Articles tagged with Clinical Trials
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A randomized clinical trial examined two nutritional strategies: multinutrient supplementation and food-related behavioral activation therapy. The combination of both strategies showed promise in preventing new episodes of major depressive disorder among overweight and obese adults over one year.
A low-calorie fasting-mimicking diet has been shown to reduce intestinal inflammation and increase intestinal stem cells, promoting the expansion of beneficial gut microbiota. The study suggests that this regimen may have potential in mitigating inflammatory bowel disease (IBD) pathology.
A new study published in JAMA found that nutritional supplements do not prevent depression, but lifestyle coaching to improve diet and eating behavior may reduce the risk. Participants who received a healthy dietary behavioral therapy experienced a reduction in depressive episodes when attending recommended sessions.
A randomized clinical trial found that a behavioral intervention with counseling sessions improved sustained physical activity and reduced sedentary behavior in patients with type 2 diabetes. The study compared the intervention to standard care with general physician recommendations.
A Children's Oncology Group study shows that postoperative radiation improves outcomes for children with ependymoma, achieving seven-year progression-free survival for over 75% of patients and overall survival for 85%. The findings provide evidence that radiation can improve outcomes despite age and tumor subtype.
A large multi-centre study of over 1,200 patients with REM sleep behaviour disorder found a high risk of Parkinson's disease progression and identified several strong predictors, including motor difficulties and mild cognitive impairment. The study's findings will improve clinical trial selection and therapy development.
A randomized clinical trial among over 1,300 students found that offering breakfast in the classroom increased the proportion of students with obesity. However, this effect did not translate to a combined measure of overweight and obesity after 2 ½ years.
UCSF researchers created a blockchain-based system to ensure the integrity of clinical trials data, creating an immutable audit trail that makes tampering visible. The system allows for real-time reporting of adverse events and protects data from corruption.
The partnership aims to advance genetic diagnosis and therapy for patients with muscle wasting neuromuscular diseases, including motor neurone disease and muscular dystrophy. AIIMS will launch its first patient trials, providing insight into the different genes present in India's populations.
A new oral medication targeting NF-κB, a key link between loss of dystrophin and disease progression, has been well-tolerated in boys with Duchenne muscular dystrophy. The Phase 1 clinical trial results indicate that the drug can reduce levels of NF-κB-regulated genes and serum proteins thought to originate from damaged muscles.
A clinical trial found that inducing labor at 41 weeks of pregnancy leads to a small reduction in birth complications, with an absolute risk difference of 1.4% in favor of the induction group. However, the results are not conclusive enough to change current practice, according to a linked editorial.
Cancer clinical trial patients need care plans after trials end, yet little is known about initiating advance planning discussions. Researchers emphasize the importance of engaging patients and families in conversations about end-of-life care and palliative care. They stress the need for better data on post-trial needs and expectations.
EHRA 2019 will feature a record number of late-breaking trials and scientific abstracts showcasing cutting-edge science on cardiac rhythm disorders. Original research will also be presented, including the development of a wearable ECG device.
A Vanderbilt University Medical Center study found that using bag-mask ventilation during tracheal intubation improves outcomes and reduces the rate of severely low oxygen levels in half. The procedure, which involves squeezing air from a bag into the mouth for 60 seconds, is now being routinely used at the hospital.
Researchers at NIHR Guy's and St Thomas' Biomedical Research Centre develop a treatment involving patients' modified cells, restoring healthy levels of integrin α4β7, effective in treating Crohn's disease. The proposed Tribute Trial will test the treatment's safety and effectiveness.
Researchers found that caring contacts reduced suicidal ideation and risk by lowering odds from 15% to 9%. Simple text messages can provide support during stress and transition, improving mental health outcomes.
A randomized clinical trial involving over 650 US Army soldiers and Marines found inconsistent results for a text-based suicide prevention intervention that supplemented standard care. The study suggests potential reasons for the uncertain results in the military population, but highlights the need for further research on this issue.
A Rutgers study found that facial trauma lawsuits generally favor physicians, with nearly three-fourths of cases being dismissed before trial. The study also found that patients are most successful in jury trials and in the Midwest, with outcomes favoring plaintiffs in Midwestern courts.
Researchers at Beth Israel Deaconess Medical Center found that higher sodium intake increases lightheadedness in the DASH-Sodium trial, challenging traditional guidelines. The study's findings suggest that concerns about reducing sodium causing lightheadedness may not be scientifically based.
