the observed associations between weight status and mortality.
Researchers found that picocyanobacteria in the Baltic Sea form colonies and aggregates, influencing carbon export. This process is crucial for regulating atmospheric CO2 levels and predicting future ocean changes.
A multicentre study found patients with a rare inherited form of lupus may continue to accumulate organ damage even when disease activity appears to have declined. Long-term monitoring and more sensitive biomarkers are needed to detect ongoing subclinical inflammation and organ injury.
Researchers directly observed a heavy fermion state forming at the boundary of a one-atom-thick material and a metal, revealing new possibilities for designing quantum materials. The finding arose from hybridization between localized electrons and mobile electrons, providing direct evidence of an interfacial heavy-fermion state.
A new study published in Radiology journal found that ultrasound-guided hydrodissection provides sustained clinical and morphological improvement in patients with refractory carpal tunnel syndrome. The procedure is a steroid-free alternative that involves injecting fluid around the affected nerve to release adhesions and improve mobility.
A research team mapped individual cell types in alfalfa roots responding to cadmium, finding distinct defense mechanisms in endodermal and phloem cells. The study identified genes improving Cd tolerance, providing a molecular foundation for breeding safer forage crops.
A protein filter, MICOS, in mitochondria maintains shape and controls molecule entry/exit, crucial for energy production and disease prevention. Researchers have modeled its flexible structure, revealing gatekeeping function and potential explanation for neurodegenerative diseases.
Researchers at Kyushu University have developed a VR system that enables users to experience an immersive, theater-like view from within a compact space without wearing a headset. The system uses aerial imaging optics and a chair-mounted micromirror array to create a stereoscopic view that responds to the user's movements.
A new global definition of clinical obesity classifies far fewer children as obese, but prevalence increases with age, affecting over half of adults aged 65-74. The study suggests the new definition will help clinicians make more informed decisions about obesity assessment and treatment.
Researchers at Colorado State University have successfully planted 40,000 native sedge seedlings in Yosemite's meadows to restore ecosystem health. However, the recovery process will be slow, with the meadows still losing carbon overall, highlighting the need for continued restoration efforts.
Binghamton University researchers developed a sensor system called CoughNet, which detects coughs and identifies individuals. The system uses artificial intelligence and low-power technology, making it efficient and private, and can potentially analyze coughs for more context to detect specific diseases.
Researchers found that well-designed digital alerts can assist clinicians in high-pressure situations, prompting them to make recommended treatment decisions and recognize when patients are deteriorating. The studies demonstrated the effectiveness of electronic health record alerts in the emergency department and cardiac intensive care...
A new study using satellite data from the Surface Water and Ocean Topography (SWOT) satellite reveals significant errors in river models, particularly in areas with dams, arid climates, and Arctic rivers. These errors can lead to inaccurate climate change predictions and water resource management.
A new narrative review explores how pistachios' nutrient profile, including tryptophan, vitamin B6, magnesium, and polyphenols, may influence sleep quality, falling asleep, and the sleep-wake cycle. The review suggests that pistachios could represent a promising wholefood intervention for improving sleep, and calls for further research...
FAU is partnering with D-Wave Quantum to create a regional quantum cybersecurity workforce ecosystem in Palm Beach and Broward counties. The project will provide hands-on training and experiential learning opportunities for students and professionals, preparing them to secure systems in a quantum-enabled future.
A study on AI use in the 2024 UK election found that chatbots increased belief in true information and decreased belief in misinformation. The study also showed that chatbot research and self-directed Google search performed similarly, with no apparent impact on factual political knowledge.
A model study suggests that spatial structure can increase abiotic molecular complexity, which could be used to detect life. The researchers found that ordered structures can shift assembly indices upward, but only under certain conditions.
Researchers found that bacteria sense collisions with neighbors and reverse direction to break through congestion, allowing them to explore new spaces. This mechanism enables bacteria to navigate both crowded and structured environments, with implications for biofilm formation and robot swarm design.
Researchers found that the cancer drug zavondemstat and a closely related compound QC6352 do not primarily target KDM4, but instead work by blocking DHODH, an enzyme cancer cells rely on to produce molecules needed for rapid growth. This discovery highlights a broader challenge in cancer drug development, emphasizing the need for great...
