Articles tagged with Clinical Trials
A recent study published in the New England Journal of Medicine found that fish oil supplements containing omega-3 fatty acids did not reduce the risk of cardiovascular events in patients with diabetes. The ASCEND trial involved over 15,000 participants and followed them for an average of 7.4 years.
The ARRIVE trial found that daily aspirin did not reduce the occurrence of major cardiovascular events among participants at moderate cardiovascular risk. However, a lower-than-expected rate of cardiovascular events was observed, suggesting potential protection from modern preventative and therapeutic strategies such as statins.
A long-term study found that blood pressure lowering treatment with a calcium channel blocker plus statin reduces cardiovascular deaths by 29% compared to older therapy. Statins also show significant benefits, with 15% lower cardiovascular death rates in patients with average cholesterol levels.
A statistical analysis of two Phase 3 clinical trials reveals a decrease in dengue vaccine efficacy with increasing antigen amino acid mismatch in children aged 2-8. In contrast, older children showed broader protective responses with prior virus exposure.
A SWOG study shows that enrolled patients in cancer clinical trials exhibit similar survival rates, regardless of their rural or urban status. This suggests that uniform treatment strategies and access to quality care can help resolve cancer disparities between rural and urban populations.
The Phase 1 clinical trial will analyze the immune response and assess the safety of the experimental vaccine, which has shown promise in earlier tests in rhesus macaques. The trial is designed to enroll 28 healthy adults and will last up to one year.
A study from Columbia University neuroscientists found that the human brain employs precise logic to decision-making, allowing prior knowledge to be updated based on new evidence. Participants learned to recognize and incorporate bias in a statistically optimal manner without confirmation bias.
The EMBRACA trial shows that talazoparib provides a significant clinical benefit to patients with metastatic breast cancer and BRCA mutations. The study found that talazoparib improved progression-free survival, quality-of-life measures, and overall response rates compared to chemotherapy.
A phase 3 trial found that radiation therapy and cetuximab was associated with worse overall and progression-free survival compared to the current standard treatment with radiation and cisplatin. The study recommended releasing the data after an interim analysis showed that cetuximab with radiation was inferior to cisplatin and radiation.
The American College of Rheumatology has received two grants from the Office of Minority Health to increase minority participation in lupus clinical trials. The MIMICT and LuCTT programs will address challenges in recruiting minority populations affected by lupus, utilizing community health workers as referral sources.
A randomized clinical trial found an intervention reducing condomless sex acts among young transgender women, suggesting it is both feasible and effective. The project shared information about HIV, promoted condom use, and encouraged partner communication to reduce the risk of HIV transmission.
Experts review current Ebola vaccine candidates and clinical trials, highlighting key gaps in knowledge that need to be addressed by future research. More data is needed on the durability and rapidity of immune responses generated by various vaccine approaches.
MIT researchers develop a machine-learning model that reduces toxic chemotherapy and radiotherapy dosing for glioblastoma patients, maintaining tumor-shrinking potential while minimizing side effects. The model uses reinforced learning to favor lower doses and schedules, improving patient quality of life.
A large national study finds that inducing labor at 39 weeks reduces cesarean deliveries, maternal and fetal complications. Women who underwent elective induction reported less pain and lower rates of preeclampsia and gestational hypertension.
A study found that inducing labor at 39 weeks in healthy women reduces the need for cesarean sections and is as safe as waiting for spontaneous labor. The procedure may also lower the risk of preeclampsia and respiratory issues in newborns.
A family-based program and a school-readiness program showed no impact on BMI growth trajectories in one trial, while the other trial resulted in modest improvements in weight loss. The studies followed children from birth to age 3.
A new pilot clinical trial found that consuming crickets can help support the growth of beneficial gut bacteria and reduce inflammation in the body. The study showed an increase in beneficial gut bacteria like Bifidobacterium animalis and a decrease in inflammatory proteins.
A post hoc analysis of the exenatide-PD trial results showed that patients on exenatide treatment experienced improvements in severity of depression, independent of motor function improvement. Additionally, self-reported apathy and cognition also improved with exenatide.
A study found that women and older people are significantly underrepresented in clinical trials for heart disease, with women making up only 29% of participants. This lack of representation could have adverse consequences on care for these patient groups, as their bodies respond differently to treatments.
New research highlights the importance of targeted clinical trials to address the shortage, with 142 active trials worldwide and only 29 disease-modifying therapies in phase 2 or 3 development. The study suggests that considering biomarkers and risk factors can increase the power per patient screened to detect potential treatments.
Researchers emphasize need for more targeted trials to detect potential treatments for Alzheimer's disease, citing only 42 active trials on disease-modifying therapies. The study also identifies promising compounds and approaches to target amyloid and tau proteins, as well as repositioning existing drugs.
