Articles tagged with Clinical Trials
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A clinical trial found that a minimally invasive treatment for retinal detachment resulted in better visual acuity and reduced visual distortion compared to traditional surgery. The procedure, called pneumatic retinopexy (PnR), also showed significant cost benefits for healthcare systems.
A randomised controlled trial found that gut-directed hypnotherapy delivered by psychologists was effective in relieving IBS symptoms, with benefits persisting at 9-month follow-up. Group hypnotherapy was as effective as individual sessions, potentially offering a new treatment option for IBS patients.
Researchers from the BrainGate consortium demonstrate a brain-computer interface that allows people with paralysis to navigate and interact with off-the-shelf tablet devices. Participants were able to perform various tasks, including messaging, browsing, and music playback, with accuracy and speed.
A new brain-computer interface (BCI) enables people with paralysis to directly operate an off-the-shelf tablet device by thinking about making cursor movements and clicks. The participants were able to navigate through various apps, browse music selections, search for videos on YouTube, and compose emails and chats with high accuracy.
A neuroimaging study reveals that the medial prefrontal cortex (mPFC) shows increased activity when patients are shown drug cues, indicating a potential target for addiction treatment. The study aims to develop a novel non-invasive therapy using transcranial magnetic stimulation (TMS) to modulate neural networks.
Researchers at UNIGE have identified tamoxifen, a breast cancer medication, as a potential treatment for myotubular myopathy, a genetic disease that causes muscle paralysis and death before two years of age. The molecule greatly reduces the progression of the disease and boosts life expectancy in animal models by a factor of seven.
Researchers developed a new AI method to evaluate treatment effectiveness in individual patients. The method uses causal Bayesian networks and was applied to obstructive sleep apnea treatment, showing reduced mortality rates by 5%.
A new 15-minute brain scan predicts damage with 98% accuracy, helping doctors assess the extent of newborn brain damage and plan for long-term development. The scan may also aid in developing new treatments for brain injury in babies.
Scientists are conducting a phase I clinical trial combining NK cell therapy with an immunocytokine to target children with relapsed/refractory neuroblastoma. The treatment aims to kill cancer cells in a less toxic way than conventional therapies.
A new subclass of compounds, dubbed geroneuroprotectors (GNPs), has been identified as potential AD drug candidates and slow the aging process in mice. The study suggests that these compounds could provide therapeutic benefits for Alzheimer's disease and other diseases associated with aging.
A randomized clinical trial found that an exercise intervention including resistance, balance, and walking exercises improved functional capacity scales at hospital discharge. The study showed benefits for cognitive status among older hospitalized patients.
The VITAL study found that omega-3 fatty acids reduced the risk of heart attacks, particularly among African American participants. Vitamin D supplements may also lower cancer deaths over time, with a significant 25% reduction in mortality rates observed after two years of treatment.
A new oral drug significantly reduced menstrual bleeding in over 90% of premenopausal women with fibroid tumors. Elagolix also prevented estrogen-deficiency induced side effects like hot flashes and bone loss when prescribed with hormone therapy.
The SWOG Cancer Research Network and The Hope Foundation for Cancer Research provide grant support to U.S. Department of Veterans Affairs medical centers to enroll veterans in cancer clinical trials. This program aims to create a sustainable national network of sites offering new treatment options through clinical trials.
The HiLo trial found no significant difference in recurrence rates between patients given a low radiation dose compared to the standard higher dose. This means patients with low-risk thyroid cancer can benefit from fewer side effects, long-term complications, and more convenient treatment options.
A clinical trial found that eating fish twice a week as part of a Mediterranean diet can significantly decrease lung inflammation in children with mild asthma. The study involved 64 children from Greece and showed improved lung function after six months.
A novel immunotherapy combining Hu5F9-G4 and rituximab has shown safety and promise in a phase-1 clinical trial for non-Hodgkin's lymphoma. Half of the 22 patients enrolled experienced a positive response, with eight going into complete remission.
Two studies found that minimally invasive radical hysterectomy is associated with higher recurrence rates and worse overall survival for women with early-stage cervical cancer. The findings have already changed care at MD Anderson Cancer Center and could impact surgical management of all women with early-stage disease.
The Society of Vascular and Interventional Neurology presents the latest clinical trials and breakthrough technology related to vacuum aspiration for removing blood clots in stroke patients. The results aim to improve the lives of stroke patients worldwide.
Researchers investigated alternative radiation therapy regimens for early-stage breast cancer patients. The trial found that fewer, larger individual doses of radiation led to similar adverse effects as conventional radiation therapy after 10 years.
