Researchers developed percutaneous soft tissue cryotherapy as an effective treatment for cancer that has metastasized in soft tissues and bones. The procedure resulted in an average of 77% tumor shrinkage in patients after 24 months, with preserved fibrous or collagenous structures promoting better healing.
Members of the Society of Interventional Radiology have filed over 2,400 patents and patent applications, pioneering modern medicine with devices and drugs. These innovations continue to shape and change the medical landscape, enabling interventional radiologists to treat patients without invasive surgery.
Researchers successfully froze breast cancer in patients who refused surgery, with no localized treatment recurrences seen for up to five years and no significant complications noted. The study used image-guided, multiprobe cryotherapy, which provided safe and effective breast conservation with minimal discomfort.
Researchers at UCSF have discovered a key cellular defect that can lead to cancer susceptibility and are developing a new generation of inhibitory drugs to correct this defect. The new drug, PP242, has shown promising results in clinical trials and holds promise for treating various types of cancer.
Magnetic resonance-guided focal therapy offers a new treatment choice for patients with recurrent prostate cancer, providing an alternative to radiation therapy and hormone manipulation. The procedure involves tailored treatment modality and duration based on lesion size and location, preserving sexual and urinary function.
A new study from UT Southwestern Medical Center found that gastric bypass surgery can increase the risk of developing kidney stones in patients. The researchers discovered significant changes in urine composition, including elevated oxalate levels and low citrate levels, which can lead to stone formation.
Researchers found that adding tests to cystoscopy increases costs and false positives, while cystoscopy alone is the most effective in detecting tumors. The study suggests that clinicians can make judicious use of urinary markers to reduce costs and anxiety for bladder cancer patients.
A recent study from UT Southwestern Medical Center found that combination therapy yielded better results than individual drugs in treating enlarged prostate. The treatment, which combined dutasteride and tamsulosin, reduced the risk of BPH progression by 25% and PSA levels by 50%.
A new study shows that robotic-assisted laparoscopic prostatectomy (RALP) does not compromise surgical outcomes for patients with prostate cancer. Surgeons can use visual cues to improve clinical outcomes, including the color of tissue, vein locations, and signs of inflammation.
A nationwide Swedish study found no increased risk of suicide among men diagnosed with early nonpalpable prostate cancer detected by PSA testing. However, those with locally advanced or metastatic disease faced a twice-higher suicide rate compared to the general male population.
A new study published in The Journal of Urology found that open radical prostatectomy (ORP) and laparoscopic radical prostatectomy (LRP) have similar rates of postoperative mortality and morbidity. LRP was associated with shorter hospital stays and a lower risk of bladder neck or urethral obstruction.
A new study from Johns Hopkins Medicine reveals that obesity in all forms increases the risk of developing kidney stones. The researchers found that obese individuals had a higher incidence of kidney stones compared to non-obese individuals, with no difference in risk between mild and severe obesity.
A systematic review found that neonatal and infant circumcision by trained staff rarely results in problems, with relatively minor adverse events being low among infants under one year old. However, complications are more common when performed by inexperienced providers or with subpar equipment.
A systematic review found that neonatal and infant circumcision is relatively safe, with minor adverse events common but severe complications rare. The risk of complications increases with inexperienced providers or inadequate equipment, highlighting the need for improved training and safety measures.
Queen's University researchers discovered a low-dose nitroglycerin treatment may slow and halt prostate cancer disease progression without severe side effects. The study, which targeted 29 men with increasing PSA levels following surgery or radiation, showed significant slowing in disease progression in all but one patient.
A study of 129 patients found high rates of infection and mechanical failure with inflatable prostheses; however, hydraulic devices remain the best option for achieving voiding while standing and sexual intercourse. The choice of device may favor two-piece over three-piece designs.
A new study from Duke University Medical Center found that diabetes negatively affects prostate cancer outcomes in obese white men following radical prostatectomy. However, the impact of diabetes on prostate cancer progression varies by race and weight, with lower risks observed in other subgroups.
University of Florida urologists have developed a robot-assisted vasectomy reversal procedure that cuts average surgery time by 20 minutes, comparable to traditional microscope methods. The robotic procedure also shows quicker return of sperm count and improved efficiency.
Researchers have developed a vaccine that appears to reduce leukemia cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec. The study found significant reductions in residual cancer cells and complete remission in seven patients.
A systematic review found IAD to be as effective as continuous androgen deprivation while improving survival rates and sexual potency. The approach has been a valid treatment option for nonmetastatic PCa cases, offering key tolerability and quality of life benefits.
A randomised trial found that medroxyprogesterone acetate is significantly more effective than venlafaxine at reducing hot flushes in men treated with androgen suppression therapy. Cyproterone acetate was also effective, but medroxyprogesterone is recommended as the standard treatment due to its fewer side effects.
