A massive study identifies new biomarkers for renal cell carcinoma subtypes, improving diagnosis and treatment. The researchers' integrative analysis of proteogenomic datasets reveals molecular features shared by clear cell and non-clear cell RCC tumors, as well as unique features to various subtypes.
Researchers identify critical genes and transport systems in E. coli that enable rapid growth despite sterile urine environment. ABC transporters appear crucial for infection, with inhibitors potentially slowing bacterial growth and complementing antibiotic efforts.
A new poll suggests health-related costs are a major concern for older Americans of all backgrounds, with five out of six very concerning issues involving health costs. Nearly half say they're very concerned about the cost of prescription medications, while nearly half also express concerns about dental care.
A new study found that the elimination of a federal waiver requirement increased the number of clinicians prescribing buprenorphine, but didn't lead to a sharp rise in patient treatment. By December 2023, over 53,600 clinicians had prescribed buprenorphine, but numbers remained stable compared to 2022.
A new study finds that antibiotic prescriptions have rebounded to pre-pandemic levels, with 1 in 4 prescriptions going to patients who don't need them. This trend threatens to fuel antimicrobial resistance, which kills 48,000 Americans annually.
Researchers have developed a new urine-based test that identifies high-grade prostate cancer by analyzing 18 genes linked to the disease. The test, called MyProstateScore2.0, was shown to be nearly 100% correct at ruling out aggressive cancers and helped avoid up to 41% of unnecessary biopsies.
Researchers have developed a urine-based test that detects pieces of DNA fragments released by head and neck tumors, providing a non-invasive alternative to traditional blood-based biomarker tests. The test has been shown to detect cancer recurrences far earlier than would typically happen based on clinical imaging.
Researchers at Michigan Medicine discovered a pathway that reverses idiopathic pulmonary fibrosis (IPF), a common type of lung scarring. The study found that inhibiting the molecular brake MKP1 is essential for spontaneous resolution of fibrosis, offering new hope for patients with IPF.
A new study shows that a massive effort to reduce the overuse of proton pump inhibitors (PPIs) led to a nearly 30% reduction in prescriptions, but also resulted in some veterans missing out on protective use. The intervention, which imposed limits on PPI prescription size and refills, was carried out in one region of the Veterans Healt...
Researchers found a significant association between storing chemicals in attached garages and increased ALS risk. The study suggests that volatile chemicals released into the living space may contribute to this link.
A new national poll finds that 60% of people aged 50-80 have visited urgent care clinics or retail clinics for medical care in the past two years. Many sought immediate attention, vaccinations, or tests, and 75% plan to use these sites again in the next two years.
A study by Michigan Medicine found that about 1% of older adults using traditional Medicare have used asynchronous patient portal messaging to prompt a bill from their doctor or other healthcare provider. Most e-visits were with primary care providers, mainly for managing high blood pressure and diabetes.
Physicians can use a Barbie doll to help pediatric patients demonstrate musculoskeletal exam movements during virtual appointments. The study found that using the doll reduced verbal corrections and improved patient understanding.
A study led by Michigan Medicine found that around 10% of deaths following percutaneous coronary intervention are potentially preventable. Complications during procedures contributed to 20% of the nearly 1,200 deaths reported during the study period.
A new study suggests that most essential care for cardiovascular health happens in general primary care clinics, but many at high risk don't receive it. The study found that large percentages of people with major cardiovascular risk factors didn't see a primary care provider or cardiologist in the past year.
A trio of studies show increased diagnosis and treatment of anxiety, depression, and PTSD in pregnant and new mothers with private insurance, but disparities persist. The findings suggest that policy changes and increased awareness have contributed to the rise in diagnoses and treatments.
Leading investigators are creating a one-stop resource for human pancreatic data, standardizing and disseminating curated information on the human pancreas to foster collaborative and reproducible diabetes research. The PanKbase program aims to provide machine-actionable data following FAIR principles.
New studies find over half of new doctors experience some form of sexual harassment in their first year, with women and men experiencing varying rates of recognition and types of harassment. The #MeToo movement has led to increased recognition of what constitutes harassment, but more work is needed for medical schools and hospitals.
Researchers found a link between low fiber diets, mucin-degrading bacteria, and increased inflammation in mice with IBD genetics. A high-fiber diet prevented inflammation and even reversed symptoms in some cases.
A study of older adults in Medicare Advantage plans found that both members of a couple tend to stick with each other's enrollment decisions. The researchers analyzed data from over 1,800 couples and found that about 80% of Partner A individuals stayed in the same plan, and among those who changed, most partners did as well.
Patients from socially vulnerable areas show increased treatment adherence when treated at 340B-participating hospitals compared to non-participating hospitals. The study found no difference in use between 340B and non-340B hospitals but noted improved adherence among patients from disadvantaged areas.
A new study suggests that removing barriers to cervical cancer screening, surveillance, and diagnostic procedures can save lives and reduce disparities. If every eligible person gets the full screening and follow-up tests recommended, up to 23% fewer people would be diagnosed with cervical cancer and 20% fewer would die from it.
A study by Michigan Medicine found that recreational activities such as golfing, gardening, and woodworking may increase the risk of developing amyotrophic lateral sclerosis (ALS) in men. The study surveyed over 700 individuals with and without ALS to assess their hobbies and non-work related activities.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
A new study shows that hospitals struggle to consistently collect accurate racial and ethnicity data from patients who visit their emergency department multiple times. The findings suggest that nearly a quarter of adult patients and up to 32% of children receive different race or ethnicity designations on subsequent visits, indicating ...
