The study determined the cryo-electron microscopy structures of class B glucagon receptor bound to β-arrestin 1, revealing a unique tail conformation that differs from previously known arrestin-bound GPCR structures. This new mechanism may enable the development of novel biased ligands with pathway selectivity.
A study by Prof. WANG Lei and WANG Chih-chen’s group at the Institute of Biophysics (IBP) of the Chinese Academy of Sciences (CAS) establishes the relationship between oxidative protein folding and stem cell aging for the first time.
Researchers developed a precise crosslinking method to impart elastic recovery to ferroelectric materials. The new material combines elasticity with high crystallinity, offering broad application prospects in wearable electronics and smart healthcare.
The fossil discovery provides the earliest known evidence of birds consuming leafy greens from flowering plants. Analysis of microscopic residues in a 120-million-year-old bird skeleton reveals that Jeholornis was an herbivore, not a predator.
Researchers created a flexible and potent 'on-demand' whole tumor cell vaccine (TCV) that responds to near-infrared laser irradiation, boosting the immune response and effectively suppressing tumor growth. The TCV was tested in various murine xenograft models and showed promising therapeutic efficacy.
Researchers found five Green Pea galaxies with double-peaked narrow lines, suggesting dual active galactic nuclei (AGN) mergers. The study provides insights into the co-evolution of high-mass galaxies and supermassive black holes.
Researchers discovered that female gametes in flowering plants can still attract pollen tubes and produce seeds even without synergid cells. The central cell produces new types of pollen tube attractants, SALs, which are essential for fertilization recovery.
Researchers create biotissue-like rhythmic agglomerates using water and liquid metals, exhibiting aqueous properties and biorhythms. The unique capacity of liquid matter to generate biorhythms is revealed, opening opportunities for advanced soft robotic systems.
A recent study published in Nature Mental Health reveals that amotivation and anhedonia are key factors in determining social functioning among individuals with psychiatric disorders. The research found that these negative symptoms have a stronger impact on social functioning than expressive dysfunction, especially in patients with sch...
Researchers predict a significant increase in projected frequency of multiyear La Niña events under global warming. This is due to enhanced tropical-subtropical interaction and Pacific mean-state warming patterns.
A research team used space geodetic observations to study seasonal and intra-seasonal signal variations in the Earth's surface loads, finding subsidence and uplift in regions of positive and negative mass anomalies. The results indicate that space geodesy offers an effective method for studying surface loads and crustal movements.
A new process developed by researchers at the Chinese Academy of Sciences Headquarters greatly reduces bias in gene amplification, enabling high-coverage genome sequencing from single bacterial cells. The improved method uses an engineered phi29 DNA polymerase that is more efficient and robust than traditional versions.
Researchers developed a stable, porous molecular crystal using triptycene as a building block, leveraging noncovalent interactions to create a flexible material with high solubility and self-healing capabilities. The synthesized PMC exhibits excellent thermal and chemical resistance, making it suitable for various applications.
Researchers have confirmed the presence of autoproteolytic effects in Clostridium thermocellum, essential for transmembrane signal transduction. This discovery expands our knowledge of bacterial signaling mechanisms and highlights the complexity of prokaryotic signaling pathways.
Scientists have deciphered the Arctic flora's evolution over time, discovering its roots date back to the Early Late Miocene. The study reveals a complex dispersal corridor between the Arctic and western North America, with both immigration and in situ speciation contributing to biodiversity.
A team of scientists mapped the cell-type taxonomy in the macaque cortex using Stereo-seq and snRNA-seq technology. They found distinct cortical and regional specificity in glutamatergic neurons, GABAergic neurons, and non-neuronal cells, with significant correlations between cell composition and brain region structure.
Scientists identified structural origin of voltage hysteresis in manganese-rich NASICON-type cathodes and developed Mo-doping strategy to decrease defect concentration. This led to improved Coulombic efficiency and reversible capacity in Na-ion batteries.