A study by Chonnam National University explores the therapeutic potential of human dental pulp stem cell secretome in post-stroke functional recovery. The secretome attenuates oxidative stress and inflammation, enhancing recovery in a mouse model, and shows promise for a new therapeutic platform for neurological diseases.
Researchers investigated how impact direction and crystallographic texture influence the ballistic performance and fracture behavior of AZ31 Mg alloy. The study found that impact direction and crystallographic texture significantly impact the deformation, energy absorption, and fracture of Mg alloys under high-velocity impact.
A global study found ecosystems have far less 'spare' capacity than previously thought, with biodiversity playing a crucial role in providing benefits such as pollination, water purification, and carbon storage. The study suggests that functional redundancy has been overestimated, and that maintaining diversity is essential for ecosyst...
A study from MANA presents a new method to decode hidden material disorder in complex photoluminescence spectra, revealing a hierarchy of disorder in moiré heterostructures. The approach hints at a practical way to diagnose material quality issues directly from optical data.
Researchers identify key role of spatial niche in early gastric cancer initiation and progression, highlighting inflammation-associated spatial niche as fundamental regulatory unit. Targeting inflammation-associated spatial niches may enable earlier and more precise therapeutic strategies.
Researchers at Children's Hospital Colorado and the University of Colorado Anschutz School of Medicine published a comprehensive study evaluating advanced laboratory testing for mitochondrial disease. The study found that a small skin biopsy can often help diagnose mitochondrial disease, reducing the need for more invasive procedures.
MDPI's journal portfolio is now indexed in Scite and discoverable through the Scite MCP, enabling researchers to access content in AI tools like Claude, ChatGPT, and Microsoft Copilot. This collaboration provides attribution, links to the Version of Record, and article-level usage reporting.
A significant proportion of patients with HER2-positive, ER-negative breast cancer can achieve a pathologic complete response after 12 weeks of THP chemotherapy. The trial identified ER-negative or low ER-expressing tumors, low or no progesterone receptor expression, HER2 IHC 3+ tumors, and weekly paclitaxel treatment as key predictors...
A new study suggests that therapeutic food made from locally available crops like chickpeas, sorghum, and soybeans could help expand access to lifesaving nutrition care. The plant-based formulation supported better recovery from malnutrition than commercial products, with higher protein content and quality.
Researchers found that team leaders' genuine commitment to change inspires employees, particularly when leaders demonstrate strong moral values and ethical conduct. This authentic leadership inspires employees to adopt a positive attitude and actively help others adapt to new initiatives.
Researchers from University College London have disputed the existence of hypernovae, the most powerful explosions in the Universe, by suggesting that ordinary supernovae could better explain the formation of unusual stars in the Milky Way's halo and a neighboring dwarf galaxy. The study's findings indicate that the unusual composition...
A new study introduces a personalized short sleep framework, considering an individual's long-term sleep distribution. This approach showed larger effect estimates than a fixed six-hour definition on various day-to-day outcomes, including alertness, stress, and motivation.
The Global Capitalism Index (GCI) provides unprecedented insights into the globe's capitalism conditions, with regional divergences widening and notable improvements in Central Asia and declines in Latin America and Western Europe. The index also highlights the relationship between capitalism and societal outcomes such as well-being, c...
A study by the University of Osaka has identified shared disease mechanisms in lymphatic malformations, including the PI3K/AKT/mTOR pathway, and found that sirolimus, a drug targeting this pathway, is clinically effective across patients. The research also uncovered 10 additional disease-related molecules, including NFATC1, which may r...
Kumamoto University has forged a quadripartite alliance with Yamagata University and two Fraunhofer institutes to accelerate semiconductor innovation. The partnership aims to create a dynamic research cluster by combining unique strengths in cutting-edge domains such as semiconductor packaging and printed electronics.
Researchers found that movement-evoked pain activates the brain's Default Mode Network (DMN), which is associated with self-reflection and identity. This suggests that treatments like mindfulness and psilocybin may be more effective than traditional symptom-based approaches in managing chronic low back pain.
Theresa Werner, MD, has been appointed chief of the Division of Oncology at Huntsman Cancer Institute, overseeing clinical, research, and educational priorities. As a nationally recognized physician-scientist, she will advance innovative cancer care and research.
Children and adults with Fontan circulation show signs of accelerated biological aging, telomere shortening, and less favorable circulation measurements, suggesting a link between cellular aging and specific heart function features.
