A novel bivalent molecule effectively suppresses inflammatory cytokines in human nasal epithelial cells, leading to therapeutic benefits in an AR mouse model. The chemical degradation of Keap1 induced by homoPROTAC KEAP1 demonstrates efficacy in managing AR symptoms, oxidative stress and inflammation.
The article discusses an AI-integrated quality prediction and diagnostics framework for small-sample pharmaceutical manufacturing, achieving state-of-the-art results with improved accuracy and stability. The proposed PeDGAT model enhances model stability in small samples, offering a panoramic view of attribute relationships across units.
A novel C-3-substituted oleanolic acid benzyl amide derivative, A5, exhibits high efficiency and broad-spectrum anti-influenza activity against influenza A virus by targeting PA–PB1 interactions. It also modulates host macrophage inflammation and demonstrates synergistic effects when combined with oseltamivir.
The study found that PRMT1 downregulation leads to increased RIPK1 activation, causing necroptosis and apoptosis in cerebral I/R injury. PRMT1 overexpression protects against I/R injury by suppressing RIPK1 activation.
The in vivo approach eliminates laboratory manipulation, leveraging viral and nonviral vectors for genetic modification of T cells. This method preserves T cell functionality, enhancing therapeutic efficacy compared to in vitro-produced CAR T cells.
Natural compounds normalize tumor vasculature, inhibiting pathological angiogenesis and reducing tumor growth. These agents complement conventional therapies, reduce toxicity, and enhance delivery of chemotherapeutic drugs.
Researchers have developed innovative strategies combining oncolytic viruses with immunotherapies to overcome limitations of OV monotherapy. These synergistic treatments amplify the body's natural defenses, creating a powerful dual attack against cancer cells while minimizing adverse effects.
Head and neck cancer's intricate connection between energy metabolism and immune regulation holds potential for effective therapies. Tumor cells' metabolic reprogramming fuels growth and supports invasion, while altering glucose transporters and lipid metabolism promotes immune evasion.
A recent study found that menin promotes bladder cancer malignancy by enhancing TFAP2C/β-catenin signaling, suggesting its potential as a therapeutic target and prognostic marker. Menin upregulates TFAP2C expression, which regulates β-catenin gene transcription via binding to its proximal promoter.
A recent study identifies four novel proteomic subtypes of GSRCC: Metabolism, Microenvironment Dysregulation, Migration, and Proliferation. Key prognostic biomarkers PRDX2 and DDX27 were also identified, with PRDX2 linked to favorable prognosis and DDX27 associated with poor survival outcomes.
Chitinase-3-like protein 1 (CHI3L1) is recognized for its unique ability to influence multiple pathophysiological processes, despite lacking enzymatic activity. Elevated levels of CHI3L1 correlate with fibrosis severity and demonstrate superior diagnostic efficacy compared to conventional markers.
SOX2 is crucial in tumor growth, spread, and resistance to therapy, influencing cell proliferation, apoptosis resistance, and EMT. Elevated SOX2 levels are associated with poor prognosis and enable cancer cells to adapt to therapeutic pressure.
Advances in NGS have revealed non-coding regions' role in gene regulation and disease etiology. Targeting non-coding elements implicated in disease may lead to tailored therapies.
Research reveals that gut microbiota imbalances can contribute to cardiac dysfunction, inflammation, and metabolic disturbances in heart failure. Dietary interventions, probiotics, and fecal microbiota transplantation may offer innovative approaches for managing heart failure.
The study reveals how genetic mutations in fucosyltransferases contribute to disease susceptibility, leading to inflammatory responses, barrier dysfunction, and increased cancer risk. Aberrant fucosylation is linked to conditions such as liver cirrhosis, hepatocellular carcinoma, pancreatic cancer progression, and gastric cancer.
This review article explores the complexities of tumor angiogenesis and endothelial cell origins, highlighting the diverse sources and mechanisms of endothelial cell development in tumors. The study outlines the dysregulation and heterogeneity of tumor blood vessels, complicating the development of effective therapies.
Researchers explore the potential of boosting mitochondrial biogenesis to alleviate acute kidney injury by targeting energy metabolism, stress resistance, and cell survival. Promising compounds like resveratrol and ZLN005 enhance mitochondrial function while minimizing toxicity.