A nationwide clinical trial aims to investigate the effects of lifestyle interventions on brain health and cognitive function in older adults. The U.S. POINTER study, funded by a $35 million grant, will compare two lifestyle interventions focusing on healthy diet, physical activity, and social challenges.
Patrick D. Lyden, MD, is recognized for his contributions to stroke treatment and management through the development of tPA and refinement of the National Institutes of Health Stroke Scale. He continues to advance stroke care through clinical trials and research on neuroprotection.
A new position paper published in the Journal of Neuromuscular Diseases emphasizes the importance of patient-centered approach in neuromuscular disease research. The paper advocates for shared decision-making and patient involvement in research activities, including clinical trials, biobanks, and regulatory processes.
A study published in PLOS Medicine found that an educational intervention trained rural Chinese primary care doctors to prescribe antibiotics more appropriately, reducing unnecessary prescriptions for childhood upper respiratory tract infections by 36%. The intervention's long-term benefits were sustained even a year after its conclusion.
A Lancet study found that statin therapy reduced the risk of a major vascular event by about a quarter for each millimole per litre reduction in LDL cholesterol, even in older people. Statins also did not increase the risk of deaths from non-cardiovascular disease or cancer at any age.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
The SPRINT MIND trial found that intensive lowering of systolic blood pressure did not significantly reduce dementia risk, but had a measurable impact on mild cognitive impairment. The study demonstrated that intensive blood pressure control is safe for the brain and may offer avenues for prevention.
A Phase 1 clinical trial is underway at Cincinnati Children's Hospital Medical Center to test two experimental Ebola vaccines, ChAd3-EBO-Z and MVA-BN-Filo, for their safety and ability to produce an immune response. The trial aims to enroll up to 60 healthy volunteers between 18-45 years of age.
A personalized decision aid failed to help surrogate decision makers and clinicians agree on treatment goals for critically ill patients. Nearly all surrogates chose a more aggressive treatment goal despite the aid being based on their patient's values.
A clinical trial led by Wake Forest School of Medicine found that intensive control of blood pressure significantly reduced the risk of developing mild cognitive impairment (MCI) in older people. MCI is a precursor to early dementia and increases the risk of dementia progression, but reversion to normal cognition is possible.
An investigational monoclonal antibody, mAb114, has been found to be safe and well-tolerated in an early-stage clinical trial involving adults. The treatment, which targets the Ebola virus's surface protein, demonstrated promising results, with all participants experiencing mild side effects.
Shapiro's comprehensive program in early cancer drug development has provided scientific and clinical direction for multiple investigational agents. His work has contributed to the advancement of several approved drugs, including CDK4/6 inhibitors.
A Phase 1 human clinical trial has begun testing a freeze-dried, temperature-stable formulation of the experimental tuberculosis (TB) vaccine candidate ID93. The trial aims to determine if the single-vial formulation of ID93 and adjuvant GLA-SE is as effective as previously tested two-vial combination in inducing an immune response.
A multi-site randomized controlled trial is enrolling patients with critical limb ischemia to compare treatment efficacy, functional outcomes, cost effectiveness, and quality of life. The BEST-CLI Trial seeks to overcome treatment bias by involving multidisciplinary CLI teams at participating sites.
Russian scientists developed advanced implants for the Ilizarov orthopedic system, which form part of the system's variation applied for lengthening and correcting deformities in children. The new implants reduced treatment terms by two times, accelerating bone regeneration and improving tissue density.
Researchers found that super-donors have stool rich in bacteria that enhance metabolism and can provide the necessary chemicals to restore gut balance. Fecal transplants from these 'super-donors' achieve clinical remission rates double those of other donors, offering new hope for treating a range of conditions.
Researchers in Leicester are investigating the use of antibiotics to treat certain types of severe asthma, a condition affecting 1 in 20 people with asthma. The study aims to identify patients with specific subtypes of severe asthma and test new oral treatments, including doxycycline and dexpramipexole.
A promising compound TTP399 targets glucokinase protein implicated in type 2 diabetes, improving glycemic control and reducing liver fat. Phase 2 clinical trial of 190 participants shows no adverse effects, paving way for potential new treatment options.
A study found that couples interventions for individuals with type 2 diabetes can reduce partners' diabetes distress and increase marital satisfaction. The intervention also improved diastolic blood pressure, but had no significant impact on weight loss or diet and activity behaviors.
A retrospective analysis found that genetic variations in the COMT gene affected whether vitamin E decreased or increased cancer risk in study participants. The results showed a significant impact of COMT variants on cancer rates among women taking vitamin E supplements.
The study will investigate the impacts of iron deficiency on infant brain development and physical growth. The trials aim to recruit over 6000 women and children in developing countries.
