The new system identifies fish populations to a forensic level of validation, helping tackle overfishing and illegal fishing. DNA-based tools can be used across the food supply chain and provide an independent method for authenticity testing.
Weill Cornell Medical College researchers discovered that a chromosomal rearrangement in prostate cancer cells creates a new 'fusion' gene, warping DNA structure and triggering abnormal growth. The study suggests a model for how other chromosomal translocations contribute to cancer formation.
A new technique has been reported in the American Journal of Pathology that uses genetic abnormalities to predict prostate cancer relapse. The study found that copy number variations (CNVs) in both cancerous and non-cancerous tissues can accurately forecast recurrence, allowing for more targeted treatment approaches.
Researchers have found that measuring progesterone receptor expression can improve hormone-receptor-positive breast cancer management. The study identifies a subpopulation of patients with high survival rates when treated with endocrine therapy alone, and could lead to a more personalized medicine approach in breast cancer.
A team of researchers from the University of Pennsylvania School of Medicine has demonstrated that a range of diagnostic spinal fluid tests are needed to differentiate between brain diseases such as Alzheimer's disease and frontotemporal lobar degeneration. The studies found that biomarkers in cerebrospinal fluid, including tau and amy...
A new quantum mechanical-based biosensor detects biomolecules at extremely low concentrations, expanding opportunities for disease diagnostics and forensic applications. The sensor leverages biomolecule conjugation to increase sensitivity and reduce response time.
Researchers found significant variation in craniofacial characteristics, with Lisbon females exhibiting broader noses and eyes spaced further apart than Coimbra females. The difference suggests genetic variations rather than dietary or nutritional influences.
The Metabolomips group has developed a methodology for detecting gunshot residues, which can produce reliable analyses within an hour. They have also created a method to identify antipsychotic drugs in the human brain, with potential applications in forensic analysis and post-mortem diagnostic tests.
Researchers validated protease cathepsin B as a target to improve memory deficits and reduce amyloid plaque pathology in an animal model representative of most AD patients. Deleting the CatB gene improved memory deficits while reducing amyloid plaque, mimicking that found in AD.
A study aims to gauge the stress of forensic scientists, examining their job satisfaction and working environments. The researchers plan to develop policy recommendations to improve efficiency and job satisfaction.
A study published in American Journal of Pathology reveals that trefoil factor 3 (TFF3) protein, which protects the epithelial surface in normal breast tissue, also promotes tumor invasion and metastasis in breast cancer. Higher TFF3 expression is associated with a more aggressive phenotype.
Researchers develop new forensic identification technique that compares skull with pictures of living subjects to identify corpses, reducing cost and time compared to DNA analysis. The study refines reference points for face morphology analysis, enhancing accuracy and reliability.
Researchers found that unrelated individuals may be mistaken for genetic relatives due to population-specific genetic differences. This is particularly concerning for individuals of Asian or Native American descent, where false familial identification is more likely.
The American Chemical Society is developing new crime-fighting tools to deter and catch terrorists, utilizing chemical forensics to trace weaponized toxic substances. The research aims to send a message to would-be terrorists that science is prepared to stop them.
Researchers at Sam Houston State University have discovered a new biomarker, ACTA, in liver samples following cyanide poisoning, which may extend its detection window up to two months. Elevated cyanide concentrations can only be detected for up to two days under current toxicological testing.
Researchers at Notre Dame are using proton-induced x-ray emission and Accelerator Mass Spectroscopy to analyze artifacts, shedding light on trading patterns, economic conditions, and history. The techniques allow for the detection of counterfeit art work without destroying samples.
The St. Baldrick's Foundation has awarded a grant of $47,000 to the Biopathology Center at Nationwide Children's Hospital to enhance its digital pathology services. This funding will enable researchers to conduct more studies and enroll more children in clinical trials, which are their best hope for a cure.
A new software tool called Spatially Invariant Vector Quantization (SIVQ) has been developed to analyze digital pathology images with high accuracy. The program was tested on a case of micropapillary urothelial carcinoma and showed promise in separating malignancy from background tissue.
Researchers developed a method to detect cognitive decline in Parkinson's patients using MRI brain scans, revealing higher Alzheimer's patterns of atrophy predict worsening cognition. The study found an overlap between the two neurodegenerative diseases, raising hopes for early diagnosis and treatment.
Researchers obtained full DNA profiles from eight backpacks containing pipe bombs and matched them with volunteers who handled the bags for a week. This method, called consensus profiling, can help rule out DNA traces from others.
