The special issue explores the subtopics of in vivo fate of drug nanocarriers through review and research articles. Featured papers discuss intracellular uptake, impact of particle size and pH on protein corona formation, and in vivo dissolution of poorly water-soluble drugs.
The review explores recent strategies in surface functionalization, their specific biomedical applications, and comparative toxicities with non-functionalized metallic nanoparticles. It discusses the challenges for metallic NPs to undergo human clinical trials due to their aggregation and toxic nature.
Cancer immunotherapy using acoustics-based therapies has shown synergistic effects, enhancing the autogenous immune response to cancer tissue. Detailed mechanisms of sonopyrolysis-, sonoporation-, and sonoluminescence-based therapy are discussed to demonstrate its potential in cancer treatment.
The article examines autopsy, toxicological, and psychiatric reports of Portugal's first major forensic case. It highlights the importance of toxicological analysis and suggests potential new insights with current knowledge.
Researchers are bridging gaps between scientists from different fields to merge knowledge and create innovated, reliable products. Biophotonic innovations are expected to transform healthcare for the next few decades.
CRISPR/Cas technology has advanced diagnostics and gene therapy, enabling fast and accurate disease diagnosis and treating untreatable diseases like cancer and blood disorders. Recent advances in CRISPR-Cas technologies are highlighted, with a discussion of the strength and challenges for its future clinical usage.
This issue of APSB features studies on protecting against doxorubicin-induced cardiotoxicity via increasing YAP1 expression, as well as investigating alternative strategies to downregulate PD-L1 in gastric cancer cells. The journal also publishes research on a novel injectable micelle-hydrogel hybrid for localized drug delivery and tar...
The journal publishes an editorial, two mini review articles, two opinion articles, and an interview on various topics including COVID-19 diagnosis, dental implant biomaterials, ferroptosis resistance in cancer, and sonoporation. BIO Integration Journal is a peer-reviewed, open access international journal dedicated to modern medicine.
Researchers discovered a total of 23 new compounds in the endophytic fungus P. dangeardii, including azaphilone monomers, dimers, and trimers with unique structures. The compounds showed significant cytotoxicities, anti-inflammatory, or antioxidant activities.
Researchers discovered novel diarylamides with excellent in vitro UT inhibitory activity, leading to the identification of a promising preclinical candidate. Oral administration of the compound showed a superior diuretic effect in vivo without causing electrolyte imbalance or toxicity.
Researchers designed and synthesized acrylamide-based DHODH inhibitors for treating rheumatoid arthritis. The lead compound showed encouraging in vivo anti-arthritic effects in a dose-dependent manner.
Researchers have identified four potent antiviral compounds targeting the PF74 binding site, exhibiting improved metabolic stability compared to PF74. One compound, analog 20, shows similar submicromolar potency and significantly longer half-life in human liver microsomes.
Researchers found that calcium-sensing receptor (CaSR) is expressed in neutrophils, monocytes/macrophages, and T lymphocytes, regulating cytokine secretion, chemotaxis, and ligand delivery. This receptor also contributes to the development of several diseases, including sepsis, cryopyrin-associated periodic syndromes, and rheumatism.
Exercise with face masks or respirators can cause detrimental effects on the cardiovascular system, including cardiac arrhythmias and spontaneous pneumothorax. Masks designed for runners with minimal oxygen deficiency side effects are recommended for high-risk individuals.
Researchers examine the use of left atrial function indexes to evaluate left atrial function in cardiovascular disease. The study highlights their effectiveness in risk stratification and prognosis for conditions like heart failure and coronary heart disease.
Developed and validated clinical prediction models estimate the probability of patients having coronary artery disease (CAD) using a nomogram. The nomogram improves accuracy in Chinese populations by identifying individualized risk factors.
Researchers highlight the importance of myocardial fibrosis in HCM diagnosis and treatment, citing gene mutation and abnormal energy metabolism as contributing factors. The use of magnetic resonance imaging is also discussed as a diagnostic tool for fibrosis.
