Articles tagged with Antidepressants
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A recent study published in The Lancet found that Cognitive Behavioral Therapy (CBT) significantly reduced depressive symptoms in adults who had not responded to antidepressant medication. After six months, 46% of participants in the CBT group showed improvement compared to 22% in the control group.
A new antidepressant drug called GLYX-13 has shown significant reductions in depression symptoms within hours, with positive effects lasting an average of seven days from a single dose. The novel therapeutic targets brain receptors responsible for learning and memory.
GLYX-13 produced statistically significant reductions in depression scores within 24 hours and persisted for an average of seven days. The effect size observed was nearly double the effect size seen with most other antidepressant drugs after 4-6 weeks of repeated dosing.
Researchers found evidence of worsened pregnancy outcomes with SSRI antidepressants, no benefits, and increased risk of miscarriage, preterm birth, and congenital abnormalities. The study suggests prescribing these medications with caution and counseling for women trying to get pregnant.
Research found that antidepressant use, particularly SSRIs, increases the risk of intracranial and intracerebral hemorrhages by 50% and 40%, respectively. However, the actual increased risk for most people is extremely low, occurring at a rate of one additional stroke per 10,000 people per year.
Current resources and strategies for helping smokers quit are available, but often underutilized. The author recommends combining behavioral support with nicotine replacement therapy to improve success rates. Many smokers may not be aware of the support offered by free nationwide toll-free numbers like 1-800-QUIT-NOW.
A study found that 40% of stroke patients were treated for depression without proper diagnosis. Researchers say clinicians are over-treating some patients and overlooking others due to lack of access to mental health care professionals. Screening for depression after all strokes could improve treatment outcomes.
In 2011, Americans took a record 4.02 billion prescription drugs, with antidepressants and ADHD medicines showing notable increases in sales. The growth of prescriptions is attributed to the rising demand for CNS disorders medications.
A new study suggests pregnancy could have a positive impact on bipolar disorder, with fewer and shorter episodes in pregnant women. The study's findings call for large, multicenter, prospective studies to better understand the natural course of the disorder.
A systematic review found that approximately one in five elderly prescriptions are inappropriate, with medications like diphenhydramine and propoxyphene being used incorrectly. The study highlights the need for more accurate medication prescribing practices in primary care settings.
A study found that spouses of people who suffer a sudden heart attack are at an increased risk of depression, anxiety, or suicide. Men were more susceptible to depression and suicide after their wife's survival or death from an acute myocardial infarction.
Researchers discover flavor components similar to prescription mood stabilizer valproic acid, which could lead to dietary recommendations or new supplements with beneficial mood effects. The study analyzed over 1,700 substances and found similarities between certain food flavors and approved antidepressants.
Researchers discovered that fibroblast growth factor-2 (FGF2) can increase the number of glial cells, supporting neurons and promoting proper neuronal function. This study presents a fundamental new mechanism for treating depression by targeting glial cell growth.
Studies investigate the connection between serotonin, BDNF, and TG2 in depression. High levels of TG2 may disrupt serotonin signaling, leading to depressive symptoms.
Researchers identified a brain signal that can predict which depressed patients will respond to ketamine, a rapid-acting antidepressant. The signal also holds clues to the agent's mechanism of action, which may lead to more personalized treatment.
A study found that adding creatine to antidepressant treatment significantly improved response rates, with twice as fast response times and higher remission rates compared to placebo. The supplement may provide a relatively inexpensive treatment option for women who haven't responded well to traditional antidepressants.
Off-label drug use is a widespread practice in medicine, with roughly 1 in 5 prescriptions filled for an off-label use. Patients may not be aware when their prescribed medications are being used off-label, as there is no requirement for physicians to disclose this information through informed consent.
Researchers at Texas A&M University discovered that the antidepressant sertraline hydrochloride (ZOLOFT) exhibits potent mechanisms against Cryptococcus neoformans, the major causative agent of fungal meningitis. The study suggests that ZOLOFT could be repurposed as a treatment option for this deadly infection.
A hormone with anti-diabetic properties called adiponectin has been shown to reduce depressive-like symptoms in stressed mice. Administering adiponectin produced antidepressant-like effects, especially in mice with obesity and type 2 diabetes.
A study found that Medicare beneficiaries with depression who faced a coverage gap in their Part D plan were more likely to discontinue their antidepressants. The study, which analyzed data from over 65,000 patients, also found similar reductions in the use of other essential medications, including heart failure drugs and antidiabetics.
Researchers found that rapamycin enhances learning and memory in young mice and improves these faculties in old mice, negating the normal decline with age. The drug also lowered anxiety and depressive-like behavior in the rodents.