Researchers from Indiana University School of Medicine have made a breakthrough using century-old brain samples to detect mental illness. The goal is to create a simple blood test for conditions like bipolar disorder, schizophrenia, and PTSD, which could lead to faster diagnoses and improved patient care.
A new study found that false confessions are a common cause of errors in evidence, with 25% of exonerated individuals having made false confessions. The study suggests that juries and judges may be misled by false confessions, leading to miscarriages of justice.
A four-country study published in the Journal of Psychiatric and Mental Health Nursing found that verbal intervention was the favoured technique for dealing with aggressive episodes involving young offenders. The research team also recommended continuous education, sufficient resources, and further studies to improve practices.
New research from NC State University sheds light on how blow flies survive when buried underground during their development. The study found that blow flies can survive burial and provides additional information for murder investigations, helping forensic entomologists determine body burial times and potential relocations.
Researchers at Sam Houston State University are developing new methods to detect designer drugs like 'bath salts', which can produce powerful and unpredictable effects. The study uses solid phase extraction, chromatography, and spectroscopy to identify beta-keto amphetamines in biological samples.
Researchers led by Robert Linhardt of Rensselaer Polytechnic Institute have sequenced the first complex carbohydrate biopolymer, bikunin. The discovery provides a fundamental new view of these vital biomolecules, which play roles in cell structure and development, disease pathology, and blood clotting.
A new study finds that health and forensic DNA databases are growing to mirror racial disparities in arrest practices and incarceration rates. Underrepresented groups, such as African Americans and Latinos, face more severe disparities in forensic DNA databases compared to health DNA databases.
A study aims to utilize Galectin-3 and HBME-1 proteins as biomarkers for thyroid cancer diagnosis, enabling earlier detection and reducing surgical interventions. The research has the potential to improve patient outcomes by accurately identifying patients at risk of cancer.
Researchers at the University of Strathclyde have developed a DNA test that can identify deer poachers by detecting low levels of human DNA on deer carcasses. The test has been shown to be effective in recovering DNA profiles from poached deer remains, with a success rate of less than one in a billion.
Researchers used models to estimate the impact of urban land development on Coho salmon populations, predicting a significant decline in numbers due to spawner mortality syndrome. The study suggests that toxic chemical contaminants in urban storm water runoff may be the primary cause of the recurrent fish kills.
The University of Leicester has developed a test to measure the force used during a stabbing using a broken bottle. The study provides a basic classification for the presenting end of a glass bottle and illustrates how much force is required to create injuries.
Researchers found abnormal tau tangles and amyloid-beta plaques in survivors years after a single TBI, suggesting a potential link between the two conditions. The study suggests that a single TBI may initiate long-term neurodegenerative processes, offering new insights into the development of Alzheimer's disease.
A Stanford study has linked gamma-interferon, a key immune molecule, to the severity of asthma. High levels of gamma-interferon in children's blood may protect against asthma development, but severe asthmatics' lungs often have high concentrations.
A Washington State University student's research has challenged a widely held assumption on the best way to analyze ancient DNA in anthropological and forensic investigations. Direct sequencing was found to be as effective as cloning in analyzing degraded DNA, with potential cost savings and time efficiency benefits.
Researchers at UCLA have developed a patented test that uses methylation patterns in DNA to accurately predict a person's age within five years. This test could offer a new forensic tool for crime-scene investigations, as well as personalized medicine applications, such as tailoring medical interventions based on an individual's bio-ag...
Researchers at Rensselaer Polytechnic Institute developed a new process for analyzing bone tissue, providing insights into the fight against osteoporosis and aiding forensic studies. The technique uses laser-capture microscopy to determine protein signatures in nanoscale bone samples.
A DNA-based test can identify whether a cryptosporidium is of mammalian or snake origin, with prevalence figures revealing widespread infection in popular pets like corn snakes and leopard geckos. Reptile owners must be aware of the risk of cross-species infection and the importance of regular testing to prevent the spread of disease.
Researchers developed a forensic mitochondrial DNA species identification technique to distinguish between sardines and horse mackerel. The method has been applied to over 20 sardine and 20 horse mackerel species, facilitating fisheries imports monitoring and tracking.
Digital forensic examiners experience moderate stress but high job satisfaction due to unclear standards and multiple ways of collecting evidence. Police officials should consider hiring more digital forensics experts or improving their work environment.
A new pharmacogenetics test developed by Dr. Tara Sander can help identify the correct genotype and dosage for individuals, reducing adverse drug reactions and increasing effectiveness. The test has a 96% accuracy rate and holds promise for Personalized Medicine and forensic investigation.
