Researchers at Duke University Medical Center developed a blood-based test that accurately identifies who will respond to aspirin therapy and predicts patients at risk for heart attacks. The test, known as the 'aspirin response signature,' measures gene activity patterns in the blood.
Researchers at Duke University Medical Center have identified a receptor, TrkB, that may be key to preventing epilepsy. The study found that inhibiting TrkB with a drug can prevent the onset of epilepsy in mice after prolonged seizures.
A recent study published in the International Journal of Obesity highlights the critical role of parenting style and home environment in shaping children's physical activity levels and dietary habits. The researchers found that a healthy home environment and parental role modeling are essential for promoting healthy behaviors in kids, ...
Researchers have found that bazedoxifene can stop the growth of breast cancer cells, including those with resistance to current targeted therapies. The study suggests that bazedoxifene's unique mechanism of action may make it a viable treatment option for patients with advanced breast cancer.
Researchers at Duke University Hospital successfully implanted a bioengineered blood vessel into a kidney dialysis patient, marking the first US clinical trial of this technology. The new vein is an off-the-shelf product engineered using human cells and no biological properties that trigger organ rejection.
The Duke Clinical Research Institute is part of a $62 million NIH-funded initiative to combat antibiotic resistance. Researchers will focus on developing new treatments for MRSA and E. coli, improving diagnostics, and stewardship practices. The goal is to reduce the reliance on antibiotics and improve patient care.
A Singapore research team has identified a protein enzyme, MNK kinase, as a key player in the progression of chronic myeloid leukemia (CML) to its deadly terminal stage. The researchers found that targeting this enzyme could help prevent cancer stem cells from developing drug resistance and improve patient survival.
Researchers found that escitalopram reduced mental stress-induced myocardial ischemia by 2.62 times, improving cardiovascular function and reducing platelet serotonin receptor transporters. The study suggests that SSRIs or similar treatments could play a role in managing coronary heart disease.
A modified poliovirus is infecting and killing glioblastoma brain tumor cells with encouraging results in an ongoing phase 1 study, researchers report. The virus-based therapy, known as PVSRIPO, triggers the immune system to attack infected tumor cells.
A team of Duke researchers has discovered a previously unknown molecular network that regulates cell death and contributes to breast cancer drug resistance. The study found that high levels of the protein MDM2 block cell death signals, leading to drug resistance in breast cancer cells treated with lapatinib.
Researchers analyzed data from the RV144 HIV vaccine trial, which showed a 31% protection rate. They found that specific antibodies may interfere with the protective effects of other antibodies, reducing the vaccine's efficacy. This discovery can inform future vaccine development strategies to overcome these limitations.
Researchers have identified genetic factors behind nearsightedness, a condition characterized by an eye that is too long or the cornea has too much curvature. The SCO2 gene plays a crucial role in regulating copper and oxygen levels in eye tissue.
Researchers at Duke Medicine found a biomarker produced by mast cells can predict severe dengue cases. Asthma drugs targeting mast cells also showed effectiveness in limiting vascular leakage associated with dengue infections.
Cancer research studies tend to be smaller and less robust than for other diseases, raising questions about treatment effectiveness. The analysis found disparities between cancer types, with some receiving more attention than others.
Researchers at Duke University Medical Center found that new astrocytes produced from stem cells after brain injury are effective in promoting recovery. These cells make their way to the injured area to form an organized scar, which stops bleeding and allows tissue recovery.
Researchers at Duke University Medical Center discovered a three-dimensional image of beta-arrestin1, a protein that regulates GPCRs, revealing a striking difference in its active and inactive states. This finding suggests the presence of a general molecular mechanism controlling the activation of beta-arrestin1.
Researchers at Duke University Medical Center found that close family members of people with Alzheimer's disease are more likely to develop silent buildup of brain plaques associated with the disease. The study suggests unidentified genetic factors may influence the development of Alzheimer's before dementia onset.
Current diabetes research prioritizes treatment over prevention, with most trials focusing on drug therapies rather than preventive measures. The studies excluded older people and those under 18, limiting the applicability of findings to these groups.
Tracking an early immune response, researchers chart a new route for developing a long-sought HIV vaccine that boosts the body's ability to neutralize the virus. The study reveals the co-evolution of antibodies and virus in a person whose immune system mounted a broad attack against the pathogen.
Researchers have discovered five new genetic regions associated with an increased risk of ovarian cancer, found in over 40,000 women. These findings may lead to the development of new screening and prevention strategies for high-risk individuals.
Researchers found that untreated depression hinders anti-inflammatory effects of exercise and light-to-moderate alcohol consumption. Participants with depression showed no benefit in lowering C-reactive protein levels, despite normal physical activity levels.
Researchers have discovered that mutations in the TERT promoter gene are involved in some brain tumors and certain types of cancer. The study found nine tumor types highly associated with these mutations, which may provide a new target for drug development.
A potentially lethal fungal infection can anticipate and disarm the host's immune attack by sequestering copper, shutting down copper pumps in macrophages. This study opens new options for drug development to target the fungus's detoxification machinery.
Women with atrial fibrillation experience more symptoms and a lower quality of life compared to men, according to a study analyzing over 10,000 patients. Despite this, women tend to live longer than their male peers, highlighting the need for further research into gender disparities in cardiovascular disease management.
Researchers successfully transmitted tactile and motor information between rat brains, enabling behavioral puzzle-solving. The brain-to-brain interface allowed for two-way communication, with the decoder rat achieving a success rate of about 70 percent.
Researchers found that BPA suppresses a vital nerve cell function gene and raises concerns about the chemical's impact on central nervous system development. The study suggests that BPA could contribute to neurodevelopmental disorders like Rett syndrome, which is characterized by mutations in the MECP2 gene.
