Articles tagged with Clinical Trials
Two studies found that minimally invasive radical hysterectomy is associated with higher recurrence rates and worse overall survival for women with early-stage cervical cancer. The findings have already changed care at MD Anderson Cancer Center and could impact surgical management of all women with early-stage disease.
The Society of Vascular and Interventional Neurology presents the latest clinical trials and breakthrough technology related to vacuum aspiration for removing blood clots in stroke patients. The results aim to improve the lives of stroke patients worldwide.
Researchers investigated alternative radiation therapy regimens for early-stage breast cancer patients. The trial found that fewer, larger individual doses of radiation led to similar adverse effects as conventional radiation therapy after 10 years.
The IASLC affirms the strength of evidence supporting lung cancer screening, reducing mortality by 26-61% in high-risk populations. The organization recommends implementing global lung cancer screening programs, incorporating multidisciplinary teams and best-practice smoking cessation.
The NRG Oncology clinical trial BR001 found that SBRT is safe for patients with 2 metastases or 3-4 metastases in specific locations, including peripheral lung and abdomen/pelvic. The study showed zero protocol-defined dose-limiting toxicities across evaluable anatomic locations.
A study examined long-term outcomes of midurethral mesh sling operations for stress urinary incontinence, finding that 3.3% of women had their slings removed and 4.5% underwent reoperations within nine years. The reasons for removal or reoperations were not disclosed.
A new study finds that motion sickness and cybersickness share similar symptoms, including nausea, dizziness, and fatigue. The researchers suggest that virtual reality technology could be used to diagnose and prevent motion sickness in high-risk professions.
A study by NRG Oncology found that short-term androgen-deprivation therapy (ADT) combined with radiotherapy improved overall survival for men with early stage prostate adenocarcinoma for up to 10.4 years. However, the benefits dissipated after 18 years.
A study highlights the existence of barriers to the inclusion of 12 to 25-year-olds in both adult and paediatric early phase clinical trials. The legal minimum age limit in Europe is 18 years, preventing young patients from participating in trials designed for their tumor type.
A nine-week course of adjuvant trastuzumab was associated with similar disease-free survival and lower risk of cardiac toxicity compared to a one-year course in patients with HER2-positive early breast cancer. A six-month course of trastuzumab was also shown to be cost-effective, with an average cost saving of nearly £10,000 per patient.
EDAS surgery reroutes brain arteries to create new pathways for blood and oxygen, significantly decreasing stroke recurrence rates by 9.6% compared to intensive medical management alone. The study's findings are promising for applying EDAS to severe atherosclerosis of the brain arteries.
Researchers at Cold Spring Harbor Laboratory have developed a new approach called Density Estimation using Field Theory (DEFT) to analyze small datasets, inspired by theoretical physics. The method fixes shortcomings of common statistical methods, providing more certainty in conclusions.
A pooled analysis of four UK randomised controlled clinical trials found significant differences in chemotherapy side-effects between men and women with oesophagogastric cancer. Women experienced higher rates of nausea and vomiting, diarrhoea, mouth ulceration, and hair loss compared to men.
A randomized controlled trial found that a nurse-led care approach with a treat-to-target strategy significantly lowered uric acid levels and reduced the risk of gout flares and tophi compared to usual care. The study suggests that educating patients and providing regular follow-up can improve treatment adherence and outcomes.
A new blood test that detects circulating tumour DNA is being tested to determine if cancer patients need chemotherapy after surgery. The trial aims to identify high-risk patients who may benefit from aggressive treatment and low-risk patients who can avoid chemotherapy.
The WRAIR is conducting a Phase 1 clinical trial of the VRC-MARADC087-00-VP vaccine candidate, developed by NIAID, in healthy adult volunteers. The vaccine aims to stimulate rapid but durable immunity against Marburg virus, which causes severe hemorrhagic fever.
A trial published by The BMJ found that employees who used sit-stand workstations reduced their sitting time by more than an hour a day over 12 months, with improvements in job performance, psychological health, and daily anxiety. The results suggest that displacing sitting with standing may have positive effects on work-related outcomes.
The Cleveland Clinic-led research aims to improve outcomes for ACL tears by developing a new surgical technique called Bridge-Enhanced ACL Repair (BEAR). The BEAR procedure has shown promising results in preclinical and early clinical studies, and the five-year grant will coordinate a multicenter trial to evaluate its effectiveness.
A groundbreaking Phase 1 trial at the University of Southampton combines mIBG-targeted radiotherapy with two antibody therapies to boost the immune system against neuroblastoma, a common childhood cancer. The treatment aims to improve survival rates and is the first to test this combination of therapies.
