Articles tagged with Clinical Trials
The University of Cincinnati College of Medicine has launched a styrofoam recycling project to divert over 900 pounds of EPS waste from landfills each month. The program aims to reuse existing styrofoam materials, reducing the need for styrene and minimizing environmental impact.
Two clinical trials testing loncastuximab tesirine showed promising results in patients with high-risk forms of follicular lymphoma and marginal zone lymphoma. The treatment achieved impressive response rates, including a 70% complete response rate for marginal zone lymphoma and an overall response rate of 97% for follicular lymphoma.
A pilot clinical trial is testing the effectiveness of noninvasive electrical brain stimulation as a cognitive rehabilitation method for traumatic brain injury (TBI). The study aims to determine how early treatment with targeted brain stimulation can enhance cognitive recovery in moderate to severe TBI.
Researchers will compare smaller vs. larger breathing tubes in 3,180 patients to assess long-term patient-centered outcomes and safety. The study aims to fill an evidence gap on the effect of breathing tube size on shortness of breath after critical illness.
A groundbreaking phase one clinical trial explores a novel cell-based immunotherapy for breast cancer, demonstrating significant shrinkage of tumors and minimal side effects. The treatment leverages dendritic cells to trigger an organized immune system attack on cancer, offering hope for replacing or reducing the need for chemotherapy.
The COPD Foundation's PIVOT initiative aims to integrate patient-inspired health concepts into clinical trials for COPD. This framework improves research study design, enhances treatment benefit communication, and accelerates access to new therapies.
Researchers reported positive long-term results of bilateral capsulotomy for severe obsessive-compulsive disorder treatment, with high patient satisfaction even at 10 years. The study suggests MRgFUS capsulotomy may also be effective in managing other psychiatric diseases.
A clinical trial led by University of Oklahoma Health Sciences is investigating a new device designed to restore ovulation in women with polycystic ovary syndrome (PCOS)-related infertility. The REBALANCE trial aims to assess the safety and effectiveness of the device, which uses electrothermal energy to prompt ovulation.
A Phase 2 clinical trial has been initiated by Genethon and Hansa Biopharma to evaluate the efficacy and safety of imlifidase, a gene therapy for Crigler-Najjar syndrome. The trial aims to address anti-AAV antibodies, which prevent up to 1 in 3 people from benefiting from gene therapies.
A large-scale clinical trial involving over 9,000 patients reveals that text message reminders failed to improve medication refill adherence over a year. The study included diverse representation from subgroups, including females, Hispanic ethnicity, and Spanish-speaking patients.
Researchers assess 20 years of clinical trials for cell therapy's safety and efficacy in treating heart failure, highlighting progress despite challenges. The field continues to evolve through lessons learned from past studies, with ongoing trials taking novel directions.
A recent clinical trial has revealed a twice-yearly injection of Lenacapavir to be 96% effective in preventing HIV infection, surpassing daily oral PrEP. The study included racially and ethnically diverse participants, highlighting the need for more options in HIV prevention.
The ESMO Asia Congress 2024 will focus on multidisciplinary oncology in the Asian region, featuring novel treatment modalities, management of specific cancer types and pan-Asian trials. Key highlights include insights into genetics, biology and practice differences between West and Asia.
Researchers at UCSF are enrolling patients in a clinical trial to correct the genetic mutation causing sickle cell disease using non-viral CRISPR-Cas9 gene editing. The therapy aims to eliminate the need for a bone marrow transplant and create a new blood system free of the disease.
A study estimates that approximately one-third of eligible US adults without diabetes were excluded from clinical trials supporting GLP-1 and GLP-1/GIP medications. The FDA should consider updating labeling to advise caution on generalizing these medications' safety and effectiveness to excluded populations.
The study found that irritability was the most common systemic reaction in children under 2 years, followed by fever and fatigue or sleepiness. Maternal vaccination is thought to be a factor in the higher prevalence of reactions after the first dose.
The updated ASTRO guideline recommends personalized treatment approaches for patients with locally advanced rectal cancer, including non-surgical alternatives and intensified treatment regimens. The guideline aims to improve outcomes while preserving quality of life.
Insilico Medicine has received FDA clearance for ISM5939, a potential best-in-class oral small molecule inhibitor targeting ENPP1 for the treatment of solid tumors. ISM5939 demonstrated robust anti-tumor efficacy in preclinical studies and showed favorable safety profiles.
