Researchers at Stanford University School of Medicine have discovered a method to transform human leukemia cells into harmless immune cells called macrophages. This breakthrough offers potential hope for treating aggressive cancers like B-cell acute lymphoblastic leukemia.
Researchers at Stanford University and the University of Copenhagen have used ancient DNA to identify the ethnic origins of three African-born slaves found in the Caribbean. The study, published in PNAS, marks a significant breakthrough in genealogical research and sheds light on the trans-Atlantic slave trade.
Researchers developed a customized genetic construct using tiny DNA minicircles to detect cancer in mice. The technique uses a protein called secreted embryonic alkaline phosphatase, which is not produced in adults but is present in embryos.
Researchers found a small molecule that can convert an enzyme to more effectively metabolize acetaldehyde, reducing cancer risk. The study uses mice with defective ALDH2 enzymes and finds that a small molecule named Alda-89 increases the activity of ALDH3A1, a related enzyme.
A Stanford study found that many donated hearts are being rejected due to varying acceptance criteria across regions. The rejection rate decreased from 44% in 1995 to 32% in 2010, highlighting a pressing need for standardized guidelines.
A Stanford study analyzed nearly 16,000 brain images and found a common pattern of gray matter loss in three brain structures associated with high-level functions. This discovery challenges traditional classification of psychiatric disorders based on symptoms.
A Stanford study found that antibody-producing immune cells called B cells play a key role in the delayed onset of dementia after stroke. The presence of these cells, which are normally found only in the blood, can be linked to cognitive decline and memory loss in stroke patients.
Researchers at Stanford University School of Medicine identified limostatin, a hormone that decreases insulin levels during recovery from fasting or starvation, in fruit flies and found a similar protein in humans. This discovery has critical ramifications for understanding metabolism and may inform new efforts to combat diabetes.
Researchers analyzed data from Medicare and VA patients, revealing that physicians' prescribing decisions are influenced by multiple factors, including patient costs and regional variations. The study highlights the need for improvement in healthcare systems to optimize treatment selection and reduce costs.
A Stanford University School of Medicine study reveals that more equitable delivery of evidence-based care can close the gap in colon cancer survival rates between white and African-American patients. The researchers found that five-year death rates were lower for all colon cancer patients treated in integrated health-care systems, wit...
A Stanford study found that nearly 20% of very-low-birth-weight babies in California were not referred to the state's high-risk infant follow-up program. Larger neonatal intensive care units and referrals were more common among premature or medically fragile infants.
A new procedure can increase the length of human telomeres by up to 1,000 nucleotides, allowing researchers to generate large numbers of cells for study or drug development. This breakthrough may lead to new ways to treat diseases caused by shortened telomeres.
A Stanford University School of Medicine investigation found that the environment, rather than genetics, influences the state of the human immune system. The study compared monozygotic and dizygotic twins to determine the relative contributions of nature and nurture to immune variation.
Researchers at Stanford University School of Medicine have discovered a stem cell in mice that gives rise to bone, cartilage and stroma. The discovery sets the stage for therapies for skeletal disorders such as bone fractures, brittle bones, and damaged cartilage.
Researchers at Stanford University School of Medicine have developed a modified version of an aminoglycoside that works effectively in mice without causing deafness or kidney damage. The new antibiotic, N1MS, was created by modifying the drug molecule to prevent it from entering the inner-ear cell's ion channels.
Researchers have developed a safe and effective skin patch to deliver a drug that enhances the healing of diabetes-related ulcers. The patch has been shown to accelerate wound healing and prevent ulcer formation in mice, offering new hope for millions of people with diabetes.
Researchers at Stanford University School of Medicine found that faulty stem cells surrounding muscle fibers are responsible for the progression of Duchenne muscular dystrophy. A drug called losartan has been shown to inhibit fibrosis and partially restore muscle function in laboratory mice, offering new hope for potential treatments.
A study of 9,387 men with fertility issues found a correlation between poor semen quality and various health conditions, including hypertension and skin/endocrine disorders. The study suggests that treating male infertility may also benefit overall health.
Researchers at Stanford University School of Medicine found that blocking a single molecule on microglia restored their function, reversing memory loss and other Alzheimer's-like features in mice. The study suggests that microglia play a crucial role in clearing A-beta protein clusters, which contribute to the disease's progression.
Scientists have made a breakthrough in treating epidermolysis bullosa by using induced pluripotent stem cells to grow back healthy skin cells. The new technique, called therapeutic reprogramming, was tested on mice and showed promising results.
Researchers at Stanford University School of Medicine have discovered an enzyme that repairs damaged DNA but can also cause destruction. The study found that endonucleases, which are attracted to DNA/RNA hybrids, cut the DNA and damage it when present.
Scientists at Stanford University School of Medicine and colleagues have discovered a previously unknown immune response to the mitochondria of pluripotent stem cells created through nuclear transfer, which can prompt rejection in mice. This finding may pose a hurdle for using such therapies in humans, but it is considered surmountable.
The study, Mouse ENCODE, compared mouse and human genome regulatory elements to understand similarities and differences in gene control. Researchers found that the general principles of gene regulation are similar but with distinct details between species.
Researchers used big data analysis to identify crizotinib, a cancer drug, as a possible candidate for a new stent coating. The medication helped prevent stent disease and protected the endothelium without affecting blood vessel lining in mice.
A study by Stanford University School of Medicine researchers reveals that the protein retinoblastoma, a known tumor suppressor, also inhibits the vital property of pluripotency in stem cells. This finding provides a direct molecular link between cancer and stem cell science.