A study by Duke University Medical Center found that bullied children are at higher risk for psychiatric disorders, including anxiety and depressive disorders, as adults. The research used a large group of participants initially enrolled as adolescents and followed them into adulthood to assess the long-term effects of bullying.
Researchers at Duke University Medical Center identified a defect in bladder immune memory that hampers a timely attack against bacterial infections. The study found that mast cells produce an immune-suppressing molecule, leading to a lack of antibody response and stifling immune memory.
A new study from Duke University Medical Center suggests that a father's obesity may alter a genetic mechanism in the next generation, potentially raising the risk for diseases like cancer. Researchers found that paternal obesity was associated with lower DNA methylation at the IGF2 gene in offspring.
Researchers at Duke University Medical Center have found that epidermal growth factor speeds the recovery of blood-making stem cells after exposure to radiation. The finding could lead to new treatments for cancer patients and those affected by dirty bombs or nuclear disasters.
A new study finds that women treated with lumpectomy plus radiation have improved survival rates compared to those who underwent mastectomy, regardless of age or tumor type. The research suggests that less invasive surgery may be an effective alternative for treating early stage breast cancer.
Researchers at Duke University Medical Center have identified a new brain circuit controlling whisker movements in newborn mice. The circuit reveals how motor neurons integrate inputs from the LPGi region of the brainstem to enable voluntary whisking behaviors, shedding light on neural control of finger movements in humans.
Researchers have gained additional insights into an HIV vaccine that help explain its successes and failures, providing new options for vaccine designers to strengthen the drug. The study found that the vaccine-induced antibodies recognized virus-infected cells and flagged them for an attack by other immune cells.
Researchers at Duke University developed a genomic signature to diagnose flu and staph infections, distinguishing between infected and uninfected individuals with high accuracy. This approach could lead to earlier diagnoses, reduced antibiotic misuse, and improved treatment decisions.
Researchers at Duke University Medical Center have developed a way to deploy sickle-shaped red blood cells to fight cancer tumors by exploiting their ability to adhere to and block the blood vessels surrounding hypoxic tumors. The treatment causes tumor cell death through oxidative stress, resulting in delayed tumor growth.
A new study found that patients receiving implantable heart defibrillators in everyday practice have similar survival benefits to those who received the same devices in clinical trials. The study used data from a large national Medicare registry and compared over 5,300 real-world patients against more than 1,500 trial participants.
Researchers at Duke Medicine have developed an artificial protein that stimulates the body's natural immune system to fight cancer. In a study published in the Proceedings of the National Academy of Sciences, the therapy was shown to cure brain tumors in six out of eight mice, with no harm to surrounding normal tissue.
Researchers found that aerobic exercise led to greater weight and fat loss compared to resistance training, which only increased lean body mass. The combination of both exercises showed mixed results but provided a significant decrease in waist circumference.
A collaborative research effort has pinpointed the genetic footprint that links fragile X syndrome and autism. The findings identify at least 93 genes controlled by the fragile X mental retardation protein, which are also linked to other neurologic syndromes.
Researchers at Duke University Medical Center found that combining diagnostic tests more accurately predicts Alzheimer's in patients with mild cognitive impairment. The combination of MRI, FDG-PET, and cerebrospinal fluid analysis reduced misdiagnoses by 28.4% compared to individual tests.
Researchers at Duke University discovered that carbon nanotubes can accelerate the growth of neuronal cells and lower nerve-damaging chloride levels. This finding has potential applications in developing new neural engineering devices using carbon nanotubes to treat neural injuries.
Researchers found fewer benefits associated with aldosterone antagonist drugs, including no difference in deaths or hospital readmissions for cardiovascular events. However, patients taking the drugs were at higher risk of hyperkalemia and less likely to be readmitted to the hospital for heart failure.
Researchers identified 70 genetic mutations in Burkitt lymphoma tumors, including a new mutation that accelerates tumor growth. The findings could lead to the development of new treatments or targeted therapies for cancer patients.
Researchers successfully grew and sorted induced pluripotent stem cells for use in cartilage repair and studying osteoarthritis. The breakthrough uses adult stem cells converted into embryonic-like stem cells to produce cartilage tissue.
Scientists at Duke University Medical Center discovered that specific sensory neurons play a crucial role in the perception of touch in fruit fly larvae. These neurons, characterized by thin spikes and dynamic filopodia structures, are sensitive to force and trigger responses when activated.
A recent study by Duke University researchers has identified pleiotrophin as a protein that can promote the growth of blood stem cells. The finding may lead to new treatments for patients undergoing chemotherapy or bone marrow transplants, enabling them to quickly regenerate healthy blood levels.
Researchers at Duke University Medical Center have identified new subtypes of gastric cancer linked to environmental factors. The study's findings suggest that these subtypes may be targeted with specific therapies, improving treatment outcomes for the second leading cancer killer worldwide.
Researchers at Duke University Medical Center have discovered a rare type of B cell that regulates immune responses and limits autoimmunity. By infusing these cells into mice with autoimmune disease, symptoms were significantly reduced. Further research is needed to expand human B10 cells and determine their behavior in humans.
Duke researchers add anti-cancer agent bortezomib to treatment regimen for Pompe disease, improving outcomes for three infants with severe form of the disorder. The addition reverses established immune response and reduces antibodies, leading to dramatic clinical improvements.
A new study published in The Lancet found that apixaban is more effective and safer than warfarin for patients with atrial fibrillation and at least one additional risk factor for stroke. This suggests that current risk scoring systems may be less relevant when using apixaban, potentially simplifying treatment decisions.