A phase 2b clinical trial found that sodium oxybate, an oral medication mimicking alcohol's effects, significantly improves symptoms of patients with laryngeal dystonia who respond to alcohol. The treatment provided up to 5 hours of voice relief, with no serious adverse events.
A University of Michigan-led study suggests that recycled pacemakers can be used safely and effectively in patients with life-threatening cardiac conditions. The international clinical trial involved nearly 300 people across seven countries and found no significant differences in pacemaker function up to 90 days after the procedure.
Positive initial results from Genethon's gene therapy GNT0004 show stabilization of motor functions and improved dystrophin expression in patients with Duchenne Muscular Dystrophy. The therapy is expected to be launched in pivotal trial phases in Europe and the US in Q2/2025.
The NIH-developed AI algorithm, TrialGPT, can identify relevant clinical trials for eligible patients and provide a clear explanation of their eligibility. The researchers found that clinicians using TrialGPT spent 40% less time screening patients while maintaining the same level of accuracy.
Prescription rates of sodium-glucose cotransporter-2 inhibitors increased substantially within 2 years after publication of clinical trial evidence documenting benefit. The study highlights the need to understand strategies used by higher prescribing centers to increase SGLT2i adoption.
A randomized phase 2 clinical trial shows that adding high-dose, intravenous vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months. Patients also experience improved quality of life with reduced side effects.
The study found that substituting pure maple syrup for refined sugars reduced several cardiometabolic risk factors in humans, including improved blood sugar levels and lowered blood pressure. Visceral fat mass also decreased significantly in the maple syrup group. The study's findings suggest that incorporating maple syrup into daily d...
A recent study found that electronic letter reminders highlighting the cardiovascular benefits of influenza vaccines increased vaccination rates among over 2 million adults in Denmark. The strategy showed a greater impact on those who have had a heart attack, improving flu shot rates by potentially being cardioprotective. The research ...
A study found that 64% of clinical trials for the top 30 highest-revenue medicines had their data accessible to researchers, a significant improvement over prior assessments. Companies using independent platforms achieved higher eligibility rates than those relying on internal processes.
A large-scale clinical trial found that intravenous infusion of exenatide during heart surgeries involving bypass did not significantly reduce the risk of death, stroke, or organ failure. The study included approximately 1,400 adults and a randomized, double-blind, placebo-controlled design.
New study suggests that small group differences may reflect important benefits for individual patients with cardiomyopathy. The authors recommend explicitly describing patient-level data to support clinical interpretation of results.
A phase II clinical trial showed that combining radiation, chemotherapy, and immunotherapy can shrink tumors and allow surgery, resulting in significantly improved outcomes. The study found that patients who underwent surgery had a 82% reduction in risk of death at one year follow-up.
A new study found that standardized autism screening during pediatric well-child visits identifies more children with high autism likelihood at a younger age. The study used the Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) and compared it to usual care.
Researchers found semaglutide and liraglutide substantially decrease AUD hospitalization risk compared to approved medications. Clinical trials are needed to confirm these findings and explore their efficacy in treating AUD.
A randomized clinical trial shows cognitive behavioral therapy for prolonged grief outperforms present-centered therapy in treating comorbid symptoms, while both treatments demonstrate effectiveness and acceptability. The findings suggest potential for dissemination and increased patient choice.
Patients receiving MRI-guided SBRT experienced significantly fewer urinary and bowel side effects compared to CT-guided treatment. MRI guidance also correlated with improved scores on specific quality-of-life measures, including bowel function and sexual health.
Singer Amy Grant's personal testimonial highlights the urgent need for support to save women's lives by funding research into better diagnosing, treating, and preventing cardiovascular disease. The American Heart Association aims to address awareness gaps and bridge clinical care gaps in women's heart health.
The new hospital will provide patient-centered care with personalized, compassionate treatment and groundbreaking research. Patients will have access to top specialists and pioneering therapies in cancer treatment.
The London Health Sciences Centre was the first and only hospital in Canada to implant a new extravascular implantable cardioverter defibrillator (ICD) during clinical trials. The device has been shown to provide long-term safety, efficacy, and performance, offering better comfort and care for patients.
A new clinical trial found that the addition of immunotherapy drug pembrolizumab to standard treatment improved disease-free survival rates for patients with stage 3 soft tissue sarcoma. The study showed that pembrolizumab reduced recurrence or death for patients by 15 percentage points compared to standard treatment.
Researchers at UCLA Health Jonsson Comprehensive Cancer Center have shown that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with advanced small cell bladder cancer and small cell/neuroendocrine prostate cancer. The study found that the combination treatment resul...
