Articles tagged with Clinical Trials
A clinical trial testing an experimental RSV vaccine is underway at Cincinnati Children's Hospital Medical Center. The study aims to examine the safety and immune response of the vaccine, with the goal of protecting vulnerable populations such as infants, young children, and older adults from severe illness.
A new study by University of Warwick found that high-tech negative pressure wound therapy devices do not improve patient recovery or reduce healthcare costs compared to standard dressings. The research suggests that the use of these devices may need to be re-evaluated in light of the findings.
A study led by CNIO researchers shows that silibinin reduces brain metastasis lesions in mice and patients, targeting the tumor microenvironment. The treatment has shown encouraging results, with 75% of patients reacting positively and a 15.5-month average survival rate
The EVIDENT II trial found that using a healthy lifestyle smartphone app improved arterial hardness, indicating delayed ageing and lower risk of atherosclerosis. The app group showed better results in modifying their diet composition, with higher carbohydrate intake and lower fat content.
Studies show that mobile health technology can lower cardiovascular disease risk scores and improve individual components of the risk score, such as systolic blood pressure, total cholesterol, and waist-to-hip ratio. However, more research is needed to fully understand its effectiveness in modifying objective measures of health.
A study by CHOP researchers found that patients with mitochondrial disease prefer self-administered treatments, daily treatment, and guaranteed access. However, they are less likely to participate if they need to discontinue their current medications or undergo invasive procedures.
A recent study found that most clinical trial participants are willing to share their personal data with pharmaceutical companies, believing the benefits of data sharing outweigh the risks. Despite concerns about privacy and potential harm, nearly 80% of respondents felt the benefits of data sharing were more important.
Clinical Trials in a Dish (CTiD) offers a novel strategy to test drugs on patient cells before moving into actual clinical trials. CTiD studies have opened up new avenues for screening cell-based safety and toxicity at the population level, enabling efficient testing with reduced costs.
Researchers at UCLA have developed a personalized glioblastoma vaccine that shows promise in increasing long-term survival. The vaccine, known as DCVax-L, has been shown to extend median survival time from 15-17 months to 23.1 months.
A randomized clinical trial found that increased supervision by attending physicians did not significantly reduce the rate of medical errors. However, residents reported a decrease in autonomy during rounds. The study suggests that residency training programs should balance patient safety with resident learning and autonomy.
A first-in-human phase I clinical trial using neural stem cells to treat chronic spinal cord injuries showed measurable improvement in three of four participants. No serious adverse effects were observed, suggesting the approach can be performed safely.
A new clinical trial is testing whether omega-3 capsules can stop bowel cancer from returning after liver surgery. The trial, funded by Yorkshire Cancer Research, involves 450 patients and investigates the effectiveness of a highly purified form of EPA.
The NCI-MATCH trial has released findings from three treatment arms, offering hope for targeted therapies in patients with specific gene abnormalities. The trial's results could aid in identifying effective treatments for various cancers, paving the way for future research.
A 16-week study found that combining recreational football training with dietary guidance significantly improves physical fitness, reduces blood pressure, and promotes healthier weight loss. This innovative intervention demonstrates the potential for exercise and diet to prevent type 2 diabetes in middle-aged and elderly individuals.
The American College of Physicians (ACP) has released a position paper calling for policies that better support women's health, including paid family and medical leave, reduced domestic violence, and access to reproductive services. A new prediction tool may also help tailor lung cancer screening to patient benefit and preferences.
Researchers at Nemours Children's Health System developed a novel video-based informed consent process to improve participants' understanding and retention of trial information. The study found that caregivers of children who watched the video presentation retained more information about the study design five months later.
A lower-fat diet was linked to increased breast cancer overall survival among postmenopausal women, although the increase may be partly due to better survival from other causes. The study found modest increases in vegetable, fruit, and grain intake in the lower-fat group.
A novel index of coronary artery stenosis severity called resting full-cycle ratio (RFR) has been found to be diagnostically equivalent to instantaneous wave-free ratio (iFR). The study, presented at EuroPCR, suggests RFR could identify pressure-based stenosis severity independent of timing within the cardiac cycle.
A Phase 1 clinical trial is evaluating the safety and tolerability of mAb114, a single monoclonal antibody developed from an Ebola survivor. The trial aims to enroll 18-30 healthy volunteers and will not expose participants to Ebola virus.
A randomized trial found that a team approach involving intensive emotional support and frequent family meetings improved patient-centered care in ICUs, reducing hospitalization costs by 28% and lengths of stay by over three days.
