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Michigan Medicine - University of Michigan


Bias found in mental health drug research presented at major psychiatric meeting

A study analyzing industry-funded studies at psychiatric conferences found that 97.4% reported positive results for medicines being marketed, while non-industry funded studies showed a more balanced outcome. This 'presentation bias' echoes publication bias seen in major journals and may impact clinical care.

SourceMichigan Medicine - University of Michigan·JournalJournal of Clinical Psychopharmacology·DateMay 22, 2012

Study reveals how high-fat foods impact diabetes and metabolic syndrome

A University of Michigan Health System study reveals that Bcl10 is necessary for the harmful effects of high-fat foods on insulin action and blood sugar regulation. The findings suggest that even short-term changes in diet can induce insulin resistance, highlighting the importance of understanding the body's response to indulgent eating.

First, do no harm: Study finds danger in standard treatment for a serious lung disease

A new study reveals that a combination of three drugs used to treat idiopathic pulmonary fibrosis can lead to increased risk of death and hospitalization. The researchers found no improvement in lung function or slowing of disease progression with the treatment, highlighting the importance of rigorous testing methods.

SourceMichigan Medicine - University of Michigan·JournalNew England Journal of Medicine·DateMay 20, 2012

Scientists discover new type of cell with a key role in treatment-resistant asthma

Researchers at the University of Michigan have discovered a new type of cell in mice that causes asthma symptoms even in the presence of steroids. Similar cells were found in humans with asthma, suggesting a possible target for new treatment options. Further research is needed to explore the role of these cells in human asthma.

SourceMichigan Medicine - University of Michigan·JournalNature Medicine·DateMay 7, 2012

How does the immune system fight off threats to the brain? New research yields fresh insight

Researchers have discovered that immune cells in the brain use a two-tier approach to combat infections, sending signals to neighboring cells while focusing their attack on infected cells. This finding may help researchers develop new treatments for brain tumors and autoimmune diseases.

SourceMichigan Medicine - University of Michigan·JournalProceedings of the National Academy of Sciences·DateApr 30, 2012

Kidney cancer patients do better when whole kidney is not removed, U-M study shows

A new University of Michigan study found that patients with early-stage kidney cancer who underwent partial nephrectomy had better survival rates than those who received radical nephrectomy. The study analyzed data from 7,138 Medicare beneficiaries and showed that younger or medically compromised patients benefited most from the less i...

Combination of oral drugs suppresses common type of hepatitis C

Researchers developed a new combination drug therapy that successfully suppressed hepatitis C genotype 1 infection in a significant proportion of patients. The study, published in the New England Journal of Medicine, focused on treating patients who had not responded to previous treatment with PEG-interferon alfa and ribavirin.

SourceMichigan Medicine - University of Michigan·JournalNew England Journal of Medicine·DateJan 18, 2012

U-M News: Kidney failure risk higher for liver transplant patients following policy change

Research from Michigan Medicine shows a 15% increase in post-liver transplant kidney failure among recipients since the implementation of Model of End Stage Liver Disease (MELD) allocation. Modifiable risk factors identified include African American race, hepatitis C, and pre-transplant diabetes.

SourceMichigan Medicine - University of Michigan·JournalAmerican Journal of Transplantation·DateJan 17, 2012