A joint research team from Northeastern University and the National Astronomical Observatories of the Chinese Academy of Sciences has proposed a novel 21-cm forest probe to shed light on dark matter and the early formation of galaxies simultaneously. By measuring the one-dimensional power spectrum of the 21-cm forest, scientists can di...
A team from the Second Tibetan Plateau Scientific Expedition and Research (STEP) has made a significant contribution to understanding Mount Qomolangma's mean snow depth. They used a novel approach to ground-penetrating radar technology, resulting in a snow depth of 9.5 ± 1.2 meters at the summit.
Researchers have developed a new technology that uses acoustic tweezers to precisely control bacterial clusters in live mice, demonstrating a promising approach for targeted drug delivery and cellular therapy in cancer treatment. The technology, called PAHAT, enables precise non-contact manipulation of cells in living organisms.
Researchers found a major shift in Martian climate about 400,000 years ago, coinciding with the end of the last glacial period. The prevailing wind direction changed from northeast to northwest, eroding crescent-shaped dunes into longitudinal ridges.
Scientists discover evidence for possible change in Earth's geodynamics at 3.8 Ga, suggesting onset of plate subduction. The absence of heavy Si signature in oldest rocks (4.0 Ga) indicates no subduction required, but data reveals distinct shift in Si and O isotopes.
Researchers have discovered Rydberg moiré excitons in WSe2 monolayer semiconductor adjacent to graphene, exhibiting multiple energy splittings and a pronounced red shift. The discovery holds promise for applications in sensing and quantum optics due to the strong interactions with the surroundings.
Scientists have developed a new method to measure moderately saturated sources of the Ultra-Violet Optical Telescope onboard the Swift satellite. GRB 220101A is the most energetic ultraviolet/optical flare ever detected, with a luminosity approximately 400 quadrillion times that of the Sun.
A study published in Science Advances discovered that talitrids, a group of small crustaceans, independently colonized mountain habitats four times during the Oligocene and Miocene periods. Genetic adaptations allowed them to survive in colder environments and establish themselves in diverse habitats worldwide.
Researchers have found key evidence for the existence of nanohertz gravitational waves through pulsar timing observations. The Chinese Academy of Sciences has detected quadrupole correlation signatures compatible with nanohertz wave predictions at a 4.6-sigma statistical confidence level.
Researchers have discovered a binary pulsar with a 53-minute orbital period, filling the gap in the evolution of spider pulsar systems. The finding confirms the existence of an intermediate state between redback and black widow spiders, a long-held theory.
The study uses AI-assisted methods to discover novel deaminase proteins with unique functions through structural prediction and classification, expanding the utility of base editors. New DNA base editors with remarkable features were developed, enabling tailor-made applications for various breeding efforts.
The Zhurong rover's first 1-km traverse revealed extremely weak magnetic fields on the Martian surface, contradicting previous orbital measurements. This finding suggests that either the crust remained unmagnetized or was demagnetized by a massive impact, providing new insights into early Mars' magnetic, climatic, and interior history.
Astronomers have proposed a new method for measuring the distances of galaxies, utilizing double-period RR Lyrae (RR Lyr) stars. The study, published in Nature Astronomy, aims to improve the accuracy of distance measurements by leveraging the unique properties of these stars.
A recent study has found that impaired histone inheritance accelerates breast cancer growth and metastasis by disrupting the epigenetic state of cells. This disruption leads to the reactivation of genes associated with development, promoting tumor progression.
A team of researchers from QIBEBT has developed a method to produce high-quality lactic acid from lignocellulosic biomass, reducing the need for intermediate sterilization and nutrient supplementation. This breakthrough has significant implications for industrial-scale production of biodegradable materials.
Researchers have developed a three-dimensional mesoporous biosensing-membrane with neighborhood nanostructures, exhibiting excellent sensitivity and long-term stability. The membrane uses a ternary coating to assemble Prussian blue and glucose oxidase, improving cascade reaction efficiency and sensing stability.
