The Public Library of Science (PLoS) has launched PLoS Neglected Tropical Diseases, a new open access journal focused on the world's most neglected diseases. The journal aims to promote science, policy, and advocacy for diseases affecting poor countries, with a focus on rigorously peer-reviewed research.
Researchers at Cardiff University have been awarded £800,000 to commercially develop a protein-based therapeutic for treating infectious diseases. The 'Resolution Therapeutics' approach aims to enhance the body's natural defence mechanisms to promote infection clearance and reduce inflammation.
A global health expert argues that up to seven neglected tropical diseases, including river blindness and trachoma, can be brought under control with increased coverage of existing programs. This could lead to the elimination of infections in some cases and improved health outcomes for millions of people in Africa.
Northwestern University has received a four-year, $4.9 million grant from the Bill & Melinda Gates Foundation to develop and produce affordable diagnostic devices for infectious diseases. The team will focus on two targeted products and work with commercial collaborators Abbott and Inverness Medical Innovations to improve test systems.
Research by Zelalem Temesgen and colleagues found that nearly half of long-term HIV-positive patients develop resistant strains of the virus, hindering effective treatment. The authors suggest strategies such as adherence improvement and using new antiretroviral classes to improve patient outcomes.
J-P Garnier, GSK CEO, emphasizes the company's commitment to providing affordable HIV drugs and vaccines for diseases affecting the developing world. He highlights GSK's efforts to introduce modern HIV drugs at lower prices and protect innovation through patents.
A University of Houston team, with a NIH grant, is creating a quick, accurate test for the 'Cruise Ship Virus' using retroreflectors and antibody proteins. The tool has the potential to diagnose diseases like Norwalk more easily and may be applied to other infectious diseases.
The Program in Systems Immunology and Infectious Disease Modeling (PSIIM) aims to understand complex biochemical networks regulating interactions between pathogens and human cells. The program employs Simmune software to simulate biological systems, enabling scientists to predict how drugs affect cell behavior and develop new treatments.
Researchers found infectious misfolded prion protein in heart muscle, decreasing the heart's ability to pump blood. High levels of scrapie infectivity were also identified in the blood of mice used in the study.
A recent study reveals that prion disease infectivity can cause heart damage in mice, with similarities to human amyloid heart disease. The findings have significant implications for the development of new diagnostic tests and treatments for prion diseases.
Researchers found that brittle prion particles can spread infection quickly by breaking into new seeds. This discovery boosts basic understanding of prion infections and could lead to new ideas for designing drugs to prevent or discourage prion seeding.
A post-exposure vaccine has been shown to protect monkeys against the deadly Marburg virus. Researchers tested the vaccine in a study involving non-human primates and found it to be highly effective in preventing severe symptoms of the disease.
Researchers use mathematical modeling to predict that flu outbreaks will emerge in multiple locations and that containment efforts will only buy time. The study suggests that a multi-pronged preparedness strategy is needed to effectively prevent pandemics.
Researchers used mathematical modeling tools to document the spread of sea lice from commercial salmon farms to wild Pacific salmon. The study found that a single farm could lead to a massive increase in parasite load, affecting the health of young fish.
Hematologists say coagulation-factor concentrates from plasma are now deemed safe from most infectious agents, but challenges from new agents remain. Recombinant products offer a risk-free alternative, but safety studies have not definitively made the case for either.
The Models of Infectious Disease Agent Study (MIDAS) network has welcomed four new research teams to aid in developing preparedness plans for outbreaks. The new teams will use computer modeling techniques to simulate infectious disease spread and evaluate the effects of public health measures.
A team at UC Irvine will receive a $1.5 million grant to develop computer-based simulations of pandemic flu and other infectious disease outbreaks. The research aims to improve understanding of how to prepare for and contain the spread of such diseases.
The NYAS China Conference showcased groundbreaking research on chemical biology, infectious diseases, genomic medicine, and neuroscience. Experts discussed innovative approaches to drug development, disease treatment, and brain growth, highlighting the importance of global collaboration.
A recent study suggests that controlling neglected tropical diseases like leprosy and sleeping sickness may help combat the global fight against HIV/AIDS, tuberculosis, and malaria. Integrating these efforts could provide a cost-effective solution to control or eliminate seven neglected tropical diseases for just $200 million annually.
Researchers at UW-Madison have discovered a systematic mechanism for the influenza virus to package its genetic materials, enabling the development of new antiviral drugs and more efficient vaccine production. This finding has significant implications for addressing avian influenza pandemics.
