Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study published in Neural Regeneration Research found that intrathecal bumetanide increases NKCC1 expression and decreases KCC2 expression in spinal cord neurons of rats with incisional pain. This suggests that intrathecal bumetanide may have analgesic effects through inhibition of NKCC1.
A telephone-delivered telecare intervention improved chronic musculoskeletal pain compared to usual care, with nearly twice as many patients experiencing a 30% reduction in pain score. The intervention was associated with clinically meaningful improvements in pain and treatment satisfaction.
Researchers have discovered that aspirin use slows down certain aging processes of the genome, while smoking accelerates them. The study found a significant correlation between aspirin use and reduced DNA methylation changes in healthy women over 50 years old, suggesting a possible mechanism for cancer prevention.
A study published by the American Association for Cancer Research found that low-dose aspirin significantly reduces the risk of pancreatic cancer. The longer a person takes low-dose aspirin, the lower their risk of developing pancreatic cancer, with some evidence suggesting a greater reduction in risk over time.
Saint Louis University researchers have discovered a molecular pathway that causes painful chemotherapy side effects and found a potential way to block it. A drug already approved for treating multiple sclerosis may also alleviate chemotherapy-induced peripheral neuropathy (CIPN) without affecting the medication's anticancer properties.
African American women are more resistant to the anti-inflammatory effects of aspirin compared to white women, according to a new study. The research found that African American women experienced a reduced response to aspirin therapy in reducing cardiovascular disease and its risk factors.
A study led by Priscille Brodin and Laurent Marsollier found that the toxin mycolactone from Mycobacterium ulcerans limits the transmission of pain signals to the brain. This mechanism may lead to the development of new analgesics.
A major public health problem is emerging due to an increase in deaths from prescribed painkillers, with over 16,000 US deaths in 2010 alone. The review identifies factors such as increased opioid prescriptions, combined use of opioids and other substances, and social demographic factors as contributing causes.
A study found that statin users engaged in less moderate and vigorous physical activity, while having more sedentary behavior. The possible reasons for this include general muscle pain caused by statins.
Researchers create systematic map of pain acuity distribution across body, revealing surprising similarities with touch sensitivity. The study uses lasers to cause pain in healthy volunteers and a rare patient lacking touch sensation, demonstrating that pain acuity does not rely on touch.
A new study published in the New England Journal of Medicine found that naloxegol increased bowel movements among patients with opioid-induced constipation, providing rapid and sustained relief without compromising pain management. The investigational drug is designed to block opioids from binding to receptors in the gastrointestinal t...
A new online training module improved medical student clinical skills in evaluating chronic pain, with 93% of exposed students passing an exam compared to 60% of non-exposed students. The module is the first curriculum resource created through the NIH Pain Consortium's Centers of Excellence in Pain Education program.
A new study published in The Journal of Thoracic and Cardiovascular Surgery found that low-dose anticoagulation therapy can be safely used with a newer generation mechanical heart valve. Patients under 65 years old who received this valve had significantly lower risk of bleeding without an increased incidence of thromboembolism.
Researchers have discovered how cone snail venom Vc1.1 works to reduce neuropathic pain by targeting specific calcium channels in neurons. This breakthrough could lead to the development of synthetic versions of Vc1.1 to treat certain types of chronic pain.
Researchers from the University of Pennsylvania have combined graphene with a painkiller receptor to create an artificial chemical sensor. The device uses electrical responses instead of biochemical ones, allowing it to be read out by a computer. This technology has potential applications in drug development and various diagnostic tests.
Researchers found that aspirin inhibits wound healing by reducing the production of 12-HHT, a molecule promoting epithelial layer restoration. A synthetic BLT2 agonist accelerated wound healing in diabetic mice, suggesting potential treatments for chronic wounds.
Researchers identified a single-letter change in DNA that turns cold-sensitive TRP ion channels into heat-activated ones, offering potential for more specific pain relievers with less severe side effects. The study could lead to the development of analgesic compounds to treat chronic pain by targeting temperature-sensitive molecules.
A large-scale study found that patient satisfaction with postoperative pain treatment is linked to perceptions of improvement and the patient-caregiver relationship. Patients who feel involved in their care experience higher levels of satisfaction.
A study found that aspirin lowers colorectal cancer risk in people with high 15-PGDH gene levels, but not those with low levels. The research team analyzed data from nearly 128,000 participants and discovered a link between 15-PGDH and the anti-cancer effects of aspirin.
A new study from UCSF found that codeine is frequently prescribed to children in US emergency rooms, with up to 877,000 prescriptions per year. The researchers recommend using safer alternatives like ibuprofen or hydrocodone, and changing prescribing patterns to reduce codeine use.