The Tulane Cancer Center is conducting a phase III randomized clinical trial for Alpharadin, an injectable treatment targeting radioactive substance Radium-223. Early trials suggest it may prolong survival for men with bone metastases from prostate cancer.
A prospective case-control survey found that male factor infertility is associated with a higher rate of medical comorbidities, as objectively scored with the Charlson Comorbidity Index. The study suggests that men with male factor infertility may be less healthy than age-comparable fertile men, regardless of their underlying causes.
A large study found that PSA velocity has little predictive value for determining the outcome of a first prostate biopsy. However, a rapid rise in PSA levels may still suggest prostatitis or prostate cancer, warranting further evaluation. The findings suggest that clinical judgment should be used to guide biopsy decisions.
Researchers at OHSU Knight Cancer Institute have found a combination of radiation therapy and chemotherapy given before prostate removal to be safe and potentially reduce cancer recurrence rates. The treatment regimen resulted in improved outcomes, with clean cancer margins and undetectable PSA levels in patients.
A Dartmouth study has found that patients taking immunosuppressive drugs such as glucocorticoids may be at higher risk of developing bladder cancer. The research examined the long-term use of glucocorticoids in 786 bladder-cancer patients and 1,083 control subjects, revealing a potential link between the two.
Research published in the UK-based urology journal BJUI found that women exposed to DDT spraying were more likely to have sons with urogenital birth defects, which can cause missing testicles or problems with their urethra or penis. The study suggests that prolonged exposure to DDT may increase the risk of these defects.
A new study published in The Journal of Urology found a significant association between psychiatric disorders, sexual trauma, and lower urinary tract symptoms (LUTS) in women. Women with psychiatric comorbidities and history of sexual trauma were more likely to experience LUTS such as incontinence and overactive bladder.
Researchers have developed a highly sensitive PSA assay using nanotechnology, enabling early detection of prostate cancer recurrence and improving treatment outcomes. The new technology has the potential to redefine the PSA 'zero' level, allowing for earlier diagnosis and targeted therapies.
Research reveals that up to a quarter of testicular cancer survivors experience long-term neurological, hearing, and circulation problems, as well as a higher risk of secondary cancers. However, many survivors can successfully father children after treatment, with up to 80% successful pregnancies.
Researchers at Princess Margaret Hospital map a high-risk group for aggressive, 'hidden' prostate cancer, utilizing magnetic resonance imaging (MRI) to reveal tumors on the top of the prostate. The study identifies men with elevated PSA levels who benefit from MRI-guided biopsies.
A study by BUSM researchers suggests a connection between low testosterone levels and an increased risk of heart disease. The findings, published in the Journal of Andrology, support the idea that androgen replacement therapy could help reduce cardiovascular risk in hypogonadal men.
A new drug-delivery system using nanoparticles encapsulating nitric oxide or prescription drugs could significantly lessen side effects associated with oral erectile dysfunction medications. The treatment showed improved erectile function in rats and held promise for safer and more effective ED therapy for millions of men.
The periurethral suspension technique results in significantly greater continence rates at 3 months after robot-assisted laparoscopic radical prostatectomy (RALP). The median/mean interval to recovery of continence was also statistically significantly shorter in the suspension group.
The European Association of Urology has published an evidence-based guideline for incontinent urostomy, offering expert guidance for nurses. The comprehensive 80-page document covers topics such as cystectomy, pre- and post-operative care, and community follow-up, providing best practices for managing this complex condition.
Researchers at USC have identified novel genetic mechanisms that govern an individual's risk of developing prostate cancer, highlighting the role of gene 'deserts' and regulatory sequences. The study found that genetic variations in these regions can modulate gene expression, increasing the risk for certain diseases.
A new study has found that obesity increases the risk of prostate cancer recurrence in both black and white men, with no racial difference observed. Researchers analyzed data from 1,415 patients and found a significant association between higher body mass index and increased risk of cancer recurrence.
Researchers found stem-like cancer cells that share characteristics with healthy stem cells, including unlimited lifespan and migration properties. These cells were localized in the same tissue location as bladder stem cells and showed increased activity in genes related to cell proliferation and metastasis.
A new study by Louis Potters and colleagues found that permanent prostate brachytherapy is an effective treatment option for younger patients diagnosed with prostate cancer, with success rates comparable to older patients. The study analyzed data from 2,119 patients and showed that age didn't impact the long-term therapeutic outcome of...
Researchers identified that even among high-risk groups, only a few individuals had invasive bladder cancer, highlighting the need to find a higher-risk group to benefit from screening. Abstaining from smoking is crucial in preventing bladder cancer.