A randomized clinical trial examined the timing of pushing during delivery, finding no significant difference between immediate and delayed pushing in rates of natural delivery or adverse outcomes among newborns. However, rates of hemorrhage and infection were higher among women who delayed pushing.
A novel study suggests that people who participate in dementia prevention trials are primarily motivated by a desire to help others. The findings also highlight the importance of human interaction, with trial participants preferring staff-administered assessments over automated technologies.
A large meta-analysis of 81 randomised trials found no effect of vitamin D supplementation on bone mineral density, fractures, or falls in adults. The study suggests that clinical guidelines should be changed to reflect the best available evidence and that there is little justification for using vitamin D supplements for musculoskeleta...
Most industry-funded clinical trials show funder involvement in design, conduct, and reporting, raising questions about academic freedom and independence. Only a few trials were found to be independent, highlighting the need for accurate reporting of contributorship to ensure patient confidence in trial results.
A phase 1b study and a phase 2 proof of concept study have generated positive results for SNF472, demonstrating a linear pharmacokinetic behavior and improved safety profile. A randomized, placebo-controlled phase 2b study is evaluating the effect of SNF472 on cardiovascular calcification over 1 year in haemodialysis patients.
A world-first electronic capsule measures gaseous biomarkers in the gut to diagnose common and debilitating conditions, offering rapid, non-invasive diagnosis. Phase 2 clinical trials will pursue enhanced technology and target related biomarkers for improved treatment and reduced healthcare costs.
A study of 140 premenopausal women with recurrent cystitis found that those drinking more water (1.5 liters daily) experienced less frequent infections (average 1.7 vs 3.2 episodes). Drinking more water may be a safe and inexpensive alternative to antimicrobial treatment.
A phase I clinical trial found bacterial Clostridium novyi-NT spores to be tolerable and clinically effective in patients with treatment-refractory solid tumor malignancies. The therapy showed early clinical efficacy, with 86% of evaluable patients experiencing stable disease.
Researchers developed targeted plasticity therapy (TPT) to pair physical movements with vagus nerve stimulation, accelerating brain reorganization and recovery. The study found TPT to be twice as effective as traditional rehabilitation alone in doubling upper limb recovery rates.
A phase II clinical trial found that a tumor-specific vaccine combined with an immune checkpoint inhibitor shrank tumors in one third of patients with incurable cancer related to the human papilloma virus (HPV) and had a median survival of 17.5 months.
Adolescent and young adult (AYA) leukemia patients are significantly more likely to relapse than pediatric ALL patients. Factors such as lower clinical trial enrollment, shorter treatment duration, race, and insurance status contribute to this disparity.
A UCSF-led study found that wearable cardioverter defibrillators lower mortality among patients who wear them consistently, but do not significantly reduce sudden cardiac death. The devices were more effective in reducing overall mortality, with a 35.5% lower risk of death compared to those who did not wear the device.
Researchers found that both internal models are necessary for precise movement: learning to move and where to move. This discovery may lead to the development of new clinical tests and training methods for athletes, particularly those with cerebellar ataxia.
A randomized clinical trial found that about 60 percent of patients treated with antibiotics for uncomplicated acute appendicitis did not undergo appendectomy in five years. The study suggests that antibiotics may be a viable treatment option for this condition, offering an alternative to surgery.
A recent study published in BMJ reveals that European Union clinical trial registrations are incomplete, with universities struggling to meet regulatory requirements. Pharmaceutical companies, however, show relatively good compliance with EU regulations.
The SOLVE-TAVI trial found that local anesthesia is both safe and effective for patients undergoing transcatheter aortic valve replacement (TAVR), especially those with intermediate to high surgical risk. The study also showed similar outcomes between current-generation balloon-expandable and self-expanding valves.
The COAPT trial found that the MitraClip device significantly reduced hospitalization rates and mortality, while improving quality-of-life measures and functional capacity in heart failure patients with secondary mitral regurgitation. The study also showed a substantial reduction in the need for heart transplants or left ventricular as...
A new clinical trial suggests that combining CTLA4 targeted therapy with PD-1 targeted therapy may improve treatment outcomes for women with recurrent epithelial ovarian cancer. The trial found improved tumor response proportions and progression-free survival hazard rates in patients treated with the combination therapy.
A promising gene therapy for visually impaired sheep has been approved for human trials, offering hope for patients with achromatopsia. The treatment has already shown success in treating affected sheep and demonstrates the potential for a cure.
A Phase 1 clinical trial is testing the safety and immune-stimulating ability of an experimental nasal influenza vaccine in healthy children and teens. The investigational vaccine, developed by FluGen, Inc., has been designed to replicate only once in the body and prompt a robust immune response.
A UC Berkeley study reveals the brain's orbitofrontal cortex replays and revisits nearly every feature of previous decisions after placing a bet. The researchers found that gamblers' regret from losing or not betting more is the main driver of activity in this region.
