Researchers found that targeting neutrophils' metabolic process, glycolysis, reduces NET formation and subsequent blood clots in APS patients. The strategy doesn't increase bleeding risks.
A study from Michigan Medicine found that both meditation and stretching can significantly reduce cramp severity and improve quality of life for patients with cirrhosis. The researchers were surprised to find that meditation also had a positive effect on cramp severity, despite not expecting it.
After two major health policy shifts, pregnant and postpartum women with depression and anxiety received slightly more psychotherapy and paid less out-of-pocket costs. Despite the positive trends, only about 10% of women with private insurance received psychotherapy in 2019 to 2020.
A recent study found that cerebral palsy adults have a very high occurrence of pain, with 86.3% experiencing nociceptive pain and 45.8% experiencing nociplastic pain. Accurate identification of pain type and source is critical for proper treatment.
A University of Michigan-led study found that higher levels of metals in blood and urine are associated with a greater risk for ALS and shorter survival. Occupational exposure to metals was also linked to increased metal levels, emphasizing the need for accounting for environmental factors when evaluating overall exposure risk.
A study from Michigan Medicine researchers found that over 15 million adult Americans regularly consume herbal and dietary supplements containing potentially toxic liver ingredients. The largest proportion of users took turmeric or green tea supplements, while others used garcinia cambogia for weight loss.
A new poll finds that over 30% of people in their 50s and early 60s provide care to at least one person with a health issue or disability, while 1 in 10 juggle taking care of three or more people. The majority of caregivers are caring for someone with a physical disability or mobility problem, followed by memory or thinking issues.
Researchers identified key themes in patient interviews, highlighting emotional impact, diagnosis, and treatment as top concerns. Patients experienced frustration and stigma due to symptom dismissal and inadequate diagnosis, emphasizing the need for better tools to measure outcomes that matter to them.
A study by Michigan Medicine found that over- or under-dosing anticoagulants can result in serious health conditions, most often occurring after the initial prescription. The researchers evaluated five years of prescribing data and found that nearly 70% of alerts to off-label dosing occurred during a follow-up visit.
A new study from Michigan Medicine suggests that inhibiting the SWI/SNF epigenetic complex can therapeutically target oncogenic transcription factors. The research, led by Arul Chinnaiyan, builds on previous work to find genetic vulnerabilities in transcription factor-driven cancers.
A new study finds that combining an inhibitor of a metabolic pathway with chemotherapy could improve treatment outcomes in triple negative breast cancer brain metastases. Inhibiting fatty acid synthase, an enzyme critical for cancer cell survival, shows promise in improving chemotherapy efficacy.
Researchers designed a molecule, MTX-531, that impairs signaling drivers of cancer therapy resistance. In mouse models, MTX-531 led to tumor regressions in multiple head and neck cancers, showing a favorable toxicity profile.
A new study suggests that healthcare providers sitting at a patient's eye level can improve trust, satisfaction, and clinical outcomes. By analyzing the results of existing studies, researchers found that patients appreciate clinicians who are not standing over them.
A new University of Michigan study found that over 82% of Americans aged 50-80 take one or more prescription medications, with 80% open to stopping certain drugs. However, researchers stress the importance of personalized guidance for deprescribing older adults, particularly those taking medication for cardiovascular disease or diabetes.
Researchers found that personalized text messages effectively increased physical activity among patients after significant heart events, with Apple Watch users showing a 10% increase in step count. However, the benefits later tapered off as patients became accustomed to the messages.
A study published in JAMA Network Open found that years of high systolic blood pressure increase the risk of stroke, with Black and Hispanic patients facing a higher risk. Early diagnosis and controlled high blood pressure are crucial to preventing stroke, especially in these populations.
A new study suggests that even temporary increases in drinking can have lasting effects on bipolar symptoms, but the opposite isn't true. The research found that individuals with bipolar disorder who drink more than typical for them are more likely to experience an increase in depressive and/or manic symptoms over six months.
A new study published in JAMA Network Open found that mental health apps can significantly reduce symptoms of depression, anxiety, and suicidality in individuals waiting for their initial psychiatric appointment. The study, which involved over 2,000 patients, showed improvement in all groups, regardless of the app used.
New studies suggest a simplified, less restrictive low FODMAP diet may be effective for managing irritable bowel syndrome (IBS). The alternative 'FODMAP-simple' diet restricts only fructans and galacto-oligosaccharides without restricting other FODMAP groups. This approach may reduce symptoms and improve patient adherence to the diet.
A new study from the University of Michigan Health Rogel Cancer Center found that nearly three-quarters of patients who were eligible for genetic testing at diagnosis received it over the study period. Those who got testing and found they had a genetic variant were most likely to talk with their family about the results.
A study reveals that the gene SH2B1 controls feeding and energy expenditure, with mutations associated with obesity and metabolic diseases. Enhancing SH2B activity may offer a promising treatment for obesity and related conditions with fewer side effects.
A recent poll of older adults reveals that those in their 50s and early 60s who face financial stress are more likely to experience negative health effects. The study found that 47% of people aged 50-64 reported being impacted by inflation, with many cutting back on everyday expenses.
A study by Michigan Medicine found that older women over 65 who require complex heart surgery are more likely to be treated at low-quality hospitals, where they also die in greater numbers. The sex disparity in mortality doubled from high-quality to low-quality hospitals.
Researchers will combine patients' self-reports with mobile app, wearable device, genetic sample, and clinical record data to predict which approaches will work best for an individual. The goal is to improve the success of first-time mental health treatment.
A new report by the National Academies of Science, Engineering and Medicine offers key findings on reducing health inequities and improving healthcare outcomes for marginalized communities. The report highlights complex interactions driving inequality and recommends community-based approaches to address these disparities.
