Researchers created a new strain of mice with outstanding hearing as they age, studying the phenomenon known as golden ears. The study offers clues about maintaining good hearing while aging and provides a new tool to explore protective factors that allow some organisms to retain their hearing for their whole lives.
A study found that computerized alerts can reduce the prescription of heavily marketed sleep medications by 23.3% compared to generic equivalents. The alerts provided additional information on co-payments and patient education, leading to a change in clinician behavior.
Researchers found that Bortezomib shuts down cellular machines that destroy Runx2, a protein complex that blocks the growth of bone cancer cells. The study suggests that Bortezomib may represent a new treatment option for osteosarcoma, a devastating disease that responds poorly to current chemotherapies.
Experts are conducting a large-scale study to measure the hearing of people with HIV/AIDS and compare it to those without, aiming to uncover the relationship between the disease and hearing loss. The research, supported by a $1.9 million grant, will also explore potential factors contributing to age-related hearing loss in these patients.
Research from the University of Rochester Medical Center found that using common pain killers like Advil and Tylenol at the time of flu injection can blunt the vaccine's effect. The study suggests that timing and dosage of pain relievers also play a role in reducing antibody production, which is necessary for immune protection.
Scientists have discovered a compound that dramatically slows the progression of amyotrophic lateral sclerosis (ALS) in mice by extending their lifespan by 25 percent and reducing muscle wasting. The enzyme APC has been shown to protect neurons from cell death caused by SOD1 mutations, which are linked to most sporadic cases of ALS.
A study by University of Rochester Medical Center evaluates the cost effectiveness of an experimental blood pressure device called Rheos. The research suggests that Rheos can be a cost-effective treatment for individuals with drug-resistant hypertension, especially those with extremely high blood pressure or diabetes.
Scientists found that Parkinson's disease progresses more slowly in participants with the highest levels of urate. This discovery supports the idea that patients and doctors may be able to better predict the course of the illness.
A study of 166 breast cancer patients found nearly 70% had low vitamin D levels, increasing fracture risk. High-dose supplements improved levels and boosted bone mass, helping mitigate disease symptoms.
A new research center exploring deep brain stimulation for OCD has been established at the University of Rochester Medical Center, thanks to a $10.5 million award from the National Institute of Mental Health. The center will link over 50 researchers studying how DBS affects people with OCD.
A recent study found that young adults are less likely to use ambulatory or preventive care, even though their mortality rate is more than twice that of adolescents. Young adults, especially black and Hispanic males, underuse ambulatory medical care and infrequently receive preventive care.
A study published in Circulation Research suggests that compounds related to Viagra can counter heart failure by reducing abnormal cardiac growth. PDE1 inhibitors show promise as a new drug target, potentially combined with Viagra or beta blockers for enhanced efficacy.
Training in mindfulness meditation and communication can alleviate physician burnout, improve patient-centered care, and enhance a doctor's capacity to relate to patients. The program combines techniques of meditation, narrative medicine, and appreciative dialogues to promote a more open and nonjudgmental outlook.
Scientists have discovered a potential therapeutic strategy for reversing rheumatoid arthritis and osteoporosis by manipulating the levels of NF-κB p100, a key inhibitory protein. The study found that increasing NF-κB p100 levels can limit bone destruction and inflammation in both diseases.
Researchers have discovered an experimental compound that selectively kills cancerous B lymphocytes while allowing normal B cells to survive. The study found that K252a disrupts a key signaling pathway involved in the growth of lymphoma cells, offering new hope for treating non-Hodgkin lymphoma.
Researchers have discovered a potential treatment for osteoarthritis using parathyroid hormone, which may regenerate lost cartilage in joints. The treatment delays cartilage loss and improves its volume in diseased joints, offering hope for patients with joint injuries.
Researchers discovered a key compound, PGE2, that quickly restores blood cell production and continues to do so for six to eight weeks after bone marrow injury. This treatment could represent a precise way to accelerate recovery from life-threatening blood cell shortages.
A landmark study published in NEJM found that a new therapy combining CRT-D reduces the risk of death or heart failure by 34%, with a significant reduction in heart failure hospitalizations. This trial demonstrates the effectiveness of CRT-D therapy for patients with mild cardiac disease, improving both survival and quality of life.
A new study analyzing nearly 25,000 Medicare patients found that blood transfusions for hospitalized cardiac patients can be associated with increased risks of infection and death. The analysis also revealed substantial variation in transfusion practices among hospitals, highlighting the need for evidence-based guidelines.
A common food additive, Brilliant Blue G, has been identified as a potential treatment for spinal cord injury. The compound stops the cascade of molecular events that cause secondary damage, allowing patients to recover from paralysis. Researchers have successfully tested BBG in rats with spinal cord injuries, showing promising results.
Researchers found that tamoxifen kills yeast cells and prevents them from causing disease by breaking apart and dying fungus cells. The drug has potential as an effective treatment against serious fungal infections, particularly in immune-compromised patients, offering a new arsenal to help critically ill patients.
Researchers found a synthetic molecule that breaks up deposits of toxic genetic material and re-establishes cellular activity disrupted by myotonic dystrophy. The treatment could restore muscle function in people with the disease.
A commentary in JAMA emphasizes the importance of clarifying patient preferences and values during difficult diagnoses. Doctors can guide patients to use emotions and logical thinking skills together, framing information with multiple perspectives.
Researchers have discovered that two microRNAs, miR-143 and miR-145, control the differentiation and growth of vascular smooth muscle cells. These findings suggest that targeting these microRNAs may be a potential treatment for diseases such as atherosclerosis and Alzheimer's disease.