ADAMTS2 plays a pivotal role in collagen maturation and is associated with Ehlers-Danlos syndrome, angiogenesis, lymphangiogenesis, neurodevelopment, immune regulation, and cardiovascular diseases. Its multifunctional nature positions it as a potential therapeutic target for treating genetic disorders, cancer, and cardiovascular diseases.
The study reveals that WIPF1 plays a crucial role in regulating extravillous trophoblast (EVT) invasion and podosome formation, which is impaired in recurrent spontaneous abortions (RSA). WIPF1's interaction with ACTN4 and WASL facilitates lamellipodia formation and enhances EVT migration and invasion.
CISD1 expression linked to poor clinical outcomes, increased stemness levels, and tumor aggressiveness in multiple cancers. The gene's role in cellular bioenergetics also highlights its potential as a prognostic marker.
Researchers identify B-cell lymphoma 6 (BCL6) as a key player in promoting glioma cell proliferation and progression. A novel small-molecule inhibitor YK01 targets BCL6, showing potent anti-tumor effects in GBM cells and animal models.
A recent study reveals ADAMTS9-AS2/let-7a-5p axis inhibits the Warburg effect and OSCC progression, suggesting a promising therapeutic target for treatment. The study highlights the importance of metabolic reprogramming in OSCC.
Researchers are exploring targeting ferroptosis, a regulated cell death process driven by iron accumulation and lipid peroxidation, as a novel strategy to overcome the challenge of cancer stem cells. This approach has shown promise in selectively inducing cell death in CSCs while sparing normal cells.
The article explores the genetic factors, epidemiological patterns, and current management techniques associated with clubfoot. Key findings highlight the crucial role of genes like TBX4, PITX1, and HOXA in limb development and tissue differentiation.
SETD2 plays a crucial role in regulating immune cell function, influencing tumorigenesis, development, differentiation, and function of immune cells. Targeting SETD2 could modulate immune cell functions, offering novel treatments for autoimmune diseases, inflammatory conditions, and hematological malignancies.
Recent research elucidates PDE4DIP's role in driving Left Ventricular Non-Compaction (LVNC) development through regulating cell polarity, cytoskeleton, and energy metabolism. The study identifies PDE4DIP as a pathogenic gene contributing to LVNC progression.
Researchers found that TLR4 activation by prenatal LPS leads to increased 5-HT levels, impaired intestinal structure, and altered gastrointestinal motility. Targeting TLR4 may help alleviate intestinal motility abnormalities in prenatally infected offspring.
A new study highlights the potential of natural Gal-3 inhibitor, modified citrus pectin, to restore treatment efficacy in pancreatic cancer. Gal-3 inhibition in combination with gemcitabine reduces tumor growth and reverses drug resistance.
A new study reveals Shen-Bai-Jie-Du decoction inhibits colorectal tumorigenesis by regulating the TMEM131–TNF signaling pathway-mediated differentiation of immunosuppressive dendritic cells. The findings suggest that SBJDD may help restore tumor microenvironment homeostasis and offer a novel cancer therapy.
This study found that sleep fragmentation-induced testicular damage in T2DM is mediated by melatonin receptor 1a, which activates FGFR1 to suppress TAB1/TAK1 complex. Melatonin and its agonist improved lipid homeostasis, highlighting a promising therapeutic approach for male infertility in T2DM.
This issue of Acta Pharmaceutica Sinica B features research on intestinal aging, single-cell RNA sequencing, and cancer treatment. Articles explore therapeutic strategies for reducing frailty, inhibiting colorectal tumorigenesis, and developing preclinical candidates for acute liver injury.
A potent and selective RIPK2 inhibitor has been identified through the CMD-OPT model as a potential therapeutic agent for acute liver injury. The compound, RP20, demonstrates excellent kinase specificity and superior therapeutic effects in an APAP-induced ALI model.
Researchers developed a co-crosslinked hydrogel combining the rapid filling properties of hyaluronic acid (HA) with the collagen-stimulating abilities of silk fibroin. The HA-SF hydrogel promotes tissue adhesion, stimulates collagen regeneration, and achieves combined volume restoration and anti-aging via fibroblast activation.
