A new study published in Obstetrics and Gynecology analyzed data from over 310,000 Japanese women to investigate age-related and seasonal variations in menstrual cycles and body temperatures. The researchers found that the average menstrual cycle length increased until age 23, decreased until age 45, and then increased again.
Researchers at Tokyo Medical and Dental University found that laser stimulation inhibits sclerostin expression in bone without causing inflammation, providing a new treatment possibility for osteoporosis. This method may aid the development of laser-based therapies to promote bone regeneration.
Researchers identify RTL1 gene as likely culprit behind temple and Kagami-Ogata syndromes, associated with muscle symptoms in models of both conditions. The study suggests that RTL1 plays a critical role in fetal muscle development and is essential for maintaining placental fetal capillaries.
Researchers discover that the proteins transforming growth factor-β (TGF-β) and tumor necrosis factor alpha (TNF-α) promote the development of cancer-associated fibroblasts, contributing to tumor progression. TGF-β induces endothelial-mesenchymal transition (EndMT), a process involving the conversion of endothelial cells to CAFs.
TMDU researchers have engineered a material that can identify and target cancer cells using an antibody-supermolecule conjugate, potentially overcoming drug resistance. The new approach showed enhanced autophagic cell death with lower concentrations of the treatment.
Researchers at Tokyo Medical and Dental University and Harvard Medical School found that controlling the nuclear localization of PD-L1 can enhance the efficacy of immunotherapy for cancer treatment. They discovered that removal of a specific modification allows PD-L1 to enter the nucleus and regulate the immune response.
A polygenic risk score has been developed to predict drug-induced liver injury, using genomic data and organoid models. The score can identify patients at risk of liver damage, allowing for safer medication choice and dosage.
A new study in mice suggests that a molecular transporter, GLT-1, may play a crucial role in determining susceptibility to migraines. The researchers found that mice lacking the GLT-1 transporter were more prone to cortical spreading depression, a condition related to migraines, and had increased levels of glutamate outside of neurons.
Scientists developed three-dimensional heart organoids resembling the developing heart using mouse embryonic stem cells and fibroblast growth factor 4 (FGF4). The organoids exhibit functional properties similar to their in vivo counterparts, offering a promising biomimetic model for studying heart development and testing novel drugs. T...
Researchers at Tokyo Medical and Dental University identified a critical role of interferon regulatory factor-2 (IRF2) in maintaining the stemness of intestinal stem cells. IRF2-deficient mice exhibited impaired regenerative responses, highlighting its importance in preserving intestinal stem cell function.
Researchers discovered Shigella's molecular strategy to disarm host cell protective mechanisms, including apoptosis and necroptosis. By blocking apoptosis with OspD3 and activating necroptosis with OspC1, Shigella ensures its survival and proliferation.
A new study from Tokyo Medical and Dental University identified CD86 as a novel cell surface marker that enables accurate analysis of hematopoietic responses to biological stress. The researchers found that CD86-based analysis can detect early activation phases of erythropoiesis in the bone marrow within hours after toxin injection.
Researchers found APRIL protein essential for plasmacyte development and immunoglobulin production in humans. A deficiency in APRIL leads to reduced plasmacyte numbers and increased susceptibility to infections.
Scientists from Tokyo Medical and Dental University discovered a key phosphorylation site on the protein Ulk1 that regulates alternative autophagy, a process by which cells recycle dysfunctional contents. The study found that this site is essential for the activation of alternative autophagy under genotoxic stress conditions.
A team at Tokyo Medical and Dental University demonstrates a new method to increase the lifetime of qubits, enabling faster cycle times and reduced noise. This could lead to practical quantum computing applications in fields like finance and chemistry.
Researchers developed an AI system that evaluates endoscopic mucosal findings in UC patients with accuracy equivalent to expert endoscopists. This may reduce the need for invasive procedures like biopsies, saving time and money for medical institutions.
A recent study published in Frontiers in Cellular and Infection Microbiology found that re-initiating oral food intake after enteral nutrition alters the composition of both oral and gut microbiota. This alteration was associated with improved balance and function in the microbiome, particularly in fatty acid metabolism.
Studies have shown that chronic kidney disease (CKD) patients are more susceptible to salt-induced hypertension. A recent study published in Kidney International found a link between the immune system and salt sensitivity in CKD, with TNF-α triggering high blood pressure.
Primate immunodeficiency viruses have evolved to neutralize the human defense system by inactivating BST-2. The researchers identified a specific amino acid sequence in Vpu protein that enables this adaptation, allowing the virus to survive in a hostile environment.
Cancer cells exploit a protein to break through tissue boundaries, increasing motility and invasiveness.
Researchers uncover that neuronal necrosis occurs earlier in Alzheimer's progression than thought and identifies YAP as a key regulator. Early intervention with YAP supplementation can prevent neuron loss, restore cognitive function, and reduce beta-amyloid plaques.
Researchers developed a novel gas imaging system to visualize and measure gases released through the skin in real-time. The system uses VOCs present in circulating blood to diagnose metabolic disorders, genetic diseases, and cancer.
A study found that a specific protein, ARID1A, is linked to aggressive cholangiocarcinoma (ICC) and poor patient outcomes. The researchers identified ARID1A as a potential biomarker for predicting ICC prognosis, which could lead to more effective treatments.
The researchers discovered a new method for synthesizing γ-aryl-β-ketoesters using aryne chemistry, which can improve the accessibility to these critical molecules. This approach may also aid in the preparation of diverse bioactive compounds for drug discovery.
A research team has created a better way to grow an organoid model of the liver, bile duct and pancreas using human pluripotent stem cells. The resulting organoid bears a striking resemblance to its corresponding organs and demonstrates the potential for personalized modeling in studying organ development and disease.