Researchers are developing a breath test to detect cancer at an early stage by analyzing volatile organic compounds in the breath. The PAN Cancer trial aims to identify patterns of VOCs that could indicate the presence of different types of cancer.
A clinical trial tested the effectiveness of topical antibiotic mupirocin in eliminating Staphylococcus aureus colonization in hospitalized infants. The study found that mupirocin is safe and highly effective in reducing SA infection, with over 90% of treated infants testing negative for SA after treatment.
A recent study published in the Journal of Clinical Oncology found that time to biochemical failure can be used as a surrogate endpoint for locally advanced prostate cancer treatment, reducing overall survival benefit by 6% compared to traditional endpoints. The analysis of NRG-RTOG 9202 clinical trial results showed significant associ...
Global supplies of Ac-225 are insufficient to meet growing demand for radiotherapy. Two production routes show promise, relying on irradiation of parent elements to increase yields.
A new therapy has shown 'very promising' initial results in improving the sight of people with Leber congenital amaurosis type 10 (LCA10), a severe inherited retinal disease. The therapy, QR-110, was injected into one eye and left untreated in the other, resulting in improved vision and restored levels of normal CEP290 protein in cells.
The Butantan Institute and MSD will exchange proprietary process information and clinical trial data, accelerating vaccine development. The partnership aims to create a tetravalent vaccine effective against all four dengue virus serotypes.
Researchers have made a significant breakthrough in understanding the mechanisms of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder. The study found that ezogabine treatment can reduce motor neuron excitability in ALS patients, suggesting a potential new therapy for the disease.
Recent studies at SABCS 2018 highlight radiation therapy's efficacy in treating breast cancer, with trials refining treatments to provide more options for patients. Accelerated partial breast irradiation has been shown to be non-inferior to traditional whole breast irradiation.
A randomized trial found that low-dose tamoxifen (5 mg/day) halved the risk of disease recurrence and new disease in women with DCIS, LCIS, and ADH. Treatment was well-tolerated without significant adverse events.
A large clinical trial found that black women with hormone-receptor positive breast cancer had a higher risk of recurrence and death compared to white women, even when treated equally. The study suggests biological differences may contribute to the disparity in outcomes.
Researchers found that self-sampling kits can improve cervical cancer detection among women not participating in screening programs. Studies showed that HPV tests based on PCR technology were just as accurate on self-samples as those taken by clinicians, but signal amplification-based tests were less effective.
Researchers have developed a gene therapy treatment that is reversing disease symptoms in two adults with Sickle Cell Anemia. The treatment, which uses reduced-intensity preconditioning, shows promise for transportability to resource-challenged parts of the world where SCA is most common.
Researchers at Dana-Farber Cancer Institute present positive results from clinical trials of CAR T-cell therapy and immunotherapy for patients with leukemia and lymphoma. The studies show that Yescarta provides durable benefit to lymphoma patients, while pembrolizumab achieves long-lasting responses in patients with an aggressive form ...
A new study highlights the effectiveness of CAR T-cell therapy in treating diffuse large B cell lymphoma patients. The real-world outcomes show that 81% of patients responded to the therapy with 58% having no detectable cancer after four months.
A daily hydroxyurea pill has been shown to improve health outcomes for young children with sickle cell anemia in resource-challenged sub-Saharan Africa. The treatment reduced rates of pain episodes, infections, malaria, transfusions, and death by significant margins.
Researchers have developed an effective monoclonal antibody treatment, lanadelumab, that can reduce the frequency of life-threatening swelling attacks in patients with hereditary angioedema. The treatment has shown a 90% reduction in attack rate and can be self-administered every two weeks.
Researchers have developed an ointment to counter the effects of brown recluse spider bites, which can cause skin necrosis and renal failure. The trial has started in Brazil with 240 participants, comparing the effects of the ointment with a placebo.
A new study from the University of Warwick demonstrates that digital versions of established measurements for assessing back pain are just as reliable and responsive. Patients can assess their own back pain using a mobile app on their phone or tablet as effectively as current paper methods.
A randomized, controlled trial is enrolling patients with confirmed Ebola virus disease in the Democratic Republic of Congo to compare mortality among those receiving three investigational drugs with a control group. The trial aims to establish the safety and efficacy of these treatments in a comprehensive response to combat Ebola.
Two clinical trials using botulinum toxin injections to suppress post-operative atrial fibrillation (POAF) showed promising results. Patients who received BTX injections during surgery had a sustained reduction in POAF incidence and overall burden over three years, accompanied by reduced hospitalization needs.