Using 3D Lorenz Scatter Plots to detect patients with atrioventricular node double path caused by interpolated ventricular premature systoles. The study found specific patterns on 24-hour Holter recordings, revealing the presence of an atrioventricular node double conduction path.
A case of atezolizumab-induced autoimmune diabetes mellitus presenting with diabetic ketoacidosis is reported, highlighting the importance of monitoring blood glucose levels in patients treated with PD-L1 inhibitors. The patient's condition was successfully managed with cessation of atezolizumab treatment and insulin therapy.
A study reviewed 286 patients who underwent ICD implantation between 2013 and 2016, assessing appropriateness based on AUC. The results showed a high rate of appropriate ICD implantations and very low prevalence of rarely appropriate implantations.
The use of dental implants for tooth replacement requires careful consideration of biomaterials, which must integrate into the body while minimizing negative immune responses. Researchers have compared titanium and zirconia, highlighting the importance of surface modification processes and coatings in optimizing implant performance.
Researchers employed nanoparticles-based delivery systems to deliver AMPs for treating deep infections. Intelligent nanocarriers can achieve selective activation and target at infection sites, improving therapeutic efficacy against bacterial infections and reducing toxicity.
This issue of CVIA features important papers on COVID-19's impact on cardiology, including a meta-analysis of pacemaker complications and risk factors for pressure injuries during aortic surgery. Research also explores the relationship between cardiac injury and inflammatory biomarkers in severe COVID-19 patients.
The use of nanocarrier drug delivery systems can improve the bioavailability, stability and aqueous solubility of natural drugs. Four plant materials from China, including Epimedium, Rehmannia glutinosa, Panax ginseng and Angelica sinensis, are discussed in this review article.
Sonoporation, a technique combining ultrasound with microbubbles, creates openings in cell membranes, allowing enhanced drug or gene intracellular delivery. Recent advances using contrast agents are expanding applications to gene expression, apoptosis, differentiation, and epigenetic reprogramming.
Researchers highlight the importance of chest CT imaging in diagnosing COVID-19, with specific attention to pulmonary CT findings across various disease stages. The study provides a valuable reference for clinicians and radiologists seeking to accurately diagnose COVID-19 using CT scans.
Patients undergoing aortic surgery are at high risk of developing intraoperative pressure injuries due to increased incidence compared to other cardiac surgeries. Nurses should thoroughly assess risk and implement preventative interventions for high-risk patients.
Researchers discovered predictive values for blood pressure, heart rate, and ratio in a Chinese subpopulation with vasovagal syncope using simplistic tilt test. The study suggests that ratios of blood pressure to heart rate derived from ambulatory blood pressure monitoring may better predict the presence and pattern of vasovagal syncope.
Researchers explore ECMO and CRRT treatment in critically ill SARS-CoV-2 pneumonia patients, achieving a 100% survival rate for those with cardiopulmonary failure. The combined therapy is deemed an important treatment technique for critically ill patients.
A 66-year-old woman experienced a pseudoaneurysm and median nerve injury after radial artery puncture, leading to severe pain and swelling in the affected arm. The authors discuss causes and treatment measures for this complication of radial artery puncture.
Researchers explore relationship between COVID-19 severity and cardiac injury, finding elevated inflammatory biomarkers associated with higher risk of cardiac damage. High levels of IL-2R and comorbidities predict increased likelihood of cardiac injury in severe COVID-19 patients.
The journal features an original article on microfluidic technology and blood flow research, as well as review articles assessing antimicrobial peptides' potential in cancer therapy. It also discusses the interaction between COVID-19 and metabolic syndrome, and the entry mechanism of nanoparticles into tumors.
Cardiovascular Innovations and Applications (CVIA) has published selected abstracts from the 31st Great Wall International Cardiology Conference. The abstracts cover various topics including basic and translational medicine, clinical research on cardiovascular diseases, and cardiovascular-disciplinary research.
