Articles tagged with Analgesics
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A large study found that regular aspirin use is associated with a lower risk of BRAF-wild-type colorectal cancer, but not BRAF-mutated cancer. The researchers also observed a significant risk reduction for BRAF-wild-type cancer with increasing aspirin tablets per week and longer duration of use.
A new study suggests that testosterone therapy can reduce pain perception and tolerance in men with low testosterone levels caused by opioid pain relievers. The study found significant improvements in pain sensitivity during laboratory pain testing after testosterone administration compared to placebo.
A new study suggests that aspirin slows the accumulation of DNA mutations in abnormal cells in Barrett's esophagus, a pre-cancerous condition. This finding implies that aspirin may exert cancer-preventing effects by lowering mutation rates.
Researchers have identified a novel approach to moderate and severe pain therapy that could lead to lower dosage painkillers. The compounds bind to a separate site on the opioid receptor, potentially working with the body's own natural painkillers to manage pain.
A retrospective study found that higher numbers of lumbar epidural steroid injections (LESI) were associated with increased risk of bone fragility and vertebral fractures. Patients at high risk for fractures include older women, those who have had an earlier fracture, smokers, and underweight individuals.
Recent data suggest that aspirin reduces heart attacks, but also increases risk of gastrointestinal bleeding and stroke. The study found that including a cancer mortality benefit influences aspirin prescribing thresholds, making middle-aged men eligible for prevention.
Researchers found that daily sunscreen use significantly slows skin aging, with a 24% decrease in photoaging compared to discretionary application. In contrast, a survey of 1,820 physicians revealed that only about 43% had basic electronic health record systems and 10% met meaningful use criteria, highlighting challenges in EHR adoptio...
A meta-analysis of 639 trials shows that higher-dose NSAIDs like diclofenac and ibuprofen are associated with increased risks of heart disease and fatal heart attacks. The study suggests that the size of these risks can be predicted, helping physicians choose safer NSAID regimens for patients.
The guideline advises that taking aspirin or warfarin before dental procedures, cataract surgery, and dermatologic procedures is likely safe. However, patients undergoing procedures like retinal surgery or orthopaedic hip procedures may experience increased bleeding risk.
The new guideline from the American Academy of Neurology helps people with stroke and atrial fibrillation decide whether to take blood thinners during surgery. For minor procedures, the risk of bleeding is small, but for certain hip and colon procedures, it's higher.
A study published in Gaceta Sanitaria found that women are more likely to be prescribed analgesics due to socioeconomic inequality. The researchers used the Gender-related Development Index to analyze prescription patterns in areas with higher and lower gender development indices.
A study found that patients with COPD experience chronic pain comparable to those with osteoarthritis and rheumatoid arthritis, with higher use of opioids. The researchers also noted a significant impact on quality of life and healthcare costs.
A study suggests that early childhood respiratory infections, rather than analgesic use, may be driving the link between asthma and acetaminophen or ibuprofen. Researchers found a higher exposure to acetaminophen both prenatally and during infancy compared to ibuprofen.
A Kaiser Permanente study found that long-term use of prescription painkillers is associated with a higher risk of erectile dysfunction (ED) in men. Men taking high-dose opioids for at least four months were 50% more likely to receive ED prescriptions than those who did not take opioids.
Researchers have found that combining a new-generation mechanical heart valve with low-dose anticoagulation therapy significantly lowers the risk of bleeding events while maintaining stroke and neurological event rates. This study uses a new bileaflet design, and its findings may lead to reduced anticoagulation therapy for patients
A national study found that one in four teens has misused or abused a prescription drug at least once in their lifetime, with stimulants contributing to the sustained Rx epidemic. The Partnership at Drugfree.org reports that nearly a quarter of teens mistakenly believe that misusing prescription drugs is safer than using street drugs.
A study found that low-dose aspirin slowed the growth of two breast cancer lines in lab tests and reduced tumor growth in mice. The compound also inhibited tumor cells from spreading and enhanced the effect of tamoxifen, a common drug therapy for hormone-receptor positive breast cancer.
Taking painkillers before marathons increases the risk of gastrointestinal problems by 13%. The rate of symptoms rises with increasing dose. Runners who took painkillers were five times as likely to experience symptoms as those who didn't, according to a recent study.
A new study published in Critical Care finds that reducing movement in ICUs can decrease severe pain and serious adverse events, while increasing analgesic use. The training program implemented by the University of Montpellier Saint Eloi Hospital increased staff awareness and reduced side effects.
