A recent pathology study suggests that mifepristone could be a therapeutic option for women with severe uterine fibroid symptoms. The research confirms that the drug does not trigger cancerous lesions in the uterus, but rather causes benign changes such as fluid-filled glands and abnormal blood vessels.
A study found that women who have experienced pregnancy loss may continue to suffer from depression and anxiety, even after having a healthy baby. The study suggests that previous pregnancy loss should be taken into account when assessing the risk of antenatal or postnatal depression.
Researchers propose collaborative clinical trials to revitalize the US research engine, cutting time and costs while increasing approved treatments. The approach involves companies sharing costs to test new therapies or devices, promising safer and more effective treatments sooner.
Researchers have discovered that specific human astrocytes derived from stem cells can repair damaged nervous systems and promote locomotor function in spinal cord injured rats. The study reveals the importance of creating beneficial cell types through tissue culture before transplantation, providing a potential new avenue for treating...
A study published in Circulation found that patients with mild heart failure and left bundle branch block significantly benefit from CRT-D therapy, experiencing a 53% reduced risk of heart failure events. The therapy also effectively prevents cardiac remodeling and ventricular tachyarrhythmias.
A study published in the Annals of Surgery found that high-quality trauma hospitals have significantly lower death rates and spending compared to average-quality hospitals. The research suggests that achieving better quality may be less expensive in the long run, with fewer patient complications translating into cost savings.
Inducing labor without medical reason increases cesarean rates, blood loss, and hospital stays, but doesn't benefit newborns. Women who had first child found to be more susceptible to complications.
A new study suggests that severely obese women may not need to gain as much weight during pregnancy as current guidelines recommend, without undesirable outcomes. In contrast, obese and non-obese women who gained less weight suffered adverse outcomes, including a higher likelihood of delivering a small-for-gestational-age baby.
Researchers have discovered a new way to combat methicillin-resistant Staphylococcus aureus (MRSA) by targeting the bacteria's RNA degradation process. The approach, which uses an inhibitor called RNPA1000, shows promise against MRSA biofilms and other antibiotic-resistant strains.
Researchers have identified a new way genes are regulated that is unique to primates, involving Alu elements and long noncoding RNAs. This mechanism could prove to be a valuable treatment target as researchers seek to manipulate gene expression to improve human health.
A new study found that cardiac resynchronization therapy with defibrillator (CRT-D) is significantly more beneficial for women than men in preventing heart disease. Women experienced a 70% reduction in heart failure and a 72% reduction in death, compared to 35% and 45%, respectively.
Researchers discovered that breast cancer cells release heat shock protein 27 (Hsp27), which renders immune cells unresponsive and fuels tumor growth. This finding provides a new treatment target in the fight against breast cancer.
Researchers found that African Americans have a lower mortality rate after being hospitalized for acute ischemic stroke compared to whites. They were also more likely to receive aggressive treatment measures during their hospitalization.
Researchers have created a novel crystal lattice composed of gold nanoparticles and viral particles held together by strands of DNA. The structure demonstrates the potential to combine materials with different properties to create infinitesimal devices.
Hospitals with designated stroke centers in New York State have a significantly higher survival rate for patients with ischemic stroke, with a 15-20% increased likelihood of survival. Patients treated at these centers are also more likely to receive acute stroke therapy.
Scientists have discovered that HIV uses the molecule rNTP to replicate inside macrophages, allowing it to evade the immune system. By targeting this molecule, researchers may be able to develop new drugs to stop the virus in its hiding spot within the human immune system.
A University of Rochester Medical Center team has discovered an antibody that stops MRSA bacteria from growing, potentially leading to a vaccine. The researchers found that the antibody targets the glucosaminidase protein, breaking the bacteria's armor and preventing replication.
Scientists have pinpointed the type of cell responsible for brain tumors known as oligodendrogliomas, a category of malignant brain tumors. The tumor originates in and spreads through glial progenitor cells, which are often referred to as 'daughter' cells of stem cells.
Patients transported by helicopter from accident scenes are more likely to survive than those brought to trauma centers by ground ambulance. Despite being more severely injured, they require less hospital resource utilization and ultimately fare better than those transported by ground.
A new study published in the Journal of Allergy and Clinical Immunology found that both the stratum corneum and tight junctions play a crucial role in eczema development. Tightening both leaky barriers may be an effective treatment approach, targeting the faulty tight junction protein claudin-1.
A long-term study found that children exposed to head and neck radiation have a lifelong increased risk of developing thyroid cancer. The study, published in Radiation Research, indicates that even low doses of radiation can increase the risk, and that this risk continues for at least 57 years.
Children living in apartments are at higher risk of tobacco smoke exposure due to shared ventilation systems or wall contamination. The study found that over 84% of children in multi-unit housing had been exposed to tobacco smoke, compared to 70% in detached houses.
A new study published in the Annals of Surgery found that laparoscopic appendectomies may carry a higher risk of deep abdominal infections in certain patients, including those with diabetes, smoking history, and older age. The study suggests that open surgery may be a better option for these high-risk patients.
Researchers at the University of Rochester Medical Center have created a way to isolate pure preparations of neural stem cells directly from human brain tissue. This breakthrough technique saves months of time and labor in the laboratory, allowing scientists to study stem cells in unprecedented detail. The findings suggest that human n...
Research from the University of Rochester Medical Center reveals that gaps in seasonal influenza vaccination rates between elderly whites, African-Americans, and Hispanics widen when vaccine supply is delayed or decreased. The study found significant declines in vaccination rates among minority groups during years with shortages.
