Dr. Marrack recognized for significant contributions to T cell research, including understanding of autoimmune diseases and vaccine development. The L'ORÉAL-UNESCO For Women In Science Award aims to support women in science and inspire the younger generation.
Researchers have discovered that protein cdk6 inhibits breast cancer cell growth, suggesting a promising avenue for diagnosis and treatment. Cdk6 levels were found to be significantly lower in breast cancer cells compared to normal cells, with increased expression of cdk6 linked to suppressed cell growth.
Researchers identified four asthma patient subsets defined by age of onset and presence/absence of eosinophils, suggesting different biological processes and mechanisms. Early-onset asthma was associated with allergies, while late-onset asthma showed rapid lung function loss.
Research reveals distinct differences between severe asthma in children and adults, with males under 18 predominantly affected and females over 18. Children with severe asthma exhibit deceptively good lung function, challenging existing guidelines that may lead to undertreatment.
Researchers have resolved a long-standing paradox surrounding lung collectins, finding they play two roles in the lungs: dampening and promoting immune responses. This discovery sheds light on how these versatile proteins protect against both harmful pathogens and excessive inflammation.
Researchers found that higher melatonin levels in asthma patients at night lead to impaired lung function, suggesting all patients with asthma should avoid melatonin supplements until more is known about their safety. This study's findings support previous research linking melatonin to inflammation in asthma.
Children with severe asthma defy conventional understanding of inflammation-driven disease, showing little to no evidence of ongoing inflammation and permanent changes in lung tissue despite long-term therapy. Despite aggressive treatment, many patients experience uncontrolled symptoms, frequent hospitalizations, and even death.
Researchers from National Jewish Health will present data on the prevalence of obstructive sleep apnea in difficult-to-control asthma patients. Additionally, they will discuss risk factors for 'hot tub lung' caused by nontubercular mycobacteria and a genetic mutation linked to mycobacterial infections.
Researchers have identified a promising drug development strategy for lupus by targeting the Tall-1 molecule. Binding studies revealed that a short section of one binding domain on Baff-R holds promise, potentially preventing lupus-like symptoms in mice and people with autoimmune diseases.
A new anti-IgE antibody has shown promise in preventing severe allergic reactions to peanuts. The treatment increased patients' threshold sensitivity to peanut flour, allowing them to consume more without a reaction.
A recent study suggests that bacterial infections can modify the allergic response, potentially preventing asthma and allergies in children. The research found that mice infected with M. pneumoniae showed a milder reaction to allergens than control mice.
Researchers found that eczema patients have impaired immune response, preventing adequate antimicrobial peptide production in their skin. This deficiency may lead to increased susceptibility to skin infections, such as staphylococcus aureus and herpes simplex.
Researchers found that a synthetic antioxidant, AEOL 10150, significantly reduced brain tissue destruction and neurological deficits in mice after stroke. The compound protected potentially salvageable tissue surrounding the damaged cells.
Researchers found that an antioxidant compound can protect islet cells from stress and death during transplantation, leading to improved transplant success rates. The antioxidants neutralized free radicals that contribute to inflammation and cell death, allowing more islet cells to survive and function properly.
Researchers will quantify the long-term effects of PM2.5 particles on lung function and asthma exacerbations in children with moderate to severe asthma. The study aims to determine if environmental interventions can reduce asthma severity and improve lung function.
A new study by National Jewish Health reveals that smoking and pet ownership are common triggers of asthma attacks in children. Households with smokers differ from those with pets in terms of socioeconomic and psychosocial profiles, suggesting that addressing these triggers requires individualized approaches.
Researchers found that antibiotic treatment improved lung function in 56% of mild to moderate asthmatics with evidence of Mycoplasma pneumoniae or Chlamydia pneumoniae infections. Lung function also showed improvement after treatment, with an average increase of 200 milliliters.
A study found that RSV prevention in premature infants during their first winter of life can lead to better lung function and fewer respiratory issues. The treatment reduced the risk of RSV infections by 85%, resulting in fewer colds, asthma attacks, and allergies.
As bodies age, B cells lose potency due to accumulation of antigen-experienced cells. These cells, which were initially effective against previous infections, become less responsive and bind weakly to new pathogens.
A study by National Heart, Lung and Blood Institute's Asthma Clinical Research Network found that low to medium doses of inhaled steroids improve lung function in most asthma patients. However, high doses may not provide additional benefits but increase the risk of adverse effects.
Researchers at National Jewish Health have discovered a unique 'flap' on protein Tall-1 crucial to its function, which could lead to new treatments for autoimmunity. The flap-free version of the molecule triggers no biological activity but still binds to receptors.
Researchers found that an antioxidant, AEOL 10113, can prevent type 1 diabetes by modifying the immune system's recognition of antigens. The treatment lasted for up to four weeks, suggesting a promising new line of research for autoimmune diseases.
A large-scale study shows that levalbuterol is more effective and produces fewer side effects than racemic albuterol in children. The new formulation contains only the biologically active right isomer of albuterol, making it a valuable alternative for pediatric patients.
A long-term study of 150 children reveals that parents' emotional state and coping mechanisms play a significant role in the development of asthma. The research highlights two main risk factors: elevated IgE levels at six months and parenting difficulties, which increase the likelihood of asthma by 2-3 times.
Researchers are conducting a study called Prevention of Early Asthma in Kids (PEAK) to explore the potential of early treatment in preventing asthma. The study involves enrolling children aged 2-4 with wheezing episodes and one additional risk factor, taking fluticasone or a placebo twice daily for two years.
