Articles tagged with Clinical Trials
Researchers at Nemours Children's Health System developed a novel video-based informed consent process to improve participants' understanding and retention of trial information. The study found that caregivers of children who watched the video presentation retained more information about the study design five months later.
A lower-fat diet was linked to increased breast cancer overall survival among postmenopausal women, although the increase may be partly due to better survival from other causes. The study found modest increases in vegetable, fruit, and grain intake in the lower-fat group.
A novel index of coronary artery stenosis severity called resting full-cycle ratio (RFR) has been found to be diagnostically equivalent to instantaneous wave-free ratio (iFR). The study, presented at EuroPCR, suggests RFR could identify pressure-based stenosis severity independent of timing within the cardiac cycle.
A Phase 1 clinical trial is evaluating the safety and tolerability of mAb114, a single monoclonal antibody developed from an Ebola survivor. The trial aims to enroll 18-30 healthy volunteers and will not expose participants to Ebola virus.
A randomized trial found that a team approach involving intensive emotional support and frequent family meetings improved patient-centered care in ICUs, reducing hospitalization costs by 28% and lengths of stay by over three days.
The Zephyr Endobronchial Valve successfully reduced shortness of breath and improved lung function in patients with severe emphysema, with benefits lasting at least one year after treatment. Proper patient selection was key to the trial's success.
A randomized clinical trial found that sustained vitamin D supplementation reduced the likelihood of recurrent wheezing in preterm black infants by 12 months' adjusted age. The study involved 300 black infants born between 28-36 weeks and compared two vitamin D supplementation strategies.
Evolocumab treatment has been shown to effectively reduce lipoprotein(a) levels and decrease the risk of cardiovascular events. Patients with higher baseline lipoprotein(a) levels derived greater absolute benefit from evolocumab treatment, with a 24% decrease in risk of heart attack, stroke, or cardiovascular death.
A new clinical trial is underway to test two human monoclonal antibodies designed to treat MERS-CoV infection. The study will enroll 48 healthy adults and administer escalating doses of the experimental antibodies.
A clinical trial found that chiropractic care, when added to usual medical care, resulted in moderate improvements in pain intensity and disability for US military personnel with low back pain. The study suggests a potential cost-effective and low-risk treatment option for this common condition.
A new trial shows that a shorter length of trastuzumab treatment can benefit patients with breast cancer just as much as a longer treatment, with less risk of cardiac side effects. The study found that taking trastuzumab for 6 months was non-inferior to the current standard of 12 months.
A new Swansea University study finds that using anonymised routinely collected electronic health records can help track trial participants over long-term periods, providing more complete results. The use of these records reduces volunteer bias, increases reliability, and provides new insights into population health.
Researchers have developed new treatment regimens that significantly boost survival rates for children and young adults with rare forms of leukemia and lymphoma, such as T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL). The trial showed that 90% of patients lived at least four years after starting tre...
A clinical trial at the University of Chicago Medical Center found that a comprehensive care physician model reduced hospitalization rates by 15-22% and improved patient satisfaction. The model, which involves a single doctor providing care in both clinic and hospital settings, was preferred by patients and economically beneficial.
A new study published in The New England Journal of Medicine found that combining clopidogrel and aspirin reduces the risk of major stroke within 90 days after a minor stroke or transient ischemic attack (TIA) by 25%. However, this combination also increases the risk of bleeding complications.
A study published in The BMJ found that a moderate to high intensity exercise program improved physical fitness in individuals with mild to moderate dementia. However, the program did not slow cognitive decline or improve daily activities. Researchers suggest exploring other forms of exercise and considering potential negative effects ...
Researchers at Ohio State University Wexner Medical Center have developed a new, non-invasive approach to reshape the nasal tissue and improve airflow. The Vivaer Nasal Airway Remodeling device uses radiofrequency energy to treat nasal obstruction, a condition that affects millions of Americans.
A daily tablet has been shown to significantly reduce the risk of blood clots in cancer patients, with a lower rate of recurrence compared to traditional anticoagulant treatment. The study also found increased bleeding risks with the oral drug rivaroxaban.
A randomized clinical trial found that students who received eyeglasses earlier in the school year outperformed those who got them later, leading to improved math scores. The study highlighted the importance of access to vision care services for children with poor vision in rural China.
Researchers found that hands-on instruction and retention testing are critical to proper bleeding control. In-person training resulted in an 88% correct tourniquet application rate, compared to 16% for those with no training.
A recent study published in The BMJ found that vertebroplasty, a surgical procedure to repair spinal fractures, does not provide significant pain relief for patients with osteoporosis. The trial involved 180 adults and showed no difference in pain scores between those who received vertebroplasty and those who underwent a sham procedure.
