The parasitic dinoflagellate Hematodinium infects marine crustaceans globally, resulting in mortalities due to organ malfunction. The pathogen has developed into an emerging epidemic threat to China's sustainable crab culture and wild populations.
Researchers have identified ferroptosis resistance as a critical issue in cancer treatment, highlighting the need for novel therapeutic strategies. The study integrates current understanding of signaling mechanisms to develop targeted treatments for therapy-resistant cancers.
The authors review future directions of nanomedicine development focusing on the mechanism of nanoparticle entry into tumors. Designing better nanoparticles to achieve efficient clinical transformation can be informed by a deep understanding of the mechanism of nanoparticle entry or the mode of action.
This issue of CVIA features papers on current management strategies for patients with heart failure and atrial fibrillation, as well as a systematic review on epicardial adipose tissue in obstructive sleep apnea. The journal also presents research on detecting myocardial infarction using late gadolinium enhancement MRI.
COVID-19 patients are at increased risk of pulmonary thromboembolism due to endothelial injury, activated platelets, cytokine storms, and suppressed fibrinolytic systems. Early prophylaxis, antiviral therapy, and supportive treatment can mitigate this complication.
The journal features papers on AI in medicine, including new roles for clinicians and AI-aided disease prediction. It also covers the development of chest imaging analysis methods for COVID-19 diagnosis.
Researchers from Sun Yat-Sen University, Harvard University, and Guangzhou University investigated viscoelastic flow mixing in microfluidics. They found that viscoelastic fluids exhibit transiently unstable flow patterns compared to Newtonian fluids, resulting in increased mixing.
A case study reveals the effectiveness of calcium channel blockers like diltiazem in treating acute myocardial infarction due to variant angina. Nitrates are also found to be efficient therapy, inhibiting smooth muscle proliferation and arterial matrix protein synthesis.
The article reviews antimicrobial peptides (AMPs) with anticancer properties, highlighting their potential use in tumor therapy due to their ability to interact with negatively charged cell membranes. Recent advances and challenges in the application of these peptides are also discussed.
A case of in-stent thrombosis (IST) occurred in an 81-year-old man undergoing coronary bypass grafting, highlighting the complexity of antiplatelet therapy choice and genetic testing in IST risk evaluation. The patient experienced IST after converting from ticagrelor to clopidogrel therapy.
A systematic review and meta-analysis of PubMed, Embase, and the Cochrane Library reveals that patients with masked hypertension (MH) may have a similar risk of target organ damage as those with sustained hypertension (SH). This suggests that clinicians should consider target organ damage when managing MH.
A pediatric patient with anomalous origin of the left coronary artery from the pulmonary artery developed severe heart failure at 3 months old. The authors review a case and discuss the challenges in early diagnosis, highlighting the importance of considering ALCAPA as a differential diagnosis.
A meta-analysis of major complications between traditional pacemakers and leadless pacemakers found that leadless pacemakers have potential for future clinical applications. However, more randomized controlled studies are needed to explore safety and practicality.
A rare case of mediastinal tuberculoma mimicking a malignant cardiac tumor was diagnosed after postoperative pathological examination. Multimodality imaging, including echocardiography and contrast-enhanced ultrasonography, played a crucial role in distinguishing the benign condition from a malignant tumor.
The study analyzed a microarray dataset to identify differentially expressed genes in dilated cardiomyopathy, revealing 172 genes involved in various biological processes. The authors identified hub protein modules and key genes, including DLD and UQCRC2, which suggest potential therapeutic targets for the disease.
Subcutaneous S-ICD therapy is explored as an option for patients with congenital heart disease and high risk of sudden cardiac death. A case study reports successful S-ICD implantation in a patient with ccTGA and DDD pacemaker, without interference between systems.
The article reviews AI-assisted chest imaging analysis methods for COVID-19 diagnosis, demonstrating the potential of deep learning-based techniques. Establishing a database for public research and extracting lesions accurately are crucial to improve performance.
The article discusses emerging applications of AI-related medicine, including novel diagnostic approaches, metadata analytical methods, and AI-aided treatment applications in preclinical and clinical uses. New progress in AI-aided disease prediction holds tremendous potential for future clinical use.
This issue of Acta Pharmaceutica Sinica B features three original research articles exploring novel mechanisms and treatments for various diseases, including cerebral ischemia-reperfusion injury, anti-atherosclerosis, and breast cancer. The articles discuss the potential benefits of IL-4 supplementation, berberine's gut-absorption-enha...
Researchers determined the crystal structures of SARS-CoV-2 papain-like protease, revealing novel packing and solvent content. The findings provide valuable insight into inhibition mechanisms and may aid optimization of promising inhibitors for therapeutic development.
This study identifies potential anti-COVID-19 pharmacological components of TCM's Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening. The research demonstrates the utility of this approach for identifying pharmaceutically active components in Chinese herb medicines.
The D3Targets-2019-nCoV webserver uses molecular docking to predict potential drug targets for SARS-CoV-2 and identifies lead compounds via multi-site docking. The server incorporates various features, including correlated conformations and binding sites, making it a valuable tool for medicinal chemists and clinicians combating COVID-19.