Children with severe asthma are at risk of bone loss due to inadequate dietary calcium. Taking a daily calcium supplement can help prevent this condition. Researchers found that only 5-10% of children at the study site were taking a calcium supplement, highlighting the need for increased awareness and supplementation.
A study of over 5,000 children's stories found that girls with aggressive themes tend to exhibit behavioral problems at home and school. Researchers suggest engaging children in play to help them work through issues, rather than inhibiting it.
Research suggests that high levels of environmental endotoxin in homes with sensitive children may drive the immune system to produce cytokines that inhibit processes leading to asthma. Conversely, homes with children who are not sensitized to common allergens have significantly higher endotoxin levels.
Hot tubs can cause lung disease by dispersing bacteria through aerosolization, leading to symptoms like fever and weight loss. Removing the hot tub from the home is often the primary treatment for mild cases, while more severe cases require corticosteroids and antibiotics.
Researchers at National Jewish Health discovered how proteins IL-15 and IL-2 work together to control the immune response against viruses. The proteins balance the production and division of memory killer T cells, allowing the immune system to battle antigens with a controlled response.
A National Jewish Medical and Research Center study, funded by the EPA, investigates the effectiveness of HEPA filters and electrostatic air filtration systems in removing allergens and irritants from homes of children with asthma. The study aims to determine if these interventions can help lower asthma severity in some children.
Scientists at National Jewish Health have identified a key protein that regulates fat cell development, which could lead to new strategies for treating obesity and related conditions. By inserting a negative version of CREB into fat cells, researchers can inhibit the growth of new fat cells.
A study published in the New England Journal of Medicine found that anti-IgE therapy significantly improved symptoms in patients with allergic asthma, with 33% and 43% completely eliminating oral corticosteroid use. This new approach may greatly improve treatment outcomes for those with allergic asthma.
A recent study published in Nature Medicine has found that gamma/delta T cells are essential for regulating airway hyperresponsiveness, which is characterized by an exaggerated response to stimuli. The research suggests that these cells have a suppressive effect on airway constriction and may be a key target for future treatments.
National Jewish researchers identified the specific peptide, ND1, on MHC molecules that controls positive selection of T cells. This discovery helps expand understanding of how the immune system develops and may lead to new treatments for cancer and autoimmune diseases.
Researchers at National Jewish Health found cases of chronic beryllium disease in two people exposed to 2 percent beryllium copper alloy, a product used in toasters, bicycles, and electronics. Chronic beryllium disease is caused by inhaling beryllium dust into the lungs, leading to lung scarring and oxygen transfer issues.
Researchers found that patients with severe asthma who use intravenous immunoglobulin (IVIG) in conjunction with steroids have fewer hospitalizations for asthma attacks than those using only steroids. IVIG also reduces lung inflammation and increases steroid sensitivity, making it an effective treatment option for people with asthma.
A study found that spraying water with airborne bacteria in indoor swimming pools can lead to a lung disease called granulomatous pneumonitis. Lifeguards who worked long hours at pools with water features were most affected, and symptoms included cough, wheezing, and difficulty breathing.
Using nebulizers to deliver glucocorticoid medication is effective in treating asthma in children, but long-term use can suppress growth, recommends Dr. Stanley J. Szefler of National Jewish Health. A new study suggests caution when prescribing glucocorticoids for children under 5 years old.
Researchers have found that tacrolimus can effectively treat moderate-to-severe atopic dermatitis in children, with a success rate of 67-70% and minimal systemic side effects. This treatment approach offers an alternative to corticosteroid ointments, which can cause skin thinning and other complications.
A study published in the British Journal of Child Psychology and Psychiatry found that children with severe allergies are more likely to experience behavior problems such as aggression, depression, and irritability. Genetics accounts for over 70% of the relationship between allergies and behaviors like depression and aggression.
A recent study found that black teen-agers with severe asthma are three times more likely to be steroid-resistant compared to their white counterparts. The study also revealed that children with steroid-resistant asthma are more likely to be African-American and require larger amounts of oral steroids.
A study by National Jewish researchers found that families with unexpressed emotions and disorganization are more likely to have children with asthma who skip taking medication. The researchers also found that knowledge of asthma's symptoms and treatments alone is not enough to ensure a child will take medication as prescribed.
A recent study by National Jewish Health found that no significant side effects or differences were found between beclomethasone and theophylline in children with asthma. The research suggests that these medications can be used without concern for behavioral problems, but may cause changes in pre-school age children.
A new hybrid antibody developed at National Jewish Medical and Research Center can selectively turn off only the CD4 T cells attacking transplanted organs, allowing the immune system to fight other illnesses without suppression. Clinical trials are estimated to take approximately two years.
A five-year study led by National Jewish researcher Mary Klinnert will assess the value of regular home visits by nurses to homes of low-income children at high risk of asthma. The study aims to determine if intensive nurse home visits can reduce asthma prevalence or symptoms among these children.
A new study on IL-4 receptors expands scientists' understanding of the role in genetic predisposition to asthma and allergies. Researchers hope to develop innovative treatments by targeting IL-4 receptors in clinical trials.
Researchers at National Jewish Health will investigate the basic mechanisms of fibrosis and develop clinical trials to limit fibrotic response. Four interstitial lung disease research projects are underway, focusing on inflammation, growth factors, and cellular interactions.
The study found a 38% decrease in asthma symptoms and a 31% increase in child quality of life. Parents also experienced a 16% increase in perceived competence of managing their child's illness. The program used a multi-disciplinary approach to help patients control their disease.
Sarcoidosis is a mysterious disease affecting 30 people per 100,000 in the US, characterized by granulomas and inflammation. New research suggests shared environmental exposure may lead to the disease, which often affects young adults and has no cure.