A new study found that treating vitamin D deficiency improved symptoms of depression in women, suggesting a potential link between the two conditions. The study involved three women who received oral vitamin D replacement therapy and showed significant improvement in their depression scores after treatment.
A new study published in Biological Psychiatry confirms ketamine's rapid antidepressant effects in patients with bipolar disorder. Ketamine was found to significantly reduce depressive symptoms and suicidal thoughts within hours of administration.
A study found that critically ill patients taking antidepressants in ICU had higher mortality rates, with risk increasing by 73% compared to those not on the medication. The risk was highest among patients with acute coronary syndrome and those who had undergone cardiac surgery.
Patients with unipolar Major Depressive Disorder achieved significant improvements in depression symptoms and quality of life after five weeks of NeuroStar TMS therapy. The treatment resulted in a 30.5% increase in patients reporting no problems with performing usual activities.
The review explores the adverse effects of anti-epileptic drugs and antidepressants on fetal development, finding an estimated 1% of congenital malformations attributable to prescription drug use. Pregnant women are excluded from clinical trials, leaving a knowledge gap in drug safety and efficacy during pregnancy.
Researchers found that antidepressant Zoloft accumulates in yeast cells, inducing autophagy and causing membrane distortions. This response supports the idea that depression may be linked to diminished BDNF secretions and suggests alternative targets for next-generation antidepressants.
Bedwetting in children aged five years or older is common due to excessive urine production, overactive bladder, and inability to wake up. Treatment options include lifestyle modifications, medication, and bed alarms, with the latter showing long-term success in reducing nighttime water production.
Researchers found that sertraline, a common antidepressant, accumulates in yeast cells and triggers membrane curvature, suggesting a potential alternative mechanism for depression treatment. The study supports the idea that depression is linked to brain-derived neurotrophic factor (BDNF) secretions, not just serotonin.
A study published in Neurology found that certain antidepressants decrease depression in people with Parkinson's disease without worsening motor problems. The study used paroxetine and venlafaxine, two types of antidepressants with fewer side effects, and showed significant improvements in depression scores.
A new study published in Neurology found that antidepressant medications can effectively treat depression in Parkinson's patients without worsening their motor symptoms. The study, led by Irene Hegeman Richard, M.D., showed significant improvements in depression scores with paroxetine and venlafaxine, two commonly used antidepressants.
A US study has found that physicians are less likely to prescribe antidepressants to African-American and Hispanic patients with major depressive disorder. The study also reveals significant variations in prescription patterns based on patient age, payment source, and physician ownership status.
A prospective controlled study of 309 mother-infant pairs found that prenatal antipsychotic exposure was associated with significantly lower scores on a standardized neuromotor screening measure. Infants exposed to antidepressants also showed lower scores, while those with no psychotropic exposure scored highest. The study highlights t...
A new study in Biological Psychiatry has discovered that testosterone's antidepressant properties are mediated by a specific pathway in the hippocampus. Testosterone replacement therapy has been shown to effectively improve mood, particularly in men with hypogonadism.
Cedars-Sinai researchers found that rifaximin and lubiprostone are effective treatments for irritable bowel syndrome (IBS) with low side-effect profiles. The study analyzed over two dozen clinical trials and compared various drug therapies, concluding that these two drugs offer the best options for IBS patients.
A new study by UCLA researchers found that the brain responds differently to antidepressant medication based on prior treatment history. Subjects who had never taken an antidepressant showed large increases in prefrontal brain activity during placebo treatment, while those with prior experience exhibited slight decreases in activity.
A new study suggests that antidepressants, specifically duloxetine, can be an effective treatment for osteoarthritis pain. The analysis of FDA-approved studies found that duloxetine provides significant advantages over traditional treatments, including fewer side effects.
Research found that selective serotonin re-uptake inhibitor antidepressants may increase the risk of pregnancy-induced hypertension by 60%, with one SSRI associated with an 81% increase. Women should consult their doctor if concerned, as discontinuation can lead to depressive relapses and post-partum depression.
A study found that four premarketing trials for second-generation antipsychotics remained unpublished and yielded unflattering results. The researchers suggest that publication bias can blur distinctions between effective and ineffective drugs, potentially obscuring the true efficacy of these medications.
Researchers at Stanford University School of Medicine have developed a computer algorithm to quickly identify true drug side effects and interactions from millions of patient reports. The method, which includes a list of dozens of prominent drug interactions, has been tested on patients' electronic health records and confirmed accurate.