A national clinical trial found that prehospital plasma transfusion can reduce mortality in traumatically injured patients with severe bleeding. The study, published in the New England Journal of Medicine, showed a 9.8% increase in survival rates among patients who received two units of plasma during air medical transport.
The Network for Excellence in Neuroscience Clinical Trials has been renewed for five more years, enabling the study of new treatments for brain disorders. Nine clinical trials are currently underway, demonstrating the potential of NeuroNEXT to expedite research and bring treatments to patients faster.
A study found that tolvaptan treatment slowed the rate of kidney function decline in individuals with autosomal dominant polycystic kidney disease (ADPKD) for up to 11 years. The therapy also showed a lower risk of a 33% reduction in eGFR from baseline.
A new clinical trial has found that 92.9% of women with two or three sites of cancer in a single breast can undergo breast-conserving surgery, replacing mastectomy as the preferred treatment option for this condition.
The seven randomized trials funded by NCI and PCORI are enrolling slowly due to commercial insurance policies not covering proton therapy. Researchers propose a coalition approach involving insurers, centers, hospitals, vendors, and advocates to establish coverage for trial participation. The trials will compare cancer control and side...
A Mediterranean-type diet rich in fruits, vegetables, nuts, and olive oil reduced hip bone loss in people with osteoporosis within 12 months. The study, involving over 1,000 participants, showed a significant increase in bone density at the femoral neck. This could be a welcome addition to current drug treatments for osteoporosis.
A landmark study published in The Lancet found that robotic surgery is as effective as traditional open surgery in treating bladder cancer. Robotic surgery patients experienced less blood loss and shorter hospital stays but longer surgeries compared to those who underwent open surgery.
A study published in the Journal of the American Medical Association found that use of tissue plasminogen activator (tPA) for mild stroke may not provide significant benefits for patients. Researchers used data from the Greater Cincinnati Stroke Study and tracked outcomes for 313 patients with minor, non-disabling acute ischemic strokes.
A human clinical trial revealed verapamil as a safe and effective therapy to reduce insulin requirements and hypoglycemic episodes in adult subjects with recent onset Type 1 diabetes. The study found that regular oral administration of verapamil enabled patients to produce higher levels of their own insulin.
Research led by NYU School of Medicine found that physicians in small independent primary care practices (SIPs) report dramatically lower levels of burnout compared to the national average. The study suggests that independence and autonomy may provide some protection against symptoms of burnout, highlighting the importance of creating ...
The RTOG 0618 trial found Stereotactic Body Radiation Therapy (SBRT) to achieve favorable primary tumor control and local control rates in operable early-stage lung cancer patients, with a low rate of toxicity. The results suggest that SBRT may be a viable alternative to surgery for this patient population.
A study by NRG Oncology/RTOG 0424 found that MGMT promoter methylation is associated with improved progression-free and overall survival in high-risk, low-grade glioma patients. The analysis suggests that MGMT promoter methylation should be incorporated into future clinical trial designs to risk-stratify LGG patients.
A web-based health behavior change support system improved weight loss and waist circumference reduction for up to 2 years. HBCSS, combined with cognitive behavioral group therapy or as a standalone treatment, offers a personalized approach to obesity treatment.
A large randomized trial has found that endometrial scratching, a commonly offered add-on treatment for IVF, does not improve pregnancy or live birth rates. The study involved over 1300 women and measured pain discomfort scores, contradicting previous studies that suggested a benefit from the procedure.
A new study found that hopes and plans for the future are associated with lower odds of perpetrating weapon-related violence among predominantly black/African American male youths in low-resource neighborhoods. The study used survey data from a violence prevention trial in Pittsburgh.
A genetically modified poliovirus therapy developed at Duke Cancer Institute has shown significantly improved long-term survival for patients with recurrent glioblastoma, with a three-year survival rate of 21 percent. The therapy preferentially targets tumor cells and ignites a targeted immune response.
A clinical trial found that 59% of patients with biochemical recurrence of prostate cancer had their clinical management changed by fluciclovine PET/CT imaging. The study detected disease in the prostate, pelvic lymph nodes, and less commonly, bone, guiding treatment decisions for men with recurrent prostate cancer.
Women are largely underrepresented in clinical trials of heart failure medications, with limited evidence on their efficacy. Precision medicine may lead to more effective medications by incorporating sex-aware randomized clinical trials.
Long-term follow-up of BCG vaccine trial participants shows significant clinical benefits, including near-normal blood sugar levels, which persist for up to five years. The study reveals a novel metabolic mechanism that increases cellular glucose consumption, leading to improved insulin sensitivity.