The Zephyr Endobronchial Valve successfully reduced shortness of breath and improved lung function in patients with severe emphysema, with benefits lasting at least one year after treatment. Proper patient selection was key to the trial's success.
A randomized clinical trial found that sustained vitamin D supplementation reduced the likelihood of recurrent wheezing in preterm black infants by 12 months' adjusted age. The study involved 300 black infants born between 28-36 weeks and compared two vitamin D supplementation strategies.
Evolocumab treatment has been shown to effectively reduce lipoprotein(a) levels and decrease the risk of cardiovascular events. Patients with higher baseline lipoprotein(a) levels derived greater absolute benefit from evolocumab treatment, with a 24% decrease in risk of heart attack, stroke, or cardiovascular death.
A new clinical trial is underway to test two human monoclonal antibodies designed to treat MERS-CoV infection. The study will enroll 48 healthy adults and administer escalating doses of the experimental antibodies.
A clinical trial found that chiropractic care, when added to usual medical care, resulted in moderate improvements in pain intensity and disability for US military personnel with low back pain. The study suggests a potential cost-effective and low-risk treatment option for this common condition.
A new trial shows that a shorter length of trastuzumab treatment can benefit patients with breast cancer just as much as a longer treatment, with less risk of cardiac side effects. The study found that taking trastuzumab for 6 months was non-inferior to the current standard of 12 months.
A new Swansea University study finds that using anonymised routinely collected electronic health records can help track trial participants over long-term periods, providing more complete results. The use of these records reduces volunteer bias, increases reliability, and provides new insights into population health.
Researchers have developed new treatment regimens that significantly boost survival rates for children and young adults with rare forms of leukemia and lymphoma, such as T-cell acute lymphoblastic leukemia (T-ALL) or T-cell lymphoblastic lymphoma (T-LL). The trial showed that 90% of patients lived at least four years after starting tre...
A clinical trial at the University of Chicago Medical Center found that a comprehensive care physician model reduced hospitalization rates by 15-22% and improved patient satisfaction. The model, which involves a single doctor providing care in both clinic and hospital settings, was preferred by patients and economically beneficial.
A new study published in The New England Journal of Medicine found that combining clopidogrel and aspirin reduces the risk of major stroke within 90 days after a minor stroke or transient ischemic attack (TIA) by 25%. However, this combination also increases the risk of bleeding complications.
A study published in The BMJ found that a moderate to high intensity exercise program improved physical fitness in individuals with mild to moderate dementia. However, the program did not slow cognitive decline or improve daily activities. Researchers suggest exploring other forms of exercise and considering potential negative effects ...
Researchers at Ohio State University Wexner Medical Center have developed a new, non-invasive approach to reshape the nasal tissue and improve airflow. The Vivaer Nasal Airway Remodeling device uses radiofrequency energy to treat nasal obstruction, a condition that affects millions of Americans.
A daily tablet has been shown to significantly reduce the risk of blood clots in cancer patients, with a lower rate of recurrence compared to traditional anticoagulant treatment. The study also found increased bleeding risks with the oral drug rivaroxaban.
A randomized clinical trial found that students who received eyeglasses earlier in the school year outperformed those who got them later, leading to improved math scores. The study highlighted the importance of access to vision care services for children with poor vision in rural China.
Researchers found that hands-on instruction and retention testing are critical to proper bleeding control. In-person training resulted in an 88% correct tourniquet application rate, compared to 16% for those with no training.
A recent study published in The BMJ found that vertebroplasty, a surgical procedure to repair spinal fractures, does not provide significant pain relief for patients with osteoporosis. The trial involved 180 adults and showed no difference in pain scores between those who received vertebroplasty and those who underwent a sham procedure.
A Phase 2 clinical trial has started in the US to test an experimental universal influenza vaccine, M-001, for its safety and ability to produce broad protective immune responses. The trial aims to provide durable protection against multiple influenza strains, including those that might cause a pandemic.
A new University of Guelph study found that intense exercise is a major cause of death in racehorses, with thoroughbreds facing the highest risk. The study analyzed data from over 1,700 cases and found that musculoskeletal injuries were the leading cause of mortality.
A trial found that emollient bath additives provide no meaningful benefit when used in addition to standard eczema care in children. The study included 482 children and found no statistically significant difference in eczema control between the two groups. This may help guide decisions around effective prescribing in this area.
Researchers are testing a neurostimulation technique using a vagus nerve stimulator to boost motor recovery in stroke patients with poor arm function. The study has shown promising results, with approximately 85% of participants benefiting from the treatment.