Researchers at the Eastman Institute found that acidic fruit juices like orange juice decrease tooth enamel hardness by up to 84%. Whitening products have no significant effect on enamel hardness. Poor oral hygiene and frequent consumption of acidic drinks can lead to severe tooth erosion.
Researchers propose that cancer stem cells could provide an important avenue for controlling cancer if targeted by new treatments. The subpopulation of malignant cells may be the root cause of cancer, offering a potential new approach for therapy.
A landmark study demonstrates a significant reduction in heart failure or death in patients with heart disease who received CRT-D versus ICD-only. The MADIT-CRT trial showed a 29% decrease in mortality and heart failure symptoms, improving survival and outcome for patients with severe heart disease.
A telemedicine project at the University of Rochester Medical Center has improved quality of life and motor function for Parkinson's patients in nursing homes. The system, utilizing a laptop, software, and web camera, enables specialists to conduct virtual visits with trained nurses, reducing travel burden and costs.
A study published in Brain, Behavior and Immunity found a strong association between extraversion and lower levels of inflammatory chemical interleukin 6 (IL-6), which can signal increased risk of death. The research suggests that dispositional activity may confer a survival advantage.
A University of Rochester Medical Center study found that including socioeconomic status in the Framingham Risk Scoring tool can nearly double the number of patients at risk for death or disease. This could lead to increased eligibility for cholesterol-lowering medications and other treatments, with a potential 15% increase.
Scientists identified a protein that regulates mitochondrial movement in brain cells, shedding light on how the brain recovers from stroke. Understanding this mechanism may help identify novel approaches for preventing and treating neurological disorders.
A University of Rochester Medical Center study found that dioxin exposure during pregnancy can cause premature cell death and alter milk-producing genes in mammary glands. This may explain why some women struggle with breastfeeding or produce inadequate milk, affecting an estimated three to six million mothers globally.
A recent study published in Epidemiology found that hormone replacement therapy does not increase breast cancer risk for women with or without a family history. The research analyzed data from the Women's Health Initiative randomized trial and suggests that estrogen sensitivity may not be the causal pathway based on family history.
Researchers have developed a new computer simulation model that captures the human immune response to influenza type A, predicting treatment design and pandemic preparedness. The model reveals that drugs and vaccines targeting dendritic cell presentation of antigens have a significant impact on patient outcomes.
A landmark follow-up study found that ICDs reduce the risk of death from any cause by 37 percent in heart attack survivors, translating to 1.2 life-years saved, and greatly amplifying their value as a chronic therapy.
A Phase II/III study found that ginger supplements, taken three days prior to and after chemotherapy, reduced nausea levels in cancer patients by 40%. The study included 644 participants who received at least three chemotherapy treatments and showed significant anti-vomiting effects.
Boys with Duchenne Muscular Dystrophy symptoms show signs for over a year before diagnosis and disease-specific treatment, highlighting the need for early detection and intervention. A simple and inexpensive blood test could accelerate this process, enabling timely treatment and improving outcomes.
Researchers found that eliminating the gene for cyclophilin A from mice prevented the development of abdominal aortic aneurysm and atherosclerosis. The study suggests that targeting cyclophilin A could potentially address both conditions, which are linked by shared biochemical pathways.
Researchers discovered a new mechanism that affects the immune system's ability to respond to certain vaccine components. The study found that low-stability peptide:MHC class II complexes support initial T cell expansion, but competitive responses to immunodominant peptides stall the response.
A study of over 2,000 children aged 6-18 found that those exposed to secondhand smoke had lower antioxidant levels, which can help defend against biological stresses. The researchers recommend a diet rich in antioxidants from fruits and vegetables to mitigate this effect.
A new study found that iron deficiency in womb may delay auditory neural maturation in preemies, affecting sound processing and later language development. The research evaluated 80 infants over 18 months, revealing abnormal brain maturity in those with low iron levels.
Children with high blood pressure are more likely to have learning disabilities and ADHD, with a four-fold increased risk. The study also found that hypertensive children have difficulties in goal-directed tasks and working memory.
A University of Rochester Medical Center survey found teens lack knowledge about over-the-counter pain medications, with only 35% correctly identifying acetaminophen and Tylenol. Chronic misuse can lead to liver damage and accidental overdose
Researchers discover organic cation transporter 3 (oct3) plays a critical role in both Parkinson's disease and drug addiction by transporting toxic chemicals into brain cells that die in patients with the condition. Oct3 helps astrocytes remove excess dopamine, leading to feelings of euphoria but also potential brain damage.
A study by Latha Stead found that patients with diagnosed or undiagnosed obstructive sleep apnea had a higher risk of death and poor outcomes after a stroke. The research suggests that regular screening for sleep apnea in emergency department settings could improve patient outcomes.
Researchers have identified a genetic mechanism in bacteria that could lead to the development of new antibiotics. The preQ1 riboswitch regulates gene expression by controlling the availability of queuosine, a molecule essential for bacterial survival and human disease.
Researchers have made a groundbreaking discovery in the treatment of bone injuries, using teriparatide to jumpstart the body's natural healing process. The study shows significant healing and pain control in patients with unhealed bone fractures, offering new hope for those with no effective treatment options.
Researchers found that acupressure wristbands reduced nausea by 23.8% in cancer patients undergoing radiation treatment, with no difference between the two wristband groups.
A blood test can predict the seriousness of a head injury and detect the status of the blood-brain barrier, offering a simpler and faster alternative to CT scans. The test, known as S-100B, has shown accuracy in predicting traumatic abnormalities and could lead to a 30% reduction in unnecessary CT scans.
Researchers successfully trained patients with severe visual impairments after a stroke to regain some vision through intensive computer exercises. By building on existing 'blindsight,' the brain's healthy regions were stimulated to take on tasks normally handled by damaged areas.