Researchers have identified a shared molecular mechanism between pregnancy and cancer that suppresses the immune system. Progesterone was found to play a key role in this process, with blocking its signaling slowing down cancer growth in mice and activating the immune response.
Research highlights occupational nerve injuries as a predictable mechanism, often caused by compression, stretch, vibration, and repetitive muscle movements. The study aims to equip clinicians with understanding of biomechanical factors that interact with anatomy to damage nerves.
Researchers successfully increase inner ear synapses in young mice to produce supranormal hearing, supporting a hypothesis on the cause of hidden hearing loss in humans. The study suggests that preserving or increasing synapses may improve auditory processing and offer new treatment options for certain hearing disorders.
Research from Michigan Medicine found that female patients with atrial fibrillation and tricuspid regurgitation are less likely to receive simultaneous procedures during cardiac surgery, despite guideline recommendations. This disparity may be related to perceived higher risk among women.
A new biomarker has been discovered that can help predict which patients with clear cell renal cancer are at higher risk of recurrence. The 15-gene signature was found to be independently associated with worse disease-free survival and disease-specific survival in two large validation datasets.
A new study by Michigan Medicine University found that nearly all patients with buprenorphine prescriptions filled them, even when paying more out-of-pocket. The researchers suggest removing barriers to continuous prescribing as the main focus of efforts.
A Michigan Medicine study reveals that circadian rhythms play a crucial role in mobilizing innate lymphoid cells, which defend barrier tissues. The study found that clock genes regulate the activation of these cells at different times of day.
A study published in JAMA found that high out-of-pocket costs are a significant barrier to filling naloxone prescriptions. The study, which utilized data from a national pharmacy transactions database, estimated that a $10 increase in cost would decrease the rate of filling prescriptions by about 2-3 percentage points.
A new study reveals that 96% of VA hospitals and 74% of non-federal hospitals mandate influenza vaccination or waivers for staff. This surge is largely attributed to the 2020 Veterans Health Administration directive. The increased mandates aim to reduce flu transmission among patients, as health systems strive to improve patient safety.
Researchers at the University of Michigan Health Rogel Cancer Center discovered that pediatric DIPG tumors have a distinct metabolic pathway that allows them to evade treatment. By inhibiting this pathway, radiation therapy became effective in killing cancer cells.
A recent survey of over 170 surgeons reveals that most are resistant to using video for pre-operative appointments, despite being open to converting some post-operative visits to telehealth. Urologists are more likely to adopt virtual care, with 88% already using it for at least some patients.
Two studies from University of Michigan reveal that sleep helps form and update memories, including spatial awareness. Sleep deprivation impairs memory by reducing neuron reactivation and replay, leading to long-term detrimental effects on memory consolidation.
A new study published in the New England Journal of Medicine found that crinecerfont reduces adrenal androgen production by half in adults with Congenital Adrenal Hyperplasia (CAH), allowing for lower doses of corticosteroids. This could lead to fewer long-term side effects associated with high-dose corticosteroid use.
Researchers found that only 41.5% of cancer patients could successfully book a new appointment at a clinic due to various barriers, including language issues and workflow challenges.
A new poll reveals that most older adults are unaware of available resources to help them navigate aging and caregiving. Only a small minority have used programs like Area Agencies on Aging, State Health Insurance Assistance Programs, and long-term services and supports. The findings highlight the need for more awareness about these se...
A study from Michigan Medicine reveals a connection between neutrophil activation and severe cytokine release syndrome (CRS), a potentially life-threatening reaction to CAR T-Cell therapy. Researchers identified biomarkers of NETosis, a process in which neutrophils create webs that may contribute to CRS.
A study by the University of Michigan Health Frankel Cardiovascular Center found that only 23% of heart attack patients received dietary counseling within 90 days of hospitalization. Nutrition counseling, often provided by registered dietitian nutritionists, may reduce cardiovascular risk for patients.
A recent study suggests that YouTube's automated video recommendations for children do not always filter out violent or age-inappropriate content, leaving young users exposed to problematic clickbait. Researchers analyzed over 2,800 video thumbnails recommended by the platform and found that many contained disturbing images or messages.
Researchers found that extending treatments to every six weeks instead of every three weeks would require 15,000 fewer infusions and reduce greenhouse gas emissions by 200 tons per year. This change could improve patient quality of life and result in cost savings for the healthcare system.
A national study found a significant increase in the use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) among adolescents and young adults in the US. Female adolescents showed a higher increase in GLP-1RA usage compared to males, highlighting the need for education on potential safety risks during pregnancy.
New studies by University of Michigan physicians highlight the need for improved diagnosis coding to target efforts to optimize antibiotic use and reduce risk. Inappropriate prescriptions occur in up to 35% of adults treated in emergency departments, with similar rates seen in clinics serving Medicaid patients.
Researchers at University of Michigan Health have developed a normothermic perfusion system that can extend the life of organs waiting for transplant by up to 24 hours. This breakthrough allows for prolonged preservation without damage or edema, increasing the number of hearts considered for transplants.
A new study found that patients prefer professional-looking backdrops during telehealth visits, including diplomas and credentials. This affects their perception of the doctor's expertise and trustworthiness, with lower composite scores for non-traditional environments like kitchens and bedrooms.
Scientists have developed a functional model of thoracic aortic aneurysm using human cells in laboratory rats, offering new avenues for drug development and effective screening. The model successfully mimics dilation of the human aorta and has potential applications for treating this potentially fatal condition.
A new study found that treatment with piperacillin/tazobactam increased 90-day mortality by 5% compared to cefepime. The antibiotic depletes the gut microbiome, which plays a crucial role in metabolism, immunity, and preventing infections.