A new study reveals that Earth's day length may have stalled at 19 hours between 2-1 billion years ago due to tidal resonance caused by the Moon and Sun's opposing forces. This flatlined period could have allowed for a stable atmosphere, enabling photosynthetic bacteria to produce more oxygen each day.
A new SCIVVS approach accelerates probiotics quality assessment by rapidly counting live bacteria, identifying species, and testing viability in just five hours. The method also tracks the source of individual cells in a sample, promising to transform current practice in quality control and intellectual-property protection.
The LHAASO collaboration has measured the complete high-energy light curve of a gamma-ray burst (GRB) for the first time, including its entire phase from rise to decay. This observation provides a perfect dataset for testing theoretical models and could remain one of the best results for decades or centuries.
Researchers have developed a method to encapsulate polyoxometalate molecules within carbon nanotubes, enhancing the electrochemical energy storage of materials. The study found that these hybrids exhibit improved electrochemical properties due to reduced aggregation and increased electron transfer.
Researchers have identified a novel gene WTS that confers broad-spectrum resistance to clubroot disease in Brassica crops. The WTS protein complex functions as an endoplasmic reticulum-localized calcium release channel, increasing cytosolic calcium ions and activating plant defenses.
A new study has identified a chemically peculiar star in the Galactic halo as clear evidence of the existence of pair-instability supernovae (PISNe) from very massive first stars. The star's low sodium and cobalt abundances are consistent with predictions for primordial PISN from first-generation stars with 260 solar masses.
Researchers discovered that the early avian bauplan was shaped by natural selection driven by powered flight, with forelimb evolution constrained to basic 'blueprint' needed for flight. The study found avialan-like limb proportions established earlier in forelimbs than hindlimbs in theropod history.
Researchers have observed significant directed flow of hypernuclei in heavy-ion collisions, offering a new direction for studying Y–N interactions. The experiment extracted slopes of directed flow of hypernuclei and light nuclei, suggesting a similar mass number scaling.
The Chang'e project has successfully mapped the Moon's surface, composition and inner workings, providing new insights into its evolution and potential resources. Future research aims to unlock the secrets of water ice and lunar material composition.
Researchers created a synthetic yeast system that responds to dual oscillatory signals, showing significant enlargement of entrainment region and increased synchronization. The study demonstrates the importance of phase difference in regulating internal oscillator dynamics.
A team has developed a new approach to disentangle the activity-selectivity tradeoff in catalytic conversion of syngas to light olefins, achieving high CO conversion and selectivity. The strategy involves incorporating germanium-substituted aluminophosphates within the OXZEO catalyst concept.
A new Ordovician eurypterid, Archopterus anjiensis, has been found in the Wenchang Formation of Anji County, Zhejiang Province. The discovery is significant for understanding early evolution of eurypterids in Gondwana.
Researchers have identified extreme field reversals around FRB 20190520B, a persistently active repeating Fast Radio Burst. This finding provides insights into the turbulent magnetized environment surrounding the cosmic explosion, which may be caused by signal passage through a companion's halo.
Researchers have identified two novel DOF family transcription factors that enhance wheat regeneration and genetic transformation. These findings provide new insights into the transcriptional regulatory network involved in boosting wheat regeneration, offering opportunities for improving crop improvement.
Researchers identified a novel high RS gene, SSIIIb, which when combined with the loss-of-function SSIIIa gene, increased RS content in cooked rice. This breakthrough provides genetic resources for breeding high-RS rice varieties, potentially reducing obesity and related health issues.
Scientists at IMP used a new mass spectrometry technique to precisely measure the masses of key nuclei, including arsenic-64 and selenium-66. The newly measured data led to changes in the rp-process path, indicating lower neutron star density and higher outer shell temperatures.
Researchers found that right hippocampal theta power hierarchically encodes the distance between current position and goal destination. The study used intracranial electroencephalography recordings from epilepsy patients performing a virtual navigation task.