A Phase 2 clinical trial has started in the US to test an experimental universal influenza vaccine, M-001, for its safety and ability to produce broad protective immune responses. The trial aims to provide durable protection against multiple influenza strains, including those that might cause a pandemic.
A new University of Guelph study found that intense exercise is a major cause of death in racehorses, with thoroughbreds facing the highest risk. The study analyzed data from over 1,700 cases and found that musculoskeletal injuries were the leading cause of mortality.
A trial found that emollient bath additives provide no meaningful benefit when used in addition to standard eczema care in children. The study included 482 children and found no statistically significant difference in eczema control between the two groups. This may help guide decisions around effective prescribing in this area.
Researchers are testing a neurostimulation technique using a vagus nerve stimulator to boost motor recovery in stroke patients with poor arm function. The study has shown promising results, with approximately 85% of participants benefiting from the treatment.
A recent study found that many academic institutions in the US are unprepared to comply with stricter requirements for clinical trial registration and reporting. The institutions face challenges in allocating staff time and resources to meet these new regulations. As a result, some organizations have not implemented policies to punish ...
A contemporary real-world analysis of culprit vessel-only intervention (CVI) versus multivessel intervention (MVI) in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) found lower mortality rates for CVI. The study, presented at the Society for Cardiovascular Angiography and Interventions 2018 Scientific Sessio...
The Preserve clinical trial has revealed significant benefits of oral acetylcysteine and sodium bicarbonate in reducing cardiovascular complications. Researchers analyzed data from a large cohort of high-risk patients who underwent PCI, demonstrating the efficacy of this treatment approach.
The PERSPECTIVE trial presents a comprehensive review of the safety, efficacy, and durability of Zotarolimus-Eluting Stents in treating chronic total occlusion. Treatment with second-generation drug-eluting stents resulted in lower occurrence of adverse events compared to previous DES trials.
The Society for Cardiovascular Angiography and Interventions (SCAI) has released new guidelines for selecting specific categories of devices in endovascular therapy. The guidelines provide device-focused recommendations based on a review of comparative effectiveness data, including safety and efficacy of femoral-popliteal devices.
Treating leg ulcers within two weeks improves healing rates by 12% compared to standard treatment, with a success rate of 85.6%. Early intervention helps patients recover quicker and reduces the risk of complications such as amputation.
Researchers at UTHealth will investigate a stem cell therapy using MultiStem in severely injured trauma patients to prevent post-injury organ failure and improve recovery rates. The Phase 2 clinical trial aims to enroll approximately 150 patients and is subject to FDA review and approval.
A study found that elderly patients with locally advanced lung cancer who received simultaneous radiotherapy and chemotherapy had worse survival rates compared to younger patients. In contrast, those treated with sequential chemo-radiotherapy or radiotherapy alone had similar survival rates.
The USPSTF recommends exercise interventions to prevent falls in adults 65 years and older, with moderate evidence supporting this approach. Multi-factorial interventions targeting balance, gait, vision, medication use, and other risk factors are also recommended.
Two cluster-randomized trials in Africa found that conditional day 3 follow-up for children with uncomplicated fever is non-inferior to universal follow-up, allowing caregivers to return only when symptoms persist. The studies suggest that current WHO guidance may be reconsidered and could lead to more efficient use of resources.
A randomized clinical trial found that a program combining education and exercise training reduced pain and improved thoughts of pain compared to usual care. The treatment targets fear of movement and pain catastrophizing, common problems with chronic spinal pain.
The phase III ALEX trial showed that alectinib improved progression-free survival and prolonged time to CNS progression compared to crizotinib. Patients treated with alectinib also experienced longer symptom improvement in terms of health-related quality of life and lung cancer-related symptoms.
Houston Methodist is leading an international research effort for spinocerebellar ataxia (SCA), a rare inherited neurodegenerative disorder. The $6 million, five-year study aims to bring promising investigational therapies to patients with SCA1 and SCA3.
A recent study published in Annals of Family Medicine found that interventions to decrease cardiovascular disease are not one-size-fits-all. Community-based approaches, such as the Boot Camp Translation method, can elicit unique contextual messages and materials that may be more effective for specific primary care practices.
A recent study has found that treating an infected hip replacement in a single stage procedure may be as effective or better than the widely used two-stage procedure. The one-stage revision strategy is shown to have advantages for patients, including shorter hospital stays and reduced functional impairment. However, further research is...