A new study finds that PSMA PET/CT-guided targeted biopsy can detect clinically significant prostate cancer in 37% of men, compared to 21% with systematic biopsy alone. Combining the two approaches increases the detection rate to 41%.
CU Anschutz Pharmacy is launching Colorado STREAM, a five-year initiative with $25M in funding, to expand access to medications and whole-person health services in rural Colorado. The program connects community pharmacies with regional treatment centers, telehealth services, and other healthcare partners.
A recent study published in JCI Insight found that even brief e-cigarette use can cause lasting lung damage and weaken defenses against respiratory viruses. The research team exposed human lung tissues to e-cigarette vapor and observed damage to the protective barrier, triggered cellular stress, and impaired cell growth and repair.
Researchers have created a new carbon capture material, BVR-X, that can efficiently capture greenhouse gases from industrial emissions. The material can be reused and regenerated, making it suitable for practical carbon-capture technologies.
Researchers have discovered a new light-element crystal framework that enables fast lithium-ion conduction and prevents conduction bottlenecks. The framework, composed of RbLi(Li3SiO4)2, boasts a low migration barrier and high ion conductivity, making it a promising material for next-generation all-solid-state batteries.
Researchers have found that vanillin has pronounced antioxidant, anti-inflammatory and antibacterial properties, making it a potential solution for chronic wound healing. The compound, commonly used in foods for its sweet aroma, has been linked to biological activity and potential biomedical applications.
A major Adelaide University study found that outside school hours care services that completed the Activated OSHC program showed substantial improvements in physical activity and screen time practices. The program, which provides tips for creating an active environment and reducing screen time, was trialled in 200 services caring for 1...
Researchers at the University of Reading developed a low-cost blue light technology that kills 100% of Campylobacter bacteria in raw chicken, reducing the risk of food poisoning. The technique, called violet-blue photodynamic inactivation, is a viable alternative to chlorination and shows no signs of bacterial resistance.
The updated consensus recommendations provide a shared framework to support patient safety and consistency in clinical practice while continuing to build the evidence base. Key findings include careful patient selection, multidisciplinary care, and long-term follow-up as essential for CAR T-cell therapy in autoimmune diseases.
Lukas Chavez and his team at Sanford Burnham Prebys will develop an AI-powered system called Leitstern to help clinicians analyze complex data from children with cancer and identify personalized treatment options more quickly
A team of researchers used AI to collect and standardize millions of local laws from across the US, creating a searchable database that can help identify patterns and enforcement issues. The project has the potential to fundamentally shift how people interact with local regulations.
The Presidents' Impact Scholarship Program aims to attract top PhD applicants from Canada and worldwide, fostering a dynamic community of changemakers. The program will support research into real-world global challenges, emphasizing complex problem-solving skills and collaboration.
Researchers have identified a Sardinian village as a potential new 'blue zone' for exceptional longevity, with women living nearly 21 years longer than men. The study found that 13.8% of women in Bolotana reach 100 after 70, compared to 3.5% in Italy and 3.6% in the US.
A new study reveals that North Carolina's coastal forests have lost over 20% of their landmass between 1985 and 2021, with the rate of loss accelerating after 2010. Sea level rise and extreme weather events, such as hurricanes and droughts, have contributed to the widespread conversion of forests to ghost forests, shrubs, and marshes.
Researchers will investigate if persistent symptoms are driven by ongoing gut inflammation or altered gut-brain signaling. The study aims to support new personalized treatment approaches for ulcerative colitis patients with persistent IBS symptoms.
Researchers found that psychopathic traits linked to boldness, meanness, and disinhibition are associated with distinct patterns in language. Participants scored higher in disinhibition used more negative words and less positive tone, while higher meanness was associated with more positive tone and achievement-related language.
Researchers developed a nano-magnesium oxide modified pyro-hydrochar material from invasive plant biomass, achieving high fluoride adsorption capacity and stability across a broad pH range. The material combines electrostatic attraction, surface complexation, and hydrogen bonding mechanisms to capture fluoride ions.
Alexander Edwards, an accounting professor at the University of Toronto's Rotman School of Management, has been awarded the Distinguished Professor Award for his highly distinguished accomplishments and exceptional research in taxation and capital markets. The award recognizes his extraordinary level of activity in his research and sch...