A Michigan Medicine study found that pulmonary embolism death rates remained unchanged over the past decade, with higher mortality rates among men, Black patients, and those from rural areas. The study analyzed over 100,000 deaths related to pulmonary embolism between 2006 and 2019.
Late preterm infants face academic delays, but sensitive parenting and preschool enrollment can mitigate this risk. Early relational health and developmental support prior to school entry are key strategies.
The Michigan Medicaid expansion has been effective in reducing uninsurance, promoting primary care, and supporting financial well-being for low-income individuals. However, some aspects of the program, such as income-based cost-sharing, were only partially effective in achieving their aims.
A new AI tool predicts certain forms of esophageal and stomach cancer at least three years prior to diagnosis. The K-ECAN tool uses basic EHR data to identify high-risk patients, who may benefit from earlier screening and preventative measures.
Researchers discovered that bacteria employ 'surfing' proteins called ParA/MinD ATPases to transport cargo across the cell. These systems interact with each other, enabling complex movements before cell division. The findings provide a basis for developing synthetic biology tools and understanding bacterial pathogens.
A new University of Michigan poll suggests that nearly half of older adults do not know about the new RSV vaccines, while some groups show much less interest in getting the vaccine. The virus poses a significant risk to older adults with lung or immune system conditions, and those who live in nursing homes.
A new study found that fewer than a third of children have had their vision checked in the past year, with uninsured and public-insured kids having lower rates than privately insured peers. The disparity in screening rates is linked to disparities in primary care visits focused on prevention and early detection.
Researchers have found that a prostate cancer drug called proxalutamide can block SARS-CoV-2 viral entry and reduce inflammation. The compound works by binding to androgen receptors, inhibiting levels of TMPRSS2 and ACE2, and blocking infection.
Medical students reporting disabilities increased by over 25% during COVID-19 pandemic, but requests for accommodations decreased. Remote curriculum delivery may have created an optimal learning environment, reducing the need for accommodations.
A new study estimates that cancer screenings have saved the US at least $6.5 trillion and led to 12 million more years of life, with significant economic impact from breast, colon, cervical, and lung cancer screenings.
Researchers at Michigan Medicine have discovered a potential treatment for diffuse midline glioma, a type of childhood brain tumor with no effective treatments. The compound ONC201 nearly doubled survival rates in patients with the disease, and the underlying mechanism behind its success has been explained.
Chronic pain patients who take opioids need access to gold-standard multi-modal pain care, including physical therapy, cognitive behavioral therapy, and integrative medicine techniques. The experts recommend restructuring insurance models, enhancing provider education, and addressing racial inequities in care.
Researchers have found a promising new mechanism to target aggressive forms of prostate cancer, where the LSD1 protein is involved. By inhibiting LSD1, the tumor suppressor gene p53 can be reactivated, leading to suppression of tumor growth.
Researchers studied over 800 clinical assays on renal tumors with MiTF family genes TFE3 and TFEB. The findings show significant age differences between patients with TFEB amplification and those with TFE3 or TFEB translocation, with TFEB amplification being associated with poorer prognosis.
A new study shows that a rule-based natural language processing tool successfully identified patients with unstable access to transportation, food insecurity, social isolation, financial problems, and signs of abuse or exploitation. The tool performed better than deep learning algorithms in identifying these social determinants of health.
A study found that longer duration of type 2 diabetes is associated with decreased brain structure and increased white matter hyperintensities. Despite this, cognition was not affected, highlighting the need for early screening for cognitive disorders in diabetic patients.
Researchers have made a significant discovery in gene therapy, showing that genetically engineered blood stem cells can be created while still in the bone marrow. This approach eliminates the need for chemotherapy and transplantation of corrected cells, cutting costs and improving access to critical treatments.
A new adjuvanted intranasal vaccine has shown promise in protecting both young and old mice against SARS-CoV-2 infection. The vaccine combines an RNA-based molecule with a nanoemulsion, resulting in a strong immune response.
A new study published in JAMA Ophthalmology found that vision problems are more common in older adults with dementia. The study of nearly 3,000 older adults showed that even mild vision issues were associated with a higher risk of dementia.
A study by Michigan Medicine researchers reveals that modifications to amino acids in sperm may be linked to infertility. The team analyzed the molecular sequence composition of protamines, finding non-arginine amino acids with unexpected post-translational modifications that affect sperm shape and function.
A study found that taking more daily steps improves symptoms and physical limitations for people with heart failure, with little association seen beyond 5,000 steps. Participants who increased their step counts experienced improved symptom control and physical function.
A new study reveals that rapid state law changes mean many families will need to drive longer distances to access gender-affirming care for their transgender children. The restrictions have led to 25% of Americans aged 10-17 living more than a day's drive away from a clinic offering such care.
A new study finds that people with dementia account for nearly 7% of all emergency visits over age 65, with twice the rate of seeking care after accidents or behavioral crises. Better supporting dementia caregivers could prevent future emergency visits and reduce risks associated with antipsychotic medications.
Telehealth use in Michigan has increased significantly, especially for mental health needs and rural residents. The study found that 11-17% of appointments take place virtually, up from less than 1% before the pandemic.
A Michigan Medicine study in Texas found that 61.4% of older adults with cognitive impairment are still driving, but one-third of caregivers have concerns about their care recipient's ability to drive safely. Researchers emphasize the need for open discussions between caregivers and healthcare professionals to ensure safety.
