Researchers presented promising results for OncoVEXGM-CSF in treating metastatic melanoma, achieving treatment success in 32% of patients. Additionally, studies on robotic prostatectomy found excellent cancer control outcomes with disease-free survival rates at 21 months. The association between obesity and microvascular invasion was a...
Weill Cornell researchers discovered a gene responsible for mutated red blood cells in Cooley's anemia, allowing mice to produce normal red blood cells without splenectomy. The study found that blocking the JAK2 gene reduces spleen size and improves hemoglobin production.
Researchers at Weill Cornell discovered that cancer stem cells without the protein CD133 can initiate metastatic disease, leading to more aggressive tumors. This finding opens up new avenues of investigation and redirects cancer research.
Researchers have found estrogen-dependent molecular pathways play a crucial role in regulating aggressive prostate cancer. The study used innovative technology to analyze 455 prostate cancer samples and identified an 87-gene expression signature that distinguishes fusion-positive TMPRSS2-ERG cancers from other malignancies.
A re-analysis of PCPT data reveals that finasteride significantly reduces the incidence of prostate cancers, including higher-grade ones. The study also suggests that finasteride may suppress indolent cancers and could be useful in determining tumor aggressiveness.
A clinical trial found gene therapy to be safe and effective at slowing disease progression in Batten disease, a rare genetic disorder. Neurological function was assessed using a rating scale throughout an 18-month follow-up period.
The new center aims to prevent abuse and help victims achieve a life without mistreatment. The funding will support the advancement of strategies for addressing elder abuse and neglect, which affects up to 10% of older Americans annually.
The article addresses the importance of sharing data in clinical trials for heart studies, including situations where interim data should be shared with operational study personnel and sponsors. The authors emphasize the need for caution and careful consideration before releasing interim data, particularly when it comes to trial credib...
Leading cardiologists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center are presenting new basic and clinical research findings on drug-eluting stents, wound closure devices, and noninvasive coronary angiography. Dr. Antonio Gotto Jr. will present data showing the ExoSeal device speeds up clotting time and reduces patient i...
Researchers found higher levels of autozygosity among colorectal cancer patients, particularly those of Jewish heritage, which may lead to novel cancer-causing genes. The study suggests a new type of genetic signpost that clinicians can follow for a range of cancers in various population groups.
A reliable blood test for Parkinson's disease could revolutionize care and research, according to a new study. The test uses a 'metabolomic profile' to identify unique changes in dozens of small molecules in serum that are linked to the disease.
A new study proposes that intestinal dysfunction, specifically in the upper small intestine, may be the source of Type 2 diabetes. Surgical bypass operations can reverse this abnormality, leading to diabetes remission.
A new screening questionnaire, SCORED, has been shown to be more accurate and efficient in identifying individuals with silent chronic kidney disease than current clinical practice guidelines. The test correctly identifies patients at risk for CKD 88-95% of the time and defines high-risk individuals 25% fewer times.
A three-year study of inner-city middle school students found that those with media resistance skills were significantly less likely to drink alcohol as ninth graders. Developing peer refusal skills also reduced the likelihood of drinking.
A Weill Cornell team discovered that EP2 and EP4 receptors play a key role in boosting estrogen production in fat and breast cancer cells. This pathway increases the risk of hormone receptor-positive breast cancer. The study's findings suggest new targets for pharmaceutical research, including drugs that target these receptors.
Researchers found that axonal CREB plays a key role in transmitting signals from the growth cone to the nucleus, ensuring neuron survival. This discovery sheds new light on neural development and may have implications for treating neurological diseases such as Alzheimer's.
A multidisciplinary team led by Dr. Neil Bander will develop a novel nanomedicine for prostate cancer, targeting specific sites with high PSMA presence. The collaboration aims to create synergies in research and development, potentially reducing side effects and increasing effectiveness.
Researchers discovered that mast cells in the lungs release renin, an enzyme that helps trigger bronchoconstriction, a hallmark of asthma. This finding suggests potential new targets for treatment against asthma and other respiratory diseases.
A recent study by Weill Cornell Medical College reveals that the brain contains its own store of tissue plasminogen activator (tPA), a powerful enzyme that boosts blood flow to brain cells via nitric oxide synthase. This finding has significant implications for understanding stroke and Alzheimer's disease, and may lead to new treatments.
A physician-scientist is urging improved drug regulation to ensure the cardiovascular safety of non-heart drugs. This includes earlier testing and continued evaluation of drug effects post-approval.
A research team at Weill Cornell Medical College identified two genes, Pbx-1 and Prep-1, that play a critical role in regulating interleukin-10 (IL-10) production. This discovery could lead to new avenues for understanding and treating diseases such as lupus, cancer, and HIV/AIDS.
A Phase 2 study found eltrombopag increased platelet counts in 74% of patients with low platelet counts and cirrhosis due to hepatitis C. The drug also allowed more patients to complete antiviral therapy, with 36-65% completing treatment at the lowest and highest doses.
The WIN-R study found weight-based REBETOL plus PEG-INTRON improves sustained virologic response and lowers relapse rates, particularly in African-Americans with genotype 1 HCV. Weight-based dosing is also justified for very heavy patients.
Researchers have developed a key small molecule inhibitor targeting 'virulence factors' used by bacteria to thrive, offering an alternative means of stopping TB, leprosy, and other bacterial illness. The findings highlight a paradigm shift in infectious disease research beyond antimicrobials like antibiotics.
Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified cancer stem cells as a potential cause of brain tumors. The study aims to develop more accurate and specific cancer diagnoses using these stem cells.
Researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center used advanced brain-scanning technologies to detect brain areas associated with poor impulse control and negative emotion in patients with borderline personality disorder. The study found that discrete parts of the ventromedial prefrontal cortex were relatively l...