A randomised controlled trial found that high dose folic acid supplementation beyond the first trimester has no benefit for preventing pre-eclampsia. However, low dose folic acid supplements before and during early pregnancy are still strongly recommended to prevent birth defects such as spina bifida.
A study found that only 49.5% of clinical trials in Europe reported results as required by EU regulations, with commercial sponsors being more likely to comply than non-commercial ones. The researchers also discovered inconsistencies in the EU Clinical Trials Register and developed a website to track compliance.
Atrium Health Wake Forest Baptist will join nationwide clinical trial networks, NeuroNEXT and NIH StrokeNet, to develop new treatments for neurological diseases and improve stroke prevention. The institution aims to enroll patients from historically underserved groups and make meaningful contributions to both networks.
Researchers have successfully conducted a Phase I clinical trial in China, showing that stem cells extracted from baby teeth can regrow dental tissue, promoting healthy root development and increased blood flow. The treatment has been found safe and effective, with patients regaining sensation in their injured teeth.
A randomized clinical trial found that a Tai Ji Qan balance training program was more effective than other exercise programs in reducing falls among older adults at high risk. The study included 670 participants and lasted six months, with results suggesting improved fall prevention through the specific focus on balance training.
Researchers at USC and MUSC found that transcranial direct current stimulation (tDCS) significantly improved naming exercises in stroke patients with long-term aphasia. The study shows tDCS coupled with speech therapy is a promising new treatment for these patients.
A new study found that pregnant overweight and obese women can limit their weight gain with diet and exercise interventions, reducing complications but not impacting birth weight. The trials included diverse socioeconomic groups and showed that reduced weight gain did not result in fewer obstetrical complications.
A Phase 1 clinical trial is underway to evaluate the immune-boosting properties of imiquimod cream in combination with an H5N1 influenza vaccine. The study aims to enhance the immune response conferred by the pre-pandemic vaccine, potentially reducing the number of doses required to achieve sufficient immunity.
Researchers will investigate whether obstructive sleep apnea diagnosis and treatment improves stroke recovery or reduces the likelihood of another stroke. The study aims to determine whether future patients should be screened and treated for OSA to improve survival and recovery after a stroke.
Researchers examined federal payment databases to determine payments made to oncologists who authored studies in high-impact journals. The study found that a substantial proportion of payments were not disclosed, which could lead to bias and influence clinical trial results.
At ESC Congress 2018, a record 156 countries were represented, with over 4,500 abstracts presented in 500 expert sessions. Key clinical trials included MARINER, CAMELLIA-TIMI 61, and ASCEND, which may impact practice and guideline updates. The congress also featured new guidelines for hypertension care.
A clinical trial showed AI detected diabetic retinopathy as accurately as expert clinicians, with a sensitivity of 87% and specificity of 90%. Early detection may prevent vision loss, which affects 24,000 Americans annually.
A new randomized trial tested a revised set of criteria for diagnosing heart attacks, but found that using these criteria did not reduce the rate of recurrent heart attacks or cardiovascular deaths. The study suggested that the revised criteria could lead to more diagnoses and treatment, but with no adverse effects on patient outcomes.
A national approach is needed for trialing cannabinoids in children due to the lack of high-quality evidence and unregulated use of products. Collaboration among academics, industry, and provincial governments is required to conduct multiple-site clinical trials with long-term follow-up.
A new treatment has been found to significantly reduce hospital stays for patients with heart infections by halving the duration of intravenous antibiotic treatment. The POET trial showed that giving patients oral antibiotics after at least ten days of intravenous treatment was as effective and safe as continued intravenous treatment, ...
UTEP scientists have received a $6 million grant from the National Institutes of Health to develop new regimens and biomarkers for Chagas disease treatment. The researchers aim to improve the efficacy and safety of current treatments, which are toxic and have low effectiveness.
Treatment with irbesartan, a blood pressure medication, slows aortic dilatation in children and young adults with Marfan syndrome. The five-year study found a clinically important reduction in aortic dilatation rates, potentially delaying surgical intervention and reducing complications.
The VERDICT trial found that postponing invasive examination and treatment for up to 72 hours is as good as a very early approach in patients with NSTE-ACS, particularly those with high risk. This contradicts ESC guidelines on immediate versus early invasive strategies.
The trial found that using two arterial grafts, including internal thoracic and radial arteries, may provide better outcomes than a single graft. However, the results are not conclusive due to high rates of deviations from randomization.
Patients with cardiovascular disease who experience major internal bleeding are more likely to be diagnosed with cancer, particularly gastrointestinal and genitourinary tract cancers. The study, which involved over 27,000 patients in 33 countries, suggests that bleeding may serve as an early warning sign for occult cancers.