The IASLC affirms the strength of evidence supporting lung cancer screening, reducing mortality by 26-61% in high-risk populations. The organization recommends implementing global lung cancer screening programs, incorporating multidisciplinary teams and best-practice smoking cessation.
The NRG Oncology clinical trial BR001 found that SBRT is safe for patients with 2 metastases or 3-4 metastases in specific locations, including peripheral lung and abdomen/pelvic. The study showed zero protocol-defined dose-limiting toxicities across evaluable anatomic locations.
A study examined long-term outcomes of midurethral mesh sling operations for stress urinary incontinence, finding that 3.3% of women had their slings removed and 4.5% underwent reoperations within nine years. The reasons for removal or reoperations were not disclosed.
A new study finds that motion sickness and cybersickness share similar symptoms, including nausea, dizziness, and fatigue. The researchers suggest that virtual reality technology could be used to diagnose and prevent motion sickness in high-risk professions.
A study by NRG Oncology found that short-term androgen-deprivation therapy (ADT) combined with radiotherapy improved overall survival for men with early stage prostate adenocarcinoma for up to 10.4 years. However, the benefits dissipated after 18 years.
A study highlights the existence of barriers to the inclusion of 12 to 25-year-olds in both adult and paediatric early phase clinical trials. The legal minimum age limit in Europe is 18 years, preventing young patients from participating in trials designed for their tumor type.
A nine-week course of adjuvant trastuzumab was associated with similar disease-free survival and lower risk of cardiac toxicity compared to a one-year course in patients with HER2-positive early breast cancer. A six-month course of trastuzumab was also shown to be cost-effective, with an average cost saving of nearly £10,000 per patient.
EDAS surgery reroutes brain arteries to create new pathways for blood and oxygen, significantly decreasing stroke recurrence rates by 9.6% compared to intensive medical management alone. The study's findings are promising for applying EDAS to severe atherosclerosis of the brain arteries.
Researchers at Cold Spring Harbor Laboratory have developed a new approach called Density Estimation using Field Theory (DEFT) to analyze small datasets, inspired by theoretical physics. The method fixes shortcomings of common statistical methods, providing more certainty in conclusions.
A pooled analysis of four UK randomised controlled clinical trials found significant differences in chemotherapy side-effects between men and women with oesophagogastric cancer. Women experienced higher rates of nausea and vomiting, diarrhoea, mouth ulceration, and hair loss compared to men.
A randomized controlled trial found that a nurse-led care approach with a treat-to-target strategy significantly lowered uric acid levels and reduced the risk of gout flares and tophi compared to usual care. The study suggests that educating patients and providing regular follow-up can improve treatment adherence and outcomes.
A new blood test that detects circulating tumour DNA is being tested to determine if cancer patients need chemotherapy after surgery. The trial aims to identify high-risk patients who may benefit from aggressive treatment and low-risk patients who can avoid chemotherapy.
The WRAIR is conducting a Phase 1 clinical trial of the VRC-MARADC087-00-VP vaccine candidate, developed by NIAID, in healthy adult volunteers. The vaccine aims to stimulate rapid but durable immunity against Marburg virus, which causes severe hemorrhagic fever.
A trial published by The BMJ found that employees who used sit-stand workstations reduced their sitting time by more than an hour a day over 12 months, with improvements in job performance, psychological health, and daily anxiety. The results suggest that displacing sitting with standing may have positive effects on work-related outcomes.
The Cleveland Clinic-led research aims to improve outcomes for ACL tears by developing a new surgical technique called Bridge-Enhanced ACL Repair (BEAR). The BEAR procedure has shown promising results in preclinical and early clinical studies, and the five-year grant will coordinate a multicenter trial to evaluate its effectiveness.
A groundbreaking Phase 1 trial at the University of Southampton combines mIBG-targeted radiotherapy with two antibody therapies to boost the immune system against neuroblastoma, a common childhood cancer. The treatment aims to improve survival rates and is the first to test this combination of therapies.
A randomized clinical trial examined the timing of pushing during delivery, finding no significant difference between immediate and delayed pushing in rates of natural delivery or adverse outcomes among newborns. However, rates of hemorrhage and infection were higher among women who delayed pushing.
A novel study suggests that people who participate in dementia prevention trials are primarily motivated by a desire to help others. The findings also highlight the importance of human interaction, with trial participants preferring staff-administered assessments over automated technologies.
A large meta-analysis of 81 randomised trials found no effect of vitamin D supplementation on bone mineral density, fractures, or falls in adults. The study suggests that clinical guidelines should be changed to reflect the best available evidence and that there is little justification for using vitamin D supplements for musculoskeleta...
Most industry-funded clinical trials show funder involvement in design, conduct, and reporting, raising questions about academic freedom and independence. Only a few trials were found to be independent, highlighting the need for accurate reporting of contributorship to ensure patient confidence in trial results.
