Articles tagged with Antidepressants
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New studies link SSRI antidepressants to increased cataract risk, with a 15% higher risk for seniors taking the medication. Amantadine, a Parkinson's treatment, also causes corneal damage, particularly after long-term use, potentially leading to vision impairment.
The article discusses different interventions for secondary suicide prevention, focusing on high-risk patients with psychiatric illnesses. The authors argue that physicians need to be taught about the association between mental disorders and suicide and should not hesitate to ask people about their thoughts of suicide.
A new study published in CMAJ found a significant association between antidepressant use during pregnancy and an increased risk of miscarriage. The study, which analyzed data from over 5,000 women, found that selective serotonin reuptake inhibitors (SSRIs) were associated with a higher risk of miscarriage, particularly at higher doses.
Researchers identified a key receptor in the brain that influences serotonin-related antidepressants, providing a potential new target for treatment. The discovery could lead to more effective and targeted treatments for depression and anxiety with fewer side effects.
A new study suggests that magnetic stimulation therapy produced significant antidepressant effects in a subgroup of treatment-resistant patients, with remission rates of 14% compared to 5%. The treatment has few side effects and may be an effective alternative for those who don't respond to current medications.
A recent study by researchers at UCLA Health Sciences has found that over a third of drinkers aged 60 and older consume excessive amounts of alcohol, posing health risks. The study also highlights demographic factors, such as age, education level, and income, that contribute to at-risk drinking among the elderly.
A study at the Buck Institute for Age Research found that drugs promoting neurogenesis can lessen the severity of stroke and improve function in rodents. The researchers suggest these drugs, including antidepressants and mood stabilizers, may be suitable for human clinical trials to explore their potential benefits.
Researchers at UCLA developed a non-invasive biomarker to detect changes in brain function that may indicate worsening mood or suicidal thoughts. The test, using QEEG measurements, shows a sharp drop in brain activity within 48 hours of antidepressant medication start.
Scientists identified alternative routes for pharmaceuticals to enter the environment through bathing, showering, and laundering. These routes may lead to higher environmental impact for certain medications applied topically. Reducing consumption and developing better drug delivery systems can minimize environmental harm.
A systematic review of 51 studies found antidepressants to be more effective than placebos in treating depression in physically ill patients. However, adverse effects such as sexual dysfunction and dry mouth were more commonly experienced by those receiving treatment.
Researchers found that scopolamine, a muscarinic cholinergic receptor antagonist, reduced symptoms of depression within three days. The study also showed that participants experienced full symptom remission by the end of the treatment period.
Physicians can deny patient requests for antidepressants using patient-centered approaches, such as exploring the context of the request and recommending alternative diagnoses. These strategies are associated with higher visit satisfaction rates.
Researchers discovered that N-acetylserotonin, a melatonin precursor, activates the same brain growth factor circuits as BDNF, potentially explaining its antidepressant activity. This finding suggests new targets for depression treatment and may also shed light on neurodegenerative diseases.
Researchers at Oregon State University have developed a new compound that appears to balance neurotransmitters better than existing antidepressants, potentially offering improved efficacy and reduced side effects.
Patients taking antidepressant escitalopram experienced improved cognitive recovery following a stroke, outperforming those on placebo or in problem-solving therapy. This study suggests that escitalopram may be effective in promoting post-stroke recovery, despite being well-tolerated and not significantly affecting depressive symptoms.
A new study links commonly used antidepressants to delayed lactation in postpartum women. The medication's impact on serotonin regulation in the breast may contribute to this issue. Researchers call for more human research before making specific recommendations regarding SSRI use during breastfeeding.
A study found that deep brain stimulation (DBS) of the nucleus accumbens improved symptoms of depression and anxiety in patients with severe treatment-resistant depression. The procedure showed promising results with minimal side effects.
Researchers identified a causal link between serotonin receptors and depression treatment resistance. Higher autoreceptor levels in the brain were associated with reduced stress resilience and decreased response to antidepressant medication.
A study from Columbia University Medical Center found that an excess of one type of serotonin receptor in the brain's center may cause antidepressants to fail for half of patients. Researchers created a mouse model with high and low receptor levels, showing that reducing receptors can transform non-responders into responders.
A meta-analysis of randomized trials found that antidepressant medications provide substantial benefit for patients with very severe depression, but little to no benefit for those with mild or moderate symptoms. The study suggests that the efficacy of these medications largely depends on the severity of depression symptoms.
