Researchers at Moffitt Cancer Center are investigating whether an injectable dye called PV-10 can shrink tumors and reduce the spread of cancer in melanoma patients. The study shows promising results, with a significant reduction in skin cancer lesions and melanoma tumors that had spread to the lungs.
Melanoma patients with a BRAF gene mutation may be at risk of developing secondary cancers due to activated tumor growth pathways. Researchers suggest combining BRAF-inhibitor therapy with other inhibitors to prevent paradoxical activation and emergence of secondary malignancies.
Researchers at Moffitt Cancer Center identified four genetic variants associated with increased risk of death in non-small cell lung cancer patients. These variants also indicate a greater risk of death if treatment plans include surgery without chemotherapy compared to those with chemotherapy following surgery.
A new set of guidelines aims to reduce radical surgery and extend survival time for men with penile cancer, providing better quality of life. The guidelines offer various treatment options, including non-radical surgeries, laser therapy, radiation therapy, and radiochemotherapy.
Researchers at Moffitt Cancer Center discovered a gene expression signature that may lead to new immune therapies for lung cancer patients. High levels of NF-κB in lung cancer tumors can act as a suppressor, boosting the immune system to eliminate cancerous cells.
Researchers found that single men and smokers are more likely to acquire cancer-causing oral human papillomavirus (HPV), while healthy men with newly acquired HPV infections rarely persist beyond one year. The study suggests a potential link between persistent oral HPV16 infection and oropharyngeal cancer.
Researchers created educational materials to empower Spanish patients to make health care decisions, addressing language barriers and cultural ideas that hinder participation. The study aims to improve knowledge and participation for Hispanic patients in clinical trials.
Researchers at H. Lee Moffitt Cancer Center have developed a new method to rapidly identify genetic changes in small protein fragments unique to melanoma cancer cells. The approach harnesses tumor-infiltrating lymphocytes, which have been shown to reduce cancerous lesions and improve outcomes.
A combination of myxoma virus and rapamycin has been shown to infect and kill both brain cancer stem cells and differentiated compartments of glioblastoma multiforme, overcoming drug resistance. This study offers promising possibilities for overcoming barriers to treating the deadliest malignant brain tumor.
Researchers have identified genetic variants that can predict aggressive prostate cancers, enabling better treatment options for patients. The study's findings suggest a novel relationship between angiogenesis genes and prostate cancer aggressiveness.
Researchers found gastrointestinal and liver-related GVHD increases risk of death in patients with chronic GVHD. Elevated bilirubin levels, higher gastrointestinal scores, and lower gastrointestinal involvement are associated with increased mortality rates.
Researchers at Moffitt Cancer Center found that chronic myeloid leukemia patients taking tyrosine kinase inhibitors experience distressing side effects such as depression, fatigue, nausea, and changes in appearance. These issues can significantly impact patients' quality of life for the rest of their treatment period.
Researchers found that active and passive distribution methods may not have reached the intended audience, highlighting the need for culturally relevant tobacco information in Spanish. The study's findings suggest that alternative distribution strategies could improve the reach of relapse prevention materials.
Researchers at H. Lee Moffitt Cancer Center & Research Institute found that using a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and speeds up test drugs through the drug development pipeline. The study used data from recent clinical trials conducted at Moffitt...
Researchers at Moffitt Cancer Center found that a p53 deficiency can slow or delay DNA repair after radiation treatment. The study revealed that p53 regulates the expression of two enzymes, JMJD2b and SUV39H1, which control DNA folding.
A Moffitt Cancer Center study found that minority groups, including blacks, Asians, and Hispanics, hold differing beliefs about cancer prevention and feel they are less likely to get cancer. The researchers concluded that more culturally relevant information is needed to reach these populations.
Researchers found that the drug combination resulted in a 70% decrease in tumor volume compared to single-drug treatment. The study suggests that MK-1775 and gemcitabine may represent a novel approach in treating sarcomas, offering new hope for rare cancer patients.