Researchers at King's College London have identified new pain relief targets that could help chemotherapy patients who suffer from persistent pain. The discovery was made by investigating how pain occurs in nerves and found that the immune system plays a key role in causing pain.
Saint Louis University researcher Jeffrey Scherrer is investigating the link between chronic opioid use and depression risk. He will analyze medical records of 1 million patients, including those with VA and private sector prescriptions, to understand the impact of opioid exposure on mental health.
Researchers at Scripps Research Institute receive $472,500 grant to study impact of pain medication exposure in womb on developing brain. The two-year study will use rodent models to understand how subtle changes in brain wiring might lead to later changes in behavior.
A meta-analysis of randomized controlled trials found that relationship-focused training had a small but statistically significant effect on measured health outcomes in patients with conditions such as obesity and diabetes. The study suggests that a good patient-clinician relationship can produce health effects similar to some common t...
A systematic evidence review found daily low-dose aspirin can prevent preeclampsia complications by 24% and preterm birth by 14%, with no identified harms. A new approach to breast cancer research suggests reevaluating mammography screening and focusing on prevention through lifestyle changes.
A study of 1228 women found that low-dose aspirin did not improve live birth rates or reduce pregnancy loss, but showed benefits for those who had experienced a single pregnancy loss within the previous year. Women should consult their healthcare providers before taking any medication while trying to conceive.
A study of 999 patients found that low-dose aspirin use after colon cancer diagnosis was associated with improved overall survival, particularly among those with HLA class I antigen expression. The molecular mechanisms underlying this effect are not fully understood.
Patients given aspirin after non-heart-related surgery had a higher risk of serious bleeding than those who did not receive aspirin. Aspirin did not reduce incidence of post-operative heart attacks and death, according to data from POISE-2.
A recent study published in Annals of Emergency Medicine found no correlation between painkillers, including opiates, and patient satisfaction scores in emergency departments. Instead, factors such as increasing age and male gender were linked to higher satisfaction scores.
A new microfluidic method simulates blood flowing through narrowed coronary arteries to evaluate anti-clotting drugs like aspirin. The study found that while aspirin can prevent dangerous clots in some patients, it may not be effective for those with narrowed arteries.
Breast cancer is a significant global health issue, with over 1.6 million new cases diagnosed annually. The disease disproportionately affects low-income countries, where late-stage diagnosis and limited treatment options contribute to high mortality rates.
Researchers create experimental substances based on a tiny protein found in cone snail venom that could lead to the development of safe and effective oral medications for chronic nerve pain. The new substances are about 100 times more potent than morphine or gabapentin, with fewer side effects and lower risk of abuse.
Researchers found a dramatic rise in opioid analgesic prescriptions during US emergency department visits from 2001 to 2010, with some opioids increasing by 668.2 percent. Despite modest increases in painful conditions, the findings suggest a concerning trend that may lead to misuse and addiction.
Researchers at North Carolina State University have developed a new trial design to counter the caregiver placebo effect in veterinary medicine. The study found that a low-dose pain medication was effective in cats with degenerative joint disease, despite owners' initial perceptions of improvement due to the placebo effect.
Researchers found that opioid prescriptions stabilized after tripling between 1999 and 2008, but the impact of prescription drug monitoring programs (PDMPs) varies significantly by state. Nine states showed significant decreases, while eight experienced increases in MMEs dispensed per capita.
Patients with rheumatic conditions are turning to herbal cannabis for symptom relief, but medical evidence is lacking. The study advises healthcare providers to discourage patients from using this drug as therapy due to potential harm and availability of other therapies.
A new approach to breast reconstruction surgery, known as an enhanced recovery pathway, has been shown to reduce opioid painkiller use in patients by 50% and decrease hospital stays by a day on average. The method includes preoperative analgesics, nonsteroidal anti-inflammatories, and resuming food and walking soon after surgery.
Scientists at LMU developed photoreactive compounds that modulate nerve-cell function, opening new routes to treat neurological diseases like chronic pain and visual impairment. They created hybrid photoreceptors that respond to light, potentially leading to new therapies for these conditions.
Research from Oregon State University finds that low birth weight individuals have impaired kidney function, affecting drug excretion and metabolism. This may lead to reduced effectiveness of medications in treating diseases such as diabetes and hypertension.
Researchers at UCLA found a significant link between the use of acetaminophen during pregnancy and an increased risk of attention-deficit/hyperactivity disorder (ADHD) in children. The study, which examined data from over 64,000 mothers and their children, suggests that long-term acetaminophen use may disrupt fetal brain development an...
