Researchers at Stanford Medicine have developed a technique to identify patients who are at risk of suffering chemo-induced heart damage. The study uses induced pluripotent stem cells from breast cancer patients' skin cells to create human heart muscle cells, which respond more adversely to the chemotherapy drug doxorubicin.
Researchers have identified a key role for a recently discovered immune cell in age-related inflammation and disease. The discovery sheds light on the mechanisms underlying these conditions and offers promising avenues for treatment.
A new study found that low-risk drinking guidelines differ significantly across countries, reflecting varying attitudes towards alcohol consumption. Different countries assign distinct daily or weekly limits for men and women, leading to confusion among researchers and the public.
A new study led by Grant Lipman found that applying paper tape to blister-prone areas before exercise prevented both incidence and frequency of foot blisters. The tape, commonly used for wound treatment, is mildly adhesive and doesn't tear blisters if they occur.
A recent study published in JAMA Internal Medicine found that smokers have a much harder time finding work than nonsmokers. After controlling for various factors, the research showed that smokers remained unemployed longer and earned substantially less than their non-smoking counterparts.
A new study led by Stanford researchers suggests that Neanderthal Y-chromosome genes disappeared from the human genome long ago. The study found no evidence of Neanderthal DNA in human males, but discovered several genes on the Y chromosome that differ from those in humans and may have played a role in barriers to gene flow.
A phase-3 trial led by Stanford University shows baricitinib substantially reduces symptoms and improves daily functioning in refractory rheumatoid arthritis patients. The study, involving over 500 adults, found that baricitinib improved physical function and reduced markers of inflammation, with effects remaining at 24 weeks.
Researchers at Stanford University School of Medicine have devised a new approach to identify and sequence DNA from cancer cells circulating in the blood, increasing sensitivity by 15 times. The 'integrated digital error suppression' technique builds upon a method called CAPP-Seq, allowing for accurate identification of actionable muta...
A Stanford University School of Medicine study found that prenatal steroid treatment halves the risk of severe brain hemorrhage in preemies. Researchers analyzed nearly 26,000 premature infants and found a significant reduction in intraventricular hemorrhage risk for those receiving steroids.
Researchers identified a specific brain circuit involving DR2 nerve cells that predicts risk-taking preferences in rats. The findings expand on human research, suggesting the circuit may also be relevant to humans.
A recent study by researchers at Stanford University School of Medicine found that p-values are being misapplied in millions of biomedical journal articles, leading to the illusion of credible research. The study suggests that this widespread misuse may not indicate an improvement in research conduct or data analysis.
Researchers identified a critical connection between the cancer-related gene Myc and cell-surface molecules that protect tumors from the immune system. The study found that reducing Myc expression led to lower levels of protective proteins CD47 and PD-L1 on tumor cells, enabling them to evade immune detection.
A Stanford study found that vitamin D deficiency in mice leads to faster-growing and more aggressive breast cancer tumors. Researchers also identified a direct link between vitamin D levels and the expression of the ID1 gene, which plays a role in tumor growth and metastasis.
A study published in The Journal of Experimental Medicine found that hyper-aggressive immune cells that consume glucose may drive the development of coronary artery disease. Blocking this glucose overconsumption prevented inflammation and atherosclerosis, suggesting new therapeutic interventions to prevent heart attacks.
A new study led by Stanford University researchers found that the number of surgeries performed worldwide has grown, yet there remains a huge gap in surgical care between rich and poor nations. The most frequently performed operation in poor countries was cesarean section, suggesting other significant surgical needs are being given low...
Researchers at Stanford University School of Medicine have developed a simple blood test that can accurately diagnose active tuberculosis, setting the stage for a significant transformation in disease control. The test works on ordinary blood samples and distinguishes patients with active TB from those with latent TB or other diseases.
Researchers found that symmetrical RNA structures are harder to design, contradicting conventional thinking. The study uses data from over 100,000 players of the Eterna online game to develop a new rating scale for RNA-design difficulty.
Researchers at Stanford University School of Medicine developed a possible new method for preventing jet lag by exposing people to short flashes of light while they sleep. The study found that this method can speed up the brain's adjustment to time changes, reducing the delay in onset of sleepiness.
Researchers at Stanford University School of Medicine used a novel approach to analyze noncoding genomes and identified associations between genetic mutations and medical histories. The study found that specific mutations in regulatory regions were linked to conditions such as narcolepsy, cardiac disease, and hypertension.
A study by Stanford researchers found that just 1% of practicing physicians accounted for 32% of paid malpractice claims over a decade. Claim-prone physicians had distinctive characteristics, and their risk varied widely according to specialty and age.
The Stanford-Berkeley device is a noninvasive, wearable technology that analyzes sweat composition for continuous health monitoring. It provides insight into an individual's physiological state at molecular levels, allowing for real-time alerts on fatigue, dehydration, and other health problems.
A study found that low-fiber diets can lead to a decline in gut bacterial diversity, which cannot be fully recovered even after switching to a high-fiber diet. This effect is observed even across multiple generations, with nearly three-quarters of bacterial species becoming extinct within four generations.
Researchers found a change in gene expression that may have contributed to the development of a weight-bearing structure in humans, allowing for bipedalism. The study identified a region in the human genome responsible for controlling armor plate size in threespine sticklebacks, which expressed higher levels of GDF6 in freshwater fish.
Researchers at Stanford University School of Medicine found that trimming the nails of laboratory mice can cure a common and life-threatening skin disease. The technique saved 93% of mice from ulcerative dermatitis, a condition that caused deep ulcers and led to animal euthanasia.