Researchers at Moffitt Cancer Center found that microRNA-155 overexpression promotes new blood vessel growth, tumor inflammation, and metastasis in breast cancer. Controlling miR-155 expression could inhibit malignant growth, providing a new avenue of treatment.
Researchers at Moffitt Cancer Center found that HPV vaccination rates are lower among low-income girls due to factors such as physician strategies and type of practice. Pediatricians and private practice physicians have higher vaccination rates, while those in multi-specialty settings are less likely to vaccinate.
Moffitt researchers have discovered four new regions of the genome linked to ovarian cancer risk, accounting for approximately 4% of inherited component. The findings are part of a coordinated series of studies involving over 250,000 individuals and provide new insights into the disease.
Researchers at Moffitt Cancer Center have developed a small molecule, S31-1757, that inhibits the ability of STAT3 to cause malignancy. This development could impact the treatment of several tumor types, including breast, lung, prostate and others that depend on STAT3 for survival.
The study found that many young black women with BRCA mutations do not receive genetic counseling or testing, despite meeting national guidelines. This may represent a missed clinical opportunity to reduce breast cancer incidence and mortality.
Dasatinib shows promise as a treatment for higher-risk myelodysplastic syndromes (MDS), but its efficacy is limited. Patients with trisomy 8 chromosomal disorder may respond better to the therapy, warranting further investigation.
Researchers at Moffitt Cancer Center found that healthy adolescent females have predetermined expectations for becoming parents but worry about fertility and childbearing due to a life-threatening illness like cancer. The study validated a tool to assess teenage girls' hopes and feelings about reproduction.
Researchers found that patients with metastatic gastric cancer who underwent both surgery and radiation had better survival rates than those receiving one or no treatment. Radiation therapy also showed promise in reducing symptoms such as pain, obstruction, and bleeding from gastric tumors.
Moffitt researchers found that silencing the retinoblastoma gene can regulate the differentiation of myeloid-derived suppressor cells into a more aggressive form. This discovery may lead to new therapeutic strategies targeting these cells in cancer treatment.
Researchers at Moffitt Cancer Center have identified IKBKE kinase as a potential targeted therapy for patients with tobacco-associated non-small cell lung cancer. The study suggests that IKBKE overexpression is induced by tobacco smoke and can be targeted to reduce cancer progression.
Researchers at Moffitt Cancer Center have developed an automated method to estimate mammographic breast density, a major risk factor for breast cancer. The new approach assesses the variation in grayscale values in mammograms, providing a viable, automated mammographic density measure that can be used in clinical settings.
Researchers found that an acidic microenvironment can drive cancer cells to spread and propose neutralizing pH as a therapeutic opportunity. Tumors adapt by creating acidic environments through increased glucose metabolism, hampering oxygen delivery and acid elimination.
Researchers found pomalidomide provided a minimal or better response for 42% of patients with disease relapsed after treatments. The study demonstrated 'encouraging activity with manageable toxicity', paving the way for phase II studies and potential FDA approval.
Researchers found that lung and head and neck cancer patients who quit smoking before surgery had significantly lower relapse rates compared to those who smoked during the week prior to surgery. The study also identified factors such as high fears regarding cancer recurrence, depression, and low belief in quitting abilities as predicto...
A Moffitt study found Hispanics are nearly twice as likely to avoid cancer screenings due to fears and mistrust of medical professionals. The researchers suggest improving communication and building trust with patients is crucial for increasing screening rates, particularly among Hispanic and lower-income minorities.
Researchers at Moffitt Cancer Center have found that blocking myeloid-derived suppressor cells and regulatory T-cell reconstitution improves adoptive T-cell therapy for melanoma. This blockade is achieved after total body irradiation eliminates these cells, leading to delayed tumor growth and enhanced survival in mice.
Moffitt Cancer Center researchers have identified novel metabolic signatures in glioma, a type of tumor that starts in the brain. These findings may pave the way for personalized therapy and prognostic value.