A new study found that child-mortality rates declined the fastest among the poorest families in developing countries, resulting in a narrowing gap between wealth groups. The study also identified four factors contributing to this convergence: government effectiveness, rule of law, corruption control, and regulatory quality.
A Stanford/VA study found that pregnant women with post-traumatic stress disorder (PTSD) are at a higher risk of giving birth prematurely. The study analyzed over 16,000 births to female veterans and found that having PTSD in the year before delivery increased the risk by 35 percent.
A new method predicts AMD progression on a personalized basis by analyzing imaging data from routine retinal scans. The formula distinguishes likely from unlikely progressors by analyzing patient data collected by ophthalmologists and optometrists.
Researchers at Stanford University School of Medicine have found a direct link between oxytocin levels in blood and cerebrospinal fluid and anxiety. Low oxytocin levels are correlated with high anxiety scores, suggesting that oxytocin may be a biomarker for anxiety and a potential therapeutic target.
Researchers at Stanford University have found that patients with chronic fatigue syndrome exhibit distinct brain abnormalities, including reduced white-matter content and abnormal nerve tract function. The findings may lead to more definitive diagnoses and potentially identify new treatment targets.
Researchers at Stanford Medicine have devised a new way to edit the genome without using enzymes or promoters, which may lead to a safer and longer-lasting treatment for genetic diseases like hemophilia. The technique successfully cured mice with hemophilia by inserting a gene for a clotting factor missing in the animals.
Researchers developed a new strategy to detect bladder cancer using CD47, a protein that signals the immune system not to attack. The technique improves bladder cancer detection, guides precise surgery, and reduces unnecessary biopsies, increasing patients' quality of life.
Parents can learn scientifically validated autism therapy through group classes, improving their children's language skills and reducing stress. The treatment involves rewarding the child for trying to talk, with benefits including improved happiness and a sense of community.
A study by Stanford researchers found that medical practices in less competitive health-care markets charge more for services. The study analyzed U.S. health-care data from 2010 and found that areas with lower competition had higher prices for office visits, translating to tens of billions of dollars in extra spending.
Researchers found that antibiotics can exacerbate Salmonella infection in mice, turning non-superspreaders into superspreaders. The study highlights concerns about the routine use of sub-therapeutic doses of antibiotics in livestock.
Researchers found that treating inmates with sofosbuvir is cost-effective compared to other treatments approved by the FDA. The study suggests that the treatment can add up to 2.1 quality-adjusted life years and save healthcare programs from paying out more in the future.
Researchers used induced pluripotent stem cells to compare heart muscle cell survival decisions in people with and without a genetic mutation. They found that the mutation affects heart health by controlling cell survival during stress, and identified a protein involved in programmed cell death.
Two family-based therapies are found to be effective in treating anorexia nervosa in teenagers, with one approach producing faster weight gain and lower hospitalization rates. The study suggests that involving parents in treatment can lead to improved outcomes for adolescents struggling with the life-threatening eating disorder.
A study published in Science Translational Medicine found that immune cell activity within the first 24 hours after surgery can predict a patient's recovery time. The researchers used single-cell mass cytometry to analyze blood samples from patients undergoing hip-replacement procedures, revealing a unique pattern of immune response.
A new study found that pregnant women's immune cells produce more cytokines and chemokines when exposed to flu viruses, leading to a hyperinflammatory response. This unexpected finding highlights the need for new treatment approaches for severe influenza in pregnancy.
A new study by Stanford researchers found that re-analysis of clinical trial data can change conclusions, particularly when data is not shared. The study identified 37 published re-analyses, with 13 concluding that different patient populations or treatment protocols could benefit from the tested medication.
A genetic mutation caused by ultraviolet light is linked to millions of human skin cancers, according to Stanford researchers. The mutation occurs in the KNSTRN gene and can cause genomic catastrophe, leading to cutaneous squamous cell carcinomas.
A large study found that breast cancer patients with bilateral mastectomy did not have better survival rates than those who underwent lumpectomy plus radiation. The study analyzed nearly 190,000 California women and found a slightly lower survival rate among those who had unilateral mastectomy.
Researchers at Stanford University School of Medicine have mapped the binding sites and cellular expression patterns of regulatory factors in fruit flies, roundworms, and humans. The study identifies shared and distinct patterns across species, shedding light on how genes are turned on and off.
Researchers at Stanford University School of Medicine have discovered a non-addictive and safe-for-the-heart compound called Alda-1 that reduces inflammatory pain. The compound was found while searching for the reason behind moderate drinkers' less-severe heart attacks.
Stanford researchers found that targeted brain stimulation using optogenetics significantly improved motor ability and weight regain in mice affected by strokes. The study's findings have potential implications for developing new clinical therapies for stroke recovery, including the placement of electrical brain-stimulating devices.
A new study from Stanford Medicine explains how children's brains reorganize themselves as they learn math facts. The research found that the hippocampus plays a crucial role in building a schema for mathematical knowledge and provides a scaffold for learning and consolidating facts into long-term memory.
A study published by a Stanford researcher found that poor sleep quality significantly increases the risk of suicide among older adults. The study, which analyzed data from 14,456 adults aged 65 and older, confirmed that disrupted sleep is an independent risk factor for late-life suicide.
Researchers at Stanford University School of Medicine discovered that the protein Myc drives cell growth by blocking the expression of genes involved in DNA packaging and cell death. The study identifies critical genes regulated by Myc and a microRNA family, offering new therapeutic targets for Myc-dependent cancers.
Researchers found that digoxin increases the risk of death in patients with atrial fibrillation, regardless of age or other factors. The study, published in the Journal of the American College of Cardiology, suggests alternative treatments may be safer and more effective.