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Michigan Medicine - University of Michigan


U-M study challenges notion of using Herceptin only for HER2-positive breast cancer

A new University of Michigan study found that the protein HER2 plays a role even in breast cancers traditionally classified as HER2-negative. The research suggests that the drug Herceptin may have a greater impact on treating breast cancer and preventing its spread, particularly when given early to prevent tumor recurrence.

SourceMichigan Medicine - University of Michigan·JournalCancer Research·DateFeb 26, 2013

The ethics of access: Comparing 2 federal health care reform efforts

A team of University of Michigan doctors analyze the shortcomings of the Affordable Care Act and Reagan-era emergency access law, emphasizing the need for preventive care and coordinated care. The authors conclude that modern healthcare reform must address these gaps to bring the nation closer to a goal of comprehensive care for all.

SourceMichigan Medicine - University of Michigan·JournalJournal of the American Medical Association·DateFeb 20, 2013

New technique sheds light on RNA

A new technique called Bru-Seq allows researchers to label newly created RNA, enabling them to analyze the synthesis and stability of RNA in cancer cells. This breakthrough has the potential to provide deeper insights into gene expression and identify early warning signs of disease.

SourceMichigan Medicine - University of Michigan·JournalProceedings of the National Academy of Sciences·DateJan 28, 2013

Researchers uncover gene's role in rheumatoid arthritis, findings pave way for new treatments

A University of Michigan study reveals how certain genes activate cells that cause rheumatoid arthritis in mice, potentially leading to new treatments for both arthritis and other autoimmune diseases. The discovery challenges long-held theories on the association between HLA genes and autoimmune disorders.

SourceMichigan Medicine - University of Michigan·JournalThe Journal of Immunology·DateJan 24, 2013

To make old skin cells act young again, boost their surroundings, U-M scientists show

Researchers at the University of Michigan have made skin cells in senior citizens act like younger cells again by adding more filler to the surrounding extracellular matrix. The study shows that this approach can trigger a signal for cells to wake up and respond positively to alterations in their environment.

SourceMichigan Medicine - University of Michigan·JournalJournal of Investigative Dermatology·DateDec 10, 2012

Job stress and mental health problems contribute to higher rates of physician suicide

A new study from the University of Michigan found that physicians who commit suicide often have known mental health problems but fail to seek treatment due to stigma and lack of confidentiality. The study highlights the need for greater effort to address job stress, under-diagnosis, and treatment of depression among physicians.

SourceMichigan Medicine - University of Michigan·JournalGeneral Hospital Psychiatry·DateNov 12, 2012

Automated calls help patients in under-developed countries manage blood pressure, U-M study finds

A University of Michigan study found that automated calls and home blood pressure monitoring can significantly reduce blood pressures and depressive symptoms among hypertensive patients in Honduras and Mexico. The program showed promising results, especially among patients with limited literacy and income.

SourceMichigan Medicine - University of Michigan·JournalTelemedicine and e-Health·DateOct 31, 2012

New insight on managing fungal meningitis

Physicians are facing the challenge of providing early treatment for fungal meningitis as cases continue to rise. The University of Michigan Health System physician authors recommend a high dose of voriconazole, but note the risk of visual disturbances, confusion, and liver test abnormalities. To avoid these effects, reducing the drug'...

SourceMichigan Medicine - University of Michigan·JournalNew England Journal of Medicine·DateOct 24, 2012

Breathe in, breathe out: New way of imaging lungs could improve COPD diagnosis and treatment

A new approach to lung scanning, called parametric response mapping, allows for better distinction between early-stage small airway disease and emphysema in patients with chronic obstructive pulmonary disease (COPD). The technique enables precise diagnosis and treatment planning, as well as tracking COPD progression over time.

SourceMichigan Medicine - University of Michigan·JournalNature Medicine·DateOct 7, 2012

Starting to snore during pregnancy could indicate risk for high blood pressure, U-M study says

A new study from the University of Michigan found that women who start snoring during pregnancy are at increased risk for developing high blood pressure and preeclampsia. The research suggests that treating underlying sleep-disordered breathing may help mitigate up to 19% of hypertensive disorders during pregnancy.

SourceMichigan Medicine - University of Michigan·JournalAmerican Journal of Obstetrics and Gynecology·DateSep 25, 2012

Substance-use disorders linked to increased risk of death for veterans with PTSD

A new study by the University of Michigan Health System and VA Ann Arbor Healthcare System found a significant link between substance-use disorders and mortality in veterans with PTSD. Younger veterans, including those from Iraq and Afghanistan conflicts, showed a stronger association between substance-use disorders and death.

SourceMichigan Medicine - University of Michigan·JournalDrug and Alcohol Dependence·DateSep 18, 2012