A phase 1b study and a phase 2 proof of concept study have generated positive results for SNF472, demonstrating a linear pharmacokinetic behavior and improved safety profile. A randomized, placebo-controlled phase 2b study is evaluating the effect of SNF472 on cardiovascular calcification over 1 year in haemodialysis patients.
A world-first electronic capsule measures gaseous biomarkers in the gut to diagnose common and debilitating conditions, offering rapid, non-invasive diagnosis. Phase 2 clinical trials will pursue enhanced technology and target related biomarkers for improved treatment and reduced healthcare costs.
A study of 140 premenopausal women with recurrent cystitis found that those drinking more water (1.5 liters daily) experienced less frequent infections (average 1.7 vs 3.2 episodes). Drinking more water may be a safe and inexpensive alternative to antimicrobial treatment.
A phase I clinical trial found bacterial Clostridium novyi-NT spores to be tolerable and clinically effective in patients with treatment-refractory solid tumor malignancies. The therapy showed early clinical efficacy, with 86% of evaluable patients experiencing stable disease.
Researchers developed targeted plasticity therapy (TPT) to pair physical movements with vagus nerve stimulation, accelerating brain reorganization and recovery. The study found TPT to be twice as effective as traditional rehabilitation alone in doubling upper limb recovery rates.
A phase II clinical trial found that a tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) and had a median survival of 17.5 months.
Adolescent and young adult (AYA) leukemia patients are significantly more likely to relapse than pediatric ALL patients. Factors such as lower clinical trial enrollment, shorter treatment duration, race, and insurance status contribute to this disparity.
A UCSF-led study found that wearable cardioverter defibrillators lower mortality among patients who wear them consistently, but do not significantly reduce sudden cardiac death. The devices were more effective in reducing overall mortality, with a 35.5% lower risk of death compared to those who did not wear the device.
Researchers found that both internal models are necessary for precise movement: learning to move and where to move. This discovery may lead to the development of new clinical tests and training methods for athletes, particularly those with cerebellar ataxia.
A randomized clinical trial found that about 60 percent of patients treated with antibiotics for uncomplicated acute appendicitis did not undergo appendectomy in five years. The study suggests that antibiotics may be a viable treatment option for this condition, offering an alternative to surgery.
A recent study published in BMJ reveals that European Union clinical trial registrations are incomplete, with universities struggling to meet regulatory requirements. Pharmaceutical companies, however, show relatively good compliance with EU regulations.
The SOLVE-TAVI trial found that local anesthesia is both safe and effective for patients undergoing transcatheter aortic valve replacement (TAVR), especially those with intermediate to high surgical risk. The study also showed similar outcomes between current-generation balloon-expandable and self-expanding valves.
The COAPT trial found that the MitraClip device significantly reduced hospitalization rates and mortality, while improving quality-of-life measures and functional capacity in heart failure patients with secondary mitral regurgitation. The study also showed a substantial reduction in the need for heart transplants or left ventricular as...
A new clinical trial suggests that combining CTLA4 targeted therapy with PD-1 targeted therapy may improve treatment outcomes for women with recurrent epithelial ovarian cancer. The trial found improved tumor response proportions and progression-free survival hazard rates in patients treated with the combination therapy.
A promising gene therapy for visually impaired sheep has been approved for human trials, offering hope for patients with achromatopsia. The treatment has already shown success in treating affected sheep and demonstrates the potential for a cure.
A Phase 1 clinical trial is testing the safety and immune-stimulating ability of an experimental nasal influenza vaccine in healthy children and teens. The investigational vaccine, developed by FluGen, Inc., has been designed to replicate only once in the body and prompt a robust immune response.
A UC Berkeley study reveals the brain's orbitofrontal cortex replays and revisits nearly every feature of previous decisions after placing a bet. The researchers found that gamblers' regret from losing or not betting more is the main driver of activity in this region.
A randomised controlled trial found that high dose folic acid supplementation beyond the first trimester has no benefit for preventing pre-eclampsia. However, low dose folic acid supplements before and during early pregnancy are still strongly recommended to prevent birth defects such as spina bifida.
A study found that only 49.5% of clinical trials in Europe reported results as required by EU regulations, with commercial sponsors being more likely to comply than non-commercial ones. The researchers also discovered inconsistencies in the EU Clinical Trials Register and developed a website to track compliance.
Atrium Health Wake Forest Baptist will join nationwide clinical trial networks, NeuroNEXT and NIH StrokeNet, to develop new treatments for neurological diseases and improve stroke prevention. The institution aims to enroll patients from historically underserved groups and make meaningful contributions to both networks.