A team of researchers at UCSB has developed a retinal implant to replace support cells damaged by dry AMD. The phase 1/2A trial showed improvement in one patient's vision while maintaining the condition of others.
A randomized clinical trial found that higher protein intake did not increase lean body mass, muscle performance, or physical function in older men. The results suggest that the recommended daily allowance for protein may be sufficient for promoting muscle growth and well-being in this population.
New results from IMPORT LOW trial show women treated with partial or reduced breast radiotherapy report fewer side-effects, including less change in breast appearance. The study found that over half of patients did not experience moderate or marked side-effects at any point.
Women with small, low-grade tumors and a genetic profile at low risk of metastasis have only a 1.4% chance of locoregional recurrence within five years. Breast conservation surgery is as effective as mastectomy in reducing the risk of recurrence.
Researchers at the University of Maryland School of Medicine are conducting trials to test the safety and efficacy of an H7N9 influenza vaccine. The vaccine, developed by Sanofi Pasteur, will be evaluated in healthy volunteers and elderly adults, with different dosages and adjuvant combinations tested.
A new analysis has found that the PIVOT study's patient population was not representative of real-world patients, with those in the trial being older and sicker. This raises significant questions about the validity of the study's findings and potential treatment recommendations.
A clinical trial found that HRD-positive triple negative breast cancer patients respond well to standard AC chemotherapy, with better disease-free survival rates. The study used preserved tissue samples from nearly two decades ago and demonstrated the value of banking tissue for future research.
A new study casts doubt on the use of ketamine nasal sprays for treating severe depression. The pilot trial found that the dosage of ketamine through an intranasal device can vary greatly between individuals and within a day, leading to unpredictable side effects such as high blood pressure and psychotic-like symptoms.
Two new clinical trials are enrolling volunteers to test an experimental H7N9 influenza vaccine candidate in the US. The Phase 2 studies will evaluate different dosages and vaccination schedules of the inactivated vaccine, as well as an adjuvant to boost immune responses.
A Delphi Panel established 17 core outcomes for multimorbidity research, including health-related quality of life, mental health outcomes, and mortality. Researchers suggest considering a full range of outcomes based on study aims and interventions.
The MOMENTUM 3 clinical trial found that advanced heart-failure patients who received a centrifugal-flow circulatory pump had significantly lower rates of pump-related blood clots and stroke compared to those receiving an axial flow pump. Patients who received the centrifugal-flow pump also had fewer re-operations due to device malfunc...
Patients with advanced heart failure who received a novel heart pump experienced no malfunctions requiring replacement, and their risk of stroke was halved compared to those who received the established version. The new device uses fully magnetic levitation technology to push blood through the device and into the aorta.
A study found that 16.2% of dual-registered clinical trials had discrepant completion statuses, with 33.9% listed as 'completed' on ClinicalTrials.gov despite being 'ongoing' on EUCTR. This discrepancy may affect publication bias and systematic reviews.
A recent trial found that a one-off PSA test does not save lives in asymptomatic men, highlighting the need for more accurate ways to diagnose aggressive prostate cancers. The study of over 400,000 men aged 50-69 showed no significant difference in mortality rates between those who were screened and those who were not.
A single PSA test increased detection of low-risk prostate cancer, but made no significant difference in prostate cancer deaths after 10 years. This study suggests that current policy against prostate cancer screening may be justified, as potential benefits are outweighed by harms from overdetection and overtreatment.
Research at the TAT International Congress 2018 found that patients participate in phase 1 clinical trials for access to innovative cancer treatments, including targeted therapies and immunotherapy. The studies suggest that this increased participation is driven by a growing awareness of treatment options beyond traditional chemotherapy.
The Alzheimer Prevention Trials Webstudy allows people 50+ to monitor cognitive health and join clinical trials aimed at preventing dementia. The free online platform addresses the major obstacle of delayed enrollment in Alzheimer's treatments.
The National Institute of Allergy and Infectious Diseases is supporting clinical trials testing monoclonal antibodies as preventive therapies for antibiotic-resistant infections. The trials aim to prevent pneumonia caused by Pseudomonas aeruginosa and Staphylococcus aureus, two bacteria posing a significant threat to human health.
A new study published in Mayo Clinic Proceedings found that up to 37 percent of studies on clinical trials show grossly exaggerated early results. The researchers emphasized the need for physicians and patients to be cautious when considering new or early trial evidence, as it may not accurately reflect real-world outcomes.
A new e-Health platform has been developed to support healthy aging and prevent cardiovascular disease and dementia in the elderly. The HATICE trial involves over 2,500 participants aged 65 or older and aims to reduce risk factors through lifestyle changes and interactive guidance.