Scientists have developed a novel flu vaccine using bacteria, which triggers an immune response without the need for eggs. The study, led by John Treanor, showed that the experimental vaccine worked well in people, with about half of participants responding strongly to just one microgram of the vaccine.
The Cone Beam Computed Tomography (CBCT) scanner provides high-quality images without compressing the breast tissue, making it a promising supporting role to conventional mammography. Preliminary research shows that breast coverage and radiation dose are comparable to mammography.
A study published in the Journal of the National Cancer Institute found that celecoxib, a widely used arthritis drug, significantly reduces non-melanoma skin cancers. The medication achieved a 68% reduction in basal cell carcinomas and a 58% reduction in squamous cell carcinomas among high-risk patients.
Children with autism improved their creative skills by building Lego structures in new ways, learning to use creativity in everyday life. Researchers used Applied Behavior Analysis and positive reinforcement to teach the children, who were able to apply their new skills to different situations.
A recent study found that prescription rates for controlled medications nearly doubled among young adults and adolescents over the past 14 years. This increase was observed across multiple settings and demographics. Researchers attribute the trend to evolving pain management policies and increased awareness of mental health issues.
Researchers found that compounds in cranberry disrupt enzymes used by bacteria to form plaque, reducing acid production and cavities. Additionally, polyphenols from red wine waste inhibit S. mutans' activity and reduce acid production.
Researchers found that moderate alcohol consumption inhibits notch, preventing buildup of smooth muscle cells in blood vessels and contributing to narrowed arteries. This discovery could lead to the development of a new treatment for heart disease.
Reduced pericyte levels have been found to disrupt blood flow and worsen the breakdown of the blood-brain barrier, allowing toxic substances to reach brain tissue. This can lead to structural damage to neurons, impaired learning and memory, and increased risk of neurodegenerative diseases like Alzheimer's.
A novel program in Livingston County, NY, uses EMS technicians to identify and address unmet needs of elderly residents, resulting in high patient satisfaction rates. The program's success highlights the potential of innovative collaboration between healthcare providers and social services to improve quality of life for seniors.
Researchers at the University of Rochester Medical Center are using mathematical modeling to study potentially deadly flu viruses and develop new vaccines and therapies. The five-year contract aims to enhance human immune responses and identify areas for investigation into treatments for lethal viruses.
A new study by University of Rochester Medical Center found that children with high blood pressure are four times more likely to have cognitive problems. Among the study's 201 patients, 101 had hypertension and 18% had learning disabilities, compared to 9% among those without hypertension.
Microglia, immune cells long thought to be dormant, are found to constantly interact with synapses, creating and eliminating them. This discovery challenges current views of the brain and its functions.
The University of Rochester Medical Center has been awarded a $1 million contract to launch an initiative that aims to accelerate the identification of improved pain treatments. The partnership, known as Analgesic Clinical Trial Innovations, Opportunities, and Networks (ACTION), will analyze clinical trials to identify problems in tria...
A new study published in Pediatrics suggests that increasing Medicaid reimbursement for administering influenza shots may boost vaccination rates among poor children. The research analyzed state-by-state data and found a strong correlation between flu vaccination rates and Medicaid reimbursement rates.
A study of postmenopausal women found that engaging in a healthy lifestyle reduces breast cancer risk for those with and without a family history. Women who adhered to regular physical activity, maintained a healthy weight, and drank less alcohol had lower rates of invasive breast cancer.
A nationwide clinical trial is underway to test the effectiveness of ranolazine in treating ventricular arrhythmias. The study aims to determine if ranolazine decreases death and cardiac arrhythmias, as well as hospitalizations from cardiac causes.
Research published in International Psychogeriatrics found that friends and family members of highly outgoing individuals may miss signs of depression due to inconsistent expectations. Understanding these personality dynamics is crucial for accurate diagnoses and treatment monitoring.
Scientists have created a substance that targets amyloid structures in semen and weakens HIV's ability to infect the body's immune cells. The experimental compound makes it harder for HIV particles to stick to human immune cells, offering a new lead in developing a microbicide to prevent HIV transmission.
Researchers at the University of Rochester Medical Center have identified a potential molecular mechanism to prevent cardiac hypertrophy, the precursor to heart failure. The study reveals that inhibiting histone deacetylase 5 and activating the PKA enzyme can stop unwanted enlargement of the heart.
Researchers have identified Gαq as a key protein that determines the fate of damaging cells, leading to autoimmune disorders like arthritis. The discovery offers new hope for treatments and personalized therapy for patients.
A unique suicide prevention program called Sources of Strength will be tested in 36 high schools across New York and North Dakota. The program aims to train influential teen peer leaders to change coping practices in their friendship networks.
The study aims to determine the best balance between effective treatment and side effects for children with Duchenne muscular dystrophy. The researchers will assess the breathing capacity, satisfaction levels, and muscle function of patients, using three steroid treatments: prednisone, deflazacort, and a combination of both.
Researchers discover that deleted versions of the DUX4 gene trigger its overexpression in FSHD patients, leading to disease progression. The finding provides a crucial step in understanding the disease and offers a potential therapeutic target for treatment.
Researchers found that sulfasalazine enhances the body's ability to clear fungal debris from the lungs, reducing inflammation and promoting better lung function. The study offers a new avenue for research on Pneumocystis pneumonia and may lead to improved treatment options for patients with weakened immune systems.
A University of Rochester scientist has discovered a new approach to boosting the body's response to vaccinations using insulin-sensitizing drugs. This breakthrough could lead to improved vaccine efficacy for individuals with weakened immune systems, such as infants and elderly people.