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New study by neuroscientists and nephrologists offers clearest views yet on a key protein found in kidney and brain, opens avenues to treating diseases

A new study has revealed the structural nuances of a key protein found in both the kidneys and brains, shedding light on its role in treating diseases such as chronic kidney disease and Alzheimer's. The discovery of LRP2's ferrying mechanism has led to hope for novel pharmaceutical approaches.

SourceColumbia University·JournalCell·TypeObservational study·DateFeb 6, 2023

Seeing in 3D

Researchers studied albino mice to understand how the neural circuitry of vision develops and can be disrupted, finding that a gene controlling cell birthing is perturbed in albinism. The study identified a potential therapeutic target by revving up this gene, which improved depth perception in albino mice.

SourceColumbia University·JournalNeuron·TypeExperimental study·DateNov 8, 2022

The neural cartography of smell

A study published in Cell reveals that the shape of receptor proteins determines axon targeting precision in mice, helping explain how olfactory neurons send signals to specific glomeruli. This discovery could lead to early detection of olfactory deficits and understanding of brain function.

SourceColumbia University·JournalCell·TypeExperimental study·DateSep 26, 2022

Where do high-energy particles that endanger satellites, astronauts and airplanes come from?

Scientists Luca Comisso and Lorenzo Sironi used supercomputers to simulate the origin of high-energy particles in turbulent environments like the sun's atmosphere. Their research provides a clear pattern of when and how these particles form, paving the way for more accurate predictions of space weather events.

SourceColumbia University·JournalThe Astrophysical Journal Letters·TypeComputational simulation/modeling·DateSep 13, 2022

Cravings for fatty foods traced to gut-brain connection

A study published in Nature found that fat entering the intestines triggers a signal that drives mice to consume fatty foods. The gut sends signals to the brain via the vagus nerve, with two types of cells responding to different nutrients. Blocking these signals prevents mice from developing an appetite for fat.

SourceColumbia University·JournalNature·TypeExperimental study·DateSep 7, 2022

Scientists see spins in a 2D magnet

Researchers at Columbia University have discovered a way to visualize magnons in a 2D material, CrSBr, by pairing them with excitons that emit light. This breakthrough enables the observation of tiny changes in magnon spins, potentially leading to the development of more efficient quantum information networks.

SourceColumbia University·JournalNature·DateSep 7, 2022

Computer models mimic brain’s ease in telling faces apart

Researchers found that two types of computer models, deep neural networks and the Basel Face Model, are surprisingly accurate at replicating human facial similarity judgments. These models were tested on a dataset of realistic computer-generated faces and ranked by students in terms of similarity.

SourceColumbia University·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateJun 27, 2022

Nematicity is a new piece in a phase diagram puzzle

Researchers have discovered a new electronic nematic phase in twisted double bilayer graphene, which breaks the material's symmetry and allows for the re-alignment of electrons. This finding adds to our understanding of graphene-based systems and may hold implications for the study of superconductivity.

SourceColumbia University·JournalNature Physics·DateJan 6, 2022

Columbia researchers uncover altered brain connectivity after prolonged anesthesia

A study published in PNAS documents changes associated with prolonged anesthesia in the brains of mice, revealing significant alterations in synaptic architecture. The findings support reports of post-hospital cognitive dysfunction and suggest a physical link between cognitive impairment and prolonged medically induced coma.

SourceColumbia University·JournalProceedings of the National Academy of Sciences·DateFeb 17, 2021

Switching nanolight on and off

Researchers at Columbia University have developed a platform to control layered crystals using light, producing imaging capabilities beyond common limits. The discovery provides insights for optical quantum information processing and aims to solve difficult problems in computing and communications.

SourceColumbia University·JournalScience·DateFeb 4, 2021

Could we harness energy from black holes?

Physicists Luca Comisso and Felipe Asenjo propose a new method to extract energy from rotating black holes by breaking and reconnecting magnetic field lines. This process could accelerate plasma particles to negative energies, allowing for massive amounts of energy extraction with an efficiency of up to 150%.

SourceColumbia University·JournalPhysical Review D·DateJan 13, 2021

Why naming neurons can help cure brain disease

A unified classification of diverse cell types in the cerebral cortex has been proposed by a Columbia-led team, which could shed light on how our brains work and potentially lead to treatments for diseases. The new system uses single-cell RNA sequencing and can be updated regularly using algorithms.

SourceColumbia University·JournalNature Neuroscience·DateSep 2, 2020

New observations help explain the dimming of Tabby's Star

Researchers propose that Tabby's Star is experiencing long-term dimming due to a disk of debris from an exomoon accumulating around it, blocking its light. The exomoon's outer layers are being torn apart by stellar radiation, creating dust clouds that periodically pass between the star and Earth.

SourceColumbia University·JournalMonthly Notices of the Royal Astronomical Society·DateSep 16, 2019

Good medicine depends on diversity

A new national study led by Columbia University aims to understand barriers to minority group participation in genetic studies and support policies to create a more diverse genetic database. The four-year study will analyze diversity and inclusion practices at academic medical centers across the US.

SourceColumbia University·JournalScience·DateJul 1, 2019

A milestone for forecasting earthquake hazards

Researchers from Columbia University and USGS develop a physics-based model that replicates California's statistical seismic hazard model. This breakthrough marks a turning point in earthquake forecasting, providing accurate hazard estimates for engineers and regulators to make informed decisions on building codes and construction costs.

SourceColumbia University·JournalScience Advances·DateAug 22, 2018