Researchers at UC San Diego School of Medicine found that BPA's metabolite MBP interacts more strongly with estrogen receptors than BPA itself, posing a greater health threat. This discovery could lead to the development of new drugs targeting excessive estrogen activity linked to diseases.
Researchers at UC San Diego have developed advanced estimation algorithms that enable lithium-ion batteries to charge twice as fast and reduce energy consumption by 25%. The new technology allows for more efficient battery management, reducing costs and improving overall performance.
Researchers discovered microbial-dependent mechanisms that fuel cancer growth, exploiting immune cells and disrupting tissue homeostasis. Inhibiting inflammation may reduce cancer risk by up to 45%.
A recent study reveals a common RNA pathway that contributes to the degeneration of motor neurons in both ALS and dementia. The discovery provides a potential target for developing new treatments and offers insights into the normal function of key proteins involved in these diseases.
The UCSD-based Chronic Lymphocytic Leukemia Research Consortium will continue its critical work on understanding CLL's development and progression. The five-year grant will enable researchers to develop new drugs and treatments for the disease, which affects over 15,000 people annually in the US.
Researchers at UC San Diego School of Medicine found that single-site laparoscopic surgery reduced pain and narcotic use in kidney cancer patients. The study compared LESS with traditional multiport laparoscopy in 74 patients, showing a 40% reduction in pain rating and 50% less medication need.
Researchers have upended assumptions on how high cholesterol leads to inflammation and atherosclerosis. Desmosterol, a precursor to cholesterol, has been found to suppress inflammatory response genes and regulate cholesterol balance.
Researchers will investigate how cybercriminals make money, interact with victims and defenders, and establish relationships among thieves. The project aims to identify opportunities for interventions and defenses against cybercrime by understanding the human factor in security.
Bioengineers from UC San Diego are playing a key role in the NIH's new metabolomics program, which aims to accelerate diagnosis and disease treatment. The project will analyze millions of microorganisms living within the human body, providing insights into their role in health and disease.
A UC San Diego study has identified a human gene called Human Schlafen 11 that produces a protein blocking the replication of HIV in infected cells. The research may lead to diagnostic tests and therapeutic drugs to prevent AIDS progression.
Researchers have developed a degradable polymer nanoparticle that detects biologically relevant concentrations of hydrogen peroxide, allowing for the non-invasive detection of inflammation. This method enables targeted drug delivery to diseased tissue, holding promise for treating cardiovascular diseases such as atherosclerosis.
Researchers have developed a novel method to attach chemical probes to proteins, allowing them to study the biochemistry of naturally formed proteins. The technique enables scientists to understand the mechanisms behind creating better antibiotics, anti-cancer drugs, biofuels, and other natural products.
Researchers create dynamic optical projection stereolithography (DOPsL) to print microscale 3D structures in seconds, enabling better cell growth and studying, as well as regenerative medicine applications.
Neural stem cells successfully regenerates axons across the site of complete spinal transaction, leading to functional recovery in rats. The study also showed that adult cells can regenerate into neural stem cells, establishing a new relay circuit that can be measured electrically.
A study by UC San Diego researchers found that Facebook's 'get out the vote' message boosted voter turnout by an estimated 340,000 votes in 2010. The study showed that social influence and peer pressure played a crucial role in encouraging people to participate in elections.
The San Diego Supercomputer Center (SDSC) has been awarded a $810,000 grant to develop a cyberinfrastructure for rapidly sharing and streaming scientific visualizations. The project aims to provide an essential component in computational research and the current high-performance computing infrastructure.
Researchers identified a genetic mutation that speeds up metabolism of certain amino acids, leading to epilepsy and neurobehavioral symptoms in patients with autism. Nutritional supplementation with branched chain amino acids reversed symptoms in mice and showed potential for human treatment.
Six UC San Diego researchers received over $7 million in CIRM funding to study human embryonic stem cells, induced pluripotent stem cells, and hematopoietic stem cells. Their work aims to develop unlimited sources of transplantable beta-cells for diabetes patients and promote immunological tolerance to hESC-derived tissues.
A study by UC San Diego researchers identified LIN28 protein binding sites in 25% of human transcripts, causing widespread alternative splicing changes that can result in cancer or other diseases. The discovery suggests that LIN28 itself should be a therapeutic target for diseases.
A new study by bioengineers at the University of California, San Diego, challenges the long-held paradigm that enzymes are highly efficient and specific in catalyzing chemical reactions. The researchers found that at least 37 percent of E. coli's enzymes catalyze multiple metabolic reactions in actively growing cells.
A new study by Scripps researchers suggests that California heatwaves are changing due to global warming, with more humid and intense heatwaves emerging in coastal areas. The increasing trend has significant implications for the state's population living near the ocean, who may not be prepared for extreme heat despite being accustomed ...
Scientists at Scripps Institution of Oceanography discovered how fault zones weaken in select locations after an earthquake tipping point, creating 'melt welts'. These regions can lead to runaway slip and massive earthquakes. The study addresses the 'low heat flow paradox' and may improve earthquake prediction models.
A study published in PLoS ONE found that statin potency is a critical determinant of muscle-related side effects. Stronger statins like rosuvastatin were associated with higher rates of reported problems, highlighting the need for greater caution when prescribing these medications.
Astronomers have discovered galactic winds measuring up to 2,500 km/s, driven by intense bursts of star formation, potentially shutting down galaxy star formation. Young, compact galaxies with high-velocity winds are rare and may be part of a common phase in galaxy evolution.