The study examines the spatial distribution of planktonic ciliates in the western Pacific Ocean, focusing on a transect from Shenzhen to Pohnpei. Ciliate abundance is positively correlated with phosphate and pico-sized pigmented eukaryotes, while biomass is related to heterotrophic nanoflagellates and chlorophytes.
This special issue of Acta Pharmaceutica Sinica B investigates the impact of tumor microenvironment on drug delivery systems for cancer treatment. Featured papers discuss various strategies to enhance specificity, target tumor-associated macrophages and manipulate immune-vascular crosstalk.
This issue of APSB features studies on the anticancer effects of berberine, baicalein's potent antivirus ability against HSV-1, and a new class of PDE10A inhibitors for treating PAH. Additionally, several articles explore innovative drug delivery systems and novel targets for cancer therapy.
Researchers explore co-culture strategies to activate silent gene clusters in microorganisms, leading to the discovery of novel bioactive natural products with diverse and novel structures. These compounds exhibit various bioactivities, including extensive antimicrobial activities and potential cytotoxic activities.
The parasitic dinoflagellate Hematodinium infects marine crustaceans globally, resulting in mortalities due to organ malfunction. The pathogen has developed into an emerging epidemic threat to China's sustainable crab culture and wild populations.
Researchers have identified ferroptosis resistance as a critical issue in cancer treatment, highlighting the need for novel therapeutic strategies. The study integrates current understanding of signaling mechanisms to develop targeted treatments for therapy-resistant cancers.
The authors review future directions of nanomedicine development focusing on the mechanism of nanoparticle entry into tumors. Designing better nanoparticles to achieve efficient clinical transformation can be informed by a deep understanding of the mechanism of nanoparticle entry or the mode of action.
This issue of CVIA features papers on current management strategies for patients with heart failure and atrial fibrillation, as well as a systematic review on epicardial adipose tissue in obstructive sleep apnea. The journal also presents research on detecting myocardial infarction using late gadolinium enhancement MRI.
COVID-19 patients are at increased risk of pulmonary thromboembolism due to endothelial injury, activated platelets, cytokine storms, and suppressed fibrinolytic systems. Early prophylaxis, antiviral therapy, and supportive treatment can mitigate this complication.
The journal features papers on AI in medicine, including new roles for clinicians and AI-aided disease prediction. It also covers the development of chest imaging analysis methods for COVID-19 diagnosis.
Researchers from Sun Yat-Sen University, Harvard University, and Guangzhou University investigated viscoelastic flow mixing in microfluidics. They found that viscoelastic fluids exhibit transiently unstable flow patterns compared to Newtonian fluids, resulting in increased mixing.
A case study reveals the effectiveness of calcium channel blockers like diltiazem in treating acute myocardial infarction due to variant angina. Nitrates are also found to be efficient therapy, inhibiting smooth muscle proliferation and arterial matrix protein synthesis.
The article reviews antimicrobial peptides (AMPs) with anticancer properties, highlighting their potential use in tumor therapy due to their ability to interact with negatively charged cell membranes. Recent advances and challenges in the application of these peptides are also discussed.
A case of in-stent thrombosis (IST) occurred in an 81-year-old man undergoing coronary bypass grafting, highlighting the complexity of antiplatelet therapy choice and genetic testing in IST risk evaluation. The patient experienced IST after converting from ticagrelor to clopidogrel therapy.
A systematic review and meta-analysis of PubMed, Embase, and the Cochrane Library reveals that patients with masked hypertension (MH) may have a similar risk of target organ damage as those with sustained hypertension (SH). This suggests that clinicians should consider target organ damage when managing MH.
A pediatric patient with anomalous origin of the left coronary artery from the pulmonary artery developed severe heart failure at 3 months old. The authors review a case and discuss the challenges in early diagnosis, highlighting the importance of considering ALCAPA as a differential diagnosis.
A meta-analysis of major complications between traditional pacemakers and leadless pacemakers found that leadless pacemakers have potential for future clinical applications. However, more randomized controlled studies are needed to explore safety and practicality.