A recent study found that many academic institutions in the US are unprepared to comply with stricter requirements for clinical trial registration and reporting. The institutions face challenges in allocating staff time and resources to meet these new regulations. As a result, some organizations have not implemented policies to punish ...
A contemporary real-world analysis of culprit vessel-only intervention (CVI) versus multivessel intervention (MVI) in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS) found lower mortality rates for CVI. The study, presented at the Society for Cardiovascular Angiography and Interventions 2018 Scientific Sessio...
The Preserve clinical trial has revealed significant benefits of oral acetylcysteine and sodium bicarbonate in reducing cardiovascular complications. Researchers analyzed data from a large cohort of high-risk patients who underwent PCI, demonstrating the efficacy of this treatment approach.
The PERSPECTIVE trial presents a comprehensive review of the safety, efficacy, and durability of Zotarolimus-Eluting Stents in treating chronic total occlusion. Treatment with second-generation drug-eluting stents resulted in lower occurrence of adverse events compared to previous DES trials.
The Society for Cardiovascular Angiography and Interventions (SCAI) has released new guidelines for selecting specific categories of devices in endovascular therapy. The guidelines provide device-focused recommendations based on a review of comparative effectiveness data, including safety and efficacy of femoral-popliteal devices.
Treating leg ulcers within two weeks improves healing rates by 12% compared to standard treatment, with a success rate of 85.6%. Early intervention helps patients recover quicker and reduces the risk of complications such as amputation.
Researchers at UTHealth will investigate a stem cell therapy using MultiStem in severely injured trauma patients to prevent post-injury organ failure and improve recovery rates. The Phase 2 clinical trial aims to enroll approximately 150 patients and is subject to FDA review and approval.
A study found that elderly patients with locally advanced lung cancer who received simultaneous radiotherapy and chemotherapy had worse survival rates compared to younger patients. In contrast, those treated with sequential chemo-radiotherapy or radiotherapy alone had similar survival rates.
The USPSTF recommends exercise interventions to prevent falls in adults 65 years and older, with moderate evidence supporting this approach. Multi-factorial interventions targeting balance, gait, vision, medication use, and other risk factors are also recommended.
Two cluster-randomized trials in Africa found that conditional day 3 follow-up for children with uncomplicated fever is non-inferior to universal follow-up, allowing caregivers to return only when symptoms persist. The studies suggest that current WHO guidance may be reconsidered and could lead to more efficient use of resources.
A randomized clinical trial found that a program combining education and exercise training reduced pain and improved thoughts of pain compared to usual care. The treatment targets fear of movement and pain catastrophizing, common problems with chronic spinal pain.
The phase III ALEX trial showed that alectinib improved progression-free survival and prolonged time to CNS progression compared to crizotinib. Patients treated with alectinib also experienced longer symptom improvement in terms of health-related quality of life and lung cancer-related symptoms.
Houston Methodist is leading an international research effort for spinocerebellar ataxia (SCA), a rare inherited neurodegenerative disorder. The $6 million, five-year study aims to bring promising investigational therapies to patients with SCA1 and SCA3.
A recent study published in Annals of Family Medicine found that interventions to decrease cardiovascular disease are not one-size-fits-all. Community-based approaches, such as the Boot Camp Translation method, can elicit unique contextual messages and materials that may be more effective for specific primary care practices.
A recent study has found that treating an infected hip replacement in a single stage procedure may be as effective or better than the widely used two-stage procedure. The one-stage revision strategy is shown to have advantages for patients, including shorter hospital stays and reduced functional impairment. However, further research is...
A team of researchers at UCSB has developed a retinal implant to replace support cells damaged by dry AMD. The phase 1/2A trial showed improvement in one patient's vision while maintaining the condition of others.
A randomized clinical trial found that higher protein intake did not increase lean body mass, muscle performance, or physical function in older men. The results suggest that the recommended daily allowance for protein may be sufficient for promoting muscle growth and well-being in this population.
New results from IMPORT LOW trial show women treated with partial or reduced breast radiotherapy report fewer side-effects, including less change in breast appearance. The study found that over half of patients did not experience moderate or marked side-effects at any point.
Women with small, low-grade tumors and a genetic profile at low risk of metastasis have only a 1.4% chance of locoregional recurrence within five years. Breast conservation surgery is as effective as mastectomy in reducing the risk of recurrence.
Researchers at the University of Maryland School of Medicine are conducting trials to test the safety and efficacy of an H7N9 influenza vaccine. The vaccine, developed by Sanofi Pasteur, will be evaluated in healthy volunteers and elderly adults, with different dosages and adjuvant combinations tested.