A study led by Dr. Antonio Anzueto found that the newer medication moxifloxacin HCI is more effective at treating community-acquired pneumonia (CAP) in elderly patients, with a recovery rate of 97.9%, compared to 90% for the standard medication levofloxacin. The study also assessed cardiac safety and found both treatments to be safe.
Elderly people in developing countries face significant health challenges, including infectious and non-communicable diseases. Nutritional interventions such as supplementation, food fortification, or development of nutrient-rich crops may help reduce the disease burden.
A study analyzing 35 soldiers' remains identified lice carrying DNA from Bartonella quintana and Rickettsia prowazakii, linking these diseases to Napoleon's retreat from Russia. The findings suggest louse-borne diseases were a major factor in the army's decline.
The University of Pittsburgh has established an Immune Modeling Center to study immune responses to infectious diseases using mathematical modeling. The center will focus on understanding innate and adaptive immune responses to influenza A virus, Mycobacterium tuberculosis, and Francisella tularensis.
Hospitalization rates for infectious diseases have increased significantly among older adults in the US, with notable rises in septicemia, postoperative infections, and other conditions. This trend is likely linked to the aging of the population, which will lead to a projected increase in hospitalizations among older adults.
A study led by Northwestern University researchers suggests that Kawasaki disease is caused by a single respiratory viral agent, entering through the lungs and infecting bronchi. The research provides new insights into the disease's cause and course, and may lead to new treatments.
The center aims to develop tools for early detection and a deeper understanding of microbial disease transmission, connecting science to the community.
A recent study published in Science demonstrates a new and sensitive assay for infecting prion diseases, including CJD and scrapie. The research shows that persistent replication of the infectious agent provides protection against more virulent strains, without requiring misfolded prions.
Systemic corticosteroid therapy was used in 44.7% of patients with infectious mononucleosis, exceeding traditional indications. Factors associated with increased use include repeat visits and otolaryngology consultations.
Researchers found that mating between two less harmful fungal strains of the same sex produced a more virulent form, which has taken hold and is spreading. The fungus, C. gattii, infects individuals with normal immunity, causing symptoms like persistent headaches and coughing.
The joint NSF-NIH program aims to create a predictive understanding of the ecological mechanisms governing relationships between human-induced environmental changes and infectious diseases. Researchers will study how large-scale events alter disease emergence, allowing for better control of disease spread among humans, animals, and crops.
Researchers discovered that prions can rapidly 'remodel' good protein into bad, shedding important light on the molecular machinery behind infectious brain diseases. This process may also help explain the progression of Alzheimer's, Parkinson's and Huntington's diseases.
Researchers found that small prions are significantly more infectious than large ones, yet there is a lower size limit beyond which infectivity is lost. The study's findings suggest that treatments targeting large prion deposits may do more harm than good by releasing the most infectious particles.
Researchers evaluated the relationship between routine childhood vaccines and hospitalization for infectious diseases not targeted by vaccination. The study found no adverse associations between multiple vaccinations and increased risk of nontargeted infectious disease hospitalizations.
Commonly used disease models may make overly optimistic predictions about the levels of public health interventions needed. Researchers found that ignoring the latent period or assuming unrealistic distributions can result in underestimating transmission potential. The study emphasizes the need to consider these factors when making qua...
Emerging diseases can move between species, mutating into more virulent forms; WCS proposes 'One World, One Health' concept to prevent outbreaks. The global trade in wildlife poses a significant challenge, with estimated $100 billion losses due to livestock pathogens and pandemic diseases.
Scientists have developed a method to create an infectious form of the hepatitis C virus in a test tube, allowing researchers to study its life cycle and develop new drugs. This breakthrough could lead to better understanding and treatment of liver diseases associated with HCV.
Scientists at the Salk Institute have discovered that a specific conformation of the prion protein is the infectious entity behind deadly prion diseases. By altering this shape, researchers may find a strategy to control these untreatable brain-wasting diseases.
Research suggests that a variant form of abnormal prion protein lacking an anchor may be unable to signal cells to start the lethal disease process, leading to infection without symptoms. The study provides novel insights into how prion and other neurodegenerative diseases develop and hints at new approaches to prevent such diseases.
The National Institute of Allergy and Infectious Diseases (NIAID) has awarded new grants to strengthen the national biodefense and emerging infectious diseases research network. The grants support research on next-generation treatments, vaccines, and diagnostic tools for diseases such as anthrax, plague, smallpox, and West Nile fever.
A stronger version of the chickenpox vaccine has been shown to prevent shingles in older adults, reducing incidence by 51% and total burden of pain by 61%. The vaccine also significantly reduces postherpetic neuralgia, a debilitating form of chronic nerve pain.