Research models stellar explosions revealing neutrinos' previously unrecognized impact on supernovae's core and outer envelope. The study shows that neutrino interactions with halo neutrinos significantly alter the explosion's physics, changing element formation.
A team of researchers at UC San Diego developed a multi-dimensional set of brain measurements that can accurately assess a child's age. The study, published in Current Biology, shows that the 'developmental clock' within the brain captures age differences well regardless of individual variability.
Researchers found that immunologically active components called human milk oligosaccharides (HMO) may protect infants from HIV transmission. HMO act as prebiotics, inhibit pathogens from binding, and exhibit anti-inflammatory activity.
A phase 2 clinical trial has identified a potential new class of drug that achieves clinical response and remission in certain patients with moderate-to-severe ulcerative colitis. The study, conducted at the University of California San Diego, shows oral treatment with Tofacitinib to be effective.
Scientists have developed fluorescent probes that change color depending on the type of amyloid they encounter, offering hope for differentiating between related brain disorders. The technology has been licensed for commercial development of diagnostic tests.
Researchers develop SPAdes, a new algorithm to sequence genomes from single cells, enabling analysis of 'dark matter' bacteria and human pathogens. The breakthrough could lead to early detection of cancer progression by monitoring normal cells before they turn malignant.
The project aims to make neuroscience-specific compute and software tools conveniently available to students and investigators. The NSG portal will offer a streamlined process for uploading models, retrieving and storing data, and specifying parameters for running high-performance computing-based neuronal simulations.
A study published in Hepatology reports a promising new therapy for liver fibrosis, a scarring process associated with chronic liver disease that can lead to organ failure. The NADPH oxidase inhibitor GKT137831 was found to suppress fibrotic gene expression and prevent further fibrosis in mouse models.
Researchers at UC San Diego developed a method to model an organism's metabolism and gene expression simultaneously. The technology enables detailed calculations of the total cost of synthesizing chemicals, including biofuels, by accounting for material and energy requirements.
Researchers found that neutrophil elastase impairs insulin signaling and boosts resistance. Deletion of NE in obese mice improved insulin sensitivity. Neutrophils may hold the key to developing treatments for insulin resistance and diabetes.
Researchers found that younger elderly (60s-70s) show faster rates of brain tissue loss and cognitive decline than older AD patients. This discovery has profound implications for diagnosing AD and finding new treatments.
A multi-center study found that patients who undergo complete kidney removal are 3.5 times more likely to develop erectile dysfunction compared to those with kidney reconstruction. Researchers suggest that total kidney removal may also increase the risk of metabolic diseases and decrease quality of life.
Researchers identified 38 prognostic subnetworks of interacting genes that predict cancer progression in chronic lymphocytic leukemia. The study helps define how CLL evolves over time, becoming more aggressive and deadly.
Researchers at UC San Diego identified a key enzyme in malaria parasites that could lead to new anti-malarial drugs. The team discovered a selective inhibitor, ML276, which stops parasite growth even in resistant strains.
Researchers have developed a new technique to detect and target tiny electrical disturbances in the heart, resulting in an 86% success rate in treating atrial fibrillation. The CONFIRM trial found that this approach significantly improved outcomes compared to conventional catheter procedures.
Researchers have found that alpha-synuclein protein build-up inside neurons leads to misfiring due to calcium fluxes, a new insight into Parkinson's disease and other neurodegenerative disorders.
Researchers at UC San Diego have discovered a chemical called KL001 that affects the activity of cryptochrome, a key protein regulating our circadian rhythm. This finding offers a promising direction for developing new treatments for type 2 diabetes.
Researchers at the University of California, San Diego School of Medicine have identified laboratory-based biomarkers that can help understand brain-based abnormalities in schizophrenia. These endophenotypes could provide clinicians with reliable indicators of brain dysfunction, even when overt symptoms are not apparent.
Researchers at the University of California, San Diego have identified two key regulatory proteins critical to clearing away misfolded proteins that accumulate and cause neurodegeneration in Huntington's disease. PGC-1alpha and TFEB provide a new therapeutic target for treating the disease, offering hope for its treatment.
A new study reveals how sunburn occurs when UV radiation damages RNA in skin cells, triggering an inflammatory response that can lead to healing and potentially even cancer. The discovery may lead to the development of treatments that block this process without exposing patients to harmful UV light.
Scientists have identified proteins as the key to maintaining self-renewal in human epidermal progenitor cells and stem cells. The discovery highlights the importance of exosomes in regulating transcription factors, enabling cells to produce new skin cells throughout life.
The CIPRES Science Gateway is helping researchers unravel the enigmas of phylogenetics by making it possible to compare similarities and differences in DNA among large numbers of species. Phylogenetic studies are essential for understanding the history of life on earth, population changes, and evolutionary theories.
Research found epigenetic changes, specifically DNA methylation, alter genes contributing to rheumatoid arthritis (RA) inflammation and joint damage. RA fibroblast-like synoviocytes display a unique DNA methylome signature compared to normal FLS.
A study by University of California - San Diego researchers blocks the NOTCH1 signaling pathway in cancer cells, reducing their ability to replicate and self-renew. The findings suggest that therapies targeting this pathway could be effective in treating various types of cancer stem cells.
Researchers at UC San Diego mapped nearly 300,000 mouse cis-regulatory elements, annotating 11% of the mouse genome and identifying conserved non-coding sequences shared with humans. The study provides insights into the functional organization of genes and their regulation in different tissues and cell types.
Researchers identified de novo somatic mutations in three genes associated with hemimegalencephaly, a rare childhood disease. These findings suggest potential treatments targeting the known gene mutations could reduce or prevent radical surgery.