A new study aims to increase follow-up care for patients who receive abnormal stool-based fecal immunochemical tests, focusing on improving coordination between primary and specialty clinics. The goal is to improve colorectal cancer screening processes in underserved populations, increasing survival and reducing mortality.
The new framework, called SLIViT, has been developed by UCLA researchers and achieved accurate disease risk biomarkers detection from medical scans. It consistently achieves better performance compared to domain-specific state-of-the-art models.
Researchers found that heart transplant recipients from most deprived areas had a higher risk of dying within five years and experiencing organ failure compared to those from less deprived areas. Treatment at high-quality hospitals did not translate into better outcomes.
UCLA investigators presented data on chemoradiotherapy in rectal cancer, MRI-guided radiotherapy for prostate cancer, and symptom self-reporting during treatment. Researchers developed a predictive model to identify patients most likely to respond to chemoradiotherapy in rectal cancer.
A new study has found that baseline testosterone, age, and duration of ADT are key predictors of testosterone recovery. The researchers developed a nomogram to estimate recovery times based on patient-specific characteristics, providing valuable insights for improving patient outcomes.
A landmark study found specific types of brain cells fired in a way that mirrored the order and structure of a person's experience. The brain retains these unique firing patterns after the experience is concluded and can rapidly replay them while at rest.
Dr. Roger Lo has been awarded a $2 million NIH grant to investigate ways to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors. The team aims to target genetic instability and immune evasion to stabilize the melanoma genome and make it more vulnerable to immune attacks.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center developed a biobank of 294 samples from 126 patients with 25 different subtypes of bone and soft tissue sarcoma. The team created tumor organoids that retained key characteristics of the original tumors, which were then subjected to high-throughput drug screening. They iden...
A new study found that childhood trauma can have specific consequences for biological health and risk of developing 20 major diseases later in life. The study's findings differ by sex and type of stressor, highlighting the need for a precision medicine approach based on patients' sex and specific stress profile.
A UCLA-led research team has identified degeneration-associated molecular markers shared by several forms of dementia. The study also found cell type-specific changes that underlie each condition, highlighting potential new therapeutic targets.
A study by Min Deng and colleagues at UCLA identified two key dysregulated pathways in acne-affected skin: the GRN-SORT1 axis in TREM2 macrophages and the IL-13-IL-13RA1 axis in keratinocytes. These findings suggest modulating these pathways through gene therapy could lead to new acne treatments.
A new UCLA-led study found that Chinese American immigrants' cardiovascular health increases with length of residence and varies by US location. Participants who resided in Chicago showed lower mortality levels from heart disease compared to those in Los Angeles.
A UCLA-led study has identified a protective role for the asporin protein in pulmonary arterial hypertension (PAH), suggesting potential new ways to treat this incurable disease. Asporin was found to inhibit pulmonary artery smooth muscle cell proliferation and a key signaling pathway that occurs with PAH.
A new study by UCLA investigators found that Manuka honey contains compounds that can help reduce tumor growth in preclinical models. The research suggests that Manuka honey could potentially be developed into a natural supplement or standalone treatment for ER-positive breast cancer, which accounts for most breast cancer cases.
A UCLA researcher identified a compound that effectively jumpstarts the brain's memory circuitry, restoring cognitive functions in mice with Alzheimer's disease symptoms. The molecule, DDL-920, works by targeting specific neurons to enhance gamma oscillations, which are critical for memory and cognition.
Researchers at UCLA Health found that reducing inflammation may not influence the extent of liver fibrosis in MAFLD. The study suggests that other pathways could be more effective in targeting fibrosis and improving outcomes for patients.
Researchers at UCLA Health Sciences identified three distinct patient preference-based profiles among men with low-risk prostate cancer. Despite differences in preferences, physician recommendations played a crucial role in determining treatment choices. The study highlights the need for better integrating patient preferences into trea...
A recent paper surveys advances in diabetes pathogenesis and treatment, highlighting the role of genes, environmental factors, and social determinants. The study suggests that understanding these dynamics is key to developing targeted interventions to reduce diabetes risk and manage its complications.
A new study led by UCLA found a 3% to 4% prevalence of ME/CFS-like illness among participants who tested positive for SARS-CoV-2 infection, similar to those who tested negative. The research suggests COVID-19 may not be the primary cause of ME/CFS.
Researchers found specific gene variants associated with behavioral health outcomes after a stroke. The study suggests that genetic differences may predict stroke recovery trajectory, enabling personalized medicine approaches for individualized treatment.
A new study identifies the potential of specific microRNAs within extracellular vesicles as a noninvasive biomarker for predicting preeclampsia. Researchers found that women with pre-eclampsia had distinct miRNA patterns in their blood, which could help detect the condition early on.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center discovered that the protein IRF1 can both hinder and help the body's immune response to tumors, depending on which cells it is found in. The study suggests that targeting IRF1 could enhance cancer treatment effectiveness by boosting natural antitumor immunity.
A UCLA-led team created a machine-learning model that can accurately predict short-term CRRT survival, providing a data-driven tool for clinical decision-making. The study aims to improve patient outcomes and resource use by serving as a basis for future clinical trials.
A new study by UCLA Health reveals racial disparities in Huntington's disease diagnoses, with Black patients receiving diagnoses one year later than White patients. The study analyzed nearly 5,000 patient data points and found that these disparities may exacerbate underrepresentation of minority groups in clinical trials.
A UCLA Health study discovered that suvorexant, an insomnia medication, blocks brain receptors for hypocretin and prevents opioid addiction in mice. The drug maintains behavioral alertness at lower doses than those inducing sleep. Further studies are needed to determine its effectiveness in humans with opioid use disorder.