The US Department of Justice has recognized UC Irvine's Elder Abuse Forensic Center for its efforts to prevent elder abuse, with Attorney General Eric Holder praising the center and its founder Dr. Laura Mosqueda for their outstanding work.
A new study reveals a previously unrecognized link between tobacco smoking and altered DNA methylation of the coagulation factor II receptor-like 3 (F2RL3) gene, possibly identifying an early stage of smoking-associated cardiovascular pathology.
Researchers found that heavier individuals have wider femur shafts, hypothesizing this is due to increased weight and altered movement patterns. The study used 121 white male bones to eliminate racial and gender variations.
A recent pathology study suggests that mifepristone could be a therapeutic option for women with severe uterine fibroid symptoms. The research confirms that the drug does not trigger cancerous lesions in the uterus, but rather causes benign changes such as fluid-filled glands and abnormal blood vessels.
Researchers at Michigan State University have developed a system that can automatically match hand-drawn facial sketches to mug shots in law enforcement databases. The method achieved promising results, correctly identifying the suspect in 45% of cases.
A new non-surgical post-mortem technique uses minimally invasive targeted coronary angiography to determine the cause of death in up to 80% of cases. The technique is inexpensive, easy to use, and applicable to natural and unnatural deaths, offering a potential permanent change in autopsy practice.
A University of Michigan-led team has developed a potential game changer for pathologists using Spatially-Invariant Vector Quantization (SIVQ) to analyze digital images made from tissue slides. SIVQ can pinpoint cancer cells, calcifications and other critical features with high accuracy and speed.
Researchers develop molecular imaging procedure to detect beta-amyloid in brains of individuals with Alzheimer's disease, increasing clinical diagnosis accuracy. The study shows a correlation between florbetapir-PET images and presence and quantity of beta-amyloid pathology at autopsy.
Leroy Hood's automated DNA sequencer has enabled the rapid sequencing of DNA, transforming genomics and accelerating scientific discovery. The technology has led to numerous breakthroughs in disease research, personalized medicine, and pharmaceutical development.
Researchers have discovered that DNA can accurately predict a person's hair color, including red, black, blond, and brown, with accuracy rates of over 90%, 80% and 70-80%. The new DNA approach allows for differentiation between similar hair colors.
Researchers have developed a method to estimate human age from blood samples, which could be used to identify missing persons or solve crimes. The technique is based on the analysis of T cell receptors and has been shown to be highly accurate, with an error margin of nine years.
A new study uses a combination of computed tomography (CT), postmortem CT angiography (CTA) and biopsy to determine the natural causes of death, with results showing near-identical findings in 18 out of 20 cases. The minimally invasive approach has improved accuracy and reduced the need for traditional autopsy.
A new handheld device measures corrosion on machine parts using a simple, quick and cheap method. This enables the degree of corrosion to be easily measured, improving the manufacturing sector by preventing wear and tear.
The Journal of Molecular Diagnostics is published on behalf of the Association for Molecular Pathology (AMP) and the American Society for Investigative Pathology (ASIP). The journal publishes high-quality original papers on scientific advances in molecular diagnostics.
Researchers found that NGP 555 selectively targets gamma secretase, reducing Aβ42 and amyloid pathology in a transgenic mouse model. Chronic administration led to significant reduction in diffuse and neuritic plaques without GI side effects.
Indiana University-Purdue University Indianapolis researchers have developed a new methodology to improve identification of breast cancer tissue by pathology laboratories. Their work, recognized internationally, has been selected as the best scientific paper in the
Researchers at Rutgers University studied the doubly magic isotope of tin with 50 protons and 82 neutrons, providing insights into its stability and potential formation in supernova explosions. The study's findings may also contribute to developing next-generation nuclear reactors and forensic analysis techniques.
A newly developed DNA test can quickly analyze crime scene DNA and compare it to suspects' DNA, potentially keeping high-risk individuals incarcerated longer. The test, which takes four hours to produce results, is an improvement over current methods that take 24-72 hours.
Researchers found that transforming growth factor-β1 contributes to kidney disease by inducing fibrosis and nephron degeneration. Meanwhile, a new diagnostic criteria for T-cell lymphoma was discovered using mast cells and Th17 cells. Additionally, a novel peptide ASARM may implicate in impaired dentin mineralization in rickets.
A study of 872 individuals found that more education reduces dementia risk by improving brain coping mechanisms. Individuals with higher education levels exhibited similar brain pathology but better compensation for dementia effects.