A team of researchers has developed a method to establish multicellular human liver organoids that show liver tissue characteristics down to the gene and protein scale. The livers were triggered with liver diseases, such as steatohepatitis, and showed increased levels of fibrosis indicators.
Researchers developed a new molecule, HDO-antimiR, that can silence malfunctioning miRNA with heightened efficacy and lowered toxicity. It has been shown to be 12 times more efficient in binding to targeted miRNA and producing enhanced phenotypic effects in mice.
A study by Tokyo Medical and Dental University found that mice eating harder foods showed increased bone formation and changes in jawbone shape. The researchers used a novel mouse model to investigate how masticatory force affects bone structure, revealing new insights into the mechanisms of bone adaptation.
Researchers at Tokyo Medical and Dental University use genome editing to create a human stem cell model of congenital hepatic fibrosis, uncovering molecular players that contribute to the illness. They identify IL-8 and CTGF as key genes involved in the disease's progression.
Researchers found a connection between estrogen and protein Sema3A in maintaining bone health. As women lose estrogen with age, Sema3A levels drop, leading to osteocytes dying and bones losing support structure.
Researchers found that adolescent adenoids and tonsils do not shrink significantly during teenage years, contradicting previous medical consensus. This challenges existing guidelines for respiratory complications like obstructive sleep apnea, potentially leading to changes in surgical procedures.
Research in zebrafish reveals that clock genes determine daily behavioral rhythms and activity levels. The study found that eliminating these genes reduces energy supply, leading to lower locomotion and more resting behavior.
A research team at Tokyo Medical and Dental University classified hepatocellular carcinoma into three distinct subgroups based on mutation patterns, gene expression, and immune system characterization. The findings suggest that each subgroup has a unique clinical profile, enabling targeted treatment approaches.
Researchers used mouse models to explain the developmental process behind COPD, finding that immune cells called basophils induce airway degeneration by triggering a cascade of immune responses. The study's findings may lead to therapies targeting basophils or related immune cells to slow down emphysema progression.
Researchers discover microRNAs miR-146a and miR-146b play crucial role in suppressing NF-κB activation, which leads to excessive cell cycle progression and rapid tumorigenesis. The study found differences in cancer outcomes depending on the absent microRNA, offering new insights into cancer development.
Researchers developed a new dielectric blood coagulometry (DBCM) method to assess Factor Xa (FXa) activity in patients treated with FXa inhibitors. The study showed that DBCM detected FXa inhibitor-specific changes in a manner similar to more complicated methods, offering a promising easy-to-use clinical treatment option.
A new study found that the mutated MLX gene impairs the immune system by promoting inflammasome activation, leading to chronic inflammation and arterial disease. The discovery provides potential treatments, such as tocilizumab, which has shown efficacy in other inflammatory diseases.
Chronic kidney disease (CKD) is characterized by progressive loss of kidney function, which can be attributed to faulty cellular energy sensing. Researchers have identified a link between decreased AMPK activity and CKD progression, highlighting a potential therapeutic target for treatment.
Researchers discovered small populations of T cells expressing functional SAP at normal levels in patients with XLP1, potentially modifying disease severity. This finding suggests gene therapy or adoptive cellular therapy could be effective treatments for the disease.
Researchers at Tokyo Medical and Dental University developed a method to increase lentiviral particle production, enabling safe and efficient gene introduction into cells. The discovery utilizes the SPSB1 protein to activate transcription factors, leading to up to 12-fold boosted virus production.
A Japanese team of researchers found that early changes to synapse gene regulation, including the phosphorylation of SRRM2 protein, can lead to Alzheimer's disease. This discovery offers new insights into the pathology of AD and may suggest possibilities for gene therapies using virus vectors.
Research found that STAT3 is constitutively activated in CAEBV-infected T- or NK-cells, promoting cell survival and inflammation. Ruxolitinib inhibition blocks survival and reduces pro-inflammatory cytokine production, suggesting a potential therapeutic target for this fatal disorder.
International researchers led by Tokyo Medical and Dental University investigated the RSRSP stretch of the regulatory protein RBM20, finding it essential for nuclear localization and splicing regulation. The study suggests that phosphorylation of specific serine residues in this region is crucial for RBM20's function.
A new vehicle peptide has been identified for delivering therapeutically effective peptides to cancer cells. The peptide, termed peptide 1, mimics the dimerization arm of the EGF receptor, which is involved in cellular signal transductions and cancer progression.
A Tokyo Medical and Dental University-led study found that a protein signaling pathway enhances expression of genes encoding inflammatory mediators in macrophages, contributing to colonic inflammation. The research may lead to novel targets for IBD therapy.
Researchers discover microRNA molecule miR-940 that alters bone structure in late-stage prostate cancer. The molecule promotes osteoblastic lesions, which can cause severe pain and structural weakness.
A study published in Circulation Journal identified four microRNA molecules in the bloodstream that could predict the onset of atrial fibrillation. The researchers found that these microRNAs were significantly upregulated in the serum of patients with AF and diseased mice, suggesting their potential use as biomarkers for disease.
Research by Tokyo Medical and Dental University reveals that early-life Fgf21 gene demethylation reduces diet-induced obesity in adulthood. The study, published in Nature Communications, demonstrates the persistence of this epigenetic change into adulthood and its potential role in metabolic disease prevention.
Researchers at Tokyo Medical and Dental University develop a new system to visualize ubiquitin assembly in real time, revealing new insights into the molecular details of autophagy. The technique allows for the study of previously unexplored residues involved in forming ubiquitin chains.
Researchers have uncovered key events in familial frontotemporal lobar degeneration (FTLD) linked to PGRN gene mutations. They discovered that tau phosphorylation drives synapse loss and communication disruption, providing a new avenue for treatment targeting tau phosphorylation.