Scientists need to find better ways to prevent sickling in red blood cells, which impairs oxygen delivery and damages blood vessel walls and organs. Anti-sickling therapies are crucial to reducing damage and improving patient outcomes.
New research suggests that Tylenol can alleviate existential pain and anxiety by inhibiting brain signals associated with distress. The study found that participants who took Tylenol were less harsh in setting bail after writing about their own death, compared to those who took a sugar pill.
Researchers found Tylenol reduces psychological effects of fear and anxiety, suggesting the drug inhibits distress signals to the brain. The study built on previous research that acetaminophen can reduce social pain, advancing understanding of how the human brain processes different types of pain.
FitzGerald shared the prize with Carlo Patrono for developing low-dose aspirin to prevent cardiovascular disease. The breakthrough work assessed prostaglandins' role in blood clotting and saved millions of lives worldwide.
Cryoneurolysis, a new interventional radiology treatment, safely short circuits chronic pain caused by nerve damage. After treatment, patients experienced significant lasting pain relief and were able to reduce or eliminate pain medication use.
Researchers investigated the use of bone-marrow grafts to treat low-back pain. The study found that some patients experienced complete pain relief after treatment, while others showed no improvement.
A new study suggests that bone-marrow grafts may be effective in treating low-back pain, with patients experiencing significant improvements in pain relief and activity tolerance. The procedure involves injecting a concentrated form of bone-marrow cellular aspirate into affected discs.
Researchers found that dexmedetomidine alleviated symptoms of opioid-induced hyperalgesia in patients receiving high doses of remifentanil. Patients treated with dexmedetomidine reported less pain and used less morphine compared to those receiving placebo.
A UNC School of Medicine study found that cold perception is enhanced when nerve circuitry for heat is inactivated, impacting how people with chronic pain experience temperature sensations. The research also has implications for why some patients taking pain relief drugs shiver before hyperthermia sets in.
A randomized phase 3 trial found that duloxetine reduced pain from chemotherapy-induced peripheral neuropathy compared to placebo. Patients who received platinums showed greater benefits from duloxetine.
Post-menopausal women who received estrogen-only medication reported significantly lower joint pain frequencies compared to those receiving a placebo. The study found modest but sustained relief from joint pain in these women.
A Yale University study found that hyperoxia can activate stress pathways in developing lungs, leading to conditions like bronchopulmonary dysplasia. Blocking Cox2 with a pain drug reversed BPD in mice, suggesting it as a potential treatment target.
A new study in Canada has found that over 40% of healthy individuals are taking daily aspirin to prevent cardiovascular disease, despite recent literature suggesting its limited benefits. The study's authors hope to raise awareness among physicians and patients about the importance of discussing anti-platelet medication use.
The Boston University School of Medicine has launched a safe opioid prescribing education program, funded by the first of its kind $1.8 million grant from manufacturers of extended release/long-acting opioid analgesics. The program is designed to train healthcare providers on how to safely manage patients with chronic pain using opioids.
A University of Michigan Stroke Program study suggests that the combination of blood thinners and tPA treatment for stroke does not increase the risk of brain bleeding. The research, based on data from 830 patients, found no significant difference in brain bleeding rates even among those taking aspirin or clopidogrel.
A new study found that women taking aspirin have a reduced risk of developing melanoma, with the longest users showing the lowest risk. Aspirin's anti-inflammatory effects may help protect against this type of skin cancer.
Researchers found that ranolazine, an anti-anginal drug, significantly reduced weekly episodes of chest pain in patients with type 2 diabetes. The study also showed that the drug had a more pronounced effect on reducing angina frequency in patients with poorer glucose control.
A recent study by the American College of Cardiology found that patients not given aspirin before artery-clearing coronary angioplasty and stenting have a significantly higher in-hospital death rate. The study examined registry data from over 65,000 patients and found that nearly 7% did not receive aspirin as recommended.
Researchers at the University of Oxford have made a groundbreaking discovery linking brain activity to phantom pain in amputees. The study found that arm amputees with stronger phantom limb pain maintained a stronger representation of the missing hand in their brains, which was indistinguishable from those with intact limbs.
Researchers discovered that aspirin triggers the production of resolvins, naturally made by the body from omega-3 fatty acids, which resolve inflammation. Aspirin also modifies an inflammatory enzyme to produce longer acting resolvins with potent anti-inflammatory actions.