Researchers developed a biomimetic codelivery system to target cancer stem-like cells, vasculogenic mimicry, and the immune microenvironment in triple-negative breast cancer. The treatment inhibits PKM2, suppresses CSC stemness, and reverses EMT, leading to improved therapy outcomes.
Researchers discovered that psychological stress activates the NR3C1/NUPR1 axis, accelerating ovarian tumor metastasis through epithelial-mesenchymal transition. Elevated NR3C1 positively correlates with NUPR1 expression and poorer prognosis in ovarian cancer patients.
This study reveals that SRSF7 promotes pulmonary fibrosis by modulating the alternative splicing of pyruvate kinase (PKM), leading to metabolic dysregulation and fibroblast activation. Lomitapide was identified as a novel modulator of SRSF7, effectively mitigating experimental pulmonary fibrosis.
The journal publishes original research articles, reviews, and rapid communications on pharmaceutical sciences. Recent studies focus on nanomedicine-driven tumor glucose metabolic reprogramming for enhanced cancer immunotherapy and the linkage of circadian rhythm disruptions with Alzheimer's disease and therapeutic interventions.
Researchers generated high-quality haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines. The studies identified numerous single nucleotide polymorphisms, indels, and structural variants surrounding HLA class I and II genes, providing valuable resources for cancer immunology research.
This study reveals that ALKBH3, an m1A demethylase enzyme, regulates enhanced glycolysis in Dox-resistant TNBC cells. The ALKBH3/ALDOA axis promotes Dox resistance through regulation of ALDOA mRNA stability and glycolysis.
Researchers have designed a nanohybrid system that alleviates tumor hypoxia, promotes vascular normalization, and enhances antigen presentation. The system, combining PFBT@Rox Lip nanoparticles with photodynamic therapy, boosts anti-primary and metastatic tumor efficacy of immunotherapy.
A new polysaccharide from Houttuynia cordata improves survival rates and weight loss in a murine model of pneumonia caused by H1N1 and MRSA coinfection. The therapeutic effect is linked to the modulation of Treg/Th17 balance and NLRP3 inflammasome activation.
Researchers mapped the bone marrow T-cell atlas in CML patients, identifying a CML-specific T-cell population and its interaction with the bone marrow microenvironment. The study found that CD8 TE cells play a key role in regulating the CML immune microenvironment.
Researchers identify XPR1 as critical factor in promoting ovarian cancer aggressiveness through autophagy regulation and MHC-I expression. The study suggests targeting XPR1 alongside autophagy inhibition to improve immunotherapy outcomes in ovarian cancer.
A new study identifies EMP1 as a pivotal molecule driving pancreatic cancer progression and poor prognosis. EMP1 expression was shown to promote cell proliferation, migration, and invasion through the PI3K/AKT signaling pathway.
A recent study published in Genes & Diseases reveals the relationship between immune cell characteristics, blood metabolites, and urolithiasis. The research highlights how genetically predicted blood metabolites mediate the association between specific immune cell profiles and urinary stone formation.
A new study found that amylin administration exacerbates tauopathy by impairing lysosomal mechanisms in a hybrid diabetes model. The research highlights the intricate relationship between diabetes and Alzheimer's disease, suggesting that amylin plays a key role in the pancreas-brain axis.
Researchers have discovered that the down-regulation of YWHAB in ovarian cancer peritoneal metastasis cells promotes YAP signaling, enhancing chemotherapy resistance and maintaining stem-like characteristics. Targeting the YWHAB-YAP pathway may lead to innovative therapeutic strategies.
Researchers explored clinical implications of loss-of-function IKBKG/NEMO mutations in the NF-κB signaling pathway. The study revealed diverse clinical manifestations associated with these mutations, including skin abnormalities, dental anomalies, and infections.
Researchers analyzed immune cell transcriptomes to understand JIA's pathogenesis. Monocytes, monocyte-derived dendritic cells, and platelets are increased in JIA patients, while B-cell responses differ between sJIA and non-sJIA subtypes.
Recent studies show chlorpyrifos exposure impairs spermatogenesis by compromising blood-testis barrier integrity, disrupting Sertoli cell junctional function and inducing ferroptosis. Chlorpyrifos primarily metabolite TCP triggers clockophagy-mediated ferroptosis in Sertoli cells.