Patients living in areas with severe primary care shortages have a higher risk of emergency surgery, complications after surgery, and readmission. The study highlights the need for efforts to increase training and geographic distribution of primary care providers.
A new study found that Medicaid coverage extensions during the pandemic significantly increased postpartum coverage and reduced uninsurance rates. The study highlights the critical role of Medicaid in maternal health, particularly in the late postpartum period where many maternal deaths occur.
A new poll suggests that more than half of people aged 50-80 taking aspirin don't have cardiovascular disease, raising concerns about the effectiveness of routine aspirin use. Guidelines now focus on those with a history of cardiovascular issues or high risk due to personal health and family history.
A new model of glioblastoma's key feature, oncostreams, could help scientists understand how to develop new treatments for this aggressive brain cancer. The model, developed by a team at the University of Michigan, identifies a potential inhibitor that appears to dismantle oncostreams, leading to better survival in mouse models.
A study reveals that feeling young appears to reduce ageism among older adults, but those who invest in appearance are more likely to experience negative outcomes. Those who feel younger score higher on positive age-related experiences and lower on negative ageism, while those who look older face increased negative ageism and poor health.
A new study found that antidepressant dispensing to adolescents and young adults increased sharply after March 2020, particularly among females, indicating a worsening mental health crisis. The rate rose nearly 64% faster, with females experiencing a 130% increase in dispensing rates.
Researchers found that pulse oximeters underestimate blood pumping and overestimate resistance, affecting treatment decisions. Direct blood oxygen measurement is crucial for accurate guidance, especially for Black patients already at higher risk.
A new study in tens of thousands of people with obesity shows the impact of different weight management treatments on achieving a 5% weight loss. Effective treatment options include nutrition counseling, medically supervised meal replacements, anti-obesity medications, and bariatric surgery.
Research discovers key contributors to skin tightening in systemic sclerosis, including myofibroblasts and endothelial cells. Targeting the Hippo signaling pathway shows promise for reversing fibrosis.
A study by Michigan Medicine University found large disparities in HIV care for Black patients, those with autism, and individuals with co-occurring intellectual disabilities. These groups were less likely to receive antiretroviral therapy, highlighting the need for better support and education.
A new study found that women with migraines and long-term hot flashes or night sweats are at increased risk of heart disease and stroke. However, the research suggests that focusing on prevention and correcting unhealthy habits can help most women mitigate this risk. Women who have experienced both migraines and vasomotor symptoms for ...
Researchers found that injecting cross-linked hyaluronic acid dermal filler into photoaged skin stimulates collagen production within weeks, leading to short-term and long-term clinical improvements. The filler promotes the accumulation of new collagen over time, reducing wrinkles and improving skin elasticity.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
Thrombocytopenia is the third most prevalent symptom of antiphospholipid syndrome, but its cause remains poorly understood. Researchers have unveiled a new mechanism driving thrombocytopenia and identified calprotectin as a potential biomarker for APS-related thrombocytopenia.
A new poll of people aged 50 to 80 found that nearly all older adults say music helps relieve stress and improve their mental health. The study also revealed that music plays a significant role in social connections and brain health, with 98% of respondents benefiting from engaging with music.
A new study found that one bacterial species, Streptococcus mitis, dominates in IPF patients not treated with antibiotics and is associated with better lung function and survival. This protective relationship does not apply to patients who received antibiotics.
A study of 215 veterans found that nearly half experienced significant depression score drops, while about one quarter saw a halving of their scores. About 15% achieved full remission after six weeks of ketamine infusions, suggesting the treatment can provide substantial relief for those with complex mental health needs.
A new study found that nearly half of older adults who considered elective surgery were deterred by financial concerns and the need for paid time off. In contrast, those worried about post-operative pain were more likely to proceed with surgery.
A new study found a significant decline in emergency department visits related to emergency contraception, dropping by 96% between 2006 and 2020. The decrease was attributed to the FDA's approval of over-the-counter emergency contraception, which also reduced medical costs by $7.6 million.
A recent study published in Lancet Microbe suggests that immunocompromised patients are at higher risk for COVID infections, but prolonged infections lasting weeks to months are uncommon. The study found that specific conditions, such as B-cell cancers and autoimmune diseases, increase the risk of prolonged infections.
A Michigan Medicine-led study found that patients with functional seizures have a death rate almost 2.5 times higher than expected, comparable to epilepsy and serious mental health conditions. The study highlights the need for improved access to holistic, multidisciplinary treatment for functional neurological disorders.
Researchers have developed CRISPR off-switches to mitigate off-target effects, a major concern in genome editing. The new technology, based on anti-CRISPR proteins, can block CRISPR-Cas3 machine function and prevent unintended edits.
Researchers developed an AI-driven algorithm that accurately predicts death and complications after percutaneous coronary intervention (PCI). The tool uses patient feedback to provide a patient-centered, individualized risk prediction score.
A new poll found that only 7.5% of people between 50-80 have used at least one direct-to-consumer health care service, with most receiving prescriptions for a one-time treatment. Many users didn't inform their regular providers about the prescriptions.
A new study suggests that using artificial intelligence to scan surgery patients' medical records can identify those with risky drinking habits who may benefit from education or treatment. The AI system analyzed over 53,000 patient records and found three times more patients with high-risk alcohol use than diagnosis codes alone.