Vibrator use is prevalent among adult Americans, reported by 53% of women and 45% of men, associated with positive sexual function and proactive sexual health care. The studies also found no significant differences in vibrator use between heterosexual and gay/bisexual men.
The July issue of European Urology reviews prostate cancer screening studies, highlighting the need to balance mortality reduction with overdiagnosis risks. The EAU adopts the conclusions of the ERSPC study and recognizes the benefit of screening for mortality reduction.
The AUA Foundation has awarded the 2009 Astellas Rising Stars in Urology to William Roberts, MD and Edward Schaeffer, MD for their groundbreaking research projects on Benign Prostatic Hyperplasia and Phospholipase A2 signaling in prostate development. The award aims to support young urologists in pursuing careers in urologic research.
The Prostate Cancer Translational Research in Europe meeting showcased ongoing research efforts to identify biomarkers, genetic variants and new therapeutic options. Researchers discussed the importance of collaboration between clinicians and scientists to streamline current efforts and avoid duplication.
Sexual medicine experts focus on treating causes of sexual dysfunction beyond physical issues, exploring relationship dynamics and hormonal imbalance. New treatments and options for women and men are being developed to address complex sexual health needs.
A new study published in The Journal of Urology found a significant association between lower urinary tract symptoms and metabolic syndrome. Researchers analyzed data from over 1,900 men and discovered that those with mild to severe LUTS were more likely to suffer from MetS.
A new study by Johns Hopkins Medicine finds that Roux-en-Y weight loss surgery nearly doubles the risk of developing kidney stones, with an overall risk of around 8 percent. The researchers suggest that doctors can help prevent kidney stones through calcium supplements and other interventions.
A new risk assessment test, CAPRA, has been developed to predict long-term risks and pinpoint high-risk cases in prostate cancer. The test accurately predicted bone metastasis, prostate cancer-specific mortality, and all-cause mortality when localized prostate cancer is first diagnosed.
Researchers at Baylor College of Medicine discovered changes in 1,141 genes that induce the formation of new structures such as blood vessels and nerves in prostate cancer patients. These gene changes may explain why men with reactive stroma face a more aggressive disease.
A study by researchers at NewYork-Presbyterian Hospital/Columbia University Medical Center has found no statistically significant increase in hypospadias rates in New York State during the 1992-2005 period, contradicting earlier concerns about environmental chemicals. Maternal age is a significant risk factor for the birth defect.
A recent study found that carbohydrate restriction without weight loss can slow prostate tumor growth by lowering serum insulin levels. The researchers believe that this mechanism is key to fighting prostate cancer growth and potentially improving patient outcomes.
Research reveals that HGPIN carries a high predictive value for future diagnosis of prostate cancer, with a 41.8% risk identified in patients. The study recommends delaying first repeat biopsies at low PSA ranges but shorter intervals for intermediate and higher PSA ranges.
A phase I clinical trial of Zyflamend, a novel herbal therapy, demonstrates its safety and tolerability in men with high-grade prostatic intraepithelial neoplasia (HGPIN), a precursor to prostate cancer. The study confirms that Zyflamend is well-tolerated when administered orally for up to 18 months.
Researchers at NYU Langone Medical Center report early promise in animal studies for a novel antiparasitic drug as a potential treatment for metastatic melanoma. Additionally, the study found associations between specific microRNAs and patient survival in metastatic melanoma and early-stage lung cancer.
A new study from Henry Ford Hospital found that radical prostatectomy significantly increases long-term survival for men under 50 with prostate cancer. The procedure improved cancer-specific and overall survival rates compared to radiotherapy or watchful waiting, making it the recommended treatment option for younger patients.
A study published in the Journal of Urology found that cognitive therapy is an effective management strategy for urge incontinence, with patients experiencing a substantial improvement in symptoms. Cognitive therapy employs deep-breathing and guided-imagery exercises to train the brain to control the bladder without medication or surgery.
Researchers have identified two potential new targets in the fight against prostate cancer: 'cold shock' proteins that can be turned down through genetic techniques to weaken cancer cells, and higher bone density in men which may increase their risk of developing prostate cancer. Additionally, children with kidney stones are more likel...
A study of 1,495 veterans found that those exposed to Agent Orange had a nearly 50% increased risk of prostate cancer recurrence and more aggressive cancers. This highlights the need for closer monitoring and timely intervention in these patients.
Researchers at Johns Hopkins Medicine tracked how prostate cancer began in 33 men, finding a set of genetic defects in a single cell that differ for each person's cancer. The study suggests that common genetic patterns across metastatic sites indicate a single cell source.
A study by Queen's University researchers found that pelvic pain symptoms occur as frequently in adolescent boys as in adult men. Chronic pelvic pain syndrome has a significant negative impact on quality of life, including depression and social relationships.