Researchers at Weill Cornell Medical College have identified the role of Synaptojanin 1 in the synaptic vesicle cycle, a critical aspect of synaptic function. The enzyme's removal slows down endocytosis, highlighting its importance in cell-to-cell information flow.
Researchers at Weill Cornell Medical College have developed a new drug that blocks the live viral infection of Hendra and Nipah viruses, which are on the US government's list of potential threats. The peptide-based entry inhibitor has been proven effective in blocking the infection of live virus in animal cells.
A joint study will assess changes in brain structure and cognitive functions in adult cancer patients treated with chemotherapy. Researchers hope to identify neuroprotective agents to prevent chemotherapy-related cognitive dysfunction, a condition affecting many cancer patients.
Researchers at Weill Cornell Medical College have made a breakthrough by observing synaptic vesicle recycling in real time, laying to rest the 'resealable spout' theory of vesicular recycling. The study uses cutting-edge methods to show that neurotransmitter packets must be rebuilt after each cycle.
A NewYork-Presbyterian study found that adults over 65 can improve their health through simple lifestyle changes, reducing risk for diseases such as obesity and osteoporosis. Adhering to a low-calorie diet and regular exercise can help stave off the diseases of aging.
Weill Cornell Medical College has received grants to develop innovative TB drugs and treatments, with a focus on killing or interfering with the TB organism in its non-replicating phase. The research aims to shorten TB therapy from six months to just a couple of weeks, while also addressing emerging drug-resistant forms.
Researchers found that telmisartan completely protected rats from stroke when used alone or with ramipril, with no strokes noted in either group. The study suggests that telmisartan's ability to pass through the blood-brain barrier is likely behind its neuroprotective effect.
A team of researchers at Weill Cornell Medical College discovered a molecular 'switch' that selects specific kinesin motor proteins to transport surface markers to their ultimate destinations on the cell's surface. This finding holds promise for developing targeted therapies with fewer side effects for diseases like cystic fibrosis and...
Researchers found that alcohol activates a stress-linked pathway in neurons to release key genes that can influence the health and activity of brain cells. The study sheds light on how this process occurs and may help scientists understand alcohol-linked disorders such as chronic alcoholism and fetal alcohol syndrome.
A Phase 2 study found that eltrombopag elevated platelet counts to a safe level in over 75% of chronic ITP patients within two weeks, reducing bleeding symptoms. The therapy also showed similar incidence and severity of adverse effects compared to the placebo group.
Hispanic patients receive fewer vascular surgeries than the general population and have worse outcomes, with higher rates of amputation and death following procedures. Socioeconomic factors, genetic variations, and delayed treatment may contribute to these disparities.
A new study found that women over 65 with a history of smoking or heart disease are at high risk for abdominal aortic aneurysm, supporting the need for ultrasound screening. The study challenged current guidelines recommending AAA screenings only in men, citing a lack of evidence on cost-effectiveness.
A new study challenges traditional notions of triage in disaster response by highlighting the importance of regional hospital capacity and field triage accuracy. The research suggests that levels of overtriage can be beneficial, harmless or detrimental depending on local resources and response times.
Varicocele removal significantly improves testosterone levels in over two-thirds of men, leading to improved fertility and reduced symptoms of andropause such as low sex drive and depression.
Researchers from Weill Cornell Medical College report a breakthrough in isolating specialized subsets of spermatogonial stem cells that can generate a wide range of cell and tissue types. The study's findings have promising implications for regenerative medicine, offering an alternative to embryonic stem cells.
A new study from NewYork-Presbyterian Hospital/Weill Cornell Medical Center found that breast reductions of less than 500 grams per breast greatly eased women's back, neck, and shoulder pain. The procedures also improved their quality of life by allowing them to exercise more and engage in a wider variety of activities.
Researchers at Weill Cornell Medical College have discovered a crucial mechanism driving the growth of light-sensing discs in rod cells, shedding new light on retinal health and disease. The study's findings could lead to significant advances in understanding and treating eye diseases such as retinitis pigmentosa.
A Weill Cornell study finds that nicotine in cigarettes accelerates atherosclerosis, even at low levels, by activating the sympathetic nervous system and increasing heart rate. Mice exposed to low-nicotine cigarettes showed smaller atherosclerotic lesions than those exposed to regular cigarettes.
A new study published in Annals of Internal Medicine found that preventing or reducing left ventricular hypertrophy (LVH) decreases the risk of heart failure in high-blood-pressure patients. The study, led by Dr. Peter Okin, demonstrated a significant reduction in heart failure risk among patients with reduced LVH levels.
A new study by Weill Cornell Medical College found that young rats given Ritalin injections from week-old age showed significant brain changes linked to higher executive functioning and addiction. Changes resolved with time, but the findings suggest doctors must be careful in diagnosing ADHD before prescribing Ritalin.
Researchers at Weill Cornell Medical College have discovered that preconditioning, a process where the brain is challenged with a small noxious stimulus, can shield blood vessels from stroke injury. This study found a 68% reduction in stroke intensity and a 114% boost in blood flow in areas unaffected by the stroke.
A new gene therapy clinical trial has reported promising results in improving motor function for patients with Parkinson's disease. The study found significant improvements in both the off-state and on-medication phases, with some patients showing impressive gains of up to 65 percent.
Researchers at Weill Cornell Medical College have discovered two potential points of vulnerability in the XIAP protein, a key player in cancer cell survival. Targeting these activities could lead to tumor cell death and reduced tumors.
Researchers at Weill Cornell Medical College have discovered a crucial link between epithelial cells and immune system function at mucosal surfaces. The study found that epithelial cells produce a key antigen called IgA2 to keep bacteria in check, and that this process is critical for preventing infections such as HIV and rotavirus.