A study analyzing kidney functions and predictors of disease has identified 28 altered cellular states in injured kidneys. The researchers mapped kidney cell interactions with active immune responses, establishing a data source for therapeutic development.
A new poll of people aged 65-80 found that 80% believe cognitive tests can give early warning signs of memory decline and 60% think healthcare providers should offer them annually. Despite this, only 1 in 5 have had a cognitive screening test in the past year.
A Michigan Medicine study finds that patients who participate in cardiac rehabilitation have a decreased risk of death years after surgery. The greatest reduction in mortality was found in patients who completed 36 or more sessions, highlighting the need for targeted efforts to improve participation and adherence.
Scientists have created human brain organoids free of animal cells, which could greatly improve the study and treatment of neurodegenerative conditions. The novel method uses an engineered extracellular matrix to support stem cell growth, resulting in more accurate models of brain development.
A new analysis found that combining weight-based dosing and shared single-use vials in VA hospitals could reduce cancer spending by 14%. This concept could be applied nationwide to improve cost-effectiveness of cancer care.
A new study found that people with low incomes in states that expanded Medicaid received more preventive care and overall health care compared to those in non-expansion states. The likelihood of high-value care, such as medications for heart problems or osteoporosis, increased in expansion states.
A new study reveals that nearly 40% of teen girls and young women have low iron levels, with higher rates among Black, Latina, low-income, or low-BMI individuals. The study recommends considering routine screening for iron levels in adolescents and young women to prevent life-limiting symptoms associated with iron-deficiency anemia.
A study published in The Annals of Thoracic Surgery found that lower oxygen delivery thresholds are associated with reduced risk of kidney injury. Researchers recommend reevaluating current guidelines for oxygen delivery during cardiopulmonary bypass to minimize unnecessary blood transfusions and improve patient outcomes.
Research suggests that glioblastoma cells possess large-scale coordination, allowing them to respond unison to therapies. Disrupting this organization may result in more powerful treatments for brain tumors.
The Rogel Cancer Center has received a $37 million National Cancer Institute grant to support its comprehensive cancer research and treatment programs. The center, one of the top-ranked in Michigan, will continue to improve outcomes for cancer patients and survivors with innovative research and treatments.
Researchers developed a polygenic scoring system to predict ALS disease risk, improving case status prediction in Michigan and Spain. The system takes into account common genetic variants and explains 4.1% of ALS cases caused by genetic factors.
Researchers found that 'concerning' CT imaging results were associated with lower clinical outcomes and shorter hospital stays in low-risk patients with acute pulmonary embolism. This suggests that emergency physicians may be managing these patients differently, leading to unnecessary hospitalizations.
A study of hospital transfers during COVID-19 found that decision-makers, environmental factors, and patient characteristics played a significant role in transfer decisions. The researchers identified three categories of factors affecting these decisions, which often resulted in moral distress for healthcare workers.
Researchers found that only 6.8% of cancer patients underwent genetic testing within two years of diagnosis, with lower rates among Black, Hispanic, and Asian patients. The low rates are attributed to lack of integration of test results into cancer management and prevention.
A recent study from Michigan Medicine suggests relief may be possible for individuals with tinnitus, a condition characterized by ringing or hissing sounds. The innovative bi-sensory treatment device improved quality of life and reduced tinnitus loudness in nearly 70% of participants.
A new poll shows that three-quarters of people aged 50-80 have used at least one patient portal, with lower rates among those with lower incomes or physical/mental health concerns. Portal users prefer online access over phone calls for some tasks, but some still face barriers to using the platforms.
A Michigan Medicine-led study reveals that life stressors across the lifespan, including childhood trauma and adult abuse, contribute significantly to worsening health and functional outcomes for people with multiple sclerosis. The findings highlight the importance of analyzing the impact of life stressors on MS patients.
A study published in JAMA Network Open found that higher cumulative blood sugar levels after a stroke contribute to faster cognitive decline. Researchers adjusted data for various factors and discovered no association between high blood pressure or cholesterol and accelerated cognitive loss.
Researchers at Michigan Medicine have discovered a new nutrient source that pancreatic cancer cells use to grow in the absence of glucose. Uridine is found in the tumor microenvironment and its exact source remains unknown. Blocking uridine metabolism may lead to new treatment options for pancreatic cancer.
Researchers developed a new metric to analyze the relationship between nerve density and oral cancer progression. Normalized nerve density was found to be associated with poor survival rates for patients with tongue cancer, highlighting its potential as a tool for identifying aggressive tumors.
A study published in Cell Reports found that saturated fatty acids promote the immune escape of oral cancers in mouse models. Obesity helps establish a type of tumor microenvironment that promotes tumor progression by suppressing STING-type-I interferon pathway and NLRC3.
A new study from University of Michigan suggests that the perception of not enough food can be sufficient to slow aging in flies. The researchers induced hunger in flies through various methods, including altering amino acid levels and using optogenetics, and found that these flies lived significantly longer than controls.
A new study found that young adults with advanced heart disease desire to be actively involved in their medical care decisions, despite their parents' preference for a shared decision-making approach. The research highlights the importance of understanding individual preferences and personalizing communication methods with each patient.
A new Michigan statewide study found that inducing labor at 39 weeks of pregnancy does not necessarily reduce the risk of cesarean births. In fact, for some birthing individuals, it may even have the opposite effect if hospitals don't take a thoughtful approach to induction policies.
A new study published in PNAS reports surge of gamma activation in dying brains of humans and animals post-cardiac arrest, hinting at conscious-like activity.