A seven-year study published in The Lancet found that robotic surgery and open surgery are equally effective in treating bladder cancer, with no differences in complication rates. The study also showed lower blood loss and hospital stays for patients who received minimally invasive surgery.
Researchers at Johns Hopkins Bloomberg School of Public Health have developed a method to determine diet adherence from a blood sample. By analyzing small molecules called 'metabolites' in the blood, they found that levels differed significantly between participants following a prescribed diet and those not adhering to it.
Researchers have found that participants over the age of 65 experience a slower progression of Alzheimer's disease when treated with Deep Brain Stimulation (DBS-f), regardless of when their device was turned on. This suggests that DBS could be a potential treatment for mild, late-onset Alzheimer's disease.
Researchers are exploring the benefits of brain training and lifestyle interventions to prevent dementia. Studies show that mentally stimulating careers and hobbies can lower cognitive decline risk. A combined diet and exercise intervention may also improve memory and thinking skills, while protecting against brain damage.
Lenabasum demonstrates significant clinical benefit in treating diffuse cutaneous systemic sclerosis (dcSSc), improving symptoms such as skin thickening, joint pain, and lung disease. The treatment has acceptable safety and tolerability with no severe or serious adverse events.
A clinical trial testing an experimental RSV vaccine is underway at Cincinnati Children's Hospital Medical Center. The study aims to examine the safety and immune response of the vaccine, with the goal of protecting vulnerable populations such as infants, young children, and older adults from severe illness.
A new study by University of Warwick found that high-tech negative pressure wound therapy devices do not improve patient recovery or reduce healthcare costs compared to standard dressings. The research suggests that the use of these devices may need to be re-evaluated in light of the findings.
A study led by CNIO researchers shows that silibinin reduces brain metastasis lesions in mice and patients, targeting the tumor microenvironment. The treatment has shown encouraging results, with 75% of patients reacting positively and a 15.5-month average survival rate
The EVIDENT II trial found that using a healthy lifestyle smartphone app improved arterial hardness, indicating delayed ageing and lower risk of atherosclerosis. The app group showed better results in modifying their diet composition, with higher carbohydrate intake and lower fat content.
Studies show that mobile health technology can lower cardiovascular disease risk scores and improve individual components of the risk score, such as systolic blood pressure, total cholesterol, and waist-to-hip ratio. However, more research is needed to fully understand its effectiveness in modifying objective measures of health.
A study by CHOP researchers found that patients with mitochondrial disease prefer self-administered treatments, daily treatment, and guaranteed access. However, they are less likely to participate if they need to discontinue their current medications or undergo invasive procedures.
A recent study found that most clinical trial participants are willing to share their personal data with pharmaceutical companies, believing the benefits of data sharing outweigh the risks. Despite concerns about privacy and potential harm, nearly 80% of respondents felt the benefits of data sharing were more important.
Clinical Trials in a Dish (CTiD) offers a novel strategy to test drugs on patient cells before moving into actual clinical trials. CTiD studies have opened up new avenues for screening cell-based safety and toxicity at the population level, enabling efficient testing with reduced costs.
Researchers at UCLA have developed a personalized glioblastoma vaccine that shows promise in increasing long-term survival. The vaccine, known as DCVax-L, has been shown to extend median survival time from 15-17 months to 23.1 months.
A randomized clinical trial found that increased supervision by attending physicians did not significantly reduce the rate of medical errors. However, residents reported a decrease in autonomy during rounds. The study suggests that residency training programs should balance patient safety with resident learning and autonomy.
A first-in-human phase I clinical trial using neural stem cells to treat chronic spinal cord injuries showed measurable improvement in three of four participants. No serious adverse effects were observed, suggesting the approach can be performed safely.
A new clinical trial is testing whether omega-3 capsules can stop bowel cancer from returning after liver surgery. The trial, funded by Yorkshire Cancer Research, involves 450 patients and investigates the effectiveness of a highly purified form of EPA.
The NCI-MATCH trial has released findings from three treatment arms, offering hope for targeted therapies in patients with specific gene abnormalities. The trial's results could aid in identifying effective treatments for various cancers, paving the way for future research.
A 16-week study found that combining recreational football training with dietary guidance significantly improves physical fitness, reduces blood pressure, and promotes healthier weight loss. This innovative intervention demonstrates the potential for exercise and diet to prevent type 2 diabetes in middle-aged and elderly individuals.
The American College of Physicians (ACP) has released a position paper calling for policies that better support women's health, including paid family and medical leave, reduced domestic violence, and access to reproductive services. A new prediction tool may also help tailor lung cancer screening to patient benefit and preferences.