Researchers found that low doses of Ambien enhance synaptic GABA signaling, a type of nerve-cell activity beneficial for recovery. The study's results suggest potential therapeutic benefits for humans, but need replication before clinical trials can begin.
Weaker interactions between brain networks help regulate attention were found in children with ADHD, correlated to the severity of inattention symptoms. Functional MRI scans identified biomarkers that reliably differentiate children with ADHD from others.
A Stanford University School of Medicine team identified a distinctive pattern of gene expression that distinguishes people with a viral infection from those with a bacterial infection. The meta-virus signature is present even before symptoms appear and can predict up to 24 hours before illness onset.
A collaboration between computer scientists and geneticists at Stanford University has produced a novel technique for mapping the diversity of bacteria living in the human gut. The new approach revealed a far more diverse community than the researchers had anticipated, with many different strains of the same species identified.
A Stanford University School of Medicine study found that the majority of opioid prescriptions are distributed by large numbers of general practitioners, not just a small group of specialists. The top 10 percent of opioid prescribers account for 57 percent of prescriptions, similar to the overall prescribing pattern for all drugs.
Researchers used optogenetics, fMRI, and electrophysiology to track brain activity and show how stimulation frequencies affect arousal. They found that altering deep-brain circuit firing frequency dramatically alters forebrain activity and alertness levels.
A Stanford study found that infertile men have a higher risk of developing heart disease, diabetes, and other health problems. The research suggests that male infertility is associated with increased rates of mortality and general health issues, even after adjusting for obesity and smoking.
A Stanford University study has found that men treated with androgen deprivation therapy for prostate cancer are nearly twice as likely to be diagnosed with Alzheimer's disease. The researchers analyzed electronic medical records of thousands of patients, revealing a significant increase in cognitive decline among those receiving ADT.
Researchers at Stanford University School of Medicine have mapped the genome of the African turquoise killifish, a short-lived species that lives only four to six months. The study found evidence of rare genes influencing longevity and aging in other species, including humans.
Research shows that higher C-section rates up to 19% can lead to lower maternal and neonatal mortality rates, while rates above 19% show no further improvement. This study suggests re-examining policy benchmarks for C-section rates on a country-wide level.
Researchers at Stanford University School of Medicine have identified a gene that appears to reduce the risk of heart failure and improve treatment outcomes. The gene codes for a protein involved in regulating sleep, appetite, and blood pressure, which may play a protective role in the heart.
Researchers at Stanford University School of Medicine discovered that genetic material from ancient viral infections is critical to human development. Blocking the production of a specific RNA molecule stops development in its tracks, they found.
Researchers at Stanford University School of Medicine have identified a new class of RNA molecules that act as powerful tumor suppressors by inhibiting the cancer-causing protein KRAS. The study found that these RNAs, called SNORD50A/B, are deleted in over a quarter of common human cancers, leading to poorer survival rates for patients.
A Stanford University study found that ethnic minorities value high-quality end-of-life care, but face numerous barriers, including poor communication and financial issues. The study's authors emphasized the need for culturally competent care as the US population becomes increasingly diverse by 2044.
A 12-week randomized study found that pioglitazone, an insulin-sensitizing drug, alleviated depression symptoms in insulin-resistant patients. The study suggests a link between insulin resistance and depression, with improved antidepressant effects seen in more insulin-resistant participants.
Researchers discovered that the behavior of monocytes, a type of white blood cell, can indicate how soon patients will recover after hip surgery. The study found that 50% of variation in recovery time could be predicted based on these cells' behavior, which could help doctors plan better post-surgery care.
The study has tremendous potential to improve our understanding of early development, enhance disease modeling, and promote therapeutic discovery. Researchers believe that work on chimeric embryos is vital to advance this field despite ethical concerns.
Genomic data sharing networks pose a risk to individual privacy if accessed by the wrong hands. Stanford researchers demonstrate a technique to prevent hacking and protect donors' identities.
A new study found that sleep deprivation can reduce the effectiveness of stem cell transplants by up to 50%. Researchers at Stanford University discovered that a four-hour sleep deficit can impair the ability of stem cells to migrate and function properly. However, recovery sleep can restore the cells' normal function.
A new study found that elevated blood sugar levels in pregnancy are linked to an increased risk of congenital heart defects, including tetralogy of Fallot and dextrotransposition of the great arteries. High glucose levels were correlated with an increased risk of tetralogy of Fallot, but not dextrotransposition of the great arteries.
A Stanford study suggests a malfunctioning enzyme may contribute to the development of alcoholism in individuals who binge drink. The researchers identified a previously unknown biochemical assembly line that produces an essential neurotransmitter called GABA, which is thought to play a key role in countering addiction.
Researchers have developed a drug that disables C. difficile toxins, preventing intestinal damage and allowing the gut to repopulate with healthy bacteria. The breakthrough could lead to rapid human trials for treating deadly C. difficile infections.
A combination of two drugs has been found to shrink pancreatic tumors in laboratory mice. The treatment, which targets the cell's DNA rather than proteins, also slowed the growth of human lung cancer cells. Researchers are now working to test this treatment in humans with pancreatic cancer.
Researchers develop a bioengineered collagen patch loaded with Fstl1 protein to regenerate heart tissue after damage. The treatment restored function and allowed for progressive recovery in animal models.
A new study suggests that expanding treatment programs to include preschool children and adults is more beneficial, reducing transmission and disability. The study found that a broader scope of treatment would be cost-effective, with an incremental cost-effectiveness ratio of $167.
Researchers developed a drug that blocks hyaluronan buildup in pancreatic islets, preventing immune cell infiltration and destruction of insulin-producing cells. The study suggests a potential preventive treatment for type 1 diabetes in humans if initiated before the onset of the disease.