Researchers at Moffitt Cancer Center have found that men with prostate cancer who receive androgen deprivation therapy are susceptible to heightened fatigue if they carry specific variants of the IL6 and TNFA genes. This discovery highlights the importance of personalized medicine in tailoring therapies to a patient's genetic profile.
Researchers discovered a unique immune gene signature linked to microscopic lymph node-like structures in metastatic melanoma, which may predict better survival and enable personalized immunotherapy.
Researchers at Moffitt Cancer Center investigated a novel combination of danusertib and bosutinib to overcome resistance in BCR-ABL gatekeeper mutation-specific disease. They found the synergy was not due to direct inhibition, but rather through the downstream MAPK signaling cascade and impaired activity of c-MYC gene regulator.
Researchers at Moffitt Cancer Center studied the relationship between sunlight exposure patterns and timing to understand its contribution to basal cell carcinoma and squamous cell carcinoma. Blistering sunburns and working outdoors were found to be associated with both types of skin cancer.
A two-year clinical trial found no survival difference between patients receiving peripheral blood stem cells and bone marrow stem cells from unrelated donors. However, peripheral blood stem cell transplants were associated with a higher incidence of chronic graft-versus-host disease (GVHD).
Researchers at Moffitt Cancer Center have developed a promising treatment approach for metastatic melanoma using chemotherapy and adoptive cell transfer (ACT) with tumor-infiltrating lymphocytes (TIL). The therapy achieved an impressive response rate of 38% in patients. A second-generation ACT TIL trial is currently enrolling patients.
Researchers at Moffitt Cancer Center have discovered new components of the DNA damage response network, including proteins that could be targeted as sensitizers for chemotherapy. The study's findings may lead to the development of new therapeutic strategies and accelerated treatment for cancer.
Combining chemotherapy and immunotherapy results in enhanced anti-tumor effect, contrary to previous assumption that they would cancel each other out. The mechanism involves the upregulation of mannose-6-phosphate receptor on tumor cells, which is triggered by autophagy.
Prostate cancer cases expected to reach nearly 242,000 diagnoses in 2012. New guidelines introduce active surveillance as a viable alternative to immediate treatment for low-risk tumors.
The incidence of invasive cervical cancer has declined dramatically over the past several decades, thanks to increased use of Pap smears and prevention programs. However, disparities persist, particularly among underserved racial and ethnic minorities, rural areas, and low-income women.
Researchers at Moffitt Cancer Center have discovered that microRNA miR-214 plays a critical role in regulating ovarian cancer stem cell properties. The study found that miR-214 induces the expression of a stem cell transcription factor (Nanog), leading to chemoresistance and potentially serving as a therapeutic target for ovarian cancer.
A study by Moffitt Cancer Center researchers found that a series of ten self-help booklets helped nearly 70% of pregnant women remain smoke-free after giving birth. The booklets provided detailed information on quitting cigarettes during and after pregnancy, with varying effects based on household income and age.
Researchers will examine cancer cell drug resistance and focus on prevention strategies using breast cancer as a proof-of-concept model. The goal is to minimize the probability of drug-resistant cancer cells emerging, which are a major cause of current cancer treatment failure.
Researchers at Moffitt Cancer Center have discovered a novel predictor for myelodysplastic syndromes (MDS) progression risk by analyzing changes in the physical characteristics of effector memory regulatory T cells. This finding could improve prognostication and inform therapeutic decision-making.
Researchers at Moffitt Cancer Center found that racial disparities impact the likelihood of finding suitable stem cell donors for non-Caucasian patients. The study revealed greater difficulty in matching donors for African-Americans, Hispanics, and Native Americans, with limited access to unrelated donor HCT.
Researchers found evidence that melanoma manifests differently in children than in adults, particularly with regard to the likelihood and significance of lymph node metastases. Despite higher rates of metastases to sentinel nodes, survival rates for children are comparable or better than those for adults.