Researchers at the University of Rochester Medical Center have developed a compound that targets RAGE, a molecular actor involved in Alzheimer's disease. The compound, FPS-ZM1, reverses amyloid deposits, restores brain blood flow, and improves learning capabilities in mice.
A study published in the journal Menopause found that menopause is associated with certain types of memory deficits, particularly those related to working memory and sustaining attention. The study's findings validate women's experiences of 'brain fog' during this phase of life.
Wilmot researchers develop first genetically engineered mouse model for Intrahepatic Cholangiocarcinoma (IHCC), a type of bile duct cancer. The model incorporates common mutations in humans and enables testing of potential treatments, accelerating the discovery process.
A new report by a national scientific committee reveals that gains in cancer survival have come at the cost of second malignancies and cardiovascular disease. The report calls for the development of better risk estimates and prediction models to prevent serious health problems among cancer survivors.
A study led by University of Rochester Medical Center researcher Kathi L. Heffner found that poor sleepers react to stress with significantly larger increases in a marker of inflammation, which may increase risk for mental and physical health problems. This association could not be explained by other factors linked to immune impairment.
Researchers at the University of Rochester Medical Center have discovered that dorsal root ganglion neurons can create thick, healthy nerves without provoking an immune response. This breakthrough could lead to better treatment options for the over 350,000 patients with serious nerve injuries in the US each year.
Scientists studied children with newly diagnosed type 1 diabetes to understand its initial stages. They found variability in T-regulatory cell activity and increased immune-boosting cells, which may help develop new treatments.
A team of researchers has discovered how the protein SAMHD1 protects immune cells from HIV by starving the virus of necessary building blocks. This finding could lead to more effective anti-HIV drugs and new insights into other viral infections.
Infants with birth defects delivered at night or over the weekend fared just as well as those delivered on a weekday, according to a new study. The finding is good news for all parties and suggests that delivery timing shouldn't be based on day of the week.
A new study found that weight gain and dietary changes are not effective in preventing repeat preterm birth. Women who have had a prior preterm birth should follow standard weight gain guidelines during their second pregnancy to minimize risk.
Researchers at URMC discovered a link between leukemia cells and bone formation, finding that leukemia alters the balance of osteoblast and osteoclast activity. The study suggests that targeting osteoclasts could be a potential treatment strategy for leukemia.
A recent study published in Circulation: Cardiovascular Quality and Outcomes found that Asian-American heart attack patients received nearly the same quality of care as white counterparts, with improvements seen between 2003 and 2008. Despite this, disparities persist, including lower rates of aspirin use and smoking cessation counseling.
Researchers found that AICAR, an experimental therapy, protected animals from heat-induced sudden death and may hold promise for treating people with enhanced susceptibility to heat stroke. The drug works by reducing calcium leakage from RYR1, thus diminishing heat-induced contractions and muscle damage.
Researchers have identified Ric-8 as a chaperone that facilitates the transport of G proteins to the cell membrane. Without Ric-8, G proteins are destroyed and their biological processes are disrupted. Understanding the role of Ric-8 in G protein function may lead to more effective treatments for various diseases.
Women with obesity may face increased risks of preterm birth, respiratory complications, and poor breastfeeding rates. However, with proper education, motivation, and medical care, they can have healthy pregnancies and successful outcomes for both mother and baby.
Research found that people with myotonic muscular dystrophy are at higher risk for developing four specific types of cancer. Additionally, there may be an increased risk for other cancers such as eye, thyroid, pancreas, and female reproductive organs. Patients should prioritize cancer screening, particularly colon cancer screening.
A University of Rochester Medical Center study found that nearly 78% of cancer-related blood clots occur in outpatients during chemotherapy treatment. The study's findings suggest a shift towards outpatient care and the need for education and compliance to prevent blood clots.
A University of Rochester Medical Center study found that high school football and hockey players showed subtle brain injuries after routine head hits, even without concussions. The research used diffusion tensor imaging to detect changes in white matter, which are similar to axonal injury at the cellular level.
Researchers at the University of Rochester Medical Center will study different approaches to improve pain clinical trial design, including patient features, study planning, and site characteristics. The goal is to boost development of new, effective treatments for chronic and acute pain.
Scientists studying drugs for dementia treatment also find promise in treating heart failure, driven by a common enzyme. Preliminary studies suggest that blocking this enzyme may help slow the progression of both conditions.
A University of Rochester analysis found that older men are more likely to die from prostate cancer due to late-stage diagnosis. The study's lead author notes that overall health plays a significant role in life expectancy following a cancer diagnosis.
Scientists at the University of Rochester Medical Center have improved upon their previous efforts to isolate stem cells for treating multiple sclerosis and rare childhood diseases. The new method resulted in a four-fold increase in myelin coating, making these cells promising candidates for future clinical trials.
The National Institutes of Health has awarded $1.1 million to the University of Rochester Medical Center to continue its 10-year-old program training researchers in China to investigate suicide causes and prevention.
A new study reveals that nursing homes often prioritize treating residents with private insurance over those with Medicaid, resulting in higher hospitalization rates and unnecessary care. Medicaid residents are 27% more likely to be hospitalized than private-pay residents, highlighting the financial incentives driving these decisions.
Researchers at URMC discover that a medication already approved to build bone mass in patients with osteoporosis can also increase cartilage around joints, potentially treating millions suffering from arthritis. The study suggests that the drug could be repurposed as an alternative to current treatments.