A study finds diclofenac is the most commonly used NSAID in 15 countries and is included on essential medicines lists of 74 low- to high-income countries. Despite its cardiovascular risks, researchers call for diclofenac to be removed from national lists and have its global marketing authorisations revoked.
Researchers isolated and ablated neurons expressing TRPM8 protein, which senses cold temperatures in the skin. Mice without these neurons couldn't feel cold but still responded to heat and touch, shedding light on pain treatment advancements.
A study reveals racial differences in chronic pain management, with black patients experiencing less frequent pain level documentation and more urine drug tests. This may impact the effectiveness of pain management for black patients who overcome barriers to opioid prescriptions.
Researchers suggest that a small number of cheap generic drugs can treat most non-communicable diseases (NCDs), improving availability in poorer nations. Better selection and sourcing of generics, as well as increased investment and policies, are key to making life-saving medicines affordable to all.
A recent study found that the prescription opioid overdose rate in NYC increased seven-fold between 1990 and 2006, with fatalities concentrated among white residents. The study suggests a different public health approach is needed for this demographic, as their profile differs from heroin consumers.
A new study from Kaiser Permanente found that men on long-acting opioids are 5 times more likely to have low testosterone levels than those on short-acting opioids. The study compared 81 men with chronic pain and found that long-acting opioids significantly increased the risk of low testosterone.
A new patent issued for an experimental compound RTX, which represents a potential new class of drugs to alleviate intractable pain. The method patent covers intrathecal administration of RTX, promising to improve lives of people with severe pain.
A new study reports that non-steroidal anti-inflammatory drugs (NSAIDs) cause acute kidney injury (AKI) in children, with younger patients more seriously affected and at higher risk of chronic kidney disease. The study found that 30% of patients experienced mild chronic kidney damage after recovery from AKI.
A new poll from the University of Michigan found that only 35% of parents are very concerned about misuse of narcotic pain medicines by children and teens. Despite rising rates of abuse and overdoses, most parents do not support policies to discourage misuse or return unused medications.
A study of over 2,300 participants found that regular aspirin use was associated with a higher risk of developing neovascular age-related macular degeneration. Aspirin use increased the risk by 1.9% at 15 years compared to non-users.
A study found that taking a triple combination of blood pressure drugs and common painkillers increases the risk of serious kidney problems, especially at the start of treatment. Patients taking this combination are 31% more likely to develop kidney injury.
Researchers found that post-operative intravenous paracetamol reduced cumulative morphine dose by 66% compared to continuous morphine infusion in infants undergoing major surgery. The study suggests that intravenous paracetamol may be an interesting alternative as primary analgesic in neonates and infants.
A research team from Université Laval has discovered a molecular pathway by which morphine can increase pain, leading to potential new strategies to improve treatment of post-operative and chronic pain. The researchers identified specialized cells called microglia as the culprit behind morphine-induced pain hypersensitivity.
Researchers used electric stimulation to release an opiate-like substance that reduces pain in the brain. The study found a significant improvement in patients' threshold for cold pain, but not their clinical pain levels. Repeated sessions are required for lasting effects.
Researchers found a specific type of sensory nerve cell that responds to itch-inducing stimuli but not pain, suggesting a possible solution for chronic itch. This discovery may help develop treatments for life-saving medications and improve our understanding of the relationship between pain and itch.
A brain imaging study found that THC, the psychoactive ingredient in cannabis, reduces the emotional reaction to pain but does not reduce the intensity of pain. The study suggests that individual responses to cannabis-based pain relief may vary greatly.
Patients who quit smoking and took aspirin and statin before undergoing treatment for blocked leg arteries were less likely to suffer complications six months later. The study found that more than half of patients studied failed to receive minimal medical therapy, despite doctors' efforts.
A recent study found that true aspirin resistance is extremely rare, with no cases identified. However, coated aspirin may lead to a false diagnosis due to delayed absorption and coating effects.
The overprescription of opioids is contributing to increased fatal drug overdoses and diversion to the illegal market. Researchers recommend a shift towards alternative pain management approaches.
Researchers found a significant association between NSAID use and reduced risk of hepatocellular carcinoma (HCC) and death from chronic liver disease. Aspirin use was found to have the strongest protective effect, with participants experiencing a 41% reduced risk of HCC and 45% reduced risk of CLD mortality.
Researchers at the University of Warwick have discovered a potential new treatment to prevent strokes in high-risk patients. Using ultrasound scanning, they found that tirofiban, an anti-platelet drug, can suppress microemboli in patients who have developed clots despite previous treatment with aspirin.