A national survey found that only 21% of Americans with clinical depression receive adequate treatment, while half go untreated. Disparities in mental healthcare access persist, particularly for African Americans and Mexican Americans, who face significant barriers to care.
A new study found that antidepressant medication during inpatient treatment can significantly reduce the risk of hospital readmission among suicidal adolescents. The research also highlights concerns over the use of multiple medications in this population, which was associated with a three-fold increased risk of readmission.
Researchers found that antidepressant medications can substantially change patients' personalities, particularly those with high neuroticism and low extraversion. Personality changes were linked to long-term improvements in mood, suggesting a potential mechanism for modern antidepressants.
A study of over 136,000 postmenopausal women found a 45% higher risk of stroke and a 32% higher risk of death among those taking antidepressants compared to non-users. The researchers note that while the overall risk is small, it can have significant implications for large patient populations.
Postmenopausal women taking antidepressants may be at higher risk of stroke and death compared to those not taking the medication. Researchers emphasize the need for individualized risk assessment and further study to determine the exact association.
A new study reveals that most antidepressants miss the mark on a key brain protein called monoamine oxidase A (MAO-A), which is highly elevated during clinical depression. This finding has important implications for understanding why antidepressants don't always work, with potential benefits for developing more effective treatments.
A study found no association between antiepileptic drugs and increased suicidal thoughts or actions in individuals with bipolar disorder. In fact, antiepileptic drug treatment may have a protective effect on suicidality, particularly among those not receiving other treatments.
A study found that antidepressants can change personality traits like neuroticism and extraversion while alleviating depressive symptoms. Individuals taking the medication reported significant decreases in neuroticism and increases in extraversion compared to those receiving placebo or cognitive therapy.
A meta-analysis of 22 studies found that sedatives and hypnotics, antidepressants, and benzodiazepines significantly increase the risk of falling in older adults. The study suggests that psychotropic medications contribute to falls and fracture risks, emphasizing the need for careful medication management in elderly populations.
A UBC study found significant associations between sedatives, antidepressants, and anti-psychotics with falling among seniors. Safer alternatives like counseling and less-sedating therapies may be more appropriate for certain conditions.
Flibanserin, originally developed as an antidepressant, has been shown to improve sexual desire and satisfaction in women with low libido. The results of pooled clinical trials found significant improvements in sexual encounters, desire, and distress associated with sexual dysfunction.
Researchers found that depression-related genes and stress-related genes have almost no overlap, indicating that chronic stress does not cause the same molecular changes as depression. This finding challenges the long-held belief that stressful life events are a major cause of depression.
New research suggests that augmenting antidepressant therapy with omega-3 fatty acid supplements does not provide benefit for patients with coronary heart disease and depression. The study found no difference in improvement between groups on the Beck Depression Inventory-II scores.
A new study published in BMC Medicine found that the popular antidepressant nortriptyline is associated with a dramatic increase in suicidal thoughts among men. Compared to its competitor escitalopram, nortriptyline was linked to a 9.8-fold increase in emerging suicidal thoughts and a 2.4-fold increase in worsening suicidal thoughts.
Researchers at Medical University of South Carolina pioneer bilateral epidural prefrontal cortical stimulation, providing significant improvement in depressive symptoms. Five patients showed average improvement of 54.9% after seven months, including three who reached remission.
Studies found that antidepressant medication exposure during pregnancy is associated with an increased risk of preterm birth and low five-minute Apgar scores. Exposure was also linked to a higher risk of admission to the neonatal intensive care unit (NICU). The study suggests that treatment of depression during pregnancy may be warrant...
A new biomarker test has been developed to predict the effectiveness of antidepressant medication in patients with major depression, allowing for quick switching to more effective treatments. The test measures changes in brain-wave patterns and showed an accuracy rate of 74%.
A new study found that adding psychosocial therapy to medication can improve depression scores short-term and long-term in stroke patients, leading to better perceived recovery, physical condition, and social participation. Depression following stroke is a significant public health problem affecting one-third of patients.
The rate of antidepressant treatment increased significantly in the US between 1996 and 2005, from 5.84% to 10.12%, affecting racial and ethnic minorities at lower rates, with 18-69 year olds being most likely to use these medications
A study by researchers from four Madrid-based health centres found that family conflict is not a significant factor in the use of psychopharmaceuticals among Spanish women. The results show that 24% of women take antidepressants, with benzodiazepines used by 30.6%, primarily for sleep aid.