A new study found that daily moderate drinking decreases atherosclerosis in mice, while binge drinking increases its development. Moderate drinking also lowered LDL cholesterol and reduced plaque volume, whereas binge drinking led to increased inflammation and weight gain.
Researchers recommend low-salt diets, exercise, and weight loss as primary treatments for hypertension. Alternative options like Coenzyme Q10, potassium supplements, and devices like RESPeRATE and Zona Plus may also be effective in managing blood pressure.
A clinician-scientist team, led by Joseph M. Miano and Craig Benson, has created a model resource that identifies and outlines the function of common mutations in the human genome. They believe this information will help guide the development of new prevention and treatment options for diseases.
A new study finds that type 2 diabetes and obesity independently contribute to higher risks of pregnancy complications. Women with both conditions have poorer outcomes, including preterm birth, blood loss, and prolonged hospital stays.
Researchers at URMC discovered a receptor called GPR56 that plays an important role in cancer progression and may trigger angiogenesis. This discovery could lead to more effective treatments for malignant melanoma by shutting down VEGF production at its source.
A study analyzed data from 844 individuals with early-stage Multiple Sclerosis and found that disease-modifying drugs provide modest health gains, but their cost is more than 8 times higher than considered reasonable. The study's authors highlight the need to reevaluate treatment costs to control healthcare expenses.
Researchers at the University of Rochester Medical Center identified a collagen-binding protein allowing Streptococcus mutans to invade heart tissue, causing endocarditis. The discovery may lead to a screening tool to gauge dental patients' vulnerability.
Physicians have identified six new cases of purpura, a debilitating skin condition caused by cocaine contaminated with the de-worming drug levamisole. Treatment involves stopping cocaine use and administering steroids to prevent inflammation.
Researchers successfully modified messenger RNA to override a 'red light' signal, producing a full-length protein instead. This breakthrough may aid treatment strategies for genetic disorders caused by premature stop codons.
The first controlled clinical trial for Juvenile Batten disease begins this summer, enrolling 30 patients who will take mycophenolate or a placebo for eight weeks. Researchers hope to slow or halt disease progression with immunosuppression.
Researchers found that a specific section of the AKAP12 gene responds to retinoid treatment, reducing vascular cell growth. The study suggests that this gene could be a target for treating vascular diseases and potentially other cancers.
Researchers at University of Rochester Medical Center have identified two genes, CDK6 and CDK4, that are amplified in the worst cases of esophageal cancer, providing data to support a new investigational treatment. The study found that targeting these genes may halt the growth of cancer cells.
A new study published in Neurobiology of Aging suggests that the pathological forms of amyloid beta and tau proteins may collude to decrease the survival of brain cells. This finding raises hopes for early markers and treatment strategies to combat the disease by targeting mitochondrial dysfunction.
Researchers from the University of Rochester Medical Center presented studies on nutritional insufficiencies, including supplement use, folate and niacin levels, and artificial food dye effects. The studies aim to identify effective interventions for children with autism spectrum disorders and explore potential environmental factors.
Researchers have identified genetic mutations that predict risk of sudden cardiac death and cardiac events in patients with Long QT syndrome. The findings could lead to personalized treatment approaches for individuals with the condition, who are often at risk but may not exhibit typical clinical symptoms.
Researchers found that exposed children were almost five times more likely to need intensive care and more than 11 times more likely to need intubation. Children's length of stay in the hospital was significantly associated with smoke exposure and chronic conditions.
A recent study suggests that low vitamin D levels among black people may contribute to racial differences in hypertension. The research found that nearly 61% of blacks had vitamin D levels in the lowest one-fifth of the population sample, compared to 11% of whites.
A study by neurosurgeons at the University of Rochester Medical Center found that anti-depressants can boost brain cells after injury, improving depression and memory. The medication, imipramine, increased the number of neurons in the hippocampus, a key area for memory, and enhanced novel object recognition tests.
Researchers found obese patients with metabolic syndrome and high blood pressure are at substantial risk for cardiac, pulmonary, and neurologic complications. The study provides a simple way to identify patients who may face higher risks following surgery.
Research published at University of Rochester Medical Center found that high induction and primary C-section rates in low-risk pregnant women have no impact on newborn health. The study's findings question the increasing trend of interventions at delivery in the US, suggesting that 'more is not always better'.
A new fusion molecule with three parts activates the immune system to attack cancer cells directly, while keeping it dormant until needed. The approach has shown promising results in lab experiments and mice with cancer, inhibiting tumor growth and activating immune cells.
The Rheos System, a device that regulates blood pressure like a pacemaker regulates heart rhythm, helped lower blood pressure by 33 points. This substantial drop could require up to five additional drugs to control difficult-to-treat hypertension in patients with resistant hypertension.
A University of Rochester Medical Center study found that a mother's iron deficiency early in pregnancy can have a long-lasting effect on the child's brain development, even if it's not severe enough to cause anemia. The research suggests that monitoring a pregnant woman's iron status beyond anemia is crucial.
Researchers found that acetylation regulates DNA maintenance, favoring protection of genetic information. This discovery may lead to interventions enhancing the body's natural preservation of genetic info, potentially delaying aging-related diseases.
Researchers found that ultrafine particles can activate platelets, increasing the risk of cardiovascular disease, particularly in people with diabetes. The study provides new insights into air pollution's impact on heart health, emphasizing the importance of controlling exposure to pollutants for vulnerable populations.