A new study published in JAMA Network Open found that brief cognitive behavioral therapy via video telehealth reduces suicide attempts and suicidal ideation, providing critical insight into treatment options for those struggling with suicidal thoughts. The study also shows that this therapy is effective in reducing depressive symptoms.
Researchers found that non-invasive stereotactic radiosurgery significantly improves tumor control and reduces symptoms such as tinnitus, cranial nerve deterioration, and vestibular dysfunction. Early treatment can prevent tumors from growing over time and spare patients from irreversible problems.
The Phase IIa trial of ISM001-055 showed dose-dependent improvement in forced vital capacity (FVC) and percent predicted FVC, suggesting potential to slow or reverse disease progression. The treatment also demonstrated a favorable pharmacokinetics profile with minimal adverse events.
The VANCE trial demonstrates that Singapore has the expertise and capabilities to run large-scale global cell therapy trials. The study shows promising results for patients with recurrent or metastatic NPC treated with EBV-CTL therapy, with median survival rates of up to 29.9 months.
The ISSCR has developed a comprehensive Continuing Education (CE) course on stem cell-based therapies, covering fundamental biology, clinical trials, and patient communication. The open-access course aims to equip healthcare providers with accurate information, empowering them to navigate the complexities of this evolving field.
Researchers at MD Anderson Cancer Center present promising new treatments, including a gastric cancer therapy using T cell antigen coupler technology. Additionally, COVID-19 mRNA vaccines are shown to improve responses to immune checkpoint inhibitors in patients with non-small cell lung and melanoma cancers.
University of Cincinnati researchers highlight the importance of emergency consent in acute stroke trials due to time-sensitive nature and high mortality rate. They argue for more efficient alternatives to traditional informed consent, emphasizing patient autonomy and beneficence.
A new study published in The British Journal of Cancer found that whole genome sequencing can help identify treatment recommendations for cancer patients. The study evaluated the regional implementation of the 100,000 Genomes Project and found that different types of cancer were associated with varying rates of recommended actions.
Researchers at UCSD found psilocybin therapy reduces eating disorder psychopathology and improves quality-of-life in patients with anorexia nervosa, but results vary widely among individuals. Genetic variations may influence treatment outcomes.
Rice bioengineers create a mathematical model that challenges long-held assumptions about IL-12's behavior in the body, suggesting repeated doses cause immune cells to hoard IL-12 before it reaches the bloodstream. The findings have significant implications for IL-12 therapy design and may lead to more effective dosing regimens.
A randomized clinical trial found that simultaneous administration of mRNA COVID-19 and inactivated influenza vaccines had comparable reactogenicity to sequential administration. This suggests a safe option for co-administration of these vaccines.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
A phase 2 clinical trial found that the combination of vidutolimod and nivolumab led to tumor control in 55% of patients, with higher levels of immune-related proteins detected in responders. The study also uncovered unique signatures of TLR9 activation and a link between gut microbiome and response to therapy.
Researchers found that both methods restored blood circulation in about 30% of patients, with no difference in survival or quality of life. The study's results may impact future guidelines for cardiac arrest treatment.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
A post hoc analysis of the ARCADIA trial found no significant difference in major ischemic and hemorrhagic events between apixaban and aspirin in patients with a history of cancer and cryptogenic stroke. The study suggests that both treatments may be effective, but further research is needed to confirm these results.
The NoNO Trial, a seven-year randomized controlled trial, aims to study the efficacy of using nitric oxide in treating congenital diaphragmatic hernia (CDH) in newborns. The study will compare outcomes before and after de-implementation of nitric oxide at participating centers.
A study led by WVU epidemiologist Bethany Barone Gibbs found that alternating sitting and standing at work reduces sedentary behavior but has no effect on lowering blood pressure. Prolonged static standing may even have negative effects on cardiovascular health due to a physiological mechanism called the muscle pump.
A four-year study funded by a $2.5 million grant will investigate the impact of spinal cord transcutaneous stimulation combined with gait training on motor recovery in individuals with traumatic brain injury. The research aims to improve clinical treatment strategies and decision-making for improved gait and functional recovery.
A study found that using an orbital atherectomy device to remove calcium from blocked coronary arteries before stenting procedures did not improve patient outcomes. The device was used on patients with moderately severe calcification, rather than extreme cases, and did not show significant benefits.
A KAIST team created a face-conforming LED mask with improved efficacy in skin rejuvenation. The FSLED mask demonstrated a 340% improvement in deep skin elasticity compared to conventional masks, showing significant benefits for anti-aging treatment.