A study by Tokyo Medical and Dental University found that protein YAP rescued SCA1 pathology when expressed during development, but not as an adult. The researchers also discovered a link between YAP and the transcriptional co-activator RORα, which plays a crucial role in cerebellum development.
Researchers found that nearly half of neuroblastoma samples had gene loss or imbalance in DNA damage response-associated molecules located on chromosome 11. PARP inhibitors, commonly used for ovarian cancer treatment, showed promise as a potential therapeutic approach for targeting childhood cancer.
Researchers at Tokyo Medical and Dental University have discovered that overexpression of the MKL1 protein in macrophages contributes to inflammation development in IBD. Targeting this protein may hold potential for treating IBD, a condition with currently no cure.
Osteocytes are identified as the major source of receptor activator of nuclear factor-κB ligand (RANKL) during orthodontic tooth movement, regulating bone remodeling and osteoclastic differentiation.
Researchers at Tokyo Medical and Dental University identified two variants of single-nucleotide polymorphism associated with SVC arrhythmogenicity. These genetic factors, age, body mass index, and left ventricular ejection fraction, play a role in atrial fibrillation development.
Researchers at Tokyo Medical and Dental University identified a protein called MELK essential for correct HIV-1 coat removal. Depleting MELK reduced virus infectivity, while restoring it restored normal infection processes.
Researchers at Tokyo Medical and Dental University have identified a molecule called YAP that determines whether liver cells proliferate or are eliminated, depending on the presence or absence of injury. This balance is crucial for maintaining organ structure and function.
Researchers at Tokyo Medical and Dental University identified two microRNAs that can improve pancreatic cancer response to gemcitabine, a common chemotherapy drug. These findings suggest novel combined treatments for this devastating disease. MicroRNA levels can also predict prognosis in pancreatic cancer patients.
Research found that reduced mastication in mice led to suppressed maxillofacial bone and muscle growth, as well as reduced neural activity in the hippocampus, a key component of memory. This study suggests maintaining or strengthening masticatory function may help prevent dementia and memory/learning dysfunction.
Researchers at Tokyo Medical and Dental University identified equivalent monocyte progenitors in humans, expanding our understanding of immune cell development. The study found distinct subgroups of cells with different protein expressions, shedding light on potential therapeutic applications targeting these cells.
Researchers created a rapid biosensor to detect early-stage flu virus infections, outperforming existing kits in sensitivity and speed. The new device can identify minuscule amounts of H1N1 virus, allowing for timely administration of antiviral medication.
Researchers at Tokyo Medical and Dental University developed a new process to improve the detection of cancer stem cells in brain tumors. The approach uses iron chelation to increase fluorescence levels, allowing for more accurate identification and removal of these cells. This breakthrough has potential to translate to clinical practice.
A metabolic pathway regulating the formation of a crucial embryonic structure has been discovered, shedding light on how embryos develop and how certain drugs can affect pregnancy. The study's findings have significant implications for understanding statin use in pregnant women and may lead to safer drug regimens.
Researchers found that autophagy degrades Cep63 to regulate centrosome number, preventing genomic instability. Cells deficient in autophagy have extra centrosomes, highlighting the role of autophagy in maintaining genomic stability.
A novel type of cell death, called ballooning cell death (BCD), has been identified in Huntington's disease. BCD is associated with mutant huntingtin and causes cells to expand like a balloon before rupturing.
A team of researchers at Tokyo Medical and Dental University has identified a molecule called CD72 that prevents the immune system from mistakenly reacting to a component of the body's own cells. This breakthrough could lead to new treatments for systemic lupus erythematosus (SLE), a disease associated with inflammation of various organs.
A new technique developed by Tokyo Medical and Dental University has improved bone regeneration by using double-layered cell constructs that can be transplanted onto bone defects. The technique increases the speed of bone repair and provides flexibility and durability ideal for surgical applications.
Researchers at Tokyo Medical and Dental University have successfully stimulated local bone augmentation in mice jawbones using a protein/peptide combination carried by an injectable gel carrier. The study demonstrates the potential for non-surgical treatment of alveolar bone loss, which may lead to tooth loss.
A recent study using a highly sensitive blood coagulation test called dielectric blood coagulometry (DBCM) found that non-Atrial Fibrillation patients with high CHADS2 scores exhibited hypercoagulability. DBCM detected small changes in blood coagulation, particularly in those at higher risk of stroke.
Researchers at Tokyo Medical and Dental University developed a novel DNA/RNA heteroduplex oligonucleotide (HDO) that significantly improves gene silencing and reduces liver dysfunction. The high potency of vitamin E-conjugated HDO results in improved delivery to the liver, leading to enhanced therapeutic effects.
A highly efficient CRISPR/Cas system has been developed for targeted long cassette insertion into the mouse genome, achieving efficiency of up to 50%. This breakthrough technology enables the creation of humanized mice for modeling genetic diseases and improving gene therapy safety.