Researchers identified a genetic manipulation that increases brain cell development in mice, leading to improved sensitivity to antidepressant drugs. The study found that deleting the Nf1 gene results in long-lasting improvements in neurogenesis, enhancing anti-depressive and anti-anxiety effects.
A study suggests deleting a protein that regulates nerve cell growth can increase new nerve cells and speed up antidepressant effects, potentially offering a novel therapeutic approach for depression. The research found that mice without this protein showed improved symptoms of depression and anxiety even without medication.
The Lancet Editorial expresses concerns about the new DSM-5 edition's lack of exclusion for bereavement. The current draft diagnoses feelings of deep sadness after loss as depression, rather than grief, with no evidence base for treating recently bereaved individuals with antidepressants.
A new study presented at the American Academy of Orthopaedic Surgeons meeting found that patients taking antidepressants before hip replacement surgery reported greater pain and lower satisfaction with their procedure. Assessing a patient's mental health status prior to surgery is crucial for predicting outcomes.
A Pittsburgh study found that regional differences in Medicare drug spending are primarily due to the use of more expensive brand-name drugs, rather than volume. The study suggests that promoting the use of generic medications could lower out-of-pocket costs for patients and save Medicare money.
Researchers at Northwestern University are developing novel technologies to treat depression and other mood disorders using smartphones, web-based platforms, and virtual human coaches. These innovative approaches aim to provide immediate support, increase accessibility, and reduce costs.
A new analysis of clinical trial data found that treatment with fluoxetine did not increase or decrease suicidality in children compared to placebo. The study also showed that two different antidepressant drugs were effective at reducing suicidal behavior and depressive symptoms in adult and geriatric patients.
A new editorial aims to clarify drug and alcohol addiction terminology by defining current treatments' modes of action and targets. The authors suggest that a better understanding of these elements would aid in the development of more effective treatments, particularly for opioid and tobacco addictions.
A systematic review of FDA warnings and alerts over 20 years found that communicating health risks can be a complex science, with varying impacts on drug use and health behaviors. The most effective notices were those warning about serious adverse events, but even these had variable effects.
The TEAMcare program, based on the Chronic Care Model, activates patients to monitor their own health and empowers them to control their diseases. This approach results in improved depression outcomes, better-controlled blood pressure and cholesterol levels, and enhanced quality of life for patients with depression and diabetes.
As the US healthcare system faces significant challenges with multimorbidity, research articles and policy briefs offer solutions to improve care for patients with multiple chronic conditions. A study found that primary care attributes like comprehensiveness and patient-centeredness are associated with lower mortality rates.
Researchers found that a brief adherence program improves blood sugar test results and depression symptoms in patients with Type 2 diabetes and depression. The study showed that 60.9% of patients with integrated care had improved blood sugar test results, compared to 35.7% with usual primary care.
Most patients need several sequential treatment steps to achieve remission from major depression. The Lancet review highlights the importance of primary care providers recognizing and addressing depression in chronic physical disorders. Deep brain stimulation holds promise as a future treatment option.
Researchers have found a blood test that can predict how well a depressed patient responds to antidepressants, such as escitalopram. The test measures vascular endothelial growth factor (VEGF) levels, with higher VEGF levels associated with greater relief from depression.
A unique Swedish study of 691 widower men showed that finding a new partner within four to five years of losing their wife significantly reduced the risk of developing depression, anxiety, and sleep disorders. In contrast, those who remained single faced higher risks and were more likely to use sleeping pills and antidepressants.
A 10-year study on Medicaid patients with depression found substantial spending increases (29%) but only slight improvement in antidepressant use and decline in follow-up visits. Meanwhile, psychotherapy utilization fluctuated, and hospitalizations decreased.
A Finnish study published in the European Heart Journal found that combining antipsychotic and antidepressant drugs increases the risk of sudden cardiac death during an acute coronary event. The study suggests a need to improve screening for cardiovascular risk factors in psychiatric patients and avoid combining these medications.
A study published in the journal Pain found that opioid-dependent patients treated with escitalopram experienced significant reductions in pain severity and interference. The findings suggest that antidepressants may be an effective alternative to non-opioid pharmacologic therapies for managing chronic pain in this population.
A study funded by the NIH found that perinatal exposure to antidepressants in rats led to stunted brain growth, abnormal behavior, and miswired brain circuitry. The researchers discovered reduced neuronal density and faulty communication between the brain's hemispheres.
Researchers found that antidepressants given to rats during development led to brain abnormalities and behavioral traits similar to autism spectrum disorder. The study suggests a potential link between selective serotonin reuptake inhibitors and the rise in developmental disorders in children.