New research reveals that opioid use changes the activity of a specific protein needed for normal brain function, affecting both pain relief and tolerance. The study found that blocking this protein can reduce addiction-related behaviors, but increasing its activity lowers pain relief response and leads to faster morphine tolerance.
A study of 64,322 children found that mothers who used acetaminophen during pregnancy were at higher risk for their children developing ADHD-like behaviors and hyperkinetic disorders. The use of acetaminophen in multiple trimesters increased the risk further.
Chronic musculoskeletal pain affects an estimated 100 million Americans, with low back pain and degenerative joint processes being common causes. Non-steroidal anti-inflammatory drugs (NSAIDs) are not effective in many chronic pain scenarios, but antidepressants and anticonvulsants can provide remarkable relief.
A new study of 11,000 teenagers found that combining school-based Life Skills Training with home-based Strengthening Families program significantly reduced prescription drug abuse rates by 10%. The six-year study also identified the most cost-effective programs, with Life Skills Training costing just $15 per child.
A new tool, Conjunctive Exploratory Navigation Interface (CENI), combines two search modes to provide a more focused search and retrieve the most pertinent information. CENI outperformed traditional keyword-based lookup interfaces in a study involving crowdsourced testers.
A year-long study found that pregabalin reduced RLS symptoms and was less likely to cause worsening symptoms compared to pramipexole. Dopaminergic drugs were associated with symptom augmentation in some patients, highlighting the need for caution when treating RLS patients.
University of Adelaide researchers have identified a crucial mechanism that can prevent liver failure resulting from excessive paracetamol consumption. By targeting the transient receptor potential melanostatine-2 (TRPM2) channel, they hope to develop new treatments for paracetamol overdose and potentially other liver-damaging poisonings.
A new drug treatment has been found to be effective against chronic pain caused by nerve damage, including post-herpetic neuralgia. Fifty-eight per cent of participants taking the drug found it effective, reducing pain by at least 30 per cent.
Handwashing and zinc are likely effective in preventing colds, with some evidence suggesting they also work for adults. Antihistamines combined with decongestants and pain medications can provide relief from symptoms, while ibuprofen and acetaminophen help with pain and fever.
Researchers found a significant inverse association between aspirin use and vestibular schwannoma growth in a retrospective series of 689 people. Aspirin intake may inhibit tumor growth, providing a potential therapeutic role for this anti-inflammatory medication.
Scientists have identified a 'brake' ion channel TREK2 in sensory neurons that limits spontaneous pain by stabilizing membrane potential. This discovery may lead to new pain relief treatments for conditions like neuropathic pain.
Researchers at UD developed a smart hydrogel that delivers medicine in response to mechanical force, reducing inflammation and pain in osteoarthritis. Preliminary results indicate biocompatibility and potential applications beyond osteoarthritis.
A study published in Nature Chemical Biology found that a molecular switch in the nerves responsible for detecting pain can 'short-circuit', intensifying pain. This alternative pathway activates the pain nerves, increasing the sensation of pain.
Researchers at Scripps Research Institute describe two new drug scaffolds that target the kappa opioid receptor, offering novel tools for treating pain, addiction, and other disorders. The compounds, called biased agonists, activate the receptor without recruiting beta arrestin, a molecule associated with depression.
Researchers discovered how sodium controls opioid receptors, a major class of brain cell receptors. The findings suggest new therapeutic approaches to treat pain and mood disorders. Sodium's effect on receptor activity is crucial for developing better opioid-receptor-targeting drugs.
Researchers at the University of Missouri have developed a comprehensive, nonsurgical treatment that significantly improves symptoms of pelvic floor dysfunction in women. The treatment involves muscle strengthening and relaxation techniques, resulting in an average 80% improvement in urinary incontinence, defecatory dysfunction, and pe...
A study by Beth Israel Deaconess Medical Center found that patients' expectations, whether positive, negative, or neutral, significantly influence the effects of both medications and placebos on migraine pain. The researchers discovered that a positive message and powerful medication are essential for effective clinical care.
Researchers at University of Nottingham discovered a potential drug to reduce osteoarthritis pain by targeting cannabinoid receptor2 (CB2), which also reduces joint inflammation. The synthetic compound JWH133 showed promise in animal models and human spinal cord tissue studies.
Researchers discovered a compound in traditional Chinese herbal medicine that effectively alleviates both inflammatory and nerve pain, with no tolerance to addiction. The compound, dehydrocorybulbine, was found to be reproducible and has potential as a new nonaddictive treatment for chronic neuropathic pain.
Research finds mTOR activation in neurons of dorsal horn contributes to morphine tolerance and hyperalgesia; rapamycin treatment improves opioid tolerance and hyperalgesia in rats. Targeting the mTOR pathway may enhance pain management.