Dry mouth, caused by decreased salivary function, affects one in four Americans and is linked to over 400 prescription and non-prescription drugs. Patients may experience symptoms like constant thirst, difficulty eating or speaking, and increased tooth decay risk.
Researchers found that combining antidepressants with electroconvulsive therapy (ECT) improves depression symptoms more than using ECT alone, reducing memory problems, particularly when using nortriptyline or unilateral ECT on the right side of the brain.
Researchers found that amitriptyline can directly stimulate molecules that help neurons grow and resist toxins, suggesting a separate mechanism for its antidepressant effects. The study suggests that this property may be the key to understanding how some antidepressants work.
A study found that government warnings about antidepressant suicidality led to unintended changes in depression diagnosis among children and adults, resulting in reduced diagnoses and treatment, particularly for pediatric patients and young adults.
A multi-center study found that antidepressant citalopram had no significant effect on reducing repetitive behaviors in children with autism spectrum disorder. The study included 149 children aged five to 17 and tested the treatment over a 12-week period.
A new study published in Clinical Nursing Research found that marijuana use is common among HIV/AIDS patients in the US to alleviate symptoms such as anxiety, depression, and nausea. The study suggests that therapeutic marijuana use merits further consideration among policy makers, despite potential risks associated with its use.
A new experimental mouse model has been developed to investigate mechanisms of antidepressant action, revealing both neurogenesis-dependent and -independent pathways. The study found that chronic antidepressant treatment reversed behavioral dysfunctions in mice, but only when hippocampal neurogenesis was allowed to occur.
A study published by Mayo Clinic researchers found that pregabalin decreases hot flash severity and frequency, offering a treatment option for women who cannot take hormonal therapies or antidepressants. The medication appears to have a similar benefit as gabapentin and newer classes of antidepressants, with a lower dosage requirement.
Researchers found that only 22% of participants met trial criteria, had shorter bouts of depression, quicker response to medication, and fewer side effects compared to excluded patients. The study suggests that antidepressants should not be seen as a panacea and calls for more research on treatment-resistant depression patients.
A study found that women with severe premenstrual syndrome are more likely to relapse after stopping antidepressant medication, and shorter treatment durations may contribute to this risk. Women who achieved symptom remission during treatment were less likely to experience a relapse.
A recent study found that only a small percentage of patients with depression qualify for clinical studies, suggesting the results may not be generalizable to most patients. The study showed better outcomes for those who met inclusion criteria, highlighting the need for more inclusive trial designs.
A study by researchers at the University of Iowa found that disrupting ASIC1a, a brain protein involved in fear behavior and anxiety, produces an antidepressant-like effect in mice. The results suggest that ASIC1a inhibition could represent a new approach to antidepressant therapy.
Patients with heart disease who develop depression are at a greater risk for heart failure, with a two-fold increased incidence. Antidepressant therapy did not appear to lower this risk, suggesting that depression may be an emerging risk factor for cardiovascular outcomes.
Research suggests that depression can increase the risk of sudden cardiac death and fatal coronary heart disease in women. Women with more severe depressive symptoms or those who reported taking antidepressants were at higher risk for these events.
Research found that relatively healthy women with severe depression are at increased risk of cardiac events, including SCD and fatal CHD. Antidepressant use was strongly associated with this risk, particularly Sudden Cardiac Death.
Research at Yale University finds stress-related losses of synapses in the hippocampal region precede helpless behavior in depression and PTSD. Rapid-acting antidepressants may restore lost synapses for immediate relief from depressive symptoms.
A new study suggests that people with minimal manic symptoms or mixed depression presentations may be at greater risk of experiencing treatment-emergent mania when taking antidepressants. Researchers recommend exploring alternative treatments like mood stabilizers to manage depressive phases of bipolar illness.
A comprehensive meta-analysis of 12 new-generation antidepressants found sertraline and escitalopram to be the most effective and acceptable options. They showed better efficacy compared to other drugs, with escitalopram being more efficacious than duloxetine by 33%.
A study by Université Laval researchers found that omega-3 supplements significantly improved menopause-related mental health problems, including depression and hot flashes, in women aged 40 to 55. However, the effectiveness of omega-3s for more severe depressive symptoms was limited.
Fibromyalgia patients experience disability and reduced quality of life due to chronic pain and fatigue. Antidepressant medications have been found to improve symptoms by reducing pain, improving sleep, and boosting mood.