Dr. Sanaz Memarzadeh and her team aim to improve treatment outcomes for patients with platinum-resistant ovarian cancer using adoptive T-cell therapy and natural killer cells. They hope to identify new targets and biomarkers for effective treatments.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have received a $1.8 million grant to advance personalized cancer therapy for prostate cancer patients. They aim to predict and prevent long-term side effects from radiation treatment, improving quality of life for men diagnosed with the disease.
Research by UCLA Health confirms that Tai Chi reduces inflammation and improves anti-viral defenses in breast cancer survivors, while cognitive behavioral therapy shows greater increases in anti-viral gene transcripts. The study found significant reductions in inflammatory biomarkers among Tai Chi participants.
A new UCLA Health study found that resilient individuals have neural activity in brain regions associated with emotional regulation and better cognition. They also exhibited a healthy gut microbiome with reduced inflammation and improved gut barrier function.
A study led by UCLA Health found that emotional awareness and expression therapy (EAET) significantly reduces chronic pain among older adults compared to cognitive behavioral therapy. EAET helps patients confront and release traumatic emotions, leading to a clinically significant reduction in pain symptoms.
A new AI model has been shown to significantly improve the accuracy of diagnosing prostate cancer by 45 times compared to doctors' measurements alone. The system assists in mapping out the boundaries of cancerous tissue, reducing the risk of underestimation and enabling more precise treatment planning and effective surgical procedures.
A new study by a global consortium provides insight into how tumors evolve, shedding light on the intricate processes underlying cancer evolution. The findings define optimal algorithms to analyze tumor evolution, enhancing diagnostic accuracy and treatment planning.
A clinical trial shows that a combination of injectable naltrexone and extended-release oral bupropion reduces methamphetamine use for up to 12 weeks. The study found a significant increase in methamphetamine-negative urine tests among participants receiving the two-drug therapy.
Researchers tracked mpox cases in a surveillance network of 13 emergency departments, finding three new cases among gay and bisexual men who have sex with men. The study highlights the need for vigilance and vaccination to prevent further transmission.
A study by UCLA researchers found that one in six primary care patients reported cannabis use, with most using it for symptom management despite identifying as recreational users. The study suggests the need for routine cannabis screening in healthcare settings.
Researchers at UCLA have identified a key protein MYCT1 that enables blood stem cells to sense and interpret signals from their environment. The study's findings could lead to the development of methods to expand blood stem cells in a lab dish, making life-saving transplants more available.
A genomic study of over 5,000 veterans with advanced prostate cancer reveals significant differences in frequencies of alterations associated with race and ethnicity. Alterations in immunotherapy targets were more common in Black veterans, potentially leading to opportunities for precision-based therapy.
A study by UCLA Health Jonsson Comprehensive Cancer Center researchers found that combining experimental immunotherapy drugs with chemotherapy significantly improves progression-free survival and overall survival for patients with metastatic colorectal cancer. The median progression-free survival was 6.2 months compared to 2.1 months f...
A recent study has cataloged gene-isoform variation in the developing human brain, providing crucial insights into neurodevelopmental and psychiatric disorders. The research found thousands of isoform switches that occur during brain development, implicating previously uncharacterized RNA-binding proteins.
A UCLA Health study has unveiled the link between genetic risk of autism and observed cellular activity in the brain. Researchers analyzed post-mortem brain tissue from 66 individuals, including those with autism spectrum disorder, to identify changes in cortical cell types and transcription factor networks.
A study found distinct brain connectivity patterns in six-week-old infants at risk for developing autism spectrum disorder. These early differences predict behavior and may lead to ASD-related behaviors by altering social development.
Researchers found that repetitive practice leads to changes in working memory circuits, making them more stable and refined. The study's findings have implications for addressing memory-related disorders.
A UCLA-led study reveals that chemotherapy for early-stage breast cancer in women over 65 can lead to a significant decline in physical function. The study found that 30% of older women who received chemotherapy experienced a substantial decline, with climbing stairs and walking being the most affected activities.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have found a combination immunotherapy treatment that enhances the immune response for people with malignant gliomas. Adding an immune-boosting agent, poly-ICLC, to a personalized dendritic cell vaccine improves the immune response and activity of T cells in patients.
Researchers at UCLA Health discovered a novel, energy-efficient mechanism of working memory that reduces metabolic cost even during sleep. The discovery is published in Nature Communications and may provide an early diagnostic for Alzheimer's disease and related dementia.
Research suggests that four proposed AI search engines for automating search and retrieval of digital histopathology slides have inadequate performance for routine clinical care. The algorithms showed less than 50% accuracy in some cases, highlighting the need for rigorous external validations and standardization before clinical adoption.
A machine learning tool called PheNet can identify patients with rare, undiagnosed diseases years earlier, improving outcomes and reducing cost and morbidity. By analyzing patterns in electronic health records, the tool ranks patients by likelihood of having a disorder like common variable immunodeficiency.
Researchers at UCLA Health have developed a potential biomarker for stroke risk using a network of inflammatory molecules in the blood. The study, published in the journal Stroke, found that patients with higher concentrations of these molecules had an 84% chance of experiencing a stroke during their lifetime.
The US Preventive Services Task Force recommends biennial breast cancer screenings starting at age 40 for all women, aiming to enhance early detection and tackle disparities. However, challenges remain in ensuring equitable access to screening technologies and addressing gaps in evidence regarding AI-powered image interpretation.
A new UCLA Health study found that undocumented Latinx patients who sought care in emergency rooms during the pandemic received the COVID-19 vaccine at the same rate as U.S. citizens. The group had higher rates of prior COVID-19 infection compared to other groups.