The study reveals a unique RNA binding pocket in SARS-CoV-2 nucleocapsid protein, which could guide the design of novel antiviral agents. The crystal structure provides atomic resolution features that may lead to the development of specific targeting sites for SARS-CoV-2.
The latest issue of Cardiovascular Innovations and Applications (CVIA) features research articles on COVID-19, including a study predicting death in severe patients. The journal also publishes papers on the impact of ventricular pacing and Marfan syndrome diagnosis.
This article discusses the integration of ultrasound imaging in medicine and biology, enabling advanced techniques such as molecular imaging and therapy. The use of ultrasound contrast agents and microbubble cavitation has opened up new opportunities for intracellular delivery and cancer treatment.
A new article proposes a scale-adaptive auto-context-guided fetal US segmentation framework with structured random forests, improving the accuracy of fetal biometric measurements. The proposed method outperforms state-of-the-art methods in terms of segmentation accuracy for fetal head circumference and abdominal circumference.
Researchers have identified potential therapeutic effects of dipyridamole in treating severely ill patients with COVID-19. The study also revealed unique drug targeting sites on the SARS-CoV-2 nucleocapsid protein, which can help guide the design of novel antiviral agents.
The rapid development of AI in medicine has led to new opportunities for clinicians. However, concerns about replacement have been raised. The authors explore the unlikelihood of complete replacement and propose adaptations to enable successful integration.
The journal features original research articles on Parkinson's Disease and drug-induced interstitial lung disease, as well as a case report and opinion piece on breast cancer management during the COVID-19 pandemic. Open access publishing and author support are also highlighted.
A Singapore breast surgical unit developed strategies to balance COVID-19 battle with breast cancer care, emphasizing multidisciplinary teamwork and patient stratification. Prompt adaptation to restricted resources and balancing risks are crucial in providing optimal patient care.
The article discusses drug-induced interstitial lung diseases caused by breast cancer treatments, which can be fatal. Multi-disciplinary integration of clinical practice and pharmacology may reduce the incidence of these diseases.
Researchers investigated the potential therapeutic effects of dipyridamole on severely ill patients with COVID-19. The study found that dipyridamole supplementation significantly decreased D-dimer concentrations and improved clinical outcomes in comparison to control patients, suggesting its anticoagulation and antiviral effects.
This latest issue of Cardiovascular Innovations and Applications (CVIA) features groundbreaking research on identification of novel TTN mutations and discovery of digenic mutations. The issue includes studies on the genetic causes of dilated cardiomyopathy and the effects of glycyrrhizic acid on vascular injury.
The BIO Integration Virtual Conference Series July 2020 examines the intersection of nanomedicine, biology, and technology. Key topics include the integration of naturally occurring bioactive compounds into nanomedicine and nanoparticles meditated LncRNA silencing for effective cancer radiotherapy.
Small interfering RNA (siRNA) shows potential for treating human diseases by selectively silencing pathological pathways. The review examines siRNA therapeutics in preclinical and clinical trials, challenges faced in siRNA therapy, and the feasibility of combining siRNA with anticancer drugs.
The BIO Integration Journal bridges the gap between laboratory, clinic, and biotechnology industries, offering a cross-disciplinary platform for biomedical research advances. Featured papers emphasize interdisciplinary integration in COVID-19 research and immunotherapy strategies.
Researchers successfully tested an automated device for Parkinson's disease stage discrimination in individuals who cannot walk without support. The study concludes that automation can be achieved, offering improved accuracy and increased accessibility for patients with gait disorders.
Researchers have developed bioactive factors-imprinted scaffold vehicles to promote bone healing by improving the stability and half-life of exogenous biofactors. The vehicles were used in various forms, including rigid bone graft substitutes, soft sponge-like scaffolds, and injectable vehicles, to enhance bone repair.
Bacteria-based nanobiohybrids have the potential to provide a targeted and effective approach for cancer treatment. Nanobiohybrid systems combine bacteria with nanomaterials in cancer therapy, offering advantages such as tumor targeting ability, genetic modifiability, and multimodal therapy.
Minor ginsenosides have diverse pharmacological activities, including anti-cancer, anti-diabetic, neuroprotective, immunomodulator, and anti-inflammatory effects. The utilization of microorganisms and their enzymes for biotransformation and biosynthesis are considered highly specific, safe, and environmentally friendly production methods.
Cardiovascular Innovations and Applications (CVIA) journal was introduced at the 26th GW-ICC meeting, focusing on novel developments in cardiovascular disease. The journal aims to promote cardiovascular innovations and applications for better public health globally.
This special issue examines cancer screening, treatment, survivorship, access to care, and global health. Research articles investigate colorectal cancer screening, patient perceptions of stool DNA-based testing, financial barriers to specialty care for uninsured patients, and the role of primary health care in China's reform.
Firearm-related injuries result in thousands of deaths and injuries each year, with estimated economic costs of FRIs being immense. The average inpatient length of stay for an FRI was almost 7 days at a cost of $22,000, resulting in $679 million annually on inpatient care.