The National Institute of Allergy and Infectious Diseases has awarded UC Irvine a $40 million grant to establish the Pacific-Southwest Center for Biodefense and Emerging Infectious Diseases Research. The center will focus on developing vaccines, antidotes, and new methods to prevent infectious diseases.
The University of Manchester's Centre for the History of Science, Technology and Medicine is conducting a three-month study on infectious diseases. The project will examine the evolving risk of diseases, changing detection requirements, and cutting-edge science to inform future research and management policies.
Researchers have watched infectious prion proteins invade and move within brain cells, shedding light on transmissible spongiform encephalopathies (TSE) diseases. The findings may lead to ways to prevent or minimize their effects.
The conference aimed to incorporate ecological methods into traditional epidemiological studies, exploring how environmental changes influence disease dynamics. Experts emphasized the need for building a bridge between ecology and epidemiology to address emerging pathogens effectively.
The Sapling Foundation grant will support OneWorld Health's efforts to develop new medicines for infectious diseases affecting the developing world. The Institute develops affordable treatments for diseases like visceral leishmaniasis, malaria, and diarrhea, with a focus on pre-clinical studies and clinical trials.
Researchers tested genetic diversity on Italian agile frog tadpoles exposed to a North American virus, finding that disease susceptibility paralleled population genetic variability. The study highlights the risks of population bottlenecks and inbreeding and suggests a method for predicting responses to new infectious diseases.
Extensive scientific evidence confirms no link between vaccines and neurodevelopmental disorders like autism. Immunization remains crucial for protecting children from serious infectious diseases, says the Infectious Diseases Society of America.
A novel self-replicating microorganism, nanobacteria, has been linked to kidney stone formation in astronauts and may pose an infectious risk. The discovery provides additional clues to understanding the link between nanobacteria and pathologic calcification-related diseases.
A substance called poly-gamma-DL-glutamic acid (PGA) has been shown to protect Staphylococcus epidermidis bacteria from natural human defenses. The discovery could lead to new treatments for S. epidermidis infections, which can cause serious conditions like sepsis and endocarditis.
Yale researchers, Jorge Galán, Ruslan Medzhitov, and John Carlson, have been awarded $3 million to investigate Campylobacter jejuni and its impact on the immune system. The funding will support their work in understanding infectious disease mechanisms and developing new treatments.
Researchers found that infectious prions can survive digestive juices and cross the human intestinal barrier by linking with ferritin, an iron-storing protein. This breakthrough discovery provides insight into the mechanisms of prion transmission and may lead to the development of methods to block prion uptake.
Researchers found that the fungal genome's sex-determining region shares similarities with the human Y chromosome, including cluster formation of functionally related genes. This discovery may provide insight into infertility in fungi and humans, as well as disease mechanisms in C. neoformans.
A three-year study of over 46,000 seniors in Washington state found that peak CAP rates coincide with flu season and are more common among men. Quitting smoking and getting influenza vaccinations can reduce the risk of pneumonia, while other factors like heart problems and dementia increase vulnerability.
The NIH awarded Indiana University a $7 million grant to establish the Midwest Sexually Transmitted Infections and Topical Microbicides Cooperative Research Center. The center will focus on researching epidemiology, acquisition, prevention, and pathogenesis of sexually transmitted infections in young women.
A study found that the Pall Leukotrap Affinity Prion Reduction Filter reduces infectious vCJD prions in red blood cell concentrates below detection limits. The filter also reduced scrapie prions, a similar TSE, from blood, with no clinical symptoms reported in animals treated with filtered blood.
The Imperial College London team, led by Dr. Danny Altmann, is developing new vaccines against anthrax and other bio-weapons using state-of-the-art technologies. The research will also contribute to a better understanding of emerging infectious diseases and the development of effective diagnostics and treatments.
The NIAID's Large-Scale Antibody and T Cell Epitope Discovery Program aims to deepen understanding of immune function against certain infectious agents. Researchers will discover new epitopes from various microbes, including those that could be used in bioterrorist attacks, to design improved medical countermeasures.
Researchers develop mathematical model to predict mosquito-borne infection risk, finding that peak biting rates occur near breeding sites and highest human density. The proportion of infectious mosquitoes peaks where older populations are found, leading to surprising predictions about risk hotspots.
The Infectious Diseases Society of America states that endocarditis and meningitis are better treated with bactericidal drugs, while urinary tract infections can be effectively managed with bacteriostatic drugs